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    SLC51B SLC51 subunit beta [ Homo sapiens (human) ]

    Gene ID: 123264, updated on 17-Jun-2024

    Summary

    Official Symbol
    SLC51Bprovided by HGNC
    Official Full Name
    SLC51 subunit betaprovided by HGNC
    Primary source
    HGNC:HGNC:29956
    See related
    Ensembl:ENSG00000186198 MIM:612085; AllianceGenome:HGNC:29956
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    OSTB; PBAM2; OSTBETA; SLC51A1BP
    Summary
    Predicted to enable protein heterodimerization activity and transmembrane transporter activity. Involved in bile acid secretion. Located in basolateral plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Biased expression in small intestine (RPKM 39.7), duodenum (RPKM 31.2) and 4 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SLC51B in Genome Data Viewer
    Location:
    15q22.31
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (65045387..65053397)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (62854823..62862823)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (65337725..65345735)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene SPG21 abhydrolase domain containing, maspardin Neighboring gene H3K27ac hESC enhancers GRCh37_chr15:65281459-65281960 and GRCh37_chr15:65281961-65282460 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9589 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9590 Neighboring gene mitochondrial methionyl-tRNA formyltransferase Neighboring gene transmembrane protein 126A pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6549 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6550 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9591 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65346770-65347270 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65347271-65347771 Neighboring gene RAS like family 12 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65363995-65364494 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr15:65377155-65377680 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65378209-65378734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9592 Neighboring gene kelch repeat and BTB domain containing 13 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65379400-65380041 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65385262-65385762 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:65386379-65386880 Neighboring gene ubiquitin associated protein 1 like

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ26090, MGC118959, MGC118960, MGC118961

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables bile acid transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein heterodimerization activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in bile acid and bile salt transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in bile acid and bile salt transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in bile acid secretion IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    involved_in positive regulation of protein exit from endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein glycosylation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of protein targeting to membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of protein stability ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in basolateral plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of protein-containing complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of protein-containing complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    organic solute transporter subunit beta
    Names
    OST-beta
    SLC51A1 binding protein
    organic solute transporter beta subunit
    solute carrier family 51 beta subunit
    solute carrier family 51 subunit beta

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_178859.4NP_849190.2  organic solute transporter subunit beta

      See identical proteins and their annotated locations for NP_849190.2

      Status: VALIDATED

      Source sequence(s)
      AC013553, AI793107, AK129601
      Consensus CDS
      CCDS10199.1
      UniProtKB/Swiss-Prot
      Q3SYF5, Q86UW2
      Related
      ENSP00000335292.2, ENST00000334287.3
      Conserved Domains (1) summary
      pfam15048
      Location:3122
      OSTbeta; Organic solute transporter subunit beta protein

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      65045387..65053397
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005254159.6XP_005254216.1  organic solute transporter subunit beta isoform X1

      See identical proteins and their annotated locations for XP_005254216.1

      UniProtKB/Swiss-Prot
      Q3SYF5, Q86UW2
      Conserved Domains (1) summary
      pfam15048
      Location:3122
      OSTbeta; Organic solute transporter subunit beta protein

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      62854823..62862823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)