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    KIF1A kinesin family member 1A [ Homo sapiens (human) ]

    Gene ID: 547, updated on 5-Jul-2024

    Summary

    Official Symbol
    KIF1Aprovided by HGNC
    Official Full Name
    kinesin family member 1Aprovided by HGNC
    Primary source
    HGNC:HGNC:888
    See related
    Ensembl:ENSG00000130294 MIM:601255; AllianceGenome:HGNC:888
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ATSV; MRD9; HSN2C; SPG30; SPG30A; SPG30B; UNC104; C2orf20; NESCAVS
    Summary
    The protein encoded by this gene is a member of the kinesin family and functions as an anterograde motor protein that transports membranous organelles along axonal microtubules. Mutations at this locus have been associated with spastic paraplegia-30 and hereditary sensory neuropathy IIC. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Apr 2012]
    Expression
    Biased expression in brain (RPKM 88.6), adrenal (RPKM 8.2) and 1 other tissue See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See KIF1A in Genome Data Viewer
    Location:
    2q37.3
    Exon count:
    55
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (240713767..240821403, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (241210501..241320366, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (241653184..241760820, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC285191 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241637868-241638651 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:241646918-241647077 Neighboring gene aquaporin 12A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241651331-241652138 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241673162-241673662 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr2:241678910-241680109 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241736458-241736958 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241736959-241737459 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241737588-241738429 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241751150-241751760 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241756052-241756691 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241760048-241760622 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:241771685-241772681 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241778610-241779110 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241807760-241808260 Neighboring gene alanine--glyoxylate aminotransferase Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:241834201-241834836 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:241836109-241836744 Neighboring gene mab-21 like 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    capsid gag The ability of exogenously expressed FEZ1 binding to kinesin-1 to promote early HIV-1 infection, leading to the movement of HIV-1 CA core to the nucleus PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ30229, MGC133285, MGC133286, DKFZp686I2094

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytoskeletal motor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables plus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in anterograde axonal transport TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in anterograde neuronal dense core vesicle transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cytoskeleton-dependent intracellular transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in dense core granule cytoskeletal transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of dendritic spine development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of dendritic spine morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in retrograde neuronal dense core vesicle transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in vesicle-mediated transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in axon IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in dendrite IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuronal dense core vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in neuronal dense core vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in synapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    kinesin-like protein KIF1A
    Names
    axonal transporter of synaptic vesicles
    kinesin, heavy chain, member 1A, homolog of mouse
    microtubule-based motor KIF1A
    unc-104- and KIF1A-related protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029724.1 RefSeqGene

      Range
      4900..111444
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_367

    mRNA and Protein(s)

    1. NM_001244008.2NP_001230937.1  kinesin-like protein KIF1A isoform 1

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      Consensus CDS
      CCDS58757.1
      UniProtKB/TrEMBL
      X5D7J0
      Related
      ENSP00000438388.1, ENST00000498729.9
      Conserved Domains (8) summary
      smart00129
      Location:5361
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:501605
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:16721774
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam00169
      Location:16771770
      PH; PH domain
      pfam12423
      Location:814861
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:12971397
      DUF3694; Kinesin protein
      pfam16183
      Location:358524
      Kinesin_assoc; Kinesin-associated
    2. NM_001320705.2NP_001307634.1  kinesin-like protein KIF1A isoform 3

      Status: REVIEWED

      Source sequence(s)
      AB210029, AB290172, AC011298, AW246876, BC111780
      Consensus CDS
      CCDS92991.1
      UniProtKB/TrEMBL
      A0A3B3IU40, X5D7J0
      Related
      ENSP00000498196.1, ENST00000648364.1
      Conserved Domains (8) summary
      smart00129
      Location:5361
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:501605
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:15801682
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam00169
      Location:15851678
      PH; PH domain
      pfam12423
      Location:814860
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:12051305
      DUF3694; Kinesin protein
      pfam16183
      Location:358524
      Kinesin_assoc; Kinesin-associated
    3. NM_001330289.2NP_001317218.1  kinesin-like protein KIF1A isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784, AK054791, AW246876
      Consensus CDS
      CCDS92992.1
      UniProtKB/TrEMBL
      A0A3B3IT28, X5D7J0
      Related
      ENSP00000497586.1, ENST00000648680.1
      Conserved Domains (8) summary
      smart00129
      Location:5361
      KISc; Kinesin motor, catalytic domain. ATPase
      cd00060
      Location:501605
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:15891691
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam00169
      Location:15941687
      PH; PH domain
      pfam12423
      Location:814860
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:12051314
      DUF3694; Kinesin protein
      pfam16183
      Location:358524
      Kinesin_assoc; Kinesin-associated
    4. NM_001330290.2NP_001317219.1  kinesin-like protein KIF1A isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784, AK054791, AW246876
      Consensus CDS
      CCDS92993.1
      UniProtKB/TrEMBL
      A0A3B3ITE5, X5D7J0
      Related
      ENSP00000497678.1, ENST00000649306.1
    5. NM_001379631.1NP_001366560.1  kinesin-like protein KIF1A isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      UniProtKB/TrEMBL
      X5D7J0
    6. NM_001379632.1NP_001366561.1  kinesin-like protein KIF1A isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      UniProtKB/TrEMBL
      X5D7J0
      Conserved Domains (6) summary
      cd00060
      Location:492596
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:16641766
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam12423
      Location:805852
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:12331389
      DUF3694; Kinesin protein
      pfam16183
      Location:358515
      Kinesin_assoc; Kinesin-associated
    7. NM_001379633.1NP_001366562.1  kinesin-like protein KIF1A isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      Consensus CDS
      CCDS92990.1
      UniProtKB/TrEMBL
      A0A3B3ITW6, X5D7J0
      Related
      ENSP00000497293.1, ENST00000648129.1
    8. NM_001379634.1NP_001366563.1  kinesin-like protein KIF1A isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      UniProtKB/TrEMBL
      X5D7J0
    9. NM_001379635.1NP_001366564.1  kinesin-like protein KIF1A isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      UniProtKB/TrEMBL
      X5D7J0
      Conserved Domains (6) summary
      cd00060
      Location:526630
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:16131715
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam12423
      Location:839885
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:11831338
      DUF3694; Kinesin protein
      pfam16183
      Location:358549
      Kinesin_assoc; Kinesin-associated
    10. NM_001379636.1NP_001366565.1  kinesin-like protein KIF1A isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      Consensus CDS
      CCDS92989.1
      UniProtKB/TrEMBL
      A0A3B3ITF7, X5D7J0
      Related
      ENSP00000497739.1, ENST00000647885.1
      Conserved Domains (7) summary
      cd01233
      Location:16091711
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam00769
      Location:624678
      ERM; Ezrin/radixin/moesin family
      pfam12423
      Location:805852
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:11491331
      DUF3694; Kinesin protein
      pfam16183
      Location:358515
      Kinesin_assoc; Kinesin-associated
      cd22726
      Location:491605
      FHA_KIF1A; forkhead associated (FHA) domain found in kinesin-like protein KIF1A
    11. NM_001379637.1NP_001366566.1  kinesin-like protein KIF1A isoform 12

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      UniProtKB/TrEMBL
      X5D7J0
      Conserved Domains (7) summary
      cd01233
      Location:15961698
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam00769
      Location:649703
      ERM; Ezrin/radixin/moesin family
      pfam12423
      Location:830877
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:11741318
      DUF3694; Kinesin protein
      pfam16183
      Location:358540
      Kinesin_assoc; Kinesin-associated
      cd22726
      Location:516630
      FHA_KIF1A; forkhead associated (FHA) domain found in kinesin-like protein KIF1A
    12. NM_001379638.1NP_001366567.1  kinesin-like protein KIF1A isoform 13

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      UniProtKB/TrEMBL
      X5D7J0
      Conserved Domains (6) summary
      cd00060
      Location:501605
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:15881690
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam12423
      Location:814860
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:11581313
      DUF3694; Kinesin protein
      pfam16183
      Location:358524
      Kinesin_assoc; Kinesin-associated
    13. NM_001379639.1NP_001366568.1  kinesin-like protein KIF1A isoform 14

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      Consensus CDS
      CCDS92987.1
      UniProtKB/TrEMBL
      A0A3F2YNW9, X5D7J0
      Related
      ENSP00000322791.8, ENST00000320389.12
      Conserved Domains (6) summary
      cd00060
      Location:492596
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:15791681
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam12423
      Location:805851
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:11491304
      DUF3694; Kinesin protein
      pfam16183
      Location:358515
      Kinesin_assoc; Kinesin-associated
    14. NM_001379640.1NP_001366569.1  kinesin-like protein KIF1A isoform 15

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      UniProtKB/TrEMBL
      X5D7J0
      Conserved Domains (6) summary
      cd00060
      Location:492596
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:15701672
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam12423
      Location:805851
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:11481295
      DUF3694; Kinesin protein
      pfam16183
      Location:358515
      Kinesin_assoc; Kinesin-associated
    15. NM_001379641.1NP_001366570.1  kinesin-like protein KIF1A isoform 16

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      UniProtKB/TrEMBL
      X5D7J0
      Conserved Domains (6) summary
      cd00060
      Location:492596
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:15711661
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam12423
      Location:805851
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:11491296
      DUF3694; Kinesin protein
      pfam16183
      Location:358515
      Kinesin_assoc; Kinesin-associated
    16. NM_001379642.1NP_001366571.1  kinesin-like protein KIF1A isoform 17

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      UniProtKB/TrEMBL
      X5D7J0
      Conserved Domains (6) summary
      cd00060
      Location:492596
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:16721774
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam12423
      Location:805852
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:12411397
      DUF3694; Kinesin protein
      pfam16183
      Location:358515
      Kinesin_assoc; Kinesin-associated
    17. NM_001379645.1NP_001366574.1  kinesin-like protein KIF1A isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      Consensus CDS
      CCDS92990.1
      UniProtKB/TrEMBL
      A0A3B3ITW6, X5D7J0
      Related
      ENSP00000498082.1, ENST00000650130.1
    18. NM_001379646.1NP_001366575.1  kinesin-like protein KIF1A isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      UniProtKB/TrEMBL
      X5D7J0
      Related
      ENSP00000497935.2, ENST00000648047.2
      Conserved Domains (6) summary
      cd00060
      Location:526630
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:16131715
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam12423
      Location:839885
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:11831338
      DUF3694; Kinesin protein
      pfam16183
      Location:358549
      Kinesin_assoc; Kinesin-associated
    19. NM_001379648.1NP_001366577.1  kinesin-like protein KIF1A isoform 19

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      UniProtKB/TrEMBL
      X5D7J0
      Conserved Domains (3) summary
      cd00060
      Location:517621
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:16051707
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
    20. NM_001379649.1NP_001366578.1  kinesin-like protein KIF1A isoform 18

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      Consensus CDS
      CCDS92988.1
      UniProtKB/TrEMBL
      A0A3B3IUA1, X5D7J0
      Related
      ENSP00000498099.1, ENST00000647731.1
      Conserved Domains (6) summary
      cd00060
      Location:492596
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:15801682
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam12423
      Location:805851
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:11491305
      DUF3694; Kinesin protein
      pfam16183
      Location:358515
      Kinesin_assoc; Kinesin-associated
    21. NM_001379650.1NP_001366579.1  kinesin-like protein KIF1A isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      Consensus CDS
      CCDS46561.1
      UniProtKB/Swiss-Prot
      B0I1S5, F5H045, O95068, Q12756, Q13355, Q14752, Q2NKJ6, Q4LE42, Q53T78, Q59GH1, Q63Z40, Q6P1R9, Q7KZ57
      UniProtKB/TrEMBL
      X5D7J0
      Related
      ENSP00000497824.1, ENST00000650053.1
      Conserved Domains (6) summary
      cd00060
      Location:492596
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:15711673
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam12423
      Location:805851
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:11491296
      DUF3694; Kinesin protein
      pfam16183
      Location:358515
      Kinesin_assoc; Kinesin-associated
    22. NM_001379651.1NP_001366580.1  kinesin-like protein KIF1A isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      Consensus CDS
      CCDS46561.1
      UniProtKB/Swiss-Prot
      B0I1S5, F5H045, O95068, Q12756, Q13355, Q14752, Q2NKJ6, Q4LE42, Q53T78, Q59GH1, Q63Z40, Q6P1R9, Q7KZ57
      UniProtKB/TrEMBL
      X5D7J0
      Conserved Domains (6) summary
      cd00060
      Location:492596
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:15711673
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam12423
      Location:805851
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:11491296
      DUF3694; Kinesin protein
      pfam16183
      Location:358515
      Kinesin_assoc; Kinesin-associated
    23. NM_001379653.1NP_001366582.1  kinesin-like protein KIF1A isoform 2

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      Consensus CDS
      CCDS46561.1
      UniProtKB/Swiss-Prot
      B0I1S5, F5H045, O95068, Q12756, Q13355, Q14752, Q2NKJ6, Q4LE42, Q53T78, Q59GH1, Q63Z40, Q6P1R9, Q7KZ57
      UniProtKB/TrEMBL
      X5D7J0
      Conserved Domains (6) summary
      cd00060
      Location:492596
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:15711673
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam12423
      Location:805851
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:11491296
      DUF3694; Kinesin protein
      pfam16183
      Location:358515
      Kinesin_assoc; Kinesin-associated
    24. NM_004321.8NP_004312.2  kinesin-like protein KIF1A isoform 2

      See identical proteins and their annotated locations for NP_004312.2

      Status: REVIEWED

      Source sequence(s)
      AC011298, AC112784
      Consensus CDS
      CCDS46561.1
      UniProtKB/Swiss-Prot
      B0I1S5, F5H045, O95068, Q12756, Q13355, Q14752, Q2NKJ6, Q4LE42, Q53T78, Q59GH1, Q63Z40, Q6P1R9, Q7KZ57
      UniProtKB/TrEMBL
      X5D7J0
      Related
      ENSP00000497030.1, ENST00000649096.1
      Conserved Domains (6) summary
      cd00060
      Location:492596
      FHA; Forkhead associated domain (FHA); found in eukaryotic and prokaryotic proteins. Putative nuclear signalling domain. FHA domains may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine. In eukaryotes, many FHA domain-containing proteins ...
      cd01233
      Location:15711673
      PH_KIFIA_KIFIB; KIFIA and KIFIB protein pleckstrin homology (PH) domain
      cd01365
      Location:4361
      KISc_KIF1A_KIF1B; Kinesin motor domain, KIF1_like proteins
      pfam12423
      Location:805851
      KIF1B; Kinesin protein 1B
      pfam12473
      Location:11491296
      DUF3694; Kinesin protein
      pfam16183
      Location:358515
      Kinesin_assoc; Kinesin-associated

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      240713767..240821403 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047444819.1XP_047300775.1  kinesin-like protein KIF1A isoform X1

      UniProtKB/TrEMBL
      X5D7J0
    2. XM_047444821.1XP_047300777.1  kinesin-like protein KIF1A isoform X3

      UniProtKB/TrEMBL
      X5D7J0
    3. XM_047444820.1XP_047300776.1  kinesin-like protein KIF1A isoform X2

      UniProtKB/TrEMBL
      X5D7J0
      Related
      ENSP00000384231.5, ENST00000404283.9
    4. XM_047444818.1XP_047300774.1  kinesin-like protein KIF1A isoform X1

      UniProtKB/TrEMBL
      X5D7J0
      Related
      ENSP00000398686.2, ENST00000448728.2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      241210501..241320366 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054342651.1XP_054198626.1  kinesin-like protein KIF1A isoform X1

      UniProtKB/TrEMBL
      X5D7J0
    2. XM_054342653.1XP_054198628.1  kinesin-like protein KIF1A isoform X3

      UniProtKB/TrEMBL
      X5D7J0
    3. XM_054342652.1XP_054198627.1  kinesin-like protein KIF1A isoform X2

      UniProtKB/TrEMBL
      X5D7J0
    4. XM_054342650.1XP_054198625.1  kinesin-like protein KIF1A isoform X1

      UniProtKB/TrEMBL
      X5D7J0
    5. XM_054342654.1XP_054198629.1  kinesin-like protein KIF1A isoform X4

      UniProtKB/TrEMBL
      A0A3B3ITK3