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    GON7 GON7 subunit of KEOPS complex [ Homo sapiens (human) ]

    Gene ID: 84520, updated on 17-Jun-2024

    Summary

    Official Symbol
    GON7provided by HGNC
    Official Full Name
    GON7 subunit of KEOPS complexprovided by HGNC
    Primary source
    HGNC:HGNC:20356
    See related
    Ensembl:ENSG00000170270 MIM:617436; AllianceGenome:HGNC:20356
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PNAS-127; C14orf142
    Summary
    Located in cytosol; nucleolus; and nucleoplasm. Part of EKC/KEOPS complex. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in colon (RPKM 9.4), kidney (RPKM 8.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GON7 in Genome Data Viewer
    Location:
    14q32.12
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (93202894..93207065, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (87434784..87438955, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (93669239..93673410, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene modulator of apoptosis 1 Neighboring gene lysosomal enzyme trafficking factor Neighboring gene H3K27ac hESC enhancer GRCh37_chr14:93672647-93673506 Neighboring gene ubiquitin protein ligase E3 component n-recognin 7 Neighboring gene ribosomal protein L18a pseudogene 1 Neighboring gene BTB domain containing 7 Neighboring gene ribosomal protein L36a pseudogene 4

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC104244, MGC133207

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in tRNA threonylcarbamoyladenosine modification IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of EKC/KEOPS complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of EKC/KEOPS complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    EKC/KEOPS complex subunit GON7
    Names
    GON7, KEOPS complex subunit homolog
    uncharacterized protein C14orf142

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_032490.5NP_115879.2  EKC/KEOPS complex subunit GON7

      See identical proteins and their annotated locations for NP_115879.2

      Status: VALIDATED

      Source sequence(s)
      AL110118, BC021733
      Consensus CDS
      CCDS41981.1
      UniProtKB/Swiss-Prot
      Q0D2N1, Q0P6C4, Q3B7W5, Q9BXV9
      Related
      ENSP00000306320.4, ENST00000306954.5
      Conserved Domains (1) summary
      pfam15387
      Location:398
      DUF4611; Domain of unknown function (DUF4611)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      93202894..93207065 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Reference GRCh38.p14 ALT_REF_LOCI_1

    Genomic

    1. NT_187601.1 Reference GRCh38.p14 ALT_REF_LOCI_1

      Range
      317456..321627 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      87434784..87438955 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)