U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from MedGen

    • Showing Current items.

    BICRA BRD4 interacting chromatin remodeling complex associated protein [ Homo sapiens (human) ]

    Gene ID: 29998, updated on 5-Mar-2024

    Summary

    Official Symbol
    BICRAprovided by HGNC
    Official Full Name
    BRD4 interacting chromatin remodeling complex associated proteinprovided by HGNC
    Primary source
    HGNC:HGNC:4332
    See related
    Ensembl:ENSG00000063169 MIM:605690; AllianceGenome:HGNC:4332
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CSS12; GLTSCR1; SMARCK1
    Summary
    Enables transcription regulator activator activity. Involved in positive regulation of transcription, DNA-templated. Located in nucleus. Part of SWI/SNF complex. Implicated in Coffin-Siris syndrome. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in spleen (RPKM 1.9), prostate (RPKM 1.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See BICRA in Genome Data Viewer
    Location:
    19q13.33
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (47608196..47703277)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (50439021..50534101)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (48111453..48206534)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene zinc finger protein 541 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14868 Neighboring gene RNA, 7SL, cytoplasmic 322, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10856 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10857 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14869 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10860 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10861 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10859 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10858 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10862 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10863 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10864 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10865 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10866 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48115860-48116691 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48118354-48119183 Neighboring gene BICRA antisense RNA 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48123829-48124389 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48130149-48130723 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48135834-48136477 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48148954-48149534 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48153858-48154564 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48164109-48164610 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48164611-48165110 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48196325-48196884 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48196885-48197442 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48201812-48202354 Neighboring gene Sharpr-MPRA regulatory region 9389 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10867 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:48228755-48229521 Neighboring gene uncharacterized LOC124904733 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48238171-48238671 Neighboring gene EH domain containing 2 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10868 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14870 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:48249496-48249996 Neighboring gene small nucleolar RNA, C/D box 23 Neighboring gene NOP53 ribosome biogenesis factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Coffin-Siris syndrome 12
    MedGen: C5444111 OMIM: 619325 GeneReviews: Not available
    not available

    EBI GWAS Catalog

    Description
    Genomewide association study for determinants of HIV-1 acquisition and viral set point in HIV-1 serodiscordant couples with quantified virus exposure.
    EBI GWAS Catalog

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription regulator activator activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of GBAF complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of SWI/SNF complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of SWI/SNF complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of chromatin NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleus IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    BRD4-interacting chromatin-remodeling complex-associated protein
    Names
    BRD4 interacting chromatin remodelling complex associated protein
    glioma tumor suppressor candidate region gene 1 protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001394372.1NP_001381301.1  BRD4-interacting chromatin-remodeling complex-associated protein

      Status: VALIDATED

      Source sequence(s)
      AC008985, AC010331, AC010519
      Consensus CDS
      CCDS46134.1
      UniProtKB/Swiss-Prot
      A8MW01, Q9NZM4
      UniProtKB/TrEMBL
      A0A087WWH3
      Related
      ENSP00000469738.2, ENST00000594866.3
      Conserved Domains (2) summary
      PHA03247
      Location:314792
      PHA03247; large tegument protein UL36; Provisional
      pfam15249
      Location:10911192
      GLTSCR1; Conserved region of unknown function on GLTSCR protein
    2. NM_015711.3NP_056526.3  BRD4-interacting chromatin-remodeling complex-associated protein

      See identical proteins and their annotated locations for NP_056526.3

      Status: VALIDATED

      Source sequence(s)
      AA961479, AA994408, AF182077, BC032065, BX362862
      Consensus CDS
      CCDS46134.1
      UniProtKB/Swiss-Prot
      A8MW01, Q9NZM4
      UniProtKB/TrEMBL
      A0A087WWH3
      Related
      ENSP00000379946.2, ENST00000396720.7
      Conserved Domains (2) summary
      PHA03247
      Location:314792
      PHA03247; large tegument protein UL36; Provisional
      pfam15249
      Location:10911192
      GLTSCR1; Conserved region of unknown function on GLTSCR protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      47608196..47703277
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      50439021..50534101
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)