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    STAT5B signal transducer and activator of transcription 5B [ Homo sapiens (human) ]

    Gene ID: 6777, updated on 9-Jun-2024

    Summary

    Official Symbol
    STAT5Bprovided by HGNC
    Official Full Name
    signal transducer and activator of transcription 5Bprovided by HGNC
    Primary source
    HGNC:HGNC:11367
    See related
    Ensembl:ENSG00000173757 MIM:604260; AllianceGenome:HGNC:11367
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    STAT5; GHISID2
    Summary
    The protein encoded by this gene is a member of the STAT family of transcription factors. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein mediates the signal transduction triggered by various cell ligands, such as IL2, IL4, CSF1, and different growth hormones. It has been shown to be involved in diverse biological processes, such as TCR signaling, apoptosis, adult mammary gland development, and sexual dimorphism of liver gene expression. This gene was found to fuse to retinoic acid receptor-alpha (RARA) gene in a small subset of acute promyelocytic leukemias (APLL). The dysregulation of the signaling pathways mediated by this protein may be the cause of the APLL. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in fat (RPKM 26.3), ovary (RPKM 25.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See STAT5B in Genome Data Viewer
    Location:
    17q21.2
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 17 NC_000017.11 (42199177..42288370, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 17 NC_060941.1 (43055661..43144521, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 17 NC_000017.10 (40351195..40428409, complement)

    Chromosome 17 - NC_000017.11Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40336245-40337046 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40345000-40345530 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12191 Neighboring gene hypocretin neuropeptide precursor Neighboring gene GH3 domain containing Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8519 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12192 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr17:40439573-40440073 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8520 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8521 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12193 Neighboring gene signal transducer and activator of transcription 5A Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12194 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8524 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8522 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8523 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr17:40480835-40481564 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr17:40481565-40482295 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12195 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12196 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8525 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12197 Neighboring gene signal transducer and activator of transcription 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8526 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8527 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 8528 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12198 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12199 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 12200 Neighboring gene uncharacterized LOC102725238 Neighboring gene caveolae associated protein 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env CD4 ligation with HIV gp120 inhibits T cell receptor-induced tyrosine phosphorylation and expression of STAT5 by blocking activation and expression of JAK3 PubMed
    capsid gag Silencing C-terminally truncated STAT5 expression by siRNA enhances HIV-1 RNA and p24 Gag expression in chronically HIV-infected U1 cell line PubMed
    gag STAT5 binds to the HIV-1 LTR during HIV infection, activating LTR transcription and leading to the upregulation of HIV-1 p24 Capsid production and an increase in the number of p24+ cells PubMed
    integrase gag-pol Analysis of HIV-1 proviral integration sites in antiretroviral treatment patients indicates that STAT5B gene favors HIV-1 integration for expansion and persistence of infected cells, suggesting HIV-1 IN interacts with STAT5B PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in B cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in Peyer's patch development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in T cell differentiation in thymus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in T cell homeostasis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in activated T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell surface receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell surface receptor signaling pathway via JAK-STAT NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in cellular response to epidermal growth factor stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to growth factor stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to hormone stimulus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cytokine-mediated signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in defense response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in development of secondary female sexual characteristics IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in development of secondary male sexual characteristics IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in erythrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in female pregnancy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gamma-delta T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in growth hormone receptor signaling pathway via JAK-STAT IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in growth hormone receptor signaling pathway via JAK-STAT IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lactation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in lipid storage IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in luteinization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mast cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in myeloid cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in natural killer cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in natural killer cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in natural killer cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of erythrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of myeloid cell apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of B cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of activated T cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of erythrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gamma-delta T cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of interleukin-2 production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of multicellular organism growth IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of natural killer cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of natural killer cell mediated cytotoxicity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of natural killer cell proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in progesterone metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of epithelial cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of multicellular organism growth ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of steroid metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to estradiol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to interleukin-15 IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to interleukin-2 IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to interleukin-4 IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to peptide hormone IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_positive_effect taurine metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in transcription by RNA polymerase II IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of RNA polymerase II transcription regulator complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of RNA polymerase II transcription regulator complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    signal transducer and activator of transcription 5B
    Names
    transcription factor STAT5B

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_007271.1 RefSeqGene

      Range
      5001..82230
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_192

    mRNA and Protein(s)

    1. NM_012448.4NP_036580.2  signal transducer and activator of transcription 5B

      See identical proteins and their annotated locations for NP_036580.2

      Status: REVIEWED

      Source sequence(s)
      BC065227, U47686
      Consensus CDS
      CCDS11423.1
      UniProtKB/Swiss-Prot
      P51692, Q8WWS8
      UniProtKB/TrEMBL
      A0A8V8TP16
      Related
      ENSP00000293328.3, ENST00000293328.8
      Conserved Domains (4) summary
      cd10420
      Location:573717
      SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
      cd16855
      Location:139330
      STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
      cd16849
      Location:332489
      STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
      pfam02865
      Location:2124
      STAT_int; STAT protein, protein interaction domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000017.11 Reference GRCh38.p14 Primary Assembly

      Range
      42199177..42288370 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047436593.1XP_047292549.1  signal transducer and activator of transcription 5B isoform X2

      UniProtKB/TrEMBL
      A0A8V8TP16
    2. XM_024450897.2XP_024306665.1  signal transducer and activator of transcription 5B isoform X1

      UniProtKB/Swiss-Prot
      P51692, Q8WWS8
      UniProtKB/TrEMBL
      A0A8V8TP16
      Related
      ENSP00000513923.1, ENST00000698776.1
      Conserved Domains (4) summary
      cd10420
      Location:573717
      SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
      cd16855
      Location:139330
      STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
      cd16849
      Location:332489
      STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
      pfam02865
      Location:2124
      STAT_int; STAT protein, protein interaction domain
    3. XM_017024977.2XP_016880466.1  signal transducer and activator of transcription 5B isoform X2

      UniProtKB/TrEMBL
      A0A8V8TP16
      Related
      ENST00000698801.1
      Conserved Domains (4) summary
      cd10420
      Location:479623
      SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
      pfam01017
      Location:47236
      STAT_alpha; STAT protein, all-alpha domain
      pfam02864
      Location:238488
      STAT_bind; STAT protein, DNA binding domain
      cl03749
      Location:231
      STAT_int; STAT protein, protein interaction domain
    4. XM_024450898.2XP_024306666.1  signal transducer and activator of transcription 5B isoform X1

      UniProtKB/Swiss-Prot
      P51692, Q8WWS8
      UniProtKB/TrEMBL
      A0A8V8TP16
      Conserved Domains (4) summary
      cd10420
      Location:573717
      SH2_STAT5b; Src homology 2 (SH2) domain found in signal transducer and activator of transcription (STAT) 5b proteins
      cd16855
      Location:139330
      STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
      cd16849
      Location:332489
      STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)
      pfam02865
      Location:2124
      STAT_int; STAT protein, protein interaction domain
    5. XM_005257626.5XP_005257683.1  signal transducer and activator of transcription 5B isoform X3

      UniProtKB/TrEMBL
      A0A8V8TM91
      Related
      ENSP00000513953.1, ENST00000698815.1
      Conserved Domains (3) summary
      smart00964
      Location:2125
      STAT_int; STAT protein, protein interaction domain
      cd16855
      Location:139330
      STAT5_CCD; Coiled-coil domain of Signal Transducer and Activator of Transcription 5 (STAT5)
      cd16849
      Location:332489
      STAT5_DBD; DNA-binding domain of Signal Transducer and Activator of Transcription 5 (STAT5)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060941.1 Alternate T2T-CHM13v2.0

      Range
      43055661..43144521 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054316998.1XP_054172973.1  signal transducer and activator of transcription 5B isoform X1

      UniProtKB/Swiss-Prot
      P51692, Q8WWS8
      UniProtKB/TrEMBL
      A0A8V8TP16
    2. XM_054317001.1XP_054172976.1  signal transducer and activator of transcription 5B isoform X2

      UniProtKB/TrEMBL
      A0A8V8TP16
    3. XM_054317000.1XP_054172975.1  signal transducer and activator of transcription 5B isoform X2

      UniProtKB/TrEMBL
      A0A8V8TP16
    4. XM_054316999.1XP_054172974.1  signal transducer and activator of transcription 5B isoform X1

      UniProtKB/Swiss-Prot
      P51692, Q8WWS8
      UniProtKB/TrEMBL
      A0A8V8TP16
    5. XM_054317002.1XP_054172977.1  signal transducer and activator of transcription 5B isoform X3

      UniProtKB/TrEMBL
      A0A8V8TM91