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    IVNS1ABP influenza virus NS1A binding protein [ Homo sapiens (human) ]

    Gene ID: 10625, updated on 7-Apr-2024

    Summary

    Official Symbol
    IVNS1ABPprovided by HGNC
    Official Full Name
    influenza virus NS1A binding proteinprovided by HGNC
    Primary source
    HGNC:HGNC:16951
    See related
    Ensembl:ENSG00000116679 MIM:609209; AllianceGenome:HGNC:16951
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ND1; ARA3; NS-1; IMD70; NS1BP; FLARA3; KLHL39; NS1-BP; HSPC068
    Summary
    Involved in RNA splicing; negative regulation of protein ubiquitination; and response to virus. Located in cytosol. Implicated in immunodeficiency 70. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bone marrow (RPKM 56.1), kidney (RPKM 31.5) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See IVNS1ABP in Genome Data Viewer
    Location:
    1q25.3
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (185296388..185317243, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (184653292..184680201, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (185265520..185286375, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene SWT1 RNA endoribonuclease homolog Neighboring gene ribosomal protein L5 pseudogene 5 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:185226026-185226636 Neighboring gene uncharacterized LOC105371651 Neighboring gene proteasome (prosome, macropain) 26S subunit, non-ATPase, 7 pseudogene Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:185285701-185286314 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1647 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2242 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 2243 Neighboring gene microtubule associated protein 1 light chain 3 beta pseudogene Neighboring gene CBS mRNA stabilizing lncRNA Neighboring gene Sharpr-MPRA regulatory region 834 Neighboring gene RNA, U7 small nuclear 183 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag HIV-1 Gag is identified to have a physical interaction with influenza virus NS1A binding protein (IVNS1ABP; NS1BP) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ10069, FLJ10411, FLJ10962, FLJ35593, FLJ36593, KIAA0850, DKFZp686K06216

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    part_of spliceosomal complex TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of transcription regulator complex TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    influenza virus NS1A-binding protein
    Names
    NCX downstream gene 1
    NS1-binding protein
    aryl hydrocarbon receptor-associated 3
    aryl hydrocarbon receptor-associated protein 3
    kelch-like family member 39
    kelch-like protein 39

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_006469.5NP_006460.2  influenza virus NS1A-binding protein

      See identical proteins and their annotated locations for NP_006460.2

      Status: VALIDATED

      Source sequence(s)
      AB020657, AF205218, AK000931, AL137640
      Consensus CDS
      CCDS1368.1
      UniProtKB/Swiss-Prot
      A8K8R6, Q1G4T6, Q1G4T7, Q5TF75, Q6NW38, Q7LCG2, Q9NZX0, Q9Y480, Q9Y6Y0
      Related
      ENSP00000356468.3, ENST00000367498.8
      Conserved Domains (4) summary
      PHA03098
      Location:23638
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:502545
      Kelch; KELCH repeat [structural motif]
      cd18306
      Location:14137
      BTB_POZ_NS1BP; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Influenza virus NS1A-binding protein (NS1-BP)
      cd18502
      Location:129225
      BACK_NS1BP_IVNS1ABP; BACK (BTB and C-terminal Kelch) domain found in influenza virus NS1A-binding protein (NS1-BP)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      185296388..185317243 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047434096.1XP_047290052.1  influenza virus NS1A-binding protein isoform X2

    2. XM_047434070.1XP_047290026.1  influenza virus NS1A-binding protein isoform X1

      UniProtKB/Swiss-Prot
      A8K8R6, Q1G4T6, Q1G4T7, Q5TF75, Q6NW38, Q7LCG2, Q9NZX0, Q9Y480, Q9Y6Y0
    3. XM_047434109.1XP_047290065.1  influenza virus NS1A-binding protein isoform X3

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      184653292..184680201 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333888.1XP_054189863.1  influenza virus NS1A-binding protein isoform X1

      UniProtKB/Swiss-Prot
      A8K8R6, Q1G4T6, Q1G4T7, Q5TF75, Q6NW38, Q7LCG2, Q9NZX0, Q9Y480, Q9Y6Y0
    2. XM_054333889.1XP_054189864.1  influenza virus NS1A-binding protein isoform X2

    3. XM_054333890.1XP_054189865.1  influenza virus NS1A-binding protein isoform X3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_016389.2: Suppressed sequence

      Description
      NM_016389.2: This RefSeq was permanently suppressed because it is a nonsense-mediated mRNA decay (NMD) candidate.