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    FLT4 fms related receptor tyrosine kinase 4 [ Homo sapiens (human) ]

    Gene ID: 2324, updated on 17-Jun-2024

    Summary

    Official Symbol
    FLT4provided by HGNC
    Official Full Name
    fms related receptor tyrosine kinase 4provided by HGNC
    Primary source
    HGNC:HGNC:3767
    See related
    Ensembl:ENSG00000037280 MIM:136352; AllianceGenome:HGNC:3767
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PCL; CHTD7; FLT-4; FLT41; LMPH1A; LMPHM1; VEGFR3; VEGFR-3
    Summary
    This gene encodes a tyrosine kinase receptor for vascular endothelial growth factors C and D. The protein is thought to be involved in lymphangiogenesis and maintenance of the lymphatic endothelium. Mutations in this gene cause hereditary lymphedema type IA. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in spleen (RPKM 7.7), lung (RPKM 6.7) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FLT4 in Genome Data Viewer
    Location:
    5q35.3
    Exon count:
    34
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (180601506..180650298, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (181157398..181206988, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (180028506..180076600, complement)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180016691-180017360 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180017361-180018030 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180018031-180018700 Neighboring gene uncharacterized LOC124901154 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:180023713-180023884 Neighboring gene secretoglobin family 3A member 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180029578-180030078 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr5:180046831-180048030 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180059019-180059648 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180059649-180060278 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:180066955-180067601 Neighboring gene ReSE screen-validated silencer GRCh37_chr5:180069214-180069370 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:180072499-180073164 Neighboring gene coiled-coil domain containing 86 pseudogene Neighboring gene long intergenic non-protein coding RNA 2222

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables growth factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein homodimerization activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transmembrane receptor protein tyrosine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables vascular endothelial growth factor receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables vascular endothelial growth factor receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables vascular endothelial growth factor receptor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in angiogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in blood vessel morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell surface receptor protein tyrosine kinase signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to vascular endothelial growth factor stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to vascular endothelial growth factor stimulus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lung alveolus development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lymph vessel development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lymphangiogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in lymphangiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in multicellular organism development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in peptidyl-tyrosine phosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of ERK1 and ERK2 cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of JNK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell population proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of endothelial cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of endothelial cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of kinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of protein kinase C signaling IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein phosphorylation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of vascular endothelial growth factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein autophosphorylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of blood vessel remodeling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in respiratory system process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in sprouting angiogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in vascular endothelial growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within vascular endothelial growth factor receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vascular endothelial growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in vascular endothelial growth factor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in vasculature development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in extracellular region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    vascular endothelial growth factor receptor 3
    Names
    Feline McDonough Sarcoma (FMS)-like tyrosine kinase 4
    VEGF receptor-3
    fms related tyrosine kinase 4
    fms-like tyrosine kinase 4
    primary congenital lymphedema
    tyrosine-protein kinase receptor FLT4
    NP_001341918.1
    NP_002011.2
    NP_891555.2
    XP_011532780.1
    XP_011532786.1
    XP_016864752.1
    XP_016864755.1
    XP_016864757.1
    XP_047272958.1
    XP_047272959.1
    XP_054208150.1
    XP_054208151.1
    XP_054208152.1
    XP_054208153.1
    XP_054208154.1
    XP_054208155.1
    XP_054208156.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011536.1 RefSeqGene

      Range
      5025..53119
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001354989.2NP_001341918.1  vascular endothelial growth factor receptor 3 isoform 3 precursor

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) contains an alternate 3' terminal exon compared to variant 1. This results in an isoform (3) with a shorter C-terminus compared to isoform 1.
      Source sequence(s)
      AC122714
      Consensus CDS
      CCDS87360.1
      UniProtKB/TrEMBL
      E9PD35
      Related
      ENSP00000426057.1, ENST00000502649.5
      Conserved Domains (6) summary
      cd05862
      Location:245329
      Ig_VEGFR; Immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R)
      cd05863
      Location:352418
      Ig_VEGFR-3; Immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 3 (VEGFR-3)
      smart00408
      Location:693755
      IGc2; Immunoglobulin C-2 Type
      smart00410
      Location:564657
      IG_like; Immunoglobulin like
      cd05102
      Location:8371176
      PTKc_VEGFR3; Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 3
      pfam13895
      Location:137224
      Ig_2; Immunoglobulin domain
    2. NM_002020.5NP_002011.2  vascular endothelial growth factor receptor 3 isoform 2 precursor

      See identical proteins and their annotated locations for NP_002011.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate 3' terminal exon compared to variant 1. This results in an isoform (2) with a shorter C-terminus compared to isoform 1.
      Source sequence(s)
      AC122714, AY233382, DB455035, X68203
      Consensus CDS
      CCDS43412.1
      UniProtKB/Swiss-Prot
      P35916
      Related
      ENSP00000377016.3, ENST00000393347.7
      Conserved Domains (10) summary
      cd05862
      Location:245329
      Ig1_VEGFR; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R)
      cd05863
      Location:352418
      Ig2_VEGFR-3; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 3 (VEGFR-3)
      smart00408
      Location:693755
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:564657
      IG; Immunoglobulin
      smart00410
      Location:238327
      IG_like; Immunoglobulin like
      pfam07679
      Location:678765
      I-set; Immunoglobulin I-set domain
      cd05102
      Location:8371176
      PTKc_VEGFR3; Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 3
      pfam07714
      Location:8451169
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13895
      Location:138224
      Ig_2; Immunoglobulin domain
      cl11960
      Location:570658
      Ig; Immunoglobulin domain
    3. NM_182925.5NP_891555.2  vascular endothelial growth factor receptor 3 isoform 1 precursor

      See identical proteins and their annotated locations for NP_891555.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      AC122714, AY233383, DB455035, X68203
      Consensus CDS
      CCDS4457.1
      UniProtKB/Swiss-Prot
      A8K6L4, B5A926, P35916, Q16067, Q86W07, Q86W08
      Related
      ENSP00000261937.6, ENST00000261937.11
      Conserved Domains (10) summary
      cd05862
      Location:245329
      Ig1_VEGFR; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R)
      cd05863
      Location:352418
      Ig2_VEGFR-3; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 3 (VEGFR-3)
      smart00408
      Location:693755
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:564657
      IG; Immunoglobulin
      smart00410
      Location:238327
      IG_like; Immunoglobulin like
      pfam07679
      Location:678765
      I-set; Immunoglobulin I-set domain
      cd05102
      Location:8371176
      PTKc_VEGFR3; Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 3
      pfam07714
      Location:8451169
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13895
      Location:138224
      Ig_2; Immunoglobulin domain
      cl11960
      Location:570658
      Ig; Immunoglobulin domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      180601506..180650298 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017009268.2XP_016864757.1  vascular endothelial growth factor receptor 3 isoform X4

    2. XM_017009263.2XP_016864752.1  vascular endothelial growth factor receptor 3 isoform X2

    3. XM_011534478.4XP_011532780.1  vascular endothelial growth factor receptor 3 isoform X1

      Conserved Domains (10) summary
      cd05862
      Location:322406
      Ig1_VEGFR; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R)
      cd05863
      Location:429495
      Ig2_VEGFR-3; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 3 (VEGFR-3)
      smart00408
      Location:770832
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:641734
      IG; Immunoglobulin
      smart00410
      Location:315404
      IG_like; Immunoglobulin like
      pfam07679
      Location:755842
      I-set; Immunoglobulin I-set domain
      cd05102
      Location:9141253
      PTKc_VEGFR3; Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 3
      pfam07714
      Location:9221246
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13895
      Location:215301
      Ig_2; Immunoglobulin domain
      cl11960
      Location:647735
      Ig; Immunoglobulin domain
    4. XM_011534484.3XP_011532786.1  vascular endothelial growth factor receptor 3 isoform X7

      Conserved Domains (10) summary
      cd05862
      Location:92176
      Ig1_VEGFR; First immunoglobulin (Ig)-like domain of vascular endothelial growth factor (VEGF) receptor(R)
      cd05863
      Location:199265
      Ig2_VEGFR-3; Second immunoglobulin (Ig)-like domain of vascular endothelial growth factor receptor 3 (VEGFR-3)
      smart00408
      Location:540602
      IGc2; Immunoglobulin C-2 Type
      smart00409
      Location:411504
      IG; Immunoglobulin
      smart00410
      Location:85174
      IG_like; Immunoglobulin like
      pfam07679
      Location:525612
      I-set; Immunoglobulin I-set domain
      cd05102
      Location:6841023
      PTKc_VEGFR3; Catalytic domain of the Protein Tyrosine Kinase, Vascular Endothelial Growth Factor Receptor 3
      pfam07714
      Location:6921016
      Pkinase_Tyr; Protein tyrosine kinase
      pfam13895
      Location:171
      Ig_2; Immunoglobulin domain
      cl11960
      Location:417505
      Ig; Immunoglobulin domain
    5. XM_047417002.1XP_047272958.1  vascular endothelial growth factor receptor 3 isoform X5

    6. XM_017009266.2XP_016864755.1  vascular endothelial growth factor receptor 3 isoform X3

    7. XM_047417003.1XP_047272959.1  vascular endothelial growth factor receptor 3 isoform X6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      181157398..181206988 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054352178.1XP_054208153.1  vascular endothelial growth factor receptor 3 isoform X4

    2. XM_054352176.1XP_054208151.1  vascular endothelial growth factor receptor 3 isoform X2

    3. XM_054352175.1XP_054208150.1  vascular endothelial growth factor receptor 3 isoform X1

    4. XM_054352181.1XP_054208156.1  vascular endothelial growth factor receptor 3 isoform X7

    5. XM_054352179.1XP_054208154.1  vascular endothelial growth factor receptor 3 isoform X5

    6. XM_054352177.1XP_054208152.1  vascular endothelial growth factor receptor 3 isoform X3

    7. XM_054352180.1XP_054208155.1  vascular endothelial growth factor receptor 3 isoform X6