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    SOCS1 suppressor of cytokine signaling 1 [ Homo sapiens (human) ]

    Gene ID: 8651, updated on 17-Jun-2024

    Summary

    Official Symbol
    SOCS1provided by HGNC
    Official Full Name
    suppressor of cytokine signaling 1provided by HGNC
    Primary source
    HGNC:HGNC:19383
    See related
    Ensembl:ENSG00000185338 MIM:603597; AllianceGenome:HGNC:19383
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    JAB; CIS1; SSI1; TIP3; CISH1; SSI-1; TIP-3; AISIMD; SOCS-1
    Summary
    This gene encodes a member of the STAT-induced STAT inhibitor (SSI), also known as suppressor of cytokine signaling (SOCS), family. SSI family members are cytokine-inducible negative regulators of cytokine signaling. The expression of this gene can be induced by a subset of cytokines, including IL2, IL3 erythropoietin (EPO), CSF2/GM-CSF, and interferon (IFN)-gamma. The protein encoded by this gene functions downstream of cytokine receptors, and takes part in a negative feedback loop to attenuate cytokine signaling. Knockout studies in mice suggested the role of this gene as a modulator of IFN-gamma action, which is required for normal postnatal growth and survival. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in appendix (RPKM 6.5), lymph node (RPKM 5.3) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SOCS1 in Genome Data Viewer
    Location:
    16p13.13
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 16 NC_000016.10 (11254417..11256204, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 16 NC_060940.1 (11290646..11292433, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 16 NC_000016.9 (11348274..11350061, complement)

    Chromosome 16 - NC_000016.10Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984859 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11304646-11305240 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10420 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10421 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10422 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10423 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10424 Neighboring gene CRISPRi-validated cis-regulatory element chr16.1224 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10425 Neighboring gene Sharpr-MPRA regulatory region 4189 Neighboring gene uncharacterized LOC105371082 Neighboring gene ReSE screen-validated silencer GRCh37_chr16:11344039-11344246 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10426 Neighboring gene heterogeneous nuclear ribonucleoprotein C pseudogene 4 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10427 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7197 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7198 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7199 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7200 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 7201 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 10428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11359883-11360383 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr16:11365871-11366567 Neighboring gene transition protein 2 Neighboring gene protamine 3

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Autoinflammatory syndrome with immunodeficiency
    MedGen: C5543547 OMIM: 619375 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Combined analysis of genome-wide association studies for Crohn disease and psoriasis identifies seven shared susceptibility loci.
    EBI GWAS Catalog
    Genetic variants associated with disordered eating.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Multiple common variants for celiac disease influencing immune gene expression.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    HIV-infected clinical samples upregulate SOCS1 expression in ex vivo cultures of monocyte derived dendritic cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120-induced IL-23 upregulated SOCS1 protein in T cells, which inhibits IFN-gamma production and killing of CEF-pulsed monocytes PubMed
    env SOCS1 protein expression is upregulated in T cells cultured with HIV-1 gp120-treated myeloid dendritic cell medium but is significantly inhibited in the presence of anti-IL-23 antibody PubMed
    Nef nef HIV-1 Nef suppresses immunoglobulin class-switch DNA recombination by inducing IkappaBalpha and SOCS proteins, which block CD154, IL-4 and IL-10 cytokine signaling via NF-kappaB and STAT transcription factors PubMed
    Pr55(Gag) gag Both HIV-1 Gag/p24 and SOCS1 are detected in HIV-1 virus-like particles by Western assay, indicating that SOCS1 is incorporated into HIV-1 PubMed
    gag The suppressor of cytokine signaling 1 (SOCS1) directly binds to the matrix and nucleocapsid regions of the HIV-1 p55 Gag and enhances its stability and trafficking, resulting in the efficient production of HIV-1 particles PubMed
    Tat tat HIV-1 upregulates SOCS1 expression in human monocytes, dendritic cells and HEK-TLR4-MD2-CD14 cells via the N-terminal region including Tat 1-45 (Tat 3--72 fragment did not demonstrate this activity) PubMed
    tat Primary human Muller glia cells treated with both HIV-1 clade B and clade C Tat upregulate the expression of suppressor of cytokine signaling 1 (SOCS1) PubMed
    capsid gag Both HIV-1 Gag/p24 and SOCS1 are detected in HIV-1 virus-like particles by Western assay, indicating that SOCS1 is incorporated into HIV-1 PubMed
    matrix gag The suppressor of cytokine signaling 1 (SOCS1) directly binds to the matrix and nucleocapsid regions of the HIV-1 p55 Gag and enhances its stability and trafficking, resulting in the efficient production of HIV-1 particles PubMed
    nucleocapsid gag The suppressor of cytokine signaling 1 (SOCS1) directly binds to the matrix and nucleocapsid regions of the HIV-1 p55 Gag and enhances its stability and trafficking, resulting in the efficient production of HIV-1 particles PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables 1-phosphatidylinositol-3-kinase regulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables insulin-like growth factor receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables kinase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase inhibitor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell surface receptor signaling pathway via JAK-STAT IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to amino acid stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cytokine-mediated signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in fat cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intracellular signal transduction IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in macrophage differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of CD8-positive, alpha-beta T cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of insulin receptor signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of receptor signaling pathway via JAK-STAT IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of receptor signaling pathway via JAK-STAT ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of receptor signaling pathway via JAK-STAT NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in negative regulation of tyrosine phosphorylation of STAT protein IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of tyrosine phosphorylation of STAT protein ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in phosphatidylinositol phosphate biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of CD4-positive, alpha-beta T cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of regulatory T cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of cytokine production IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of protein phosphorylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in cytoplasmic ribonucleoprotein granule IDA
    Inferred from Direct Assay
    more info
     
    located_in cytoplasmic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    part_of phosphatidylinositol 3-kinase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    suppressor of cytokine signaling 1
    Names
    JAK binding protein
    STAT induced SH3 protein 1
    STAT-induced STAT inhibitor 1
    Tec-interacting protein 3
    cytokine-inducible SH2 protein 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_003745.2NP_003736.1  suppressor of cytokine signaling 1

      See identical proteins and their annotated locations for NP_003736.1

      Status: REVIEWED

      Source sequence(s)
      AC009121
      Consensus CDS
      CCDS10546.1
      UniProtKB/Swiss-Prot
      O15097, O15524, Q9NSA7
      UniProtKB/TrEMBL
      Q4JHT5
      Related
      ENSP00000329418.2, ENST00000332029.4
      Conserved Domains (2) summary
      cd10382
      Location:68165
      SH2_SOCS1; Src homology 2 (SH2) domain found in suppressor of cytokine signaling (SOCS) proteins
      cd03735
      Location:169211
      SOCS_SOCS1; SOCS (suppressors of cytokine signaling) box of SOCS1-like proteins. Together with CIS1, the CIS/SOCS family of proteins is characterized by the presence of a C-terminal SOCS box and a central SH2 domain. SOCS1, like CIS1 and SOCS3, is involved in the ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000016.10 Reference GRCh38.p14 Primary Assembly

      Range
      11254417..11256204 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060940.1 Alternate T2T-CHM13v2.0

      Range
      11290646..11292433 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)