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    ARSK arylsulfatase family member K [ Homo sapiens (human) ]

    Gene ID: 153642, updated on 5-Mar-2024

    Summary

    Official Symbol
    ARSKprovided by HGNC
    Official Full Name
    arylsulfatase family member Kprovided by HGNC
    Primary source
    HGNC:HGNC:25239
    See related
    Ensembl:ENSG00000164291 MIM:610011; AllianceGenome:HGNC:25239
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MPS10; TSULF
    Summary
    Sulfatases (EC 3.1.5.6), such as ARSK, hydrolyze sulfate esters from sulfated steroids, carbohydrates, proteoglycans, and glycolipids. They are involved in hormone biosynthesis, modulation of cell signaling, and degradation of macromolecules (Sardiello et al., 2005 [PubMed 16174644]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in thyroid (RPKM 2.9), ovary (RPKM 2.9) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See ARSK in Genome Data Viewer
    Location:
    5q15
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 5 NC_000005.10 (95555101..95605102)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 5 NC_060929.1 (96056040..96106030)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 5 NC_000005.9 (94890805..94940806)

    Chromosome 5 - NC_000005.10Genomic Context describing neighboring genes Neighboring gene family with sequence similarity 81 member B Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr5:94775487-94776419 Neighboring gene RTRAF pseudogene 2 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:94821776-94822394 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:94822395-94823011 Neighboring gene SKI3 subunit of superkiller complex Neighboring gene RNA, U6 small nuclear 308, pseudogene Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr5:94926949-94928148 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr5:94955347-94955962 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16182 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 16183 Neighboring gene Sharpr-MPRA regulatory region 2204 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr5:94957159-94957658 Neighboring gene uncharacterized LOC112267933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 22798 Neighboring gene G protein-coupled receptor 150

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp313G1735

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables arylsulfatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables arylsulfatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables arylsulfatase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables glucuronate-2-sulfatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables glucuronate-2-sulfatase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lysosome IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    arylsulfatase K
    Names
    ASK
    glucuronate-2-sulfatase
    telethon sulfatase
    NP_937793.1
    XP_047272776.1
    XP_054207790.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_198150.3NP_937793.1  arylsulfatase K precursor

      See identical proteins and their annotated locations for NP_937793.1

      Status: VALIDATED

      Source sequence(s)
      AC008547, AC090071, AY875939
      Consensus CDS
      CCDS4073.1
      UniProtKB/Swiss-Prot
      A2BDE3, B4E1I4, Q3ZCW3, Q6UWY0, Q8N3Q8
      Related
      ENSP00000369346.4, ENST00000380009.9
      Conserved Domains (1) summary
      cd16171
      Location:32447
      ARSK; arylsulfatase family, member K ....arylsulfatase k short ask flags precursor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000005.10 Reference GRCh38.p14 Primary Assembly

      Range
      95555101..95605102
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047416820.1XP_047272776.1  arylsulfatase K isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060929.1 Alternate T2T-CHM13v2.0

      Range
      96056040..96106030
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054351815.1XP_054207790.1  arylsulfatase K isoform X1