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    SEC31A SEC31 homolog A, COPII coat complex component [ Homo sapiens (human) ]

    Gene ID: 22872, updated on 1-Mar-2024

    Summary

    Official Symbol
    SEC31Aprovided by HGNC
    Official Full Name
    SEC31 homolog A, COPII coat complex componentprovided by HGNC
    Primary source
    HGNC:HGNC:17052
    See related
    Ensembl:ENSG00000138674 MIM:610257; AllianceGenome:HGNC:17052
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HPBKS; ABP125; ABP130; HSPC275; HSPC334; NEDSOSB; SEC31L1
    Summary
    The protein encoded by this gene shares similarity with the yeast Sec31 protein, and is a component of the outer layer of the coat protein complex II (COPII). The encoded protein is involved in vesicle budding from the endoplasmic reticulum (ER) and contains multiple WD repeats near the N-terminus and a proline-rich region in the C-terminal half. It associates with the protein encoded by the SEC13 homolog, nuclear pore and COPII coat complex component (SEC13), and is required for ER-Golgi transport. Monoubiquitylation of this protein by CUL3-KLHL12 was found to regulate the size of COPII coats to accommodate unusually shaped cargo. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
    Expression
    Ubiquitous expression in ovary (RPKM 48.8), thyroid (RPKM 42.6) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SEC31A in Genome Data Viewer
    Location:
    4q21.22
    Exon count:
    33
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 4 NC_000004.12 (82818509..82900569, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 4 NC_060928.1 (86147772..86229788, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 4 NC_000004.11 (83739662..83821722, complement)

    Chromosome 4 - NC_000004.12Genomic Context describing neighboring genes Neighboring gene stearoyl-CoA desaturase 5 Neighboring gene uncharacterized LOC124900727 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15533 Neighboring gene microRNA 575 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr4:83718175-83718696 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 15534 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:83719673-83720390 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr4:83720391-83721107 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:83821333-83821852 Neighboring gene H3K27ac hESC enhancer GRCh37_chr4:83821853-83822372 Neighboring gene THAP9 antisense RNA 1 Neighboring gene small nucleolar RNA, C/D box 143 Neighboring gene small nucleolar RNA, C/D box 144 Neighboring gene THAP domain containing 9 Neighboring gene lin-54 DREAM MuvB core complex component Neighboring gene ReSE screen-validated silencer GRCh37_chr4:83887737-83887940 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21666 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 21667 Neighboring gene RNA, U6 small nuclear 615, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120/MBL complex co-localizes with intracellular COPII vesicle markers Sec31A and Sec13 in neuronal cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough SEC31A

    Included gene: THAP9-AS1

    Clone Names

    • KIAA0905, MGC90305, DKFZp686N07171

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables calcium-dependent protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables structural molecule activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in COPII-coated vesicle cargo loading IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in COPII-coated vesicle cargo loading IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in endoplasmic reticulum organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in intracellular protein transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to calcium ion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of COPII vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of COPII vesicle coat IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of COPII vesicle coat NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in COPII-coated ER to Golgi transport vesicle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ER to Golgi transport vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum exit site IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum exit site IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of vesicle coat IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein transport protein Sec31A
    Names
    SEC31 homolog A, COPII coating complex component
    SEC31-like protein 1
    SEC31-related protein A
    web1-like protein
    yeast Sec31p homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029569.3 RefSeqGene

      Range
      14419..87063
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001077206.4NP_001070674.1  protein transport protein Sec31A isoform 4

      See identical proteins and their annotated locations for NP_001070674.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate in-frame exon in the 3' coding region, compared to variant 5. The encoded isoform (4) has the same N- and C-termini, but is shorter and has a different internal amino acid compared to isoform 1.
      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS43244.1
      UniProtKB/Swiss-Prot
      O94979
      Related
      ENSP00000309070.7, ENST00000311785.11
      Conserved Domains (4) summary
      COG2319
      Location:31353
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1365
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:84340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:573696
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    2. NM_001077207.4NP_001070675.1  protein transport protein Sec31A isoform 1

      See identical proteins and their annotated locations for NP_001070675.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) encodes the longest isoform (1). Both variants 5 and 10 encode the same protein.
      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS3596.1
      UniProtKB/Swiss-Prot
      B4DIW6, B7ZKZ7, B7ZL00, H7C2W3, O94979, Q17RR5, Q5H9P6, Q5XG74, Q659G7, Q6ZU90, Q7LCX9, Q86TJ0, Q8IZH4, Q9P048, Q9P0A6, Q9UM05, Q9UM06
      Related
      ENSP00000378721.2, ENST00000395310.7
      Conserved Domains (4) summary
      COG2319
      Location:31353
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1365
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:84340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:573696
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    3. NM_001077208.4NP_001070676.1  protein transport protein Sec31A isoform 3

      See identical proteins and their annotated locations for NP_001070676.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the 3' coding region, compared to variant 5. The encoded isoform (3) has the same N- and C-termini, but is shorter than isoform 1. Both variants 3 and 9 encode the same isoform (3).
      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS47088.1
      UniProtKB/Swiss-Prot
      O94979
      Related
      ENSP00000424635.1, ENST00000508502.5
      Conserved Domains (4) summary
      COG2319
      Location:31353
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1365
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:84340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:573696
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    4. NM_001191049.2NP_001177978.1  protein transport protein Sec31A isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an exon in the 5' region, resulting in a distinct 5' UTR , use of an upstream in-frame start codon, and also uses an alternate in-frame splice site in the 3' coding region, compared to variant 5. The encoded isoform (5) is shorter, has a distinct N-terminus, and lacks an internal region, compared to isoform 1
      Source sequence(s)
      AI802473, AK295810, BC039834, BE710081, DA218900, DC342364
      Consensus CDS
      CCDS54773.1
      UniProtKB/Swiss-Prot
      O94979
      Related
      ENSP00000408027.2, ENST00000443462.6
      Conserved Domains (4) summary
      COG2319
      Location:26348
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:65114
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:79335
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:568691
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    5. NM_001300744.3NP_001287673.1  protein transport protein Sec31A isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) lacks two consecutive alternate in-frame exons in the central coding region and an alternate in-frame exon in the 3' coding region, compared to variant 5. The encoded isoform (6) has the same N- and C-termini, but is shorter and has an alternate internal amino acid compared to isoform 1.
      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS75155.1
      UniProtKB/Swiss-Prot
      O94979
      Related
      ENSP00000426886.1, ENST00000513858.5
      Conserved Domains (4) summary
      COG2319
      Location:31353
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1365
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:84340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:534657
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    6. NM_001300745.3NP_001287674.1  protein transport protein Sec31A isoform 7

      See identical proteins and their annotated locations for NP_001287674.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks two consecutive alternate in-frame exons in the central coding region and uses an alternate in-frame splice site in the 3' coding region, compared to variant 5. The encoded isoform (7) has the same N- and C-termini, but is shorter than isoform 1.
      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS75156.1
      UniProtKB/Swiss-Prot
      O94979
      Related
      ENSP00000424451.1, ENST00000505984.5
      Conserved Domains (4) summary
      COG2319
      Location:31353
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1365
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:84340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:534657
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    7. NM_001318119.2NP_001305048.1  protein transport protein Sec31A isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks 3 nucleotides in its 5' UTR and uses an alternate in-frame splice site in the 3' coding region, compared to variant 5. The encoded isoform (3) has the same N- and C-termini, but is shorter than isoform 1. Both variants 3 and 9 encode the same isoform (3).
      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS47088.1
      UniProtKB/Swiss-Prot
      O94979
      Conserved Domains (4) summary
      COG2319
      Location:31353
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1365
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:84340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:573696
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    8. NM_001318120.2NP_001305049.1  protein transport protein Sec31A isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) differs in the 5' UTR compared to variant 5. Both variants 5 and 10 encode the same protein (isoform 1). This variant is a read-through transcript between the upstream non-coding THAP9-AS1 locus (GeneID:100499177) and the downstream SEC31A locus (GeneID:22872).
      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS3596.1
      UniProtKB/Swiss-Prot
      B4DIW6, B7ZKZ7, B7ZL00, H7C2W3, O94979, Q17RR5, Q5H9P6, Q5XG74, Q659G7, Q6ZU90, Q7LCX9, Q86TJ0, Q8IZH4, Q9P048, Q9P0A6, Q9UM05, Q9UM06
      Related
      ENSP00000347329.2, ENST00000355196.6
      Conserved Domains (4) summary
      COG2319
      Location:31353
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1365
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:84340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:573696
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16
    9. NM_001400154.1NP_001387083.1  protein transport protein Sec31A isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS93555.1
      UniProtKB/TrEMBL
      D6REX3
    10. NM_001400155.1NP_001387084.1  protein transport protein Sec31A isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS93555.1
      UniProtKB/TrEMBL
      D6REX3
      Related
      ENSP00000421633.1, ENST00000505472.5
    11. NM_001400156.1NP_001387085.1  protein transport protein Sec31A isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
    12. NM_001400157.1NP_001387086.1  protein transport protein Sec31A isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
    13. NM_001400158.1NP_001387087.1  protein transport protein Sec31A isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
    14. NM_001400159.1NP_001387088.1  protein transport protein Sec31A isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
    15. NM_001400160.1NP_001387089.1  protein transport protein Sec31A isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
    16. NM_001400161.1NP_001387090.1  protein transport protein Sec31A isoform 32

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
    17. NM_001400162.1NP_001387091.1  protein transport protein Sec31A isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
    18. NM_001400164.1NP_001387093.1  protein transport protein Sec31A isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS3596.1
      UniProtKB/Swiss-Prot
      B4DIW6, B7ZKZ7, B7ZL00, H7C2W3, O94979, Q17RR5, Q5H9P6, Q5XG74, Q659G7, Q6ZU90, Q7LCX9, Q86TJ0, Q8IZH4, Q9P048, Q9P0A6, Q9UM05, Q9UM06
      Related
      ENSP00000400926.1, ENST00000448323.5
    19. NM_001400165.1NP_001387094.1  protein transport protein Sec31A isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
    20. NM_001400166.1NP_001387095.1  protein transport protein Sec31A isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS3596.1
      UniProtKB/Swiss-Prot
      B4DIW6, B7ZKZ7, B7ZL00, H7C2W3, O94979, Q17RR5, Q5H9P6, Q5XG74, Q659G7, Q6ZU90, Q7LCX9, Q86TJ0, Q8IZH4, Q9P048, Q9P0A6, Q9UM05, Q9UM06
    21. NM_001400167.1NP_001387096.1  protein transport protein Sec31A isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
    22. NM_001400168.1NP_001387097.1  protein transport protein Sec31A isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
    23. NM_001400180.1NP_001387109.1  protein transport protein Sec31A isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
    24. NM_001400184.1NP_001387113.1  protein transport protein Sec31A isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
    25. NM_001400186.1NP_001387115.1  protein transport protein Sec31A isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
    26. NM_001400188.1NP_001387117.1  protein transport protein Sec31A isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
    27. NM_001400190.1NP_001387119.1  protein transport protein Sec31A isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS47088.1
    28. NM_001400191.1NP_001387120.1  protein transport protein Sec31A isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS47088.1
    29. NM_001400193.1NP_001387122.1  protein transport protein Sec31A isoform 3

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS47088.1
    30. NM_001400194.1NP_001387123.1  protein transport protein Sec31A isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
    31. NM_001400197.1NP_001387126.1  protein transport protein Sec31A isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
    32. NM_001400198.1NP_001387127.1  protein transport protein Sec31A isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
    33. NM_001400200.1NP_001387129.1  protein transport protein Sec31A isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
    34. NM_001400202.1NP_001387131.1  protein transport protein Sec31A isoform 20

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
    35. NM_001400203.1NP_001387132.1  protein transport protein Sec31A isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
    36. NM_001400204.1NP_001387133.1  protein transport protein Sec31A isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
    37. NM_001400205.1NP_001387134.1  protein transport protein Sec31A isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
    38. NM_001400206.1NP_001387135.1  protein transport protein Sec31A isoform 21

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
    39. NM_001400207.1NP_001387136.1  protein transport protein Sec31A isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS3597.1
    40. NM_001400208.1NP_001387137.1  protein transport protein Sec31A isoform 22

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
    41. NM_001400209.1NP_001387138.1  protein transport protein Sec31A isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS3597.1
    42. NM_001400210.1NP_001387139.1  protein transport protein Sec31A isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
    43. NM_001400211.1NP_001387140.1  protein transport protein Sec31A isoform 23

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
    44. NM_001400212.1NP_001387141.1  protein transport protein Sec31A isoform 24

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
    45. NM_001400213.1NP_001387142.1  protein transport protein Sec31A isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS75156.1
    46. NM_001400214.1NP_001387143.1  protein transport protein Sec31A isoform 25

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
    47. NM_001400215.1NP_001387144.1  protein transport protein Sec31A isoform 26

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      UniProtKB/TrEMBL
      H7BXG7
    48. NM_001400216.1NP_001387145.1  protein transport protein Sec31A isoform 27

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
    49. NM_001400217.1NP_001387146.1  protein transport protein Sec31A isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS43244.1
      Related
      ENSP00000426569.1, ENST00000509142.5
    50. NM_001400218.1NP_001387147.1  protein transport protein Sec31A isoform 28

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
    51. NM_001400219.1NP_001387148.1  protein transport protein Sec31A isoform 29

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      UniProtKB/TrEMBL
      D6RHZ5
    52. NM_001400220.1NP_001387149.1  protein transport protein Sec31A isoform 29

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      UniProtKB/TrEMBL
      D6RHZ5
      Related
      ENSP00000425999.1, ENST00000508479.5
    53. NM_001400221.1NP_001387150.1  protein transport protein Sec31A isoform 30

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      UniProtKB/TrEMBL
      A0A1S5UZ19
    54. NM_001400222.1NP_001387151.1  protein transport protein Sec31A isoform 30

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      UniProtKB/TrEMBL
      A0A1S5UZ19
    55. NM_001400223.1NP_001387152.1  protein transport protein Sec31A isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS75155.1
      Related
      ENSP00000421464.1, ENST00000500777.6
    56. NM_001400224.1NP_001387153.1  protein transport protein Sec31A isoform 31

      Status: REVIEWED

      Source sequence(s)
      AC021105, AC108469
      UniProtKB/TrEMBL
      H7BXG7
      Related
      ENSP00000264405.5, ENST00000264405.9
    57. NM_016211.5NP_057295.2  protein transport protein Sec31A isoform 2

      See identical proteins and their annotated locations for NP_057295.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two consecutive alternate in-frame exons in the central coding region, compared to variant 5. The encoded isoform (2) has the same N- and C-termini, but is shorter than isoform 1.
      Source sequence(s)
      AC021105, AC108469
      Consensus CDS
      CCDS3597.1
      Related
      ENSP00000337602.5, ENST00000348405.8
      Conserved Domains (4) summary
      COG2319
      Location:31353
      WD40; WD40 repeat [General function prediction only]
      sd00039
      Location:1365
      7WD40; WD40 repeat [structural motif]
      cl02567
      Location:84340
      WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
      cl14807
      Location:534657
      ACE1-Sec16-like; Ancestral coatomer element 1 (ACE1) of COPII coat complex assembly protein Sec16

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000004.12 Reference GRCh38.p14 Primary Assembly

      Range
      82818509..82900569 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060928.1 Alternate T2T-CHM13v2.0

      Range
      86147772..86229788 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_014933.3: Suppressed sequence

      Description
      NM_014933.3: This RefSeq was removed because currently there is insufficient support for the transcript.