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    YRDC yrdC N6-threonylcarbamoyltransferase domain containing [ Homo sapiens (human) ]

    Gene ID: 79693, updated on 5-Mar-2024

    Summary

    Official Symbol
    YRDCprovided by HGNC
    Official Full Name
    yrdC N6-threonylcarbamoyltransferase domain containingprovided by HGNC
    Primary source
    HGNC:HGNC:28905
    See related
    Ensembl:ENSG00000196449 MIM:612276; AllianceGenome:HGNC:28905
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IRIP; SUA5; DRIP3; GAMOS10
    Summary
    Predicted to enable nucleotidyltransferase activity and tRNA binding activity. Acts upstream of or within negative regulation of transport. Predicted to be located in membrane and mitochondrion. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Ubiquitous expression in bone marrow (RPKM 17.4), testis (RPKM 11.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    1p34.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (37802945..37808208, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (37669833..37675096, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (38268617..38273880, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene valosin containing protein lysine methyltransferase pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 678 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 679 Neighboring gene mannosidase endo-alpha like Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 680 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 681 Neighboring gene chromosome 1 open reading frame 122 Neighboring gene metal regulatory transcription factor 1 Neighboring gene ribosomal protein S2 pseudogene 13 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 682 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr1:38330961-38332160 Neighboring gene inositol polyphosphate-5-phosphatase B Neighboring gene RNA, U6 small nuclear 584, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ23476, FLJ26165

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables L-threonylcarbamoyladenylate synthase IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables double-stranded RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables nucleotidyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    threonylcarbamoyl-AMP synthase
    Names
    dopamine receptor interacting protein 3
    hIRIP
    ischemia/reperfusion inducible protein
    ischemia/reperfusion-inducible protein homolog
    yrdC N(6)-threonylcarbamoyltransferase domain containing
    yrdC domain containing
    yrdC domain-containing protein, mitochondrial
    NP_078916.3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024640.4NP_078916.3  threonylcarbamoyl-AMP synthase precursor

      See identical proteins and their annotated locations for NP_078916.3

      Status: VALIDATED

      Source sequence(s)
      AL524812, AL929472, AY172561
      Consensus CDS
      CCDS30675.1
      UniProtKB/Swiss-Prot
      Q4W4X8, Q6NVW3, Q7L4E4, Q7Z2I4, Q86U90, Q9H5F8
      Related
      ENSP00000362135.2, ENST00000373044.3
      Conserved Domains (1) summary
      pfam01300
      Location:77255
      Sua5_yciO_yrdC; Telomere recombination

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      37802945..37808208 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      37669833..37675096 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)