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    RPL3L ribosomal protein L3 like [ Homo sapiens (human) ]

    Gene ID: 6123, updated on 3-Apr-2024

    Summary

    Official Symbol
    RPL3Lprovided by HGNC
    Official Full Name
    ribosomal protein L3 likeprovided by HGNC
    Primary source
    HGNC:HGNC:10351
    See related
    Ensembl:ENSG00000140986 MIM:617416; AllianceGenome:HGNC:10351
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CMD2D
    Summary
    This gene encodes a protein that shares sequence similarity with ribosomal protein L3. The protein belongs to the L3P family of ribosomal proteins. Unlike the ubiquitous expression of ribosomal protein genes, this gene has a tissue-specific pattern of expression, with the highest levels of expression in skeletal muscle and heart. It is not currently known whether the encoded protein is a functional ribosomal protein or whether it has evolved a function that is independent of the ribosome. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in heart (RPKM 32.1), prostate (RPKM 5.1) and 2 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See RPL3L in Genome Data Viewer
    Location:
    16p13.3
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (1943974..1954689, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (1963946..1975094, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (1993975..2004690, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1961835-1962392 Neighboring gene heparan sulfate-glucosamine 3-sulfotransferase 6 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1968509-1969070 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1969071-1969634 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1969635-1970196 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:1970197-1970760 Neighboring gene Sharpr-MPRA regulatory region 1858 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:1991100-1991989 Neighboring gene uncharacterized LOC124903625 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7010 Neighboring gene methionine sulfoxide reductase B1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2003405-2004394 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2007755-2008596 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7011 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7012 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10241 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10242 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr16:2012172-2013117 Neighboring gene NADH:ubiquinone oxidoreductase subunit B10 Neighboring gene small nucleolar RNA, H/ACA box 10 Neighboring gene ribosomal protein S2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of ribosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables structural constituent of ribosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in negative regulation of myotube differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of striated muscle tissue development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in translation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in translation NAS
    Non-traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    ribosomal protein uL3-like
    Names
    60S ribosomal protein L3-like
    large ribosomal subunit protein uL3-like

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_005061.3NP_005052.1  ribosomal protein uL3-like

      See identical proteins and their annotated locations for NP_005052.1

      Status: REVIEWED

      Source sequence(s)
      AC005363
      Consensus CDS
      CCDS10450.1
      UniProtKB/Swiss-Prot
      Q92901
      UniProtKB/TrEMBL
      B2R7Y3
      Related
      ENSP00000268661.7, ENST00000268661.8
      Conserved Domains (1) summary
      PTZ00103
      Location:1398
      PTZ00103; 60S ribosomal protein L3; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      1943974..1954689 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011522571.3XP_011520873.1  ribosomal protein uL3-like isoform X1

      UniProtKB/TrEMBL
      B2R7Y3
      Conserved Domains (2) summary
      PTZ00103
      Location:6403
      PTZ00103; 60S ribosomal protein L3; Provisional
      cl00324
      Location:12378
      RplC; Ribosomal protein L3 [Translation, ribosomal structure and biogenesis]

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_025791799.1 Reference GRCh38.p14 PATCHES

      Range
      10122..21271 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333186.1XP_054189161.1  ribosomal protein uL3-like isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      1963946..1975094 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054313574.1XP_054169549.1  ribosomal protein uL3-like isoform X1