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    RORC RAR related orphan receptor C [ Homo sapiens (human) ]

    Gene ID: 6097, updated on 3-Apr-2024

    Summary

    Official Symbol
    RORCprovided by HGNC
    Official Full Name
    RAR related orphan receptor Cprovided by HGNC
    Primary source
    HGNC:HGNC:10260
    See related
    Ensembl:ENSG00000143365 MIM:602943; AllianceGenome:HGNC:10260
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TOR; RORG; RZRG; IMD42; NR1F3; RZR-GAMMA
    Summary
    The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in liver (RPKM 16.0), thyroid (RPKM 15.9) and 18 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See RORC in Genome Data Viewer
    Location:
    1q21.3
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (151806071..151831802, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (150929559..150955307, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (151778547..151804278, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene TDRKH antisense RNA 1 Neighboring gene leucine rich repeat and Ig domain containing 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:151781322-151781822 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:151787417-151787917 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:151794559-151795060 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:151795061-151795560 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:151797330-151798265 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:151801527-151802212 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:151802899-151803586 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1327 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1328 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1329 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1725 Neighboring gene C2CD4D and THEM5 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1726 Neighboring gene C2 calcium dependent domain containing 4D Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:151820400-151821167 Neighboring gene thioesterase superfamily member 5

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC129539

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in T-helper 17 cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in adipose tissue development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to sterol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in circadian regulation of gene expression ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in intracellular receptor signaling pathway IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of DNA-templated transcription ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of circadian rhythm ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of fat cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of glucose metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of steroid metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in xenobiotic metabolic process ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    nuclear receptor ROR-gamma
    Names
    nuclear receptor RZR-gamma
    nuclear receptor subfamily 1 group F member 3
    retinoic acid-binding receptor gamma
    retinoid-related orphan receptor gamma

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_029118.1 RefSeqGene

      Range
      5071..30802
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1322

    mRNA and Protein(s)

    1. NM_001001523.2NP_001001523.1  nuclear receptor ROR-gamma isoform b

      See identical proteins and their annotated locations for NP_001001523.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding region compared to variant 1. The resulting isoform (b) is shorter and has a distinct N-terminus compared to isoform a.
      Source sequence(s)
      AL834219, CB161467, DB148892
      Consensus CDS
      CCDS30856.1
      UniProtKB/TrEMBL
      B3KUU9, F1D8P6
      Related
      ENSP00000349164.6, ENST00000356728.11
      Conserved Domains (2) summary
      cd06939
      Location:247485
      NR_LBD_ROR_like; The ligand binding domain of Retinoid-related orphan receptors, of the nuclear receptor superfamily
      cd06968
      Location:497
      NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers
    2. NM_005060.4NP_005051.2  nuclear receptor ROR-gamma isoform a

      See identical proteins and their annotated locations for NP_005051.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (a).
      Source sequence(s)
      AL834219, BC031554, CB161467, U16997
      Consensus CDS
      CCDS1004.1
      UniProtKB/Swiss-Prot
      P51449, Q5SZR9, Q8N5V7, Q8NCY8
      UniProtKB/TrEMBL
      B2RDT1, Q53FZ4, Q6I9R9
      Related
      ENSP00000327025.6, ENST00000318247.7
      Conserved Domains (2) summary
      cd06939
      Location:268506
      NR_LBD_ROR_like; The ligand binding domain of Retinoid-related orphan receptors, of the nuclear receptor superfamily
      cd06968
      Location:24118
      NR_DBD_ROR; DNA-binding domain of Retinoid-related orphan receptors (RORs) is composed of two C4-type zinc fingers

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      151806071..151831802 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006711484.5XP_006711547.3  nuclear receptor ROR-gamma isoform X2

    2. XM_047427201.1XP_047283157.1  nuclear receptor ROR-gamma isoform X1

      Related
      ENSP00000498691.1, ENST00000651814.1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      150929559..150955307 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054338087.1XP_054194062.1  nuclear receptor ROR-gamma isoform X2

      UniProtKB/TrEMBL
      B4DPR1
    2. XM_054338086.1XP_054194061.1  nuclear receptor ROR-gamma isoform X1