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    TANC2 tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2 [ Homo sapiens (human) ]

    Gene ID: 26115, updated on 3-Apr-2024

    Summary

    Official Symbol
    TANC2provided by HGNC
    Official Full Name
    tetratricopeptide repeat, ankyrin repeat and coiled-coil containing 2provided by HGNC
    Primary source
    HGNC:HGNC:30212
    See related
    Ensembl:ENSG00000170921 MIM:615047; AllianceGenome:HGNC:30212
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    rols; ROLSA; IDDALDS
    Summary
    Predicted to be involved in dense core granule cytoskeletal transport; regulation of dendritic spine development; and regulation of dendritic spine morphogenesis. Predicted to act upstream of or within in utero embryonic development. Located in dendritic spine. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in brain (RPKM 6.5), testis (RPKM 5.9) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    17q23.2-q23.3
    Exon count:
    29
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (62966235..63427703)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (63836303..64297911)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (61043596..61505064)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8814 Neighboring gene tRNA methyltransferase subunit 11-2 pseudogene 3 Neighboring gene microRNA 633 Neighboring gene Sharpr-MPRA regulatory region 13093 Neighboring gene NANOG hESC enhancer GRCh37_chr17:61122317-61122818 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:61143140-61143657 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:61143658-61144174 Neighboring gene zinc finger protein pseudogene Neighboring gene MED14-independent group 3 enhancer GRCh37_chr17:61259160-61260359 Neighboring gene DNAJB6 pseudogene 8 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:61310050-61310550 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:61310551-61311051 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:61382271-61382865 Neighboring gene NANOG hESC enhancer GRCh37_chr17:61423641-61424164 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:61438304-61438804 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:61438805-61439305 Neighboring gene DENR pseudogene 3 Neighboring gene Sharpr-MPRA regulatory region 4360 Neighboring gene uncharacterized LOC105371856 Neighboring gene Sharpr-MPRA regulatory region 7022 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:61503073-61503811 Neighboring gene ReSE screen-validated silencer GRCh37_chr17:61512442-61512609 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:61513919-61514833 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:61514834-61515748 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8815 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8816 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:61524253-61525066 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:61525067-61525879 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:61528047-61528547 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:61533342-61534200 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:61534201-61535059 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12545 Neighboring gene cytochrome b561 Neighboring gene peptidylprolyl isomerase A pseudogene 55

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10215, FLJ11824, KIAA1148, KIAA1636, DKFZp564D166

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in dense core granule cytoskeletal transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of dendritic spine development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of dendritic spine morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of dendritic spine morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in axon IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in dendritic spine IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in dendritic spine IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    protein TANC2
    Names
    putative ankyrin-repeat containing protein
    rolling pebbles homolog B
    tetratricopeptide repeat, ankyrin repeat and coiled-coil domain-containing protein 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394998.1NP_001381927.1  protein TANC2 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC005828, AC005972, AC006270, AC015923
      Consensus CDS
      CCDS92376.1
      UniProtKB/TrEMBL
      A0A8I5KXR5
      Related
      ENSP00000510600.1, ENST00000689528.1
      Conserved Domains (6) summary
      PHA03095
      Location:9301224
      PHA03095; ankyrin-like protein; Provisional
      PHA03247
      Location:15111740
      PHA03247; large tegument protein UL36; Provisional
      COG0457
      Location:13241459
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      COG0666
      Location:11701296
      ANKYR; Ankyrin repeat [Signal transduction mechanisms]
      sd00006
      Location:13311356
      TPR; TPR repeat [structural motif]
      sd00045
      Location:11741204
      ANK; ANK repeat [structural motif]
    2. NM_001411076.1NP_001398005.1  protein TANC2 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AC005828, AC005972, AC006270, AC015923
      Consensus CDS
      CCDS92375.1
      Related
      ENSP00000374171.4, ENST00000389520.8
    3. NM_025185.4NP_079461.2  protein TANC2 isoform 1

      See identical proteins and their annotated locations for NP_079461.2

      Status: VALIDATED

      Source sequence(s)
      AC005828, AC005972, AC006270, AC015923
      Consensus CDS
      CCDS45754.1
      UniProtKB/Swiss-Prot
      Q9HAC3, Q9HCD6, Q9NW88, Q9NXY9, Q9ULS2
      Related
      ENSP00000387593.2, ENST00000424789.6
      Conserved Domains (10) summary
      cd00204
      Location:10941219
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:12471272
      TPR; TPR repeat [structural motif]
      pfam03153
      Location:14021629
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam12796
      Location:11041196
      Ank_2; Ankyrin repeats (3 copies)
      pfam12859
      Location:14271498
      ANAPC1; Anaphase-promoting complex subunit 1
      pfam13191
      Location:341383
      AAA_16; AAA ATPase domain
      pfam13414
      Location:12931356
      TPR_11; TPR repeat
      pfam13428
      Location:13261368
      TPR_14; Tetratricopeptide repeat
      pfam13637
      Location:888937
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:11001130
      ANK; ANK repeat [structural motif]

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      62966235..63427703
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011524597.3XP_011522899.1  protein TANC2 isoform X1

      Conserved Domains (9) summary
      cd00204
      Location:11681293
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:13311356
      TPR; TPR repeat [structural motif]
      pfam03153
      Location:14871714
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam12796
      Location:11781270
      Ank_2; Ankyrin repeats (3 copies)
      pfam12859
      Location:15121583
      ANAPC1; Anaphase-promoting complex subunit 1
      pfam13191
      Location:415457
      AAA_16; AAA ATPase domain
      pfam13414
      Location:13771441
      TPR_11; TPR repeat
      pfam13637
      Location:9621011
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:11741204
      ANK; ANK repeat [structural motif]
    2. XM_006721810.4XP_006721873.1  protein TANC2 isoform X16

      UniProtKB/TrEMBL
      J3KRP9
      Conserved Domains (5) summary
      cd00204
      Location:11681293
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:11781270
      Ank_2; Ankyrin repeats (3 copies)
      pfam13191
      Location:415457
      AAA_16; AAA ATPase domain
      pfam13637
      Location:9621011
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:11741204
      ANK; ANK repeat [structural motif]
    3. XM_011524598.3XP_011522900.1  protein TANC2 isoform X2

      Conserved Domains (9) summary
      cd00204
      Location:11681293
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:13211346
      TPR; TPR repeat [structural motif]
      pfam03153
      Location:14771704
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam12796
      Location:11781270
      Ank_2; Ankyrin repeats (3 copies)
      pfam12859
      Location:15021573
      ANAPC1; Anaphase-promoting complex subunit 1
      pfam13191
      Location:415457
      AAA_16; AAA ATPase domain
      pfam13414
      Location:13671431
      TPR_11; TPR repeat
      pfam13637
      Location:9621011
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:11741204
      ANK; ANK repeat [structural motif]
    4. XM_006721807.4XP_006721870.1  protein TANC2 isoform X3

      Conserved Domains (10) summary
      cd00204
      Location:11681293
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:13211346
      TPR; TPR repeat [structural motif]
      pfam03153
      Location:14761703
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam12796
      Location:11781270
      Ank_2; Ankyrin repeats (3 copies)
      pfam12859
      Location:15011572
      ANAPC1; Anaphase-promoting complex subunit 1
      pfam13191
      Location:415457
      AAA_16; AAA ATPase domain
      pfam13414
      Location:13671430
      TPR_11; TPR repeat
      pfam13428
      Location:14001442
      TPR_14; Tetratricopeptide repeat
      pfam13637
      Location:9621011
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:11741204
      ANK; ANK repeat [structural motif]
    5. XM_006721811.5XP_006721874.1  protein TANC2 isoform X17

      UniProtKB/TrEMBL
      J3KRP9
      Conserved Domains (5) summary
      cd00204
      Location:11681293
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      pfam12796
      Location:11781270
      Ank_2; Ankyrin repeats (3 copies)
      pfam13191
      Location:415457
      AAA_16; AAA ATPase domain
      pfam13637
      Location:9621011
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:11741204
      ANK; ANK repeat [structural motif]
    6. XM_011524600.3XP_011522902.1  protein TANC2 isoform X6

      Conserved Domains (9) summary
      cd00204
      Location:11311256
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:12941319
      TPR; TPR repeat [structural motif]
      pfam03153
      Location:14501677
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam12796
      Location:11411233
      Ank_2; Ankyrin repeats (3 copies)
      pfam12859
      Location:14751546
      ANAPC1; Anaphase-promoting complex subunit 1
      pfam13191
      Location:378420
      AAA_16; AAA ATPase domain
      pfam13414
      Location:13401404
      TPR_11; TPR repeat
      pfam13637
      Location:925974
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:11371167
      ANK; ANK repeat [structural motif]
    7. XM_047435731.1XP_047291687.1  protein TANC2 isoform X8

    8. XM_047435733.1XP_047291689.1  protein TANC2 isoform X10

    9. XM_047435734.1XP_047291690.1  protein TANC2 isoform X11

    10. XM_047435738.1XP_047291694.1  protein TANC2 isoform X18

      Related
      ENSP00000462109.1, ENST00000583356.5
    11. XM_011524601.3XP_011522903.1  protein TANC2 isoform X7

      Conserved Domains (9) summary
      cd00204
      Location:11311256
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:12941319
      TPR; TPR repeat [structural motif]
      pfam03153
      Location:14501677
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam12796
      Location:11411233
      Ank_2; Ankyrin repeats (3 copies)
      pfam12859
      Location:14751546
      ANAPC1; Anaphase-promoting complex subunit 1
      pfam13191
      Location:378420
      AAA_16; AAA ATPase domain
      pfam13414
      Location:13401404
      TPR_11; TPR repeat
      pfam13637
      Location:925974
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:11371167
      ANK; ANK repeat [structural motif]
    12. XM_047435732.1XP_047291688.1  protein TANC2 isoform X9

    13. XM_011524602.3XP_011522904.1  protein TANC2 isoform X13

      Conserved Domains (9) summary
      cd00204
      Location:10941219
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:12571282
      TPR; TPR repeat [structural motif]
      pfam03153
      Location:14131640
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam12796
      Location:11041196
      Ank_2; Ankyrin repeats (3 copies)
      pfam12859
      Location:14381509
      ANAPC1; Anaphase-promoting complex subunit 1
      pfam13191
      Location:341383
      AAA_16; AAA ATPase domain
      pfam13414
      Location:13031367
      TPR_11; TPR repeat
      pfam13637
      Location:888937
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:11001130
      ANK; ANK repeat [structural motif]
    14. XM_011524599.2XP_011522901.1  protein TANC2 isoform X4

      Conserved Domains (9) summary
      cd00204
      Location:11521277
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:13151340
      TPR; TPR repeat [structural motif]
      pfam03153
      Location:14711698
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam12796
      Location:11621254
      Ank_2; Ankyrin repeats (3 copies)
      pfam12859
      Location:14961567
      ANAPC1; Anaphase-promoting complex subunit 1
      pfam13191
      Location:399441
      AAA_16; AAA ATPase domain
      pfam13414
      Location:13611425
      TPR_11; TPR repeat
      pfam13637
      Location:946995
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:11581188
      ANK; ANK repeat [structural motif]
    15. XM_017024429.2XP_016879918.1  protein TANC2 isoform X5

    16. XM_047435735.1XP_047291691.1  protein TANC2 isoform X12

    17. XM_047435737.1XP_047291693.1  protein TANC2 isoform X14

    18. XM_017024430.3XP_016879919.1  protein TANC2 isoform X15

      Conserved Domains (9) summary
      cd00204
      Location:10041129
      ANK; ankyrin repeats; ankyrin repeats mediate protein-protein interactions in very diverse families of proteins. The number of ANK repeats in a protein can range from 2 to over 20 (ankyrins, for example). ANK repeats may occur in combinations with other ...
      sd00006
      Location:11671192
      TPR; TPR repeat [structural motif]
      pfam03153
      Location:13231550
      TFIIA; Transcription factor IIA, alpha/beta subunit
      pfam12796
      Location:10141106
      Ank_2; Ankyrin repeats (3 copies)
      pfam12859
      Location:13481419
      ANAPC1; Anaphase-promoting complex subunit 1
      pfam13191
      Location:251293
      AAA_16; AAA ATPase domain
      pfam13414
      Location:12131277
      TPR_11; TPR repeat
      pfam13637
      Location:798847
      Ank_4; Ankyrin repeats (many copies)
      sd00045
      Location:10101040
      ANK; ANK repeat [structural motif]

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      63836303..64297911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054315677.1XP_054171652.1  protein TANC2 isoform X1

    2. XM_054315678.1XP_054171653.1  protein TANC2 isoform X2

    3. XM_054315682.1XP_054171657.1  protein TANC2 isoform X6

    4. XM_054315686.1XP_054171661.1  protein TANC2 isoform X10

    5. XM_054315683.1XP_054171658.1  protein TANC2 isoform X7

    6. XM_054315689.1XP_054171664.1  protein TANC2 isoform X13

    7. XM_054315692.1XP_054171667.1  protein TANC2 isoform X16

    8. XM_054315679.1XP_054171654.1  protein TANC2 isoform X3

    9. XM_054315693.1XP_054171668.1  protein TANC2 isoform X17

    10. XM_054315684.1XP_054171659.1  protein TANC2 isoform X8

    11. XM_054315687.1XP_054171662.1  protein TANC2 isoform X11

    12. XM_054315694.1XP_054171669.1  protein TANC2 isoform X18

    13. XM_054315685.1XP_054171660.1  protein TANC2 isoform X9

    14. XM_054315680.1XP_054171655.1  protein TANC2 isoform X4

    15. XM_054315688.1XP_054171663.1  protein TANC2 isoform X12

    16. XM_054315690.1XP_054171665.1  protein TANC2 isoform X14

    17. XM_054315681.1XP_054171656.1  protein TANC2 isoform X5

    18. XM_054315691.1XP_054171666.1  protein TANC2 isoform X15

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_015623.2: Suppressed sequence

      Description
      NM_015623.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.
    2. NM_030658.2: Suppressed sequence

      Description
      NM_030658.2: This RefSeq was suppressed temporarily based on the calculation that the annotated protein was shorter than a protein or proteins from a putative ortholog.