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    FARSB phenylalanyl-tRNA synthetase subunit beta [ Homo sapiens (human) ]

    Gene ID: 10056, updated on 19-Sep-2024

    Summary

    Official Symbol
    FARSBprovided by HGNC
    Official Full Name
    phenylalanyl-tRNA synthetase subunit betaprovided by HGNC
    Primary source
    HGNC:HGNC:17800
    See related
    Ensembl:ENSG00000116120 MIM:609690; AllianceGenome:HGNC:17800
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    FRSB; RJBS; PheHB; PheRS; FARSLB; RILDBC; HSPC173; NEDBLLA; RILDBC1
    Summary
    This gene encodes a highly conserved enzyme that belongs to the aminoacyl-tRNA synthetase class IIc subfamily. This enzyme comprises the regulatory beta subunits that form a tetramer with two catalytic alpha subunits. In the presence of ATP, this tetramer is responsible for attaching L-phenylalanine to the terminal adenosine of the appropriate tRNA. A pseudogene located on chromosome 10 has been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
    Expression
    Ubiquitous expression in brain (RPKM 8.3), testis (RPKM 8.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See FARSB in Genome Data Viewer
    Location:
    2q36.1
    Exon count:
    19
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (222566899..222656092, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (223052236..223141156, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (223431618..223520811, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene sphingosine-1-phosphate phosphatase 2 Neighboring gene RNA, U6 small nuclear 619, pseudogene Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:223383170-223383762 Neighboring gene glyceraldehyde 3 phosphate dehydrogenase pseudogene 49 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:223400343-223400843 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 12372 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:223502966-223503113 Neighboring gene uncharacterized LOC105373902 Neighboring gene tripartite motif containing 60 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 17167 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:223521038-223521234 Neighboring gene uncharacterized LOC124907985 Neighboring gene monoacylglycerol O-acyltransferase 1 Neighboring gene RRAS2 pseudogene 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables magnesium ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables phenylalanine-tRNA ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in phenylalanyl-tRNA aminoacylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phenylalanyl-tRNA aminoacylation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein heterotetramerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in translation TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in membrane HDA PubMed 
    part_of phenylalanine-tRNA ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of phenylalanine-tRNA ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of phenylalanine-tRNA ligase complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    phenylalanine--tRNA ligase beta subunit
    Names
    phenylalanine tRNA ligase 1, beta, cytoplasmic
    phenylalanine-tRNA ligase beta chain
    phenylalanine-tRNA synthetase-like, beta subunit
    phenylalanyl-tRNA synthetase beta chain
    phenylalanyl-tRNA synthetase beta subunit
    phenylalanyl-tRNA synthetase-like, beta subunit
    NP_005678.3
    XP_006712232.1
    XP_011508768.1
    XP_054196057.1
    XP_054196058.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005687.5NP_005678.3  phenylalanine--tRNA ligase beta subunit

      See identical proteins and their annotated locations for NP_005678.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the shorter transcript and encodes the functional protein.
      Source sequence(s)
      AC097461, AF042346, BG721840
      Consensus CDS
      CCDS2454.1
      UniProtKB/Swiss-Prot
      B4DFM0, O95708, Q4ZFX1, Q57ZJ5, Q9NSD9, Q9NZZ6
      UniProtKB/TrEMBL
      A8K666
      Related
      ENSP00000281828.6, ENST00000281828.8
      Conserved Domains (4) summary
      smart00873
      Location:118279
      B3_4; B3/4 domain
      PLN02265
      Location:1589
      PLN02265; probable phenylalanyl-tRNA synthetase beta chain
      cd00769
      Location:392588
      PheRS_beta_core; Phenylalanyl-tRNA synthetase (PheRS) beta chain core domain. PheRS belongs to class II aminoacyl-tRNA synthetases (aaRS) based upon its structure. While class II aaRSs generally aminoacylate the 3'-OH ribose of the appropriate tRNA, PheRS is an ...
      pfam03484
      Location:310374
      B5; tRNA synthetase B5 domain

    RNA

    1. NR_130154.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) contains an alternate internal exon compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AC097461, BC022273

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      222566899..222656092 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011510466.3XP_011508768.1  phenylalanine--tRNA ligase beta subunit isoform X1

      See identical proteins and their annotated locations for XP_011508768.1

      UniProtKB/TrEMBL
      B7ZB32
      Conserved Domains (1) summary
      cl27259
      Location:1490
      B5; tRNA synthetase B5 domain
    2. XM_006712169.3XP_006712232.1  phenylalanine--tRNA ligase beta subunit isoform X1

      See identical proteins and their annotated locations for XP_006712232.1

      UniProtKB/TrEMBL
      B7ZB32
      Conserved Domains (1) summary
      cl27259
      Location:1490
      B5; tRNA synthetase B5 domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      223052236..223141156 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054340083.1XP_054196058.1  phenylalanine--tRNA ligase beta subunit isoform X1

      UniProtKB/TrEMBL
      B7ZB32
    2. XM_054340082.1XP_054196057.1  phenylalanine--tRNA ligase beta subunit isoform X1

      UniProtKB/TrEMBL
      B7ZB32