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    TP73 tumor protein p73 [ Homo sapiens (human) ]

    Gene ID: 7161, updated on 26-Jan-2024

    Summary

    Official Symbol
    TP73provided by HGNC
    Official Full Name
    tumor protein p73provided by HGNC
    Primary source
    HGNC:HGNC:12003
    See related
    Ensembl:ENSG00000078900 MIM:601990; AllianceGenome:HGNC:12003
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    P73; CILD47
    Summary
    This gene encodes a member of the p53 family of transcription factors involved in cellular responses to stress and development. It maps to a region on chromosome 1p36 that is frequently deleted in neuroblastoma and other tumors, and thought to contain multiple tumor suppressor genes. The demonstration that this gene is monoallelically expressed (likely from the maternal allele), supports the notion that it is a candidate gene for neuroblastoma. Many transcript variants resulting from alternative splicing and/or use of alternate promoters have been found for this gene, but the biological validity and the full-length nature of some variants have not been determined. [provided by RefSeq, Feb 2011]
    Expression
    Broad expression in skin (RPKM 3.5), prostate (RPKM 1.2) and 14 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TP73 in Genome Data Viewer
    Location:
    1p36.32
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (3652516..3736201)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (3162389..3247802)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (3569080..3652765)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 121 Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:3541953-3542615 Neighboring gene tumor protein p63 regulated 1 like Neighboring gene H3K27ac hESC enhancer GRCh37_chr1:3557544-3558044 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:3558876-3559121 Neighboring gene WD repeat containing, antisense to TP73 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3566888-3567731 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 122 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 61 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 62 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 63 Neighboring gene TP73 antisense RNA 3 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 64 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:3596796-3596963 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3597253-3597988 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3600129-3600889 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3605575-3606096 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3606097-3606618 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3623899-3624726 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3624727-3625555 Neighboring gene ReSE screen-validated silencer GRCh37_chr1:3631158-3631397 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3634425-3634984 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3634985-3635544 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3636665-3637223 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3637224-3637783 Neighboring gene TP73 antisense RNA 2 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3637784-3638342 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 65 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3650019-3650807 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_7436 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3661686-3662521 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3662522-3663358 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 123 Neighboring gene Gfo/Idh/MocA-like oxidoreductase domain containing 3, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3678785-3679286 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3679287-3679786 Neighboring gene coiled-coil domain containing 27 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3687696-3688374 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 124 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3689661-3690176 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:3690177-3690692 Neighboring gene MPRA functional variant 1:3691528:A:G red blood cell enhancer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:3691725-3692240 Neighboring gene small integral membrane protein 1 (Vel blood group)

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Ciliary dyskinesia, primary, 47, and lissencephaly
    MedGen: C5561951 OMIM: 619466 GeneReviews: Not available
    not available

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    No evidence available (Last evaluated 2012-07-06)

    ClinGen Genome Curation Page
    Triplosensitivity

    No evidence available (Last evaluated 2012-07-06)

    ClinGen Genome Curation Page

    EBI GWAS Catalog

    Description
    Genome-wide association for abdominal subcutaneous and visceral adipose reveals a novel locus for visceral fat in women.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat HIV-1 Tat induces phosphorylation of p73 at tyrosine reside 99, leading to promote its translocation to the nuclear matrix in neuronal cells PubMed
    tat HIV-1 Tat induces accumulation and activation of p73 in neuronal cells PubMed
    tat HIV-1 Tat-mediated inhibition of miR-196a leads to upregulation of p73 and c-ABL protein expression in cells PubMed
    tat HIV-1 Tat activates the p53 transcription factor pathway leading to the induction of endogenous p53 and p73 in neuronal cells PubMed
    tat In the absence of either p53 or p73, Tat fails to induce dendritic retraction or to activate the proapoptotic proteins, such as Bax PubMed
    tat Association of tumor protein p73 with HIV-1 Tat prevents the acetylation of Tat on lysine 28 by PCAF, and requires the cysteine-rich domain (amino acids 30 to 40) of Tat, which binds to the N-terminal region (amino acids 1 to 120) of p73 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription activator activity, RNA polymerase II-specific IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    enables DNA-binding transcription factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific ISA
    Inferred from Sequence Alignment
    more info
     
    enables DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables MDM2/MDM4 family protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA polymerase II-specific DNA-binding transcription factor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables p53 binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in DNA damage response IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell cycle IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in kidney development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in mismatch repair TAS
    Traceable Author Statement
    more info
    PubMed 
    acts_upstream_of_or_within negative regulation of cardiac muscle cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of neuron differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of lung ciliated cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of oligodendrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein tetramerization IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_negative_effect regulation of cell cycle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    acts_upstream_of_or_within regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of_or_within regulation of mitotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in response to organonitrogen compound IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to xenobiotic stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
     
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
     
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in intracellular membrane-bounded organelle IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    tumor protein p73
    Names
    p53-like transcription factor
    p53-related protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_017035.2 RefSeqGene

      Range
      4952..88637
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001126240.3NP_001119712.1  tumor protein p73 isoform b

      See identical proteins and their annotated locations for NP_001119712.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b, also known as deltaN p73 alpha) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AB055065, AI094238, AL136528
      Consensus CDS
      CCDS44049.1
      UniProtKB/Swiss-Prot
      O15350
      Related
      ENSP00000367537.4, ENST00000378288.8
      Conserved Domains (4) summary
      cd09571
      Location:438502
      SAM_tumor-p73; SAM domain of tumor-p73 proteins
      smart00454
      Location:442501
      SAM; Sterile alpha motif
      pfam00870
      Location:64260
      P53; P53 DNA-binding domain
      pfam07710
      Location:296335
      P53_tetramer; P53 tetramerization motif
    2. NM_001126241.3NP_001119713.1  tumor protein p73 isoform c

      See identical proteins and their annotated locations for NP_001119713.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and coding sequence and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (c, also known as deltaN p73 beta) has a shorter and distinct N-terminus and a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AB055066, AI094238, AL136528
      Consensus CDS
      CCDS44050.1
      UniProtKB/Swiss-Prot
      O15350
      Related
      ENSP00000367534.1, ENST00000378285.5
      Conserved Domains (2) summary
      cd08367
      Location:78257
      P53; P53 DNA-binding domain
      pfam07710
      Location:297333
      P53_tetramer; P53 tetramerisation motif
    3. NM_001126242.3NP_001119714.1  tumor protein p73 isoform d

      See identical proteins and their annotated locations for NP_001119714.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and coding sequence and lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (d, also known as deltaN p73 gamma) has a shorter and distinct N-terminus and a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AI094238, AL136528, AY040829
      Consensus CDS
      CCDS44051.1
      UniProtKB/TrEMBL
      A0A0C4DFW9
      Related
      ENSP00000367529.1, ENST00000378280.5
      Conserved Domains (2) summary
      pfam00870
      Location:64260
      P53; P53 DNA-binding domain
      pfam07710
      Location:296335
      P53_tetramer; P53 tetramerization motif
    4. NM_001204184.2NP_001191113.1  tumor protein p73 isoform h

      See identical proteins and their annotated locations for NP_001191113.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (h, also known as TA p73 beta) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AB055066, AI094238, AL136528, Y11416
      Consensus CDS
      CCDS55566.1
      UniProtKB/Swiss-Prot
      O15350
      Related
      ENSP00000346423.4, ENST00000354437.8
      Conserved Domains (2) summary
      cd08367
      Location:127306
      P53; P53 DNA-binding domain
      pfam07710
      Location:346382
      P53_tetramer; P53 tetramerisation motif
    5. NM_001204185.2NP_001191114.1  tumor protein p73 isoform i

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) lacks an alternate coding exon compared to variant 1, that causes a frameshift. The resulting isoform (i, also known as TA p73 gamma) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AI094238, AL136528, AY040829, Y11416
      UniProtKB/Swiss-Prot
      O15350
      Conserved Domains (2) summary
      pfam00870
      Location:113309
      P53; P53 DNA-binding domain
      pfam07710
      Location:345384
      P53_tetramer; P53 tetramerization motif
    6. NM_001204186.2NP_001191115.1  tumor protein p73 isoform j

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10) lacks three alternate coding exons compared to variant 1, that causes a frameshift. The resulting isoform (j, also known as TA p73 delta) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AI094238, AL136528, Y11416
      Consensus CDS
      CCDS59965.1
      UniProtKB/Swiss-Prot
      O15350
      Related
      ENSP00000475143.1, ENST00000604074.5
      Conserved Domains (2) summary
      pfam00870
      Location:113309
      P53; P53 DNA-binding domain
      pfam07710
      Location:346384
      P53_tetramer; P53 tetramerisation motif
    7. NM_001204187.2NP_001191116.1  tumor protein p73 isoform k

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11) lacks two alternate coding exons compared to variant 1, one that causes a frameshift and the other that corrects the frameshift. The resulting isoform (k, also known as TA p73 epsilon) has a shorter and distinct internal segment compared to isoform a.
      Source sequence(s)
      AI094238, AL136528, Y11416
      Consensus CDS
      CCDS55567.1
      UniProtKB/Swiss-Prot
      O15350
      Related
      ENSP00000474626.1, ENST00000603362.6
      Conserved Domains (3) summary
      pfam00870
      Location:113309
      P53; P53 DNA-binding domain
      pfam07710
      Location:345384
      P53_tetramer; P53 tetramerization motif
      cl15755
      Location:445470
      SAM_superfamily; SAM (Sterile alpha motif )
    8. NM_001204188.2NP_001191117.1  tumor protein p73 isoform l

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12) lacks two alternate coding exons compared to variant 1. The resulting isoform (l, also known as TA p73 zeta) lacks an alternate internal segment compared to isoform a.
      Source sequence(s)
      AI094238, AL136528, Y11416
      Consensus CDS
      CCDS55568.1
      UniProtKB/Swiss-Prot
      O15350
      Related
      ENSP00000474322.1, ENST00000604479.6
      Conserved Domains (4) summary
      smart00454
      Location:400454
      SAM; Sterile alpha motif
      pfam00870
      Location:113309
      P53; P53 DNA-binding domain
      pfam07710
      Location:345384
      P53_tetramer; P53 tetramerization motif
      cl15755
      Location:400455
      SAM_superfamily; SAM (Sterile alpha motif )
    9. NM_001204189.2NP_001191118.1  tumor protein p73 isoform e

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence and lacks three alternate coding exons compared to variant 1, that causes a frameshift. The resulting isoform (3, also known as deltaN p73 delta) has a shorter and distinct N-terminus and a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      AB055065, AI094238, AL136528
      UniProtKB/Swiss-Prot
      O15350
      Conserved Domains (2) summary
      pfam00870
      Location:64260
      P53; P53 DNA-binding domain
      pfam07710
      Location:296335
      P53_tetramer; P53 tetramerization motif
    10. NM_001204190.2NP_001191119.1  tumor protein p73 isoform f

      See identical proteins and their annotated locations for NP_001191119.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 5' UTR and coding sequence and lacks two alternate coding exons compared to variant 1, one that causes a frameshift and the other that corrects the frameshift. The resulting isoform (f, also known as deltaN p73 epsilon) has a shorter and distinct N-terminus and a shorter and distinct internal segment compared to isoform a.
      Source sequence(s)
      AB055065, AI094238, AL136528
      UniProtKB/Swiss-Prot
      O15350
      Conserved Domains (3) summary
      pfam00870
      Location:64260
      P53; P53 DNA-binding domain
      pfam07710
      Location:296335
      P53_tetramer; P53 tetramerization motif
      cl15755
      Location:396421
      SAM_superfamily; SAM (Sterile alpha motif )
    11. NM_001204191.2NP_001191120.1  tumor protein p73 isoform g

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) differs in the 5' UTR and coding sequence and lacks two alternate coding exons compared to variant 1. The resulting isoform (g, also known as deltaN p73 zeta) has a shorter and distinct N-terminus and lacks an alternate internal segment compared to isoform a.
      Source sequence(s)
      AB055065, AI094238, AL136528
      UniProtKB/Swiss-Prot
      O15350
      Conserved Domains (4) summary
      smart00454
      Location:351405
      SAM; Sterile alpha motif
      pfam00870
      Location:64260
      P53; P53 DNA-binding domain
      pfam07710
      Location:296335
      P53_tetramer; P53 tetramerization motif
      cl15755
      Location:351406
      SAM_superfamily; SAM (Sterile alpha motif )
    12. NM_001204192.2NP_001191121.1  tumor protein p73 isoform m

      See identical proteins and their annotated locations for NP_001191121.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (m) is shorter at the N-terminus compared to isoform a.
      Source sequence(s)
      AI094238, AK302118, AK310432, AL136528
      Consensus CDS
      CCDS55569.1
      UniProtKB/Swiss-Prot
      O15350
      Related
      ENSP00000367539.4, ENST00000378290.4
      Conserved Domains (3) summary
      cd08367
      Location:56235
      P53; P53 DNA-binding domain
      cd09571
      Location:416480
      SAM_tumor-p73; SAM domain of tumor-p73 proteins
      pfam07710
      Location:275311
      P53_tetramer; P53 tetramerisation motif
    13. NM_005427.4NP_005418.1  tumor protein p73 isoform a

      See identical proteins and their annotated locations for NP_005418.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1), encodes isoform a, also known as TA p73 alpha.
      Source sequence(s)
      AI094238, AL136528, Y11416
      Consensus CDS
      CCDS49.1
      UniProtKB/Swiss-Prot
      B7Z7J4, B7Z8Z1, B7Z9C1, C9J521, O15350, O15351, Q17RN8, Q5TBV5, Q5TBV6, Q8NHW9, Q8TDY5, Q8TDY6, Q9NTK8
      Related
      ENSP00000367545.4, ENST00000378295.9
      Conserved Domains (4) summary
      cd09571
      Location:487551
      SAM_tumor-p73; SAM domain of tumor-p73 proteins
      smart00454
      Location:491550
      SAM; Sterile alpha motif
      pfam00870
      Location:113309
      P53; P53 DNA-binding domain
      pfam07710
      Location:345384
      P53_tetramer; P53 tetramerization motif

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      3652516..3736201
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047429524.1XP_047285480.1  tumor protein p73 isoform X1

      UniProtKB/Swiss-Prot
      B7Z7J4, B7Z8Z1, B7Z9C1, C9J521, O15350, O15351, Q17RN8, Q5TBV5, Q5TBV6, Q8NHW9, Q8TDY5, Q8TDY6, Q9NTK8
      Related
      ENSP00000518863.1, ENST00000713570.1
    2. XM_047429521.1XP_047285477.1  tumor protein p73 isoform X1

      UniProtKB/Swiss-Prot
      B7Z7J4, B7Z8Z1, B7Z9C1, C9J521, O15350, O15351, Q17RN8, Q5TBV5, Q5TBV6, Q8NHW9, Q8TDY5, Q8TDY6, Q9NTK8
      Related
      ENSP00000518864.1, ENST00000713572.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      3162389..3247802
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338580.1XP_054194555.1  tumor protein p73 isoform X1

      UniProtKB/Swiss-Prot
      B7Z7J4, B7Z8Z1, B7Z9C1, C9J521, O15350, O15351, Q17RN8, Q5TBV5, Q5TBV6, Q8NHW9, Q8TDY5, Q8TDY6, Q9NTK8
    2. XM_054338579.1XP_054194554.1  tumor protein p73 isoform X1

      UniProtKB/Swiss-Prot
      B7Z7J4, B7Z8Z1, B7Z9C1, C9J521, O15350, O15351, Q17RN8, Q5TBV5, Q5TBV6, Q8NHW9, Q8TDY5, Q8TDY6, Q9NTK8