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    IFNG interferon gamma [ Homo sapiens (human) ]

    Gene ID: 3458, updated on 3-Jun-2024

    Summary

    Official Symbol
    IFNGprovided by HGNC
    Official Full Name
    interferon gammaprovided by HGNC
    Primary source
    HGNC:HGNC:5438
    See related
    Ensembl:ENSG00000111537 MIM:147570; AllianceGenome:HGNC:5438
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IFG; IFI; IMD69
    Summary
    This gene encodes a soluble cytokine that is a member of the type II interferon class. The encoded protein is secreted by cells of both the innate and adaptive immune systems. The active protein is a homodimer that binds to the interferon gamma receptor which triggers a cellular response to viral and microbial infections. Mutations in this gene are associated with an increased susceptibility to viral, bacterial and parasitic infections and to several autoimmune diseases. [provided by RefSeq, Dec 2015]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in cytokine storm inflammatory response.
    Expression
    Biased expression in bone marrow (RPKM 3.6), lymph node (RPKM 3.2) and 8 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See IFNG in Genome Data Viewer
    Location:
    12q15
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (68154768..68159740, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (68134280..68139252, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (68548548..68553520, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene heterogeneous nuclear ribonucleoprotein A1 pseudogene 70 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6631 Neighboring gene 39S ribosomal protein L21, mitochondrial-like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6632 Neighboring gene uncharacterized LOC105369818 Neighboring gene interleukin 26 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 6633 Neighboring gene interleukin 22

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Aplastic anemia
    MedGen: C0002874 OMIM: 609135 GeneReviews: Not available
    Compare labs
    Hepatitis C virus, susceptibility to
    MedGen: C1835407 OMIM: 609532 GeneReviews: Not available
    Compare labs
    Immunodeficiency 69
    MedGen: C5436498 OMIM: 618963 GeneReviews: Not available
    not available
    Mycobacterium tuberculosis, susceptibility to
    MedGen: C1834752 OMIM: 607948 GeneReviews: Not available
    Compare labs
    Susceptibility to HIV infection
    MedGen: C1836230 OMIM: 609423 GeneReviews: Not available
    Compare labs
    Tuberous sclerosis 2
    MedGen: C1860707 OMIM: 613254 GeneReviews: Tuberous Sclerosis Complex
    Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association identifies multiple ulcerative colitis susceptibility loci.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Meta-analysis identifies 29 additional ulcerative colitis risk loci, increasing the number of confirmed associations to 47.
    EBI GWAS Catalog
    Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV/tuberculosis coinfection upregulates IFNG expression in pleural fluid mononuclear cells (PFMC) isolated from antiretroviral-naive coinfected patients (relative to patients infected with only tuberculosis) PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Asp asp A pool of ASP-overlapping peptides enhance IFN-gamma responses of T cells in HIV-1 seropositive patients PubMed
    asp Antisense reading frame-derived cryptic epitopes from the env gene induce upregulation of IFNG immune-response on the surface of CD8+ T-cells PubMed
    Envelope surface glycoprotein gp120 env Cytokines induced in vitro by HIV-1 gp120 in normal peripheral blood mononuclear cells (PBMC) include interferon-alpha (IFN-alpha) and IFN-gamma, tumor necrosis factor-alpha (TNF-alpha), IL-6, IL-10, IL-1 alpha and IL-1 beta PubMed
    env Treatment of cells with HIV-1 gp120 induces the release of IFN gamma PubMed
    env HIV-1 Env gp120 peptides can stimulate cytoplasmic IFN-gamma response in CD8+ T cells in the presence of dendritic cells PubMed
    env HIV-1 gp120-induced IL-23 upregulated SOCS1 protein in T cells, which inhibits IFN-gamma production and killing of CEF-pulsed monocytes PubMed
    env HIV-1 gp120-treated myeloid dendritic cell (mDC) downregulates IL-2 and IFN-gamma production compared to LPS-treated mDC PubMed
    env Frequent IFN-gamma and TNF-alpha NK cell responses to HIV-1 gp120 are dominant during chronic HIV-1 infection PubMed
    env HIV-1 gp120-expanded CD33+ myeloid derived suppressor cells inhibits IFN-gamma release from autologous T cells PubMed
    env IL-11 inhibits HIV-1 gp120-mediated downregulation of IFN-gamma in human NK cells PubMed
    env NK cells that respond with IFN-gamma and TNF-alpha cytokine production to HIV-1 gp120 peptides have reduced CD16 and NKp46 expression and have increased levels of CD57 PubMed
    env Gp120/IFN-gamma-mediated cytotoxicity of human brain micro vascular endothelial cells (HBMECs) involves the p38 MAPK signaling pathway PubMed
    env Peptides of gp120 representing binding regions for CD4 and chemokine receptors, as well as CD4 antibody, inhibit gp120/IFN-gamma-mediated cytotoxicity of human brain micro vascular endothelial cells (HBMECs) PubMed
    env HIV-1 gp120 in the presence of IFN-gamma induces cytotoxicity of human brain micro vascular endothelial cells (HBMECs) derived from children but not from adults PubMed
    env Interferon-alpha- and interferon-gamma-induced sialoadhesin-expressing monocytes adsorb HIV-1 through interaction with the sialic acid residues on the viral envelope glycoprotein gp120 PubMed
    env In the presence of HIV-1 gp120, stimulation through the CD28 pathway partially restores IL-2 and IFN-gamma production by T cell lines in response to anti-CD3 antibodies PubMed
    env HIV-1 gp120 inhibits natural killer (NK) cell natural cytotoxicity and this inhibition also affects the production of the proinflammatory cytokine interferon-gamma (IFN-gamma); the inhibitory activity of gp120 can be prevented by coincubation with VIP PubMed
    env Induction of the receptor activator of cytokine nuclear factor kappa B ligand (RANKL) is mediated by HIV-1 gp120; the gp120-mediated induction of RANKL is blocked by interferon-gamma PubMed
    env Secretion of IL-12 is found in macrophages primed with gamma interferon (IFN-gamma) and subsequently treated with gp120 PubMed
    env Secretion of IL-2 and IFN-gamma stimulated with anti-CD3 antibodies is inhibited by HIV-1 gp120 in T cell lines PubMed
    env Sulfate containing galactolipids such as sulfatides on responder cells may be part of the HIV-1 gp120-membrane complex that initiates the induction of interferon (IFN) PubMed
    env HIV-1 gp41 or gp120 synthetic peptides induce the production of interleukin (IL)-1 and tumor necrosis factor (TNF); in contrast, gp41 or gp120 synthetic peptides are able to depress the production of interferon (IFN)-alpha, IFN-gamma, and IL-2 PubMed
    env IFN-gamma and gp120-induced activation of Na+/H+ exchange appears to be mediated through activation of tyrosine kinase (TK), because TK inhibitors block the action of IFN-gamma and gp120 PubMed
    env Treatment of human colonic epithelial cells with recombinant gamma-interferon (rlFN gamma) induces a dose-dependent inhibition of Galactosyl ceramide (GalCer) expression on the cell surface; GalCer is a receptor for HIV-1 gp120 PubMed
    Envelope surface glycoprotein gp160, precursor env HIV-1 Env induces release of IFN-gamma from CAR-transduced T cells PubMed
    env Pretreatment of CD4+ cells with HIV-1 gp160 significantly reduces PHA-induced secretion of IFN-gamma and IL-2 but augments IL-4 production PubMed
    Envelope transmembrane glycoprotein gp41 env A synthetic peptide corresponding to the immunosuppressive domain (amino acids 574-592) of HIV-1 gp41 inhibits activation of PBMCs and upregulates the expression of IFN-gamma in peptide-treated PBMCs PubMed
    env PWM, LPS, IFN-gamma and IL-6 can increase HIV-1 gp41 binding to human B cells PubMed
    env IFN-gamma production in mononuclear leukocytes from an HIV-1-seropositive man is induced by different concentrations of a recombinant HIV-1 envelope glycoprotein gp41 and gp120 fragment PubMed
    Nef nef HIV-1 Nef-stimulated CD8+ T cells upregulate mRNAs expression for IFN-gamma, MIP-1alpha, MIP-1alphaP, MIP-1beta, TNFRSF9, XCL1, and GM-CSF compared to unstimulated cells PubMed
    nef The proportion of HIV-1 Nef-specific CD8+ T cells endowed with TNF-alpha+, IFN-gamma+, CD107A+, and MIP-1beta+ is significantly higher in patients with the lowest virus set point than those with the highest virus set point PubMed
    nef Coincubation of HIV-1 Nef and IFN-gamma downregulates COX-2 expression compared to untreated, Nef- or IFN-gamma-treated Caco-2 cells PubMed
    nef HIV-1 Nef inhibits IFN-gamma-induced apoptosis and upregulates TNF-alpha, IL-6 and MIP-3alpha production by Caco-2 cells while downregulating IL-10 production PubMed
    nef Exogenous Nef taken up by Caco-2 cells increases intestinal epithelial permeability, inhibits the IFN-gamma-induced reduction of transepitelial resistance and decreases the tight junction proteins occludin and ZO1 expression PubMed
    nef HIV-1 Nef has super antigen properties in that it binds to MHC class II antigens and activates T cells, causing T cell proliferation and production of the T helper 1 cytokines IL-2 and IFN-gamma PubMed
    nef Upon T cell activation, HIV-1 Nef expression downregulates both IL-2 and IFN-gamma production in a dose-dependent manner PubMed
    nef PBMC proliferation induced by exogenous HIV-1 Nef is associated with upregulation of interferon-gamma (IFN-gamma) PubMed
    Pr55(Gag) gag Treatment of PBMCs taken from treatment-naive HIV chronically infected individuals with a HIV-1 Gag peptide pool in the presence of ADAM10 inhibitor upregulates the levels of Tim-3 and IFN-gamma in CD8+ T cells PubMed
    gag HIV-1-exposed monocyte-derived dendritic cells induce weak secretion of IFN-gamma and low amounts of intracellular Gag expression in the presence of SAMHD1 PubMed
    gag HIV-1 Gag peptides can stimulate cytoplasmic IFN-gamma response in CD8 T cells PubMed
    gag MVA-gag induces a significant release of cytokines such as IL-2R, IL-6, IL-8, TNF-alpha, IFN-gamma, MCP-1, MIP-1alpha, MIP-1beta, and RANTES by the infected monocyte-derived dendritic cells in comparison with uninfected cells PubMed
    gag The proportion of HIV-1 Gag-specific CD8+ T cells endowed with TNF-alpha+, IFN-gamma+, CD107A+, and MIP-1beta+ is significantly higher in patients with the lowest virus set point than those with the highest virus set point PubMed
    gag IFN-gamma-stimulated expression of APOL1 in differentiated U937 monocytes contributes to inhibition of HIV-1 Gag/p24 expression PubMed
    gag Gag-specific interferon (IFN)-gamma secreting responses correlate with the rate of disease progression as defined by the annual rate of CD4 decline in patients PubMed
    gag HIV-1 Gag virus-like particles expressed by recombinant baculoviruses activate human PBMC to release IFN-gamma in a dose and time dependent manner PubMed
    gag HIV-1 Gag virus-like particle-induced human monocyte-derived dendritic cell maturation activates autologous NK cells, leading to their proliferation, and production of interferon-gamma PubMed
    gag HIV-1 Gag p24-specific CD4+ T cells producing IL-2 and IFN-gamma are increased post vaccination PubMed
    gag Interferon-gamma can counteract the inhibitory effect of peptides based on the Capsid protein of HIV-1 Gag on antibody response to Sheep Red Cell Antigen PubMed
    gag The Capsid (p24) protein of HIV-1 Gag inhibits interferon gamma induced increases in HLA-DR and cytochrome B heavy chain mRNA levels in the human monocyte-like cell line THP1 PubMed
    gag The Matrix protein of HIV-1 Gag enhances the cytokine-induced production of interferon gamma PubMed
    gag The Matrix protein of HIV-1 Gag and interferon gamma are structurally similar and have been found to bind in vitro PubMed
    Tat tat HIV-1 Tat upregulates the production of cytokines, including TNF-alpha, IL-6, IL-10, IL-12, IFN-alpha1, and IFN-gamma, in human monocyte derived-dendritic cells and in primary human Muller glia PubMed
    tat HIV-1 Tat-induced inhibition of IFN-gamma release is regulated by the interaction of Tat-RGD domain with alpha5beta1 and alpha5beta3 integrins in CD8+ T cells PubMed
    tat The contact between peptide-stimulated CD8+ T-lymphocytes and immobilized HIV-1 Tat inhibits the release of IFN-gamma PubMed
    tat HIV-1 Tat upregulates IL-2 and IFN-gamma production in stimulated CD8+ T cells PubMed
    tat JAK/STAT pathway plays a major role in Tat/IFN-gamma-mediated CXCL10 induction in macrophages PubMed
    tat The synergistic upregulation of CXCL10 expression by HIV-1 Tat and IFN-gamma is inhibited by mu-opioid receptor (MOR) antagonist beta-funaltrexamine in human astrocytes PubMed
    tat HIV-1 Tat-induced upregulation of IDO production requires the activity of IFN-gamma signaling pathway such as JAK and PI3K in human monocyte derived-dendritic cells PubMed
    tat Tat and IFN-gamma synergistically induce the expression of CXCL10, which is inhibited by MEK1/2 inhibitor and the p38 mitogen-activated protein kinase (MAPK) inhibitor PubMed
    tat HIV-1 Tat increases CXCL10 expression in IFN-gamma and TNF-alpha stimulated human astrocytes via NADPH oxidase PubMed
    tat HIV-1 Tat suppresses IFN-gamma-induced LC3B protein expression and autophagosome formation through Tat-mediated suppression of STAT1 phosphorylation PubMed
    tat Pretreatment of THP-1 cells with HIV-1 Tat/T-bet co-cultures with CD4+T cells, resulting in increased levels of IFN-gamma PubMed
    tat HIV-1 Tat impairs the IFNgamma-receptor signaling pathway, in primary human monocytes, at the level of STAT1 activation via Tat-dependent induction of suppressor of cytokine signaling-2 (SOCS-2) activity PubMed
    tat HIV-1 Tat in combination with IFN-gamma and TNF-alpha increases CXCL10 mRNA and protein in human astrocytes through the activation of the p38, Jnk, and Akt signaling pathways and their downstream transcription factors, NF-kappaB and STAT-1alpha PubMed
    tat HIV-1 Tat acts as a co-stimulatory molecule that affects viral replication by modulating host immune response through induction of T-bet expression and IFN-gamma secretion PubMed
    tat HIV-1 Tat interacts with IFN-gamma, which upregulates the Tat receptor VEGFR2/KDR, to produce cytotoxicity in human brain micro vascular endothelial cells PubMed
    tat HIV-1 Tat upregulates IFN-gamma expression by uninfected mononuclear cells PubMed
    tat HIV-1 Tat inhibits IFN-gamma release by NK cells upon contact with dendritic cells PubMed
    tat HIV-1 Tat delivered by CyaA from Bordetella pertussis induces a Th1-polarized immune response and HIV-Tat-specific gamma interferon-producing CD8(+) T cells are generated after vaccination with CyaA-E5-Tat in a CD4(+) T-cell-independent manner PubMed
    tat HIV-1 Tat synergizes with IFN-gamma to induce iNOS activity in purified rat microglial cultures PubMed
    tat IFN-gamma interacts with HIV-1 Tat to induce endothelial cells to proliferate and invade the extracellular matrix by upregulating the receptors for Tat (integrins alpha-5-beta-1 and alpha-v-beta-3), suggesting Tat and IFN-gamma play major roles in AIDS-KS PubMed
    tat IFN-gamma inhibits the transactivation of the HIV-1 LTR promoter by HIV-1 Tat PubMed
    tat HIV-1 Tat inhibits IFN-gamma induced iNOS activity in a murine macrophage cell line PubMed
    tat IL-1beta, TNF-alpha, and IFN-gamma synergize with HIV-1 Tat to promote in nude mice the development of angioproliferative Kaposi's sarcoma-like lesions PubMed
    tat HIV-1 Tat enhances translation of the interferon-inducible enzymes 2-5A synthetase and dsRNA-dependent protein kinase, suggesting interaction of Tat with interferons during HIV-1 replication PubMed
    Vif vif HIV-1 Vif downregulates the expression of interferon-gamma (IFNG) in Vif-expression T cells PubMed
    Vpr vpr Exogenous Vpr compromises subsequent pDC/NK interplay through inhibition of IFN-gamma production by NK cells PubMed
    vpr HIV-1 Vpr inhibits interferon gamma secretion in infected T cells PubMed
    vpr HIV-1 Vpr impairs NK cell function through cytokine dysregulation, including diminshed expression of CD107a, reduced production of IFN-gamma, differential regulation of IL-12 and TGF-beta, and activation of the Smad3 signalling pathway PubMed
    vpr Expression of HIV-1 Vpr in U937 cells upregulates gamma interferon expression PubMed
    capsid gag Peptides derived from HIV-1 p24 induces release of IFN-gamma in monocyte-derived DCs and macrophages PubMed
    gag PLA-p24- or p24-loaded human monocyte-derived dendritic cells enhance HIV-1-specific T-cell response by increased levels of IFN-gamma and IL-2 in comparison with PLA-loaded cells alone PubMed
    gag HIV-1 CA-stimulated CD8+ T cells upregulate mRNAs expression for IFN-gamma, MIP-1alpha, MIP-1alphaP, MIP-1beta, TNFRSF9, XCL1, and GM-CSF compared to unstimulated cells PubMed
    gag IFN-gamma-stimulated expression of APOL1 in differentiated U937 monocytes contributes to inhibition of HIV-1 Gag/p24 expression PubMed
    gag IFN-gamma and/or IL-2 responses characterized by secreting cells contribute more to the HIV-1 CA specific response in acute infection early disease (AIED) than in chronically infected individuals PubMed
    gag Pretreating dendritic cells with INF-gamma overcomes the HIV-1 CA-mediated decreased levels of presentation of ovalbumin to a SIINFEKL-specific CD8(+) T-cell hybridoma PubMed
    gag HIV-1 Capsid (p24) inhibits interferon gamma induced increases in HLA-DR and cytochrome B heavy chain mRNA levels in the human monocyte-like cell line THP1 PubMed
    gag Interferon-gamma can counteract the inhibitory effect of HIV-1 Capsid based peptides on antibody response to Sheep Red Cell Antigen PubMed
    matrix gag HIV-1 Matrix enhances the cytokine-induced production of interferon gamma PubMed
    gag HIV-1 Matrix and interferon gamma are structurally similar and have been found to bind in vitro PubMed
    reverse transcriptase gag-pol Up-regulation of LMP7 by IFN-gamma enhances proteasomal degradation of HIV-1 RT and presentation of the VIYQYMDDL epitope derived from HIV-1 RT PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables type II interferon receptor binding IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in adaptive immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within apoptotic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in astrocyte activation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in astrocyte activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cell surface receptor signaling pathway TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in cell surface receptor signaling pathway via JAK-STAT ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to virus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in defense response to virus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in extrinsic apoptotic signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in humoral immune response IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in macrophage activation involved in immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in macrophage differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in microglial cell activation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in microglial cell activation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of amyloid-beta clearance ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of epithelial cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of interleukin-17 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of smooth muscle cell proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in negative regulation of tau-protein kinase activity IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuroinflammatory response ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of CD4-positive, CD25-positive, alpha-beta regulatory T cell differentiation involved in immune response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of MHC class II biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of NMDA glutamate receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of amyloid-beta formation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of amyloid-beta formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of autophagy IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of calcidiol 1-monooxygenase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of cellular respiration ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of chemokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of core promoter binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cytokine production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of epithelial cell migration IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of exosomal secretion HDA PubMed 
    involved_in positive regulation of fructose 1,6-bisphosphate 1-phosphatase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of fructose 1,6-bisphosphate metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene expression HDA PubMed 
    acts_upstream_of_or_within positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene expression IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene expression IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of glycolytic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of inflammatory response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interleukin-1 beta production ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of interleukin-12 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interleukin-23 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of interleukin-6 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of iron ion import across plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of killing of cells of another organism IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of membrane protein ectodomain proteolysis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of neurogenesis IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of nitric oxide biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of nitric-oxide synthase biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of osteoclast differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of peptidyl-serine phosphorylation of STAT protein IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of peptidyl-serine phosphorylation of STAT protein NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of phagocytosis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein deacetylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein import into nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein localization to plasma membrane HDA PubMed 
    involved_in positive regulation of protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of protein-containing complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of signaling receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of smooth muscle cell apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of tumor necrosis factor (ligand) superfamily member 11 production IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of tumor necrosis factor production ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    acts_upstream_of_or_within positive regulation of tyrosine phosphorylation of STAT protein IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of tyrosine phosphorylation of STAT protein IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of vitamin D biosynthetic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of insulin secretion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of metabolic process IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    acts_upstream_of_or_within response to virus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in type II interferon-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in type II interferon-mediated signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in type III interferon-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    interferon gamma
    Names
    IFN-gamma
    immune interferon

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_015840.1 RefSeqGene

      Range
      5002..9974
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      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000619.3NP_000610.2  interferon gamma precursor

      See identical proteins and their annotated locations for NP_000610.2

      Status: REVIEWED

      Source sequence(s)
      AC007458, BC070256, V00543
      Consensus CDS
      CCDS8980.1
      UniProtKB/Swiss-Prot
      B5BU88, P01579, Q53ZV4
      UniProtKB/TrEMBL
      A0A7R8GUN6, A8YQE4
      Related
      ENSP00000229135.3, ENST00000229135.4
      Conserved Domains (1) summary
      pfam00714
      Location:15152
      IFN-gamma; Interferon gamma

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      68154768..68159740 complement
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      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      68134280..68139252 complement
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      GenBank, FASTA, Sequence Viewer (Graphics)