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    RNF2 ring finger protein 2 [ Homo sapiens (human) ]

    Gene ID: 6045, updated on 7-Jan-2024

    Summary

    Official Symbol
    RNF2provided by HGNC
    Official Full Name
    ring finger protein 2provided by HGNC
    Primary source
    HGNC:HGNC:10061
    See related
    Ensembl:ENSG00000121481 MIM:608985; AllianceGenome:HGNC:10061
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    BAP1; DING; BAP-1; HIPI3; RING2; LUSYAM; RING1B
    Summary
    Polycomb group (PcG) of proteins form the multiprotein complexes that are important for the transcription repression of various genes involved in development and cell proliferation. The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, transcription factor CP2 (TFCP2/CP2). Studies of the mouse counterpart suggested the involvement of this gene in the specification of anterior-posterior axis, as well as in cell proliferation in early development. This protein was also found to interact with huntingtin interacting protein 2 (HIP2), an ubiquitin-conjugating enzyme, and possess ubiquitin ligase activity. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in testis (RPKM 7.8), placenta (RPKM 6.0) and 25 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See RNF2 in Genome Data Viewer
    Location:
    1q25.3
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (185045558..185102603)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (184402444..184459513)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (185014690..185071735)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1633 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:184985922-184987121 Neighboring gene RNA, 5S ribosomal pseudogene 72 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1643 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:185034115-185035314 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:185041955-185042087 Neighboring gene ferritin heavy chain 1 pseudogene 25 Neighboring gene tRNA methyltransferase 1 like Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:185125173-185126078 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1645 Neighboring gene ribosomal protein L22 pseudogene 24 Neighboring gene SWT1 RNA endoribonuclease homolog

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Luo-Schoch-Yamamoto syndrome
    MedGen: C5561946 OMIM: 619460 GeneReviews: Not available
    not available

    EBI GWAS Catalog

    Description
    Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Phosphorylated DING (pDING) inhibits HIV-1 Tat-induced neuronal cell injury by suppressing the activity of serine/threonine kinases p38 MAPK and Cdk5 and enhancing the activity of neuroprotective factor MEF2 through the phosphotase activity of pDING PubMed
    tat HIV-1 Tat downregulates ring finger protein 2 (RNF2) in HEK 293T cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables RING-like zinc finger domain binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables chromatin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone H2AK119 ubiquitin ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ubiquitin protein ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ubiquitin protein ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    contributes_to ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in anterior/posterior axis specification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chromatin remodeling IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in epigenetic regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in gastrulation with mouth forming second IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in germ cell development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mitotic cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of MLL1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of PRC1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of PcG protein complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of PcG protein complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    part_of euchromatin IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of sex chromatin IEA
    Inferred from Electronic Annotation
    more info
     
    part_of ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of ubiquitin ligase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    E3 ubiquitin-protein ligase RING2
    Names
    HIP2-interacting protein 3
    RING finger protein 1B
    RING finger protein BAP-1
    RING-type E3 ubiquitin transferase RING2
    huntingtin-interacting protein 2-interacting protein 3
    protein DinG
    NP_009143.1
    XP_005245470.1
    XP_011508153.1
    XP_011508154.1
    XP_054194045.1
    XP_054194046.1
    XP_054194047.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_007212.4NP_009143.1  E3 ubiquitin-protein ligase RING2

      See identical proteins and their annotated locations for NP_009143.1

      Status: REVIEWED

      Source sequence(s)
      AF141327, AL109865
      Consensus CDS
      CCDS1365.1
      UniProtKB/Swiss-Prot
      B2RBS7, B3KRH1, Q5TEN1, Q5TEN2, Q99496
      Related
      ENSP00000356480.3, ENST00000367510.8
      Conserved Domains (3) summary
      COG5222
      Location:11103
      COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      cd16531
      Location:5191
      RING-HC_RING1_like; RING finger, HC subclass, found in really interesting new gene proteins RING1, RING2 and similar proteins
      cd17167
      Location:225330
      RAWUL_RING2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in really interesting new gene 2 protein (RING2)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      185045558..185102603
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011509852.3XP_011508154.1  E3 ubiquitin-protein ligase RING2 isoform X1

      See identical proteins and their annotated locations for XP_011508154.1

      UniProtKB/Swiss-Prot
      B2RBS7, B3KRH1, Q5TEN1, Q5TEN2, Q99496
      Conserved Domains (3) summary
      COG5222
      Location:11103
      COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      cd16531
      Location:5191
      RING-HC_RING1_like; RING finger, HC subclass, found in really interesting new gene proteins RING1, RING2 and similar proteins
      cd17167
      Location:225330
      RAWUL_RING2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in really interesting new gene 2 protein (RING2)
    2. XM_011509851.4XP_011508153.1  E3 ubiquitin-protein ligase RING2 isoform X1

      See identical proteins and their annotated locations for XP_011508153.1

      UniProtKB/Swiss-Prot
      B2RBS7, B3KRH1, Q5TEN1, Q5TEN2, Q99496
      Conserved Domains (3) summary
      COG5222
      Location:11103
      COG5222; Uncharacterized conserved protein, contains RING Zn-finger [General function prediction only]
      cd16531
      Location:5191
      RING-HC_RING1_like; RING finger, HC subclass, found in really interesting new gene proteins RING1, RING2 and similar proteins
      cd17167
      Location:225330
      RAWUL_RING2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in really interesting new gene 2 protein (RING2)
    3. XM_005245413.4XP_005245470.1  E3 ubiquitin-protein ligase RING2 isoform X2

      See identical proteins and their annotated locations for XP_005245470.1

      Conserved Domains (2) summary
      cd16531
      Location:242
      RING-HC_RING1_like; RING finger, HC subclass, found in really interesting new gene proteins RING1, RING2 and similar proteins
      cd17167
      Location:176281
      RAWUL_RING2; RING finger- and WD40-associated ubiquitin-like (RAWUL) domain found in really interesting new gene 2 protein (RING2)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      184402444..184459513
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338071.1XP_054194046.1  E3 ubiquitin-protein ligase RING2 isoform X1

      UniProtKB/Swiss-Prot
      B2RBS7, B3KRH1, Q5TEN1, Q5TEN2, Q99496
    2. XM_054338070.1XP_054194045.1  E3 ubiquitin-protein ligase RING2 isoform X1

      UniProtKB/Swiss-Prot
      B2RBS7, B3KRH1, Q5TEN1, Q5TEN2, Q99496
    3. XM_054338072.1XP_054194047.1  E3 ubiquitin-protein ligase RING2 isoform X2