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    MED12L mediator complex subunit 12L [ Homo sapiens (human) ]

    Gene ID: 116931, updated on 23-Nov-2023

    Summary

    Official Symbol
    MED12Lprovided by HGNC
    Official Full Name
    mediator complex subunit 12Lprovided by HGNC
    Primary source
    HGNC:HGNC:16050
    See related
    Ensembl:ENSG00000144893 MIM:611318; AllianceGenome:HGNC:16050
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NOPAR; TRALP; NIZIDS; TNRC11L; TRALPUSH
    Summary
    The protein encoded by this gene is part of the Mediator complex, which is involved in transcriptional coactivation of nearly all RNA polymerase II-dependent genes. The Mediator complex links gene-specific transcriptional activators with the basal transcription machinery. [provided by RefSeq, May 2010]
    Expression
    Broad expression in testis (RPKM 2.2), brain (RPKM 1.5) and 18 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See MED12L in Genome Data Viewer
    Location:
    3q25.1
    Exon count:
    48
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (151085664..151436653)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (153836722..154193673)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (150803451..151154441)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:150643693-150644193 Neighboring gene clarin 1 Neighboring gene CLRN1 antisense RNA 1 Neighboring gene uncharacterized LOC124909448 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14822 Neighboring gene Sharpr-MPRA regulatory region 19 Neighboring gene Sharpr-MPRA regulatory region 7583 Neighboring gene RNA, 5S ribosomal pseudogene 145 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:150959859-150960456 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:150959259-150959858 Neighboring gene G protein-coupled receptor 171 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20700 Neighboring gene purinergic receptor P2Y14 Neighboring gene Sharpr-MPRA regulatory region 3159 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr3:151033994-151035193 Neighboring gene SET pseudogene 11 Neighboring gene G protein-coupled receptor 87 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20701 Neighboring gene purinergic receptor P2Y13 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:151110665-151111260 Neighboring gene purinergic receptor P2Y12 Neighboring gene Sharpr-MPRA regulatory region 9761 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:151201363-151201864 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:151201865-151202364 Neighboring gene immunoglobulin superfamily member 10 Neighboring gene mitochondrial ribosomal protein L42 pseudogene 6 Neighboring gene long intergenic non-protein coding RNA 2066 Neighboring gene microRNA 5186

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Nizon-Isidor syndrome
    MedGen: C5394350 OMIM: 618872 GeneReviews: Not available
    not available

    EBI GWAS Catalog

    Description
    A genome-wide search for quantitative trait loci affecting the cortical surface area and thickness of Heschl's gyrus.
    EBI GWAS Catalog
    Gene network analysis in a pediatric cohort identifies novel lung function genes.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ46288, KIAA1635

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables beta-catenin binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription coactivator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables transcription factor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in positive regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of mediator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    mediator of RNA polymerase II transcription subunit 12-like protein
    Names
    mediator complex subunit 12 like
    mediator of RNA polymerase II transcription, subunit 12 homolog-like
    no opposite paired repeat protein
    thyroid hormone receptor-associated-like protein
    trinucleotide repeat-containing gene 11 protein-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_021244.2 RefSeqGene

      Range
      5002..355991
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001393769.1NP_001380698.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform 1

      Status: VALIDATED

      Source sequence(s)
      AC024886, AC078816, AC108726
      Consensus CDS
      CCDS93408.1
      UniProtKB/TrEMBL
      A0A8I5KX78, F8WAE6
      Related
      ENSP00000508695.1, ENST00000687756.1
      Conserved Domains (3) summary
      pfam09497
      Location:106161
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:18372054
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:283765
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
    2. NM_053002.6NP_443728.3  mediator of RNA polymerase II transcription subunit 12-like protein isoform 2

      See identical proteins and their annotated locations for NP_443728.3

      Status: VALIDATED

      Source sequence(s)
      AC024886, AC078816, AC108726, AF399708, AK128165
      Consensus CDS
      CCDS33876.1
      UniProtKB/Swiss-Prot
      Q86YW9, Q96PC7, Q96PC8, Q9H9M5, Q9HCD7, Q9UI69
      UniProtKB/TrEMBL
      F8WAE6
      Conserved Domains (3) summary
      pfam09497
      Location:103161
      Med12; Transcription mediator complex subunit Med12
      pfam12144
      Location:18032016
      Med12-PQL; Eukaryotic Mediator 12 catenin-binding domain
      pfam12145
      Location:283730
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      151085664..151436653
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017005676.2XP_016861165.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X1

      UniProtKB/TrEMBL
      F8WAE6
    2. XM_017005678.2XP_016861167.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X4

      UniProtKB/TrEMBL
      F8WAE6
    3. XM_017005677.2XP_016861166.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X2

      UniProtKB/TrEMBL
      F8WAE6
    4. XM_047447405.1XP_047303361.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X3

      UniProtKB/TrEMBL
      F8WAE6
    5. XM_047447406.1XP_047303362.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X5

      UniProtKB/TrEMBL
      F8WAE6
    6. XM_047447409.1XP_047303365.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X8

      UniProtKB/TrEMBL
      F8WAE6
    7. XM_047447408.1XP_047303364.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X7

      UniProtKB/TrEMBL
      F8WAE6
    8. XM_047447410.1XP_047303366.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X9

      UniProtKB/TrEMBL
      F8WAE6
    9. XM_017005680.2XP_016861169.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X11

      UniProtKB/TrEMBL
      F8WAE6
    10. XM_047447413.1XP_047303369.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X13

      UniProtKB/TrEMBL
      F8WAE6
    11. XM_047447416.1XP_047303372.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X15

      UniProtKB/TrEMBL
      F8WAE6
    12. XM_047447412.1XP_047303368.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X12

      UniProtKB/TrEMBL
      F8WAE6
    13. XM_047447414.1XP_047303370.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X14

      UniProtKB/TrEMBL
      F8WAE6
    14. XM_017005679.2XP_016861168.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X10

      UniProtKB/TrEMBL
      F8WAE6
    15. XM_047447417.1XP_047303373.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X16

      UniProtKB/TrEMBL
      F8WAE6
      Related
      ENSP00000273432.4, ENST00000273432.8
    16. XM_011512394.3XP_011510696.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X17

      UniProtKB/TrEMBL
      F8WAE6
      Conserved Domains (2) summary
      pfam09497
      Location:103161
      Med12; Transcription mediator complex subunit Med12
      pfam12145
      Location:283765
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
    17. XM_047447418.1XP_047303374.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X18

      UniProtKB/TrEMBL
      A0A8I5KY35
      Related
      ENSP00000509482.1, ENST00000686666.1
    18. XM_011512399.4XP_011510701.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X19

      Conserved Domains (2) summary
      pfam09497
      Location:103161
      Med12; Transcription mediator complex subunit Med12
      pfam12145
      Location:283765
      Med12-LCEWAV; Eukaryotic Mediator 12 subunit domain
    19. XM_047447403.1XP_047303359.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X1

      UniProtKB/TrEMBL
      F8WAE6
    20. XM_047447404.1XP_047303360.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X2

      UniProtKB/TrEMBL
      F8WAE6
    21. XM_047447407.1XP_047303363.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X6

      UniProtKB/Swiss-Prot
      Q86YW9, Q96PC7, Q96PC8, Q9H9M5, Q9HCD7, Q9UI69
      UniProtKB/TrEMBL
      F8WAE6
      Related
      ENSP00000417235.1, ENST00000474524.5
    22. XM_047447411.1XP_047303367.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X10

      UniProtKB/TrEMBL
      F8WAE6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      153836722..154193673
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054345142.1XP_054201117.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X1

      UniProtKB/TrEMBL
      F8WAE6
    2. XM_054345147.1XP_054201122.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X4

      UniProtKB/TrEMBL
      F8WAE6
    3. XM_054345144.1XP_054201119.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X2

      UniProtKB/TrEMBL
      F8WAE6
    4. XM_054345146.1XP_054201121.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X3

      UniProtKB/TrEMBL
      F8WAE6
    5. XM_054345151.1XP_054201126.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X8

      UniProtKB/TrEMBL
      F8WAE6
    6. XM_054345150.1XP_054201125.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X7

      UniProtKB/TrEMBL
      F8WAE6
    7. XM_054345152.1XP_054201127.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X9

      UniProtKB/TrEMBL
      F8WAE6
    8. XM_054345155.1XP_054201130.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X11

      UniProtKB/TrEMBL
      F8WAE6
    9. XM_054345157.1XP_054201132.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X13

      UniProtKB/TrEMBL
      F8WAE6
    10. XM_054345159.1XP_054201134.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X15

      UniProtKB/TrEMBL
      F8WAE6
    11. XM_054345156.1XP_054201131.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X12

      UniProtKB/TrEMBL
      F8WAE6
    12. XM_054345158.1XP_054201133.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X14

      UniProtKB/TrEMBL
      F8WAE6
    13. XM_054345153.1XP_054201128.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X10

      UniProtKB/TrEMBL
      F8WAE6
    14. XM_054345160.1XP_054201135.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X16

      UniProtKB/TrEMBL
      F8WAE6
    15. XM_054345161.1XP_054201136.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X17

      UniProtKB/TrEMBL
      F8WAE6
    16. XM_054345162.1XP_054201137.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X18

      UniProtKB/TrEMBL
      A0A8I5KY35
    17. XM_054345163.1XP_054201138.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X19

    18. XM_054345143.1XP_054201118.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X1

      UniProtKB/TrEMBL
      F8WAE6
    19. XM_054345145.1XP_054201120.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X2

      UniProtKB/TrEMBL
      F8WAE6
    20. XM_054345154.1XP_054201129.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X10

      UniProtKB/TrEMBL
      F8WAE6
    21. XM_054345148.1XP_054201123.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X5

      UniProtKB/TrEMBL
      F8WAE6
    22. XM_054345149.1XP_054201124.1  mediator of RNA polymerase II transcription subunit 12-like protein isoform X6

      UniProtKB/Swiss-Prot
      Q86YW9, Q96PC7, Q96PC8, Q9H9M5, Q9HCD7, Q9UI69
      UniProtKB/TrEMBL
      F8WAE6