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    GRM7 glutamate metabotropic receptor 7 [ Homo sapiens (human) ]

    Gene ID: 2917, updated on 1-Mar-2024

    Summary

    Official Symbol
    GRM7provided by HGNC
    Official Full Name
    glutamate metabotropic receptor 7provided by HGNC
    Primary source
    HGNC:HGNC:4599
    See related
    Ensembl:ENSG00000196277 MIM:604101; AllianceGenome:HGNC:4599
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    GLUR7; MGLU7; GPRC1G; MGLUR7; NEDSHBA; PPP1R87
    Summary
    L-glutamate is the major excitatory neurotransmitter in the central nervous system, and it activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors that have been divided into three groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5, and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3, while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GRM7 in Genome Data Viewer
    Location:
    3p26.1
    Exon count:
    15
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (6861115..7741533)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (6851699..7732437)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (6902802..7783220)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene GRM7 antisense RNA 3 Neighboring gene uncharacterized LOC105376943 Neighboring gene uncharacterized LOC105376945 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:6902925-6903916 Neighboring gene ReSE screen-validated silencer GRCh37_chr3:6962116-6962317 Neighboring gene GRM7 antisense RNA 2 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_71090 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_71094 Neighboring gene GRM7 antisense RNA 1 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:7724316-7724883 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:7742164-7742714 Neighboring gene H3K27ac hESC enhancer GRCh37_chr3:7829630-7830380 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:7830381-7831129 Neighboring gene uncharacterized LOC124909342 Neighboring gene NANOG hESC enhancer GRCh37_chr3:7957473-7958144 Neighboring gene uncharacterized LOC101927394

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Neurodevelopmental disorder with seizures, hypotonia, and brain imaging abnormalities
    MedGen: C5394517 OMIM: 618922 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    A genome-wide scan for breast cancer risk haplotypes among African American women.
    EBI GWAS Catalog
    Genome wide study of maternal and parent-of-origin effects on the etiology of orofacial clefts.
    EBI GWAS Catalog
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog
    Genome-wide association study of chemotherapeutic agent-induced severe neutropenia/leucopenia for patients in Biobank Japan.
    EBI GWAS Catalog
    Genome-wide association study of panic disorder in the Japanese population.
    EBI GWAS Catalog
    Genome-wide association study of personality traits in bipolar patients.
    EBI GWAS Catalog
    Novel loci for major depression identified by genome-wide association study of Sequenced Treatment Alternatives to Relieve Depression and meta-analysis of three studies.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat The gene expression of GRM7 is significantly upregulated in both clade B and clade C Tat treated SK-N-MC neuroblastoma cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ40498

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in asymmetric synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell cortex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendrite IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in dendritic shaft ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in postsynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in presynaptic active zone ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    metabotropic glutamate receptor 7
    Names
    glutamate receptor, metabotropic 7
    protein phosphatase 1, regulatory subunit 87

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029781.2 RefSeqGene

      Range
      5002..885420
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000844.4NP_000835.1  metabotropic glutamate receptor 7 isoform a precursor

      See identical proteins and their annotated locations for NP_000835.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1, also known as hmGluR7a) encodes the predominant isoform (a).
      Source sequence(s)
      AB209214, AC077690, AK123326, AK312488, X94552
      Consensus CDS
      CCDS43042.1
      UniProtKB/Swiss-Prot
      Q14831, Q8NFS2, Q8NFS3, Q8NFS4
      UniProtKB/TrEMBL
      B2R693
      Related
      ENSP00000350348.4, ENST00000357716.9
      Conserved Domains (3) summary
      cd15451
      Location:589895
      7tmC_mGluR7; metabotropic glutamate receptor 7 in group 3, member of the class C family of seven-transmembrane G protein-coupled receptors
      cd06376
      Location:43511
      PBP1_mGluR_groupIII; ligand-binding domain of the group III metabotropic glutamate receptor
      pfam07562
      Location:519569
      NCD3G; Nine Cysteines Domain of family 3 GPCR
    2. NM_181874.3NP_870989.1  metabotropic glutamate receptor 7 isoform b precursor

      See identical proteins and their annotated locations for NP_870989.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2, also known as hmGluR7b) differs in the 3' UTR and includes an alternate segment in the 3' coding region, compared to variant 1, which results in a frameshift. The encoded isoform (b) has a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC077690, AK123326, AK312488, BC136459, X94552
      UniProtKB/TrEMBL
      H7C3K2
      Related
      ENSP00000417536.1, ENST00000486284.5
      Conserved Domains (4) summary
      cd06376
      Location:47511
      PBP1_mGluR_groupIII; Ligand-binding domain of the group III metabotropic glutamate receptor
      pfam00003
      Location:602847
      7tm_3; 7 transmembrane sweet-taste receptor of 3 GCPR
      pfam01094
      Location:77484
      ANF_receptor; Receptor family ligand binding region
      pfam07562
      Location:521567
      NCD3G; Nine Cysteines Domain of family 3 GPCR

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      6861115..7741533
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448052.1XP_047304008.1  metabotropic glutamate receptor 7 isoform X1

      UniProtKB/TrEMBL
      H7C3K2
      Related
      ENSP00000419835.1, ENST00000467425.5
    2. XM_047448053.1XP_047304009.1  metabotropic glutamate receptor 7 isoform X2

      UniProtKB/TrEMBL
      H7C3K2
    3. XM_017006272.2XP_016861761.1  metabotropic glutamate receptor 7 isoform X3

      UniProtKB/TrEMBL
      Q59G95
    4. XM_017006273.2XP_016861762.1  metabotropic glutamate receptor 7 isoform X4

      UniProtKB/TrEMBL
      Q59G95
      Related
      ENSP00000516621.1, ENST00000706912.1

    RNA

    1. XR_001740135.3 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      6851699..7732437
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054346378.1XP_054202353.1  metabotropic glutamate receptor 7 isoform X5

      UniProtKB/TrEMBL
      H7C3K2
    2. XM_054346379.1XP_054202354.1  metabotropic glutamate receptor 7 isoform X1

      UniProtKB/TrEMBL
      B9EGG9, H7C3K2
    3. XM_054346380.1XP_054202355.1  metabotropic glutamate receptor 7 isoform X2

      UniProtKB/TrEMBL
      B7ZKK0, H7C3K2
    4. XM_054346381.1XP_054202356.1  metabotropic glutamate receptor 7 isoform X4

      UniProtKB/TrEMBL
      Q59G95
    5. XM_054346383.1XP_054202358.1  metabotropic glutamate receptor 7 isoform X7

    6. XM_054346382.1XP_054202357.1  metabotropic glutamate receptor 7 isoform X6

    RNA

    1. XR_008486710.1 RNA Sequence

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_181875.1: Suppressed sequence

      Description
      NM_181875.1: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.