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    AGO2 argonaute RISC catalytic component 2 [ Homo sapiens (human) ]

    Gene ID: 27161, updated on 9-Jun-2024

    Summary

    Official Symbol
    AGO2provided by HGNC
    Official Full Name
    argonaute RISC catalytic component 2provided by HGNC
    Primary source
    HGNC:HGNC:3263
    See related
    Ensembl:ENSG00000123908 MIM:606229; AllianceGenome:HGNC:3263
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PPD; Q10; CASC7; EIF2C2; LESKRES; LINC00980
    Summary
    This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
    Expression
    Ubiquitous expression in skin (RPKM 3.3), ovary (RPKM 3.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See AGO2 in Genome Data Viewer
    Location:
    8q24.3
    Exon count:
    23
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (140520156..140642313, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (141640512..141762332, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (141530255..141645732, complement)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr8:141474198-141475397 Neighboring gene uncharacterized LOC105375782 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19579 Neighboring gene MPRA-validated peak7190 silencer Neighboring gene ReSE screen-validated silencer GRCh37_chr8:141518766-141518946 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28027 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28028 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19580 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28029 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141537549-141538050 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141538051-141538550 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141554768-141555545 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141559982-141560482 Neighboring gene chromatin accessibility complex subunit 1 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:141567119-141568318 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr8:141569579-141570778 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141578119-141578876 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28030 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28031 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28032 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141603574-141604074 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28034 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:141607590-141608092 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28036 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28037 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:141619067-141620038 Neighboring gene MAGE-like protein 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141634221-141635220 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141635221-141636221 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr8:141640637-141641137 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:141643203-141643970 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr8:141643971-141644737 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19583 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr8:141655407-141656606 Neighboring gene uncharacterized LOC124902099 Neighboring gene E2F1-regulated inhibitor of cell death Neighboring gene protein tyrosine kinase 2 Neighboring gene microRNA 151a

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Lessel-Kreienkamp syndrome
    MedGen: C5436892 OMIM: 619149 GeneReviews: Not available
    not available

    EBI GWAS Catalog

    Description
    Genome-wide association analyses suggest NELL1 influences adverse metabolic response to HCTZ in African Americans.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Nef nef The interaction of HIV-1 Nef with AGO2 inhibits miRNA-induced silencing and the slicing activity of AGO2 PubMed
    nef HIV-1 Nef interacts with AGO2 and two GW motifs at residues 12-13 and 140-141 in Nef are required for AGO2 binding PubMed
    nef HIV-1 Nef co-localizes with AGO2 in multivesicular bodies PubMed
    Pr55(Gag) gag Knockdown of AGO2 by shRNA leads to enhance enrichment of HIV-1 Gag in intracellular vacuoles, but decrease viral particle release in Gag expressing cells PubMed
    gag Mov10 overexpression results in translational repression of HIV-1 Gag and that AGO2 and/or RISC function is required to induce this translational repression PubMed
    gag The efficiency of incorporation of Mov10, A3G, and A3F into viral particles, which contains both HIV-1 Gag and genomic RNA, is much higher than that of the other P-body proteins AGO2, DCP1a, DCP2, and DDX6 PubMed
    gag ABCE1, DDX6, and AGO2 proteins are associated with HIV-1 Gag in the intracellular high-molecular-weight assembly intermediates. DDX6 and AGO2 are enriched at early and late sites of Gag assembly at plasma membrane PubMed
    gag HIV-1 Gag interacts with and encapsidates AGO2 into virus particles in a miRNA- and P-body-independent manner. AGO2 is required for HIV-1 replication PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC3183, FLJ34853

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA 7-methylguanosine cap binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA binding HDA PubMed 
    enables RNA endonuclease activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA endonuclease activity TAS
    Traceable Author Statement
    more info
     
    enables RNA polymerase II complex binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables core promoter sequence-specific DNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables endoribonuclease activity, cleaving miRNA-paired mRNA IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables endoribonuclease activity, cleaving miRNA-paired mRNA IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables endoribonuclease activity, cleaving siRNA-paired mRNA IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA 3'-UTR AU-rich region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA cap binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mRNA cap binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables miRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables miRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables miRNA binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables miRNA binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to siRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables siRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables single-stranded RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables single-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables translation initiation factor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in P-body assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in RISC complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in RNA secondary structure unwinding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in RNA secondary structure unwinding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in miRNA metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in miRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in miRNA-mediated gene silencing by inhibition of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in miRNA-mediated gene silencing by inhibition of translation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in miRNA-mediated gene silencing by mRNA destabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in miRNA-mediated gene silencing by mRNA destabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of amyloid precursor protein biosynthetic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of translational initiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of angiogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of nuclear-transcribed mRNA poly(A) tail shortening ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of translation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of trophoblast cell migration IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in post-embryonic development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in pre-miRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in pre-miRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of synapse maturation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of synapse maturation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulatory ncRNA-mediated gene silencing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulatory ncRNA-mediated post-transcriptional gene silencing TAS
    Traceable Author Statement
    more info
     
    involved_in siRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in siRNA-mediated gene silencing by mRNA destabilization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in siRNA-mediated gene silencing by mRNA destabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in translation NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in translational initiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of RISC complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of RISC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of RISC complex IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    part_of RISC complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    part_of RISC-loading complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of RISC-loading complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasmic ribonucleoprotein granule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasmic ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in dendrite IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in membrane HDA PubMed 
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IC
    Inferred by Curator
    more info
    PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in postsynapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    protein argonaute-2
    Names
    PAZ Piwi domain protein
    argonaute 2, RISC catalytic component
    cancer susceptibility candidate 7 (non-protein coding)
    eukaryotic translation initiation factor 2C, 2
    long intergenic non-protein coding RNA 980
    protein slicer
    NP_001158095.1
    NP_036286.2
    XP_011515267.1
    XP_011515270.3
    XP_047277651.1
    XP_047277652.1
    XP_047277653.1
    XP_054216272.1
    XP_054216273.1
    XP_054216274.1
    XP_054216275.1
    XP_054216276.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001164623.3NP_001158095.1  protein argonaute-2 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The resulting isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AC067931, AC107375
      Consensus CDS
      CCDS55279.1
      UniProtKB/TrEMBL
      A4FVC0
      Related
      ENSP00000430176.1, ENST00000519980.5
      Conserved Domains (4) summary
      cd02846
      Location:227347
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:392783
      Piwi_ago-like; Piwi_ago-like: PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of ...
      pfam08699
      Location:176226
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:92166
      ArgoN; N-terminal domain of argonaute
    2. NM_012154.5NP_036286.2  protein argonaute-2 isoform 1

      See identical proteins and their annotated locations for NP_036286.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AC067931, AC107375
      Consensus CDS
      CCDS6380.1
      UniProtKB/Swiss-Prot
      Q8TCZ5, Q8WV58, Q96ID1, Q9UKV8
      UniProtKB/TrEMBL
      A4FVC0
      Related
      ENSP00000220592.5, ENST00000220592.10
      Conserved Domains (4) summary
      cd02846
      Location:227347
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:392817
      Piwi_ago-like; PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of which provides the ...
      pfam08699
      Location:176226
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:92166
      ArgoN; N-terminal domain of argonaute

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      140520156..140642313 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011516968.3XP_011515270.3  protein argonaute-2 isoform X3

      UniProtKB/TrEMBL
      A4FVC0
    2. XM_047421697.1XP_047277653.1  protein argonaute-2 isoform X3

      UniProtKB/TrEMBL
      A4FVC0
    3. XM_047421695.1XP_047277651.1  protein argonaute-2 isoform X2

      UniProtKB/TrEMBL
      A4FVC0
    4. XM_011516965.3XP_011515267.1  protein argonaute-2 isoform X1

      UniProtKB/TrEMBL
      A4FVC0
      Conserved Domains (5) summary
      PLN03202
      Location:39872
      PLN03202; protein argonaute; Provisional
      cd02846
      Location:241361
      PAZ_argonaute_like; PAZ domain, argonaute_like subfamily. Argonaute is part of the RNA-induced silencing complex (RISC), and is an endonuclease that plays a key role in the RNA interference pathway. The PAZ domain has been named after the proteins Piwi,Argonaut, and Zwille. ...
      cd04657
      Location:406831
      Piwi_ago-like; Piwi_ago-like: PIWI domain, Argonaute-like subfamily. Argonaute is the central component of the RNA-induced silencing complex (RISC) and related complexes. The PIWI domain is the C-terminal portion of Argonaute and consists of two subdomains, one of ...
      pfam08699
      Location:191240
      ArgoL1; Argonaute linker 1 domain
      pfam16486
      Location:42180
      ArgoN; N-terminal domain of argonaute
    5. XM_047421696.1XP_047277652.1  protein argonaute-2 isoform X3

      UniProtKB/TrEMBL
      A4FVC0

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      141640512..141762332 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054360301.1XP_054216276.1  protein argonaute-2 isoform X3

      UniProtKB/TrEMBL
      A4FVC0
    2. XM_054360300.1XP_054216275.1  protein argonaute-2 isoform X3

      UniProtKB/TrEMBL
      A4FVC0
    3. XM_054360298.1XP_054216273.1  protein argonaute-2 isoform X2

      UniProtKB/TrEMBL
      A4FVC0
    4. XM_054360297.1XP_054216272.1  protein argonaute-2 isoform X1

      UniProtKB/TrEMBL
      A4FVC0
    5. XM_054360299.1XP_054216274.1  protein argonaute-2 isoform X3

      UniProtKB/TrEMBL
      A4FVC0