POLR3K RNA polymerase III subunit K [Homo sapiens (human)] - Gene

Summary

Official Symbol: POLR3Kprovided by HGNC
Official Full Name: RNA polymerase III subunit Kprovided by HGNC
Primary source: HGNC:HGNC:14121
See related: Ensembl:ENSG00000161980 MIM:606007; AllianceGenome:HGNC:14121
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: C11; HLD21; My010; RPC10; RPC11; RPC12.5; C11-RNP3
Summary: This gene encodes a small essential subunit of RNA polymerase III, the polymerase responsible for synthesizing transfer and small ribosomal RNAs in eukaryotes. The carboxy-terminal domain of this subunit shares a high degree of sequence similarity to the carboxy-terminal domain of an RNA polymerase II elongation factor. This similarity in sequence is supported by functional studies showing that this subunit is required for proper pausing and termination during transcription. Pseudogenes of this gene are found on chromosomes 13 and 17.[provided by RefSeq, Jul 2010]
Expression: Ubiquitous expression in lymph node (RPKM 13.5), appendix (RPKM 11.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 16p13.3

Exon count:: 3

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	16	NC_000016.10 (46407..53608, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	16	NC_060940.1 (39992..47144, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	16	NC_000016.9 (96407..103608, complement)

Chromosome 16 - NC_000016.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states.
Title: Cryo-EM structures of human RNA polymerase III in its unbound and transcribing states.
Results from a study on gene expression variability markers in early-stage human embryos shows that POLR3K is a putative expression variability marker for the 3-day, 8-cell embryo stage.
Title: Variability of Gene Expression Identifies Transcriptional Regulators of Early Human Embryonic Development.
Changes in Maf1 expression affect Pol III-dependent transcription in human glioblastoma lines.
Title: Mammalian Maf1 is a negative regulator of transcription by all three nuclear RNA polymerases.

Submit: New GeneRIF Correction

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Leukodystrophy, hypomyelinating, 21 MedGen: C5543334 OMIM: 619310 GeneReviews: Not available	Compare labs

EBI GWAS Catalog

Description
Genome-wide association analysis of red blood cell traits in African Americans: the COGENT Network. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Tat	tat	HIV-1 Tat upregulates the transcription by RNA polymerase III of co-transfected or endogenous cellular Alu-repeated sequences by activating transcription factor TFIIIC	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

ECD23171 (e-PCR)
- UniSTS:304155

RH65374 (e-PCR)
- UniSTS:89411

ECD19133 (e-PCR)
- UniSTS:300140

ECD14774 (e-PCR)
- UniSTS:295794

ECD06052 (e-PCR)
- UniSTS:287114

ECD24111 (e-PCR)
- UniSTS:305095

REN94476 (e-PCR)
- UniSTS:419274

REN94477 (e-PCR)
- UniSTS:419275

G59881 (e-PCR)
- UniSTS:137164

REN94478 (e-PCR)
- UniSTS:419276

REN94479 (e-PCR)
- UniSTS:419277

REN94480 (e-PCR)
- UniSTS:419278

REN94481 (e-PCR)
- UniSTS:419279

REN94482 (e-PCR)
- UniSTS:419280

REN94483 (e-PCR)
- UniSTS:419281

REN94484 (e-PCR)
- UniSTS:419282

REN94485 (e-PCR)
- UniSTS:419283

REN94486 (e-PCR)
- UniSTS:419284

REN94487 (e-PCR)
- UniSTS:419285

REN94488 (e-PCR)
- UniSTS:419286

REN94489 (e-PCR)
- UniSTS:419287

REN94490 (e-PCR)
- UniSTS:419288

REN94491 (e-PCR)
- UniSTS:419289

REN94492 (e-PCR)
- UniSTS:419290

REN94493 (e-PCR)
- UniSTS:419291

REN94494 (e-PCR)
- UniSTS:419292

REN94495 (e-PCR)
- UniSTS:419293

REN94496 (e-PCR)
- UniSTS:419294

REN94497 (e-PCR)
- UniSTS:419295

REN94498 (e-PCR)
- UniSTS:419296

REN94499 (e-PCR)
- UniSTS:419297

REN94500 (e-PCR)
- UniSTS:419298

REN94501 (e-PCR)
- UniSTS:419299

REN94502 (e-PCR)
- UniSTS:419300

REN94503 (e-PCR)
- UniSTS:419301

REN94504 (e-PCR)
- UniSTS:419302

REN94505 (e-PCR)
- UniSTS:419303

ECD22605 (e-PCR)
- UniSTS:303591

REN94506 (e-PCR)
- UniSTS:419304

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-directed 5'-3' RNA polymerase activity	TAS Traceable Author Statement more info	PubMed
contributes_to RNA polymerase III activity	IBA Inferred from Biological aspect of Ancestor more info
enables nucleic acid binding	IEA Inferred from Electronic Annotation more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables zinc ion binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in defense response to virus	IEA Inferred from Electronic Annotation more info
involved_in innate immune response	IEA Inferred from Electronic Annotation more info
involved_in termination of RNA polymerase III transcription	IBA Inferred from Biological aspect of Ancestor more info
involved_in transcription by RNA polymerase III	TAS Traceable Author Statement more info	PubMed

Component	Evidence Code	Pubs
part_of RNA polymerase III complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RNA polymerase III complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	TAS Traceable Author Statement more info

General protein information

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Preferred Names: DNA-directed RNA polymerase III subunit RPC10

Names: DNA-directed RNA polymerase III subunit K; DNA-directed RNA polymerases III 12.5 kDa polypeptide; RNA polymerase III 12.5 kDa subunit; RNA polymerase III subunit C10; RNA polymerase III subunit C11; RNA polymerase III subunit CII; polymerase (RNA) III (DNA directed) polypeptide K, 12.3 kDa; polymerase (RNA) III subunit K

NP_057394.3

EC 2.7.7.6

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_016310.5 → NP_057394.3 DNA-directed RNA polymerase III subunit RPC10

See identical proteins and their annotated locations for NP_057394.3

Status: REVIEWED

Source sequence(s)

BC011932, DR978472, KF456133, Z69719

Consensus CDS

CCDS10395.1

UniProtKB/Swiss-Prot

Q1W6H4, Q96S35, Q9Y2Y1

Related

ENSP00000293860.5, ENST00000293860.6

Conserved Domains (2) summary

COG1594
Location:1 → 108

RPB9; DNA-directed RNA polymerase, subunit M/Transcription elongation factor TFIIS [Transcription]

cd10509
Location:61 → 108

Zn-ribbon_RPC11; C-terminal zinc ribbon domain of RPC11 subunit of RNA polymerase III