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    COX16 cytochrome c oxidase assembly factor COX16 [ Homo sapiens (human) ]

    Gene ID: 51241, updated on 11-Apr-2024

    Summary

    Official Symbol
    COX16provided by HGNC
    Official Full Name
    cytochrome c oxidase assembly factor COX16provided by HGNC
    Primary source
    HGNC:HGNC:20213
    See related
    Ensembl:ENSG00000133983 MIM:618064; AllianceGenome:HGNC:20213
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    hCOX16; HSPC203; MC4DN22; C14orf112
    Summary
    Involved in mitochondrial cytochrome c oxidase assembly. Is integral component of mitochondrial inner membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in colon (RPKM 14.7), adrenal (RPKM 14.7) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    Location:
    14q24.2
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (70325081..70359683, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (64531030..64565566, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (70791798..70826400, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC101928046 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5886 Neighboring gene uncharacterized LOC105370552 Neighboring gene ADAM metallopeptidase domain 21 pseudogene 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:70755991-70756492 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr14:70768308-70768998 Neighboring gene SYNJ2BP-COX16 readthrough Neighboring gene uncharacterized LOC124903340 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:70816287-70817486 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8651 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8652 Neighboring gene RNA, U2 small nuclear 51, pseudogene Neighboring gene synaptojanin 2 binding protein Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:70866018-70866578 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr14:70883594-70884793 Neighboring gene uncharacterized LOC124903339

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of COX16 cytochrome c oxidase assembly homolog (S. cerevisiae) by siRNA enhances the early stages of HIV-1 replication in HeLa-CD4 cells infected with viral pseudotypes HIV89.6R and HIV8.2N PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Readthrough SYNJ2BP-COX16

    Readthrough gene: SYNJ2BP-COX16, Included gene: SYNJ2BP

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in mitochondrial inner membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitochondrial inner membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    cytochrome c oxidase assembly protein COX16 homolog, mitochondrial
    Names
    COX16, cytochrome c oxidase assembly homolog

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001204090.2NP_001191019.1  cytochrome c oxidase assembly protein COX16 homolog, mitochondrial isoform 2

      See identical proteins and their annotated locations for NP_001191019.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an in-frame exon in the coding region, compared to variant 1. The encoded isoform (2) is shorter, compared to isoform 1.
      Source sequence(s)
      AW088547, CB156527, FJ460510
      UniProtKB/TrEMBL
      B8XYC5
      Conserved Domains (1) summary
      pfam14138
      Location:2464
      COX16; Cytochrome c oxidase assembly protein COX16
    2. NM_016468.7NP_057552.1  cytochrome c oxidase assembly protein COX16 homolog, mitochondrial isoform 1 precursor

      See identical proteins and their annotated locations for NP_057552.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).
      Source sequence(s)
      AW088547, FJ460510
      Consensus CDS
      CCDS9802.1
      UniProtKB/Swiss-Prot
      A6NDT5, A8K3X8, B8XYC5, Q9P0S2
      Related
      ENSP00000374562.5, ENST00000389912.7
      Conserved Domains (1) summary
      pfam14138
      Location:1888
      COX16; Cytochrome c oxidase assembly protein COX16

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      70325081..70359683 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      64531030..64565566 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)