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    STAG3 STAG3 cohesin complex component [ Homo sapiens (human) ]

    Gene ID: 10734, updated on 7-Apr-2024

    Summary

    Official Symbol
    STAG3provided by HGNC
    Official Full Name
    STAG3 cohesin complex componentprovided by HGNC
    Primary source
    HGNC:HGNC:11356
    See related
    Ensembl:ENSG00000066923 MIM:608489; AllianceGenome:HGNC:11356
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SA3; SPGF61
    Summary
    The protein encoded by this gene is expressed in the nucleus and is a subunit of the cohesin complex which regulates the cohesion of sister chromatids during cell division. A mutation in this gene is associated with premature ovarian failure. Alternate splicing results in multiple transcript variants encoding distinct isoforms. This gene has multiple pseudogenes. [provided by RefSeq, Apr 2014]
    Expression
    Biased expression in testis (RPKM 44.6), brain (RPKM 6.1) and 2 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See STAG3 in Genome Data Viewer
    Location:
    7q22.1
    Exon count:
    37
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 7 NC_000007.14 (100177724..100219334)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 7 NC_060931.1 (101417534..101459147)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 7 NC_000007.13 (99775347..99812010)

    Chromosome 7 - NC_000007.14Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr7:99757927-99758426 Neighboring gene galactose-3-O-sulfotransferase 4 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18422 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18423 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18424 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18425 Neighboring gene 60S ribosomal protein L29-like Neighboring gene glypican 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26344 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26345 Neighboring gene CASTOR family member 3, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26346 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26347 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26348 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26350 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26349 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18426 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26351 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26352 Neighboring gene PVR related immunoglobulin domain containing Neighboring gene ATAC-STARR-seq lymphoblastoid active region 26353 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99844389-99845186 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99845985-99846781 Neighboring gene uncharacterized LOC105375426 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99866902-99867424 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr7:99867949-99868470 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18427 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18428 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 18429 Neighboring gene ReSE screen-validated silencer GRCh37_chr7:99886514-99886677 Neighboring gene speedy/RINGO cell cycle regulator family member E3 Neighboring gene PMS1 homolog 2, mismatch repair system component pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of chromatin IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in chromosome, centromeric region IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular space HDA PubMed 
    part_of meiotic cohesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of meiotic cohesin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of meiotic cohesin complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in nucleolus IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in synaptonemal complex TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    cohesin subunit SA-3
    Names
    SCC3 homolog 3
    stromal antigen 3
    stromalin-3

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_034114.2 RefSeqGene

      Range
      5196..41659
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001282716.1NP_001269645.1  cohesin subunit SA-3 isoform 1

      See identical proteins and their annotated locations for NP_001269645.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1 and 2 encode the same isoform (1).
      Source sequence(s)
      AA747738, AJ007798, BC146806
      Consensus CDS
      CCDS34703.1
      UniProtKB/Swiss-Prot
      A6H8Z1, B4DZ10, D6W5U8, H7BYK9, Q8NDP3, Q9UJ98
      UniProtKB/TrEMBL
      A8K8M9, B2RU25
      Related
      ENSP00000400359.1, ENST00000426455.5
      Conserved Domains (1) summary
      pfam08514
      Location:173281
      STAG; STAG domain
    2. NM_001282717.2NP_001269646.1  cohesin subunit SA-3 isoform 2

      See identical proteins and their annotated locations for NP_001269646.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame acceptor splice site in the 3' coding region compared to variant 1. The resulting isoform (2) is 1 aa longer than isoform 1. Variants 3 and 5 both encode the same isoform (2).
      Source sequence(s)
      AC005071, AC073842
      Consensus CDS
      CCDS75642.1
      UniProtKB/TrEMBL
      A8K8M9, B2RU25, D6W5U7
      Related
      ENSP00000477973.1, ENST00000615138.5
      Conserved Domains (1) summary
      pfam08514
      Location:173281
      STAG; STAG domain
    3. NM_001282718.2NP_001269647.1  cohesin subunit SA-3 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks 2 consecutive in-frame exons in the 5' coding region compared to variant 1. The resulting shorter isoform (3) lacks an in internal protein segment compared to isoform 1.
      Source sequence(s)
      AA747738, AJ007798, AK302693, BC146806, DB097403
      Consensus CDS
      CCDS64730.1
      UniProtKB/TrEMBL
      A8K8M9, B2RU25
      Related
      ENSP00000484098.1, ENST00000620100.5
      Conserved Domains (1) summary
      pfam08514
      Location:115223
      STAG; STAG domain
    4. NM_001375438.1NP_001362367.1  cohesin subunit SA-3 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5), as well as variant 3, encodes isoform 2.
      Source sequence(s)
      AC005071, AC073842
      Consensus CDS
      CCDS75642.1
      UniProtKB/TrEMBL
      A8K8M9, B2RU25, D6W5U7
      Conserved Domains (1) summary
      pfam08514
      Location:173281
      STAG; STAG domain
    5. NM_012447.4NP_036579.2  cohesin subunit SA-3 isoform 1

      See identical proteins and their annotated locations for NP_036579.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the predominant transcript and encodes isoform 1. Variants 1 and 2 encode the same isoform.
      Source sequence(s)
      AA747738, AJ007798, BC146806
      Consensus CDS
      CCDS34703.1
      UniProtKB/Swiss-Prot
      A6H8Z1, B4DZ10, D6W5U8, H7BYK9, Q8NDP3, Q9UJ98
      UniProtKB/TrEMBL
      A8K8M9, B2RU25
      Related
      ENSP00000319318.5, ENST00000317296.9
      Conserved Domains (1) summary
      pfam08514
      Location:173281
      STAG; STAG domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000007.14 Reference GRCh38.p14 Primary Assembly

      Range
      100177724..100219334
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017011685.2XP_016867174.2  cohesin subunit SA-3 isoform X1

    2. XM_047419788.1XP_047275744.1  cohesin subunit SA-3 isoform X4

      UniProtKB/TrEMBL
      D6W5U7
    3. XM_047419796.1XP_047275752.1  cohesin subunit SA-3 isoform X9

    4. XM_017011683.3XP_016867172.1  cohesin subunit SA-3 isoform X3

      UniProtKB/TrEMBL
      A8K8M9, B2RU25
    5. XM_047419787.1XP_047275743.1  cohesin subunit SA-3 isoform X1

    6. XM_047419786.1XP_047275742.1  cohesin subunit SA-3 isoform X1

    7. XM_017011686.3XP_016867175.2  cohesin subunit SA-3 isoform X2

    8. XM_047419797.1XP_047275753.1  cohesin subunit SA-3 isoform X10

    9. XM_047419792.1XP_047275748.1  cohesin subunit SA-3 isoform X6

    10. XM_017011687.2XP_016867176.2  cohesin subunit SA-3 isoform X7

    11. XM_017011684.2XP_016867173.2  cohesin subunit SA-3 isoform X1

    12. XM_047419793.1XP_047275749.1  cohesin subunit SA-3 isoform X6

    13. XM_047419789.1XP_047275745.1  cohesin subunit SA-3 isoform X4

      UniProtKB/TrEMBL
      D6W5U7
    14. XM_047419791.1XP_047275747.1  cohesin subunit SA-3 isoform X5

      UniProtKB/Swiss-Prot
      A6H8Z1, B4DZ10, D6W5U8, H7BYK9, Q8NDP3, Q9UJ98
    15. XM_047419795.1XP_047275751.1  cohesin subunit SA-3 isoform X9

    16. XM_047419790.1XP_047275746.1  cohesin subunit SA-3 isoform X5

      UniProtKB/Swiss-Prot
      A6H8Z1, B4DZ10, D6W5U8, H7BYK9, Q8NDP3, Q9UJ98
    17. XM_047419794.1XP_047275750.1  cohesin subunit SA-3 isoform X8

    18. XM_047419798.1XP_047275754.1  cohesin subunit SA-3 isoform X11

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060931.1 Alternate T2T-CHM13v2.0

      Range
      101417534..101459147
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054357109.1XP_054213084.1  cohesin subunit SA-3 isoform X1

    2. XM_054357112.1XP_054213087.1  cohesin subunit SA-3 isoform X4

      UniProtKB/TrEMBL
      D6W5U7
    3. XM_054357121.1XP_054213096.1  cohesin subunit SA-3 isoform X9

    4. XM_054357111.1XP_054213086.1  cohesin subunit SA-3 isoform X3

    5. XM_054357106.1XP_054213081.1  cohesin subunit SA-3 isoform X1

    6. XM_054357110.1XP_054213085.1  cohesin subunit SA-3 isoform X2

    7. XM_054357122.1XP_054213097.1  cohesin subunit SA-3 isoform X10

    8. XM_054357116.1XP_054213091.1  cohesin subunit SA-3 isoform X6

    9. XM_054357118.1XP_054213093.1  cohesin subunit SA-3 isoform X7

    10. XM_054357108.1XP_054213083.1  cohesin subunit SA-3 isoform X1

    11. XM_054357117.1XP_054213092.1  cohesin subunit SA-3 isoform X6

    12. XM_054357120.1XP_054213095.1  cohesin subunit SA-3 isoform X9

    13. XM_054357114.1XP_054213089.1  cohesin subunit SA-3 isoform X5

      UniProtKB/Swiss-Prot
      A6H8Z1, B4DZ10, D6W5U8, H7BYK9, Q8NDP3, Q9UJ98
    14. XM_054357119.1XP_054213094.1  cohesin subunit SA-3 isoform X8

    15. XM_054357115.1XP_054213090.1  cohesin subunit SA-3 isoform X5

      UniProtKB/Swiss-Prot
      A6H8Z1, B4DZ10, D6W5U8, H7BYK9, Q8NDP3, Q9UJ98
    16. XM_054357107.1XP_054213082.1  cohesin subunit SA-3 isoform X1

    17. XM_054357113.1XP_054213088.1  cohesin subunit SA-3 isoform X4

      UniProtKB/TrEMBL
      D6W5U7
    18. XM_054357123.1XP_054213098.1  cohesin subunit SA-3 isoform X11