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    KCNMA1 potassium calcium-activated channel subfamily M alpha 1 [ Homo sapiens (human) ]

    Gene ID: 3778, updated on 17-Jun-2024

    Summary

    Official Symbol
    KCNMA1provided by HGNC
    Official Full Name
    potassium calcium-activated channel subfamily M alpha 1provided by HGNC
    Primary source
    HGNC:HGNC:6284
    See related
    Ensembl:ENSG00000156113 MIM:600150; AllianceGenome:HGNC:6284
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SLO; BKTM; SLO1; hSlo; IEG16; LIWAS; MaxiK; PNKD3; SAKCA; mSLO1; CADEDS; KCa1.1; SLO-ALPHA; bA205K10.1
    Summary
    This gene encodes the alpha subunit of calcium-activated BK channel. The encoded protein is involved in several physiological processes including smooth muscle contraction, neurotransmitter release and neuronal excitability. Mutations in this gene are associated with a spectrum of neurological disorders including Paroxysmal Nonkinesigenic Dyskinesia 3, Idiopathic Generalized Epilepsy 16 and Liang-Wang syndrome. [provided by RefSeq, Aug 2022]
    Expression
    Broad expression in endometrium (RPKM 7.1), brain (RPKM 4.7) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See KCNMA1 in Genome Data Viewer
    Location:
    10q22.3
    Exon count:
    45
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (76869602..77637808, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (77738326..78506527, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (78629360..79397566, complement)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene leucine rich melanocyte differentiation associated Neighboring gene uncharacterized LOC112268057 Neighboring gene Sharpr-MPRA regulatory region 6857 Neighboring gene VISTA enhancer hs1683 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:78192871-78193568 Neighboring gene VISTA enhancer hs1434 Neighboring gene Sharpr-MPRA regulatory region 3593 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr10:78383798-78384997 Neighboring gene VISTA enhancer hs748 Neighboring gene NANOG hESC enhancer GRCh37_chr10:78538831-78539723 Neighboring gene OCT4 hESC enhancer GRCh37_chr10:78568996-78569497 Neighboring gene NANOG hESC enhancer GRCh37_chr10:78582741-78583242 Neighboring gene ATP synthase membrane subunit c locus 1 pseudogene 8 Neighboring gene uncharacterized LOC124902466 Neighboring gene KCNMA1 antisense RNA 1 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:78733040-78734239 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3609 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:78841288-78841844 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:78856955-78857142 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:78873963-78874931 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:78923175-78924374 Neighboring gene NANOG hESC enhancer GRCh37_chr10:78961027-78961555 Neighboring gene KCNMA1 antisense RNA 2 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:79058612-79058814 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:79074042-79074589 Neighboring gene NANOG hESC enhancer GRCh37_chr10:79084628-79085170 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr10:79110032-79111231 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:79135632-79136831 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:79170031-79170530 Neighboring gene KCNMA1 antisense RNA 3 Neighboring gene uncharacterized LOC124902464 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr10:79291078-79292277 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:79305619-79306119 Neighboring gene H3K27ac hESC enhancers GRCh37_chr10:79324026-79324882 and GRCh37_chr10:79324883-79325737 Neighboring gene cytochrome c oxidase subunit 6C pseudogene 15 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:79352252-79352440 Neighboring gene uncharacterized LOC124902465 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2517 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:79418700-79419899 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:79432857-79433055 Neighboring gene RNA, 5S ribosomal pseudogene 321 Neighboring gene uncharacterized LOC105378372 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3611 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:79472357-79472588 Neighboring gene zinc finger protein 532 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Cerebellar atrophy, developmental delay, and seizures
    MedGen: C4539985 OMIM: 617643 GeneReviews: Not available
    Compare labs
    Epilepsy, idiopathic generalized, susceptibility to, 16
    MedGen: C5231421 OMIM: 618596 GeneReviews: Not available
    Compare labs
    Generalized epilepsy-paroxysmal dyskinesia syndrome
    MedGen: C5574945 OMIM: 609446 GeneReviews: Not available
    Compare labs
    Liang-Wang syndrome
    MedGen: C5231479 OMIM: 618729 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Common genetic variants associated with cognitive performance identified using the proxy-phenotype method.
    EBI GWAS Catalog
    Gene-age interactions in blood pressure regulation: a large-scale investigation with the CHARGE, Global BPgen, and ICBP Consortia.
    EBI GWAS Catalog
    Genome wide association study identifies KCNMA1 contributing to human obesity.
    EBI GWAS Catalog
    Genome-wide association analyses identify variants in developmental genes associated with hypospadias.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
    EBI GWAS Catalog
    Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 gp120 from both CCR5- and CXCR4-tropic HIV-1 strains opens calcium-activated potassium (K(Ca)), chloride, and calcium-permeant nonselective cation channels in macrophages; these signals are mediated by CCR5 and CXCR4 PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC71881, DKFZp686K1437

    Gene Ontology Provided by GOA

    Component Evidence Code Pubs
    located_in apical plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in caveola IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of voltage-gated potassium channel complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    Calcium-activated potassium channel subunit alpha-1; calcium-activated potassium channel subunit alpha-1
    Names
    BK channel alpha subunit
    BKCA alpha subunit
    big potassium channel alpha subunit
    calcium-activated potassium channel, subfamily M subunit alpha-1
    k(VCA)alpha
    maxi-K channel HSLO
    potassium channel, calcium activated large conductance subfamily M alpha, member 1
    potassium large conductance calcium-activated channel, subfamily M, alpha member 1
    slo homolog
    slowpoke homolog
    stretch-activated Kca channel

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012270.1 RefSeqGene

      Range
      5012..757938
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001014797.3NP_001014797.1  Calcium-activated potassium channel subunit alpha-1 isoform a

      See identical proteins and their annotated locations for NP_001014797.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes isoform a.
      Source sequence(s)
      AB209488, AC011439, BC024965, U09384
      UniProtKB/TrEMBL
      A0A1W2PNH9
      Related
      ENSP00000473714.2, ENST00000604624.6
      Conserved Domains (3) summary
      pfam00520
      Location:179396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    2. NM_001161352.2NP_001154824.1  Calcium-activated potassium channel subunit alpha-1 isoform c

      See identical proteins and their annotated locations for NP_001154824.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (c) contains a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AB113382, AC011439, BC024965, BQ574058, U11058
      Consensus CDS
      CCDS60569.1
      UniProtKB/Swiss-Prot
      F8WA96, Q12791, Q12886, Q12917, Q12921, Q12960, Q13150, Q5JQ23, Q5SQR9, Q96LG8, Q9UBB0, Q9UCX0, Q9UQK6
      UniProtKB/TrEMBL
      A0A1W2PQU4
      Related
      ENSP00000286628.8, ENST00000286628.14
      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    3. NM_001161353.2NP_001154825.1  Calcium-activated potassium channel subunit alpha-1 isoform d

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (d) contains a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AB113575, AC011439, BC024965, BQ574058, U11058
      Consensus CDS
      CCDS53545.1
      UniProtKB/TrEMBL
      A0A1W2PQU4
      Related
      ENSP00000485867.1, ENST00000626620.3
      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    4. NM_001271518.2NP_001258447.1  Calcium-activated potassium channel subunit alpha-1 isoform e

      See identical proteins and their annotated locations for NP_001258447.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) omits an in-frame coding exon. The resulting isoform (e) is shorter compared to isoform a.
      Source sequence(s)
      AB209488, AB524033, AC011439, BC024965, BC137115
      Consensus CDS
      CCDS86106.1
      UniProtKB/TrEMBL
      A0A1W2PNH9, D5MRH1
      Related
      ENSP00000491555.1, ENST00000640807.1
      Conserved Domains (4) summary
      pfam00520
      Location:156342
      Ion_trans; Ion transport protein
      pfam03493
      Location:491579
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:252337
      Ion_trans_2; Ion channel
      cl21454
      Location:356469
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    5. NM_001271519.2NP_001258448.1  Calcium-activated potassium channel subunit alpha-1 isoform f

      See identical proteins and their annotated locations for NP_001258448.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (f) contains a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC011439, AC021032, AK024857, BC024965, BC144496
      Consensus CDS
      CCDS86116.1
      UniProtKB/TrEMBL
      A0A1W2PQU4, B7ZMF5
      Related
      ENSP00000491732.1, ENST00000639406.1
      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    6. NM_001271520.2NP_001258449.1  Calcium-activated potassium channel subunit alpha-1 isoform short1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (7) is a two-exon transcript with a distinct 3'UTR compared to variant 1. The predicted protein (short1) has a distinct C-terminus and is significantly shorter than isoform a. It is unknown if this protein is stable or has any function.
      Source sequence(s)
      AL731556, BC009695, BC024965
      Consensus CDS
      CCDS73156.1
      UniProtKB/TrEMBL
      A0A087WZL8, Q6AI34
      Related
      ENSP00000482747.1, ENST00000618048.2
    7. NM_001271521.2NP_001258450.1  Calcium-activated potassium channel subunit alpha-1 isoform short2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8) is a two-exon transcript with a distinct 3'UTR compared to variant 1. The predicted protein (short2) has a distinct C-terminus and is significantly shorter than isoform a. It is unknown if this protein is stable or has any function.
      Source sequence(s)
      BC009695, BC024965
      Consensus CDS
      CCDS60572.1
      UniProtKB/TrEMBL
      S4R453
      Related
      ENSP00000475086.1, ENST00000481070.1
    8. NM_001271522.2NP_001258451.1  Calcium-activated potassium channel subunit alpha-1 isoform short3

      See identical proteins and their annotated locations for NP_001258451.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9) is a two-exon transcript with a distinct 3'UTR compared to variant 1. The predicted protein (short3) has a distinct C-terminus and is significantly shorter than isoform a. It is unknown if this protein is stable or has any function.
      Source sequence(s)
      AL731556, BC024965
      Consensus CDS
      CCDS60571.1
      UniProtKB/Swiss-Prot
      Q12791
      Related
      ENSP00000474686.1, ENST00000480683.2
    9. NM_001322829.2NP_001309758.1  Calcium-activated potassium channel subunit alpha-1 isoform g

      Status: REVIEWED

      Source sequence(s)
      AC011439, AC021032, AL157833, AL627447, AL731556, AL731560
      UniProtKB/TrEMBL
      H0Y382
      Related
      ENSP00000490978.1, ENST00000638991.1
    10. NM_001322830.2NP_001309759.1  Calcium-activated potassium channel subunit alpha-1 isoform h

      Status: REVIEWED

      Source sequence(s)
      AC011439, AC021032, AL157833, AL627447, AL731556, AL731560
      Consensus CDS
      CCDS86121.1
      UniProtKB/TrEMBL
      A0A1W2PR56, A0A1W2PRG5
      Related
      ENSP00000492492.1, ENST00000638223.1
    11. NM_001322832.2NP_001309761.1  Calcium-activated potassium channel subunit alpha-1 isoform i

      Status: REVIEWED

      Source sequence(s)
      AC011439, AC021032, AL157833, AL627447, AL731556, AL731560
      Consensus CDS
      CCDS81481.1
      UniProtKB/TrEMBL
      A0A1W2PQK5, H0Y382
      Related
      ENSP00000492005.1, ENST00000639486.1
      Conserved Domains (3) summary
      pfam00520
      Location:179396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    12. NM_001322835.2NP_001309764.1  Calcium-activated potassium channel subunit alpha-1 isoform j

      Status: REVIEWED

      Source sequence(s)
      AC011439, AC021032, AL157833, AL627447, AL731556, AL731560
      UniProtKB/TrEMBL
      H0Y382
      Related
      ENSP00000361498.6, ENST00000372421.10
      Conserved Domains (3) summary
      pfam00520
      Location:179396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    13. NM_001322836.2NP_001309765.1  Calcium-activated potassium channel subunit alpha-1 isoform k

      Status: REVIEWED

      Source sequence(s)
      AC011439, AC021032, AL157833, AL627447, AL731556, AL731560
      Consensus CDS
      CCDS86115.1
      UniProtKB/TrEMBL
      A0A1W2PP94, A0A1W2PQU4
      Related
      ENSP00000491418.1, ENST00000640141.1
    14. NM_001322837.2NP_001309766.1  Calcium-activated potassium channel subunit alpha-1 isoform l

      Status: REVIEWED

      Source sequence(s)
      AC011439, AC021032, AL157833, AL627447, AL731556, AL731560
      UniProtKB/TrEMBL
      A0A1W2PQU4
      Related
      ENSP00000491166.1, ENST00000638754.1
    15. NM_001322838.2NP_001309767.1  Calcium-activated potassium channel subunit alpha-1 isoform m

      Status: REVIEWED

      Source sequence(s)
      AC011439, AK310379, AL731575
      UniProtKB/TrEMBL
      A0A0A0MRC3
      Conserved Domains (4) summary
      pfam00520
      Location:30216
      Ion_trans; Ion transport protein
      pfam03493
      Location:365453
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:126211
      Ion_trans_2; Ion channel
      cl21454
      Location:230343
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    16. NM_001322839.2NP_001309768.1  Calcium-activated potassium channel subunit alpha-1 isoform short4

      Status: REVIEWED

      Source sequence(s)
      AL731556
    17. NM_001410940.1NP_001397869.1  Calcium-activated potassium channel subunit alpha-1 isoform n

      Status: REVIEWED

      Source sequence(s)
      AC011439, AC021032, AL157833, AL627447, AL731556, AL731560
      Consensus CDS
      CCDS91276.1
      UniProtKB/TrEMBL
      A0A1W2PNH9, A0A1W2PSD3
      Related
      ENSP00000492806.1, ENST00000639601.1
    18. NM_002247.4NP_002238.2  Calcium-activated potassium channel subunit alpha-1 isoform b

      See identical proteins and their annotated locations for NP_002238.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' UTR and has multiple coding region differences, compared to variant 1. The resulting isoform (b) contains a distinct C-terminus, compared to isoform a.
      Source sequence(s)
      AC011439, BC024965, BC137115, BQ574058, U11058, U13913
      Consensus CDS
      CCDS7352.1
      UniProtKB/TrEMBL
      A0A1W2PQU4
      Related
      ENSP00000286627.5, ENST00000286627.10
      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      76869602..77637808 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_017016222.3XP_016871711.2  calcium-activated potassium channel subunit alpha-1 isoform X41

      UniProtKB/TrEMBL
      A0A1W2PNQ3, H0Y382
      Related
      ENSP00000491008.1, ENST00000638306.1
      Conserved Domains (3) summary
      pfam00520
      Location:179387
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    2. XM_024447990.2XP_024303758.1  calcium-activated potassium channel subunit alpha-1 isoform X40

      UniProtKB/TrEMBL
      A0A1W2PNW6, A0A1W2PNY9
      Related
      ENSP00000491123.1, ENST00000638203.1
      Conserved Domains (3) summary
      pfam00520
      Location:179387
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    3. XM_024447989.2XP_024303757.1  calcium-activated potassium channel subunit alpha-1 isoform X39

      UniProtKB/TrEMBL
      A0A1W2PNY9, A0A1W2PQA0
      Related
      ENSP00000491981.1, ENST00000638606.1
      Conserved Domains (3) summary
      pfam00520
      Location:179387
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    4. XM_005269787.5XP_005269844.1  calcium-activated potassium channel subunit alpha-1 isoform X36

      UniProtKB/TrEMBL
      A0A0A0MRR0, A0A1W2PPY5
      Related
      ENSP00000491673.1, ENST00000639090.1
      Conserved Domains (3) summary
      pfam00520
      Location:179396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    5. XM_005269776.5XP_005269833.1  calcium-activated potassium channel subunit alpha-1 isoform X34

      UniProtKB/TrEMBL
      A0A0A0MRR0
      Related
      ENSP00000361480.4, ENST00000372403.9
      Conserved Domains (3) summary
      pfam00520
      Location:179396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    6. XM_047425199.1XP_047281155.1  calcium-activated potassium channel subunit alpha-1 isoform X26

      UniProtKB/TrEMBL
      H0Y382
    7. XM_005269792.3XP_005269849.1  calcium-activated potassium channel subunit alpha-1 isoform X25

      UniProtKB/TrEMBL
      A0A1W2PNH9
      Related
      ENSP00000385806.3, ENST00000404857.6
      Conserved Domains (3) summary
      pfam00520
      Location:179396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    8. XM_024447984.2XP_024303752.1  calcium-activated potassium channel subunit alpha-1 isoform X18

      UniProtKB/TrEMBL
      H0Y382, Q5SVJ9
      Related
      ENSP00000396608.2, ENST00000457953.6
      Conserved Domains (3) summary
      pfam00520
      Location:179396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    9. XM_005269781.3XP_005269838.1  calcium-activated potassium channel subunit alpha-1 isoform X17

      UniProtKB/TrEMBL
      A0A1W2PNH9, A0A1W2PR62
      Related
      ENSP00000492075.1, ENST00000639544.1
      Conserved Domains (3) summary
      pfam00520
      Location:179396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    10. XM_024447987.2XP_024303755.1  calcium-activated potassium channel subunit alpha-1 isoform X35

      UniProtKB/TrEMBL
      A0A1W2PRV4, Q5SVJ8
      Related
      ENSP00000385717.3, ENST00000404771.8
      Conserved Domains (3) summary
      pfam00520
      Location:179396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    11. XM_011539785.3XP_011538087.1  calcium-activated potassium channel subunit alpha-1 isoform X37

      UniProtKB/TrEMBL
      H0Y382
      Related
      ENSP00000492718.1, ENST00000639205.1
      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    12. XM_024447985.2XP_024303753.1  calcium-activated potassium channel subunit alpha-1 isoform X28

      UniProtKB/TrEMBL
      A0A1W2PQ61, H0Y382
      Related
      ENSP00000491927.1, ENST00000639489.1
      Conserved Domains (3) summary
      pfam00520
      Location:179396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    13. XM_024447988.2XP_024303756.1  calcium-activated potassium channel subunit alpha-1 isoform X38

      UniProtKB/TrEMBL
      A0A1W2PPZ1, A0A1W2PRB0
      Related
      ENSP00000492510.1, ENST00000640182.1
      Conserved Domains (3) summary
      pfam00520
      Location:179396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    14. XM_005269789.3XP_005269846.1  calcium-activated potassium channel subunit alpha-1 isoform X24

      UniProtKB/TrEMBL
      A0A1W2PRG5, Q5SVJ7
      Related
      ENSP00000361520.2, ENST00000372443.6
      Conserved Domains (3) summary
      pfam00520
      Location:179396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    15. XM_005269778.3XP_005269835.1  calcium-activated potassium channel subunit alpha-1 isoform X16

      UniProtKB/TrEMBL
      A0A1W2PRN5, H0Y382
      Related
      ENSP00000492414.1, ENST00000638848.1
      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    16. XM_011539780.3XP_011538082.1  calcium-activated potassium channel subunit alpha-1 isoform X15

      UniProtKB/TrEMBL
      A0A1W2PNH9
      Related
      ENSP00000491539.1, ENST00000640934.1
      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    17. XM_017016217.2XP_016871706.1  calcium-activated potassium channel subunit alpha-1 isoform X22

      UniProtKB/TrEMBL
      A0A1W2PQ93
    18. XM_017016213.3XP_016871702.1  calcium-activated potassium channel subunit alpha-1 isoform X13

      UniProtKB/TrEMBL
      A0A1W2PQ93
    19. XM_047425196.1XP_047281152.1  calcium-activated potassium channel subunit alpha-1 isoform X12

      UniProtKB/TrEMBL
      A0A1W2PNH9
    20. XM_011539775.3XP_011538077.1  calcium-activated potassium channel subunit alpha-1 isoform X7

      UniProtKB/TrEMBL
      A0A1W2PNH9
      Conserved Domains (4) summary
      pfam00520
      Location:254440
      Ion_trans; Ion transport protein
      pfam03493
      Location:589677
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:350435
      Ion_trans_2; Ion channel
      cl21454
      Location:454567
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    21. XM_011539781.4XP_011538083.1  calcium-activated potassium channel subunit alpha-1 isoform X20

      UniProtKB/TrEMBL
      A0A1W2PNH9
      Conserved Domains (4) summary
      pfam00520
      Location:254440
      Ion_trans; Ion transport protein
      pfam03493
      Location:589677
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:350435
      Ion_trans_2; Ion channel
      cl21454
      Location:454567
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    22. XM_017016211.3XP_016871700.1  calcium-activated potassium channel subunit alpha-1 isoform X10

      UniProtKB/TrEMBL
      A0A1W2PQ93
    23. XM_017016210.3XP_016871699.1  calcium-activated potassium channel subunit alpha-1 isoform X5

      UniProtKB/TrEMBL
      A0A1W2PQ93
    24. XM_011539773.3XP_011538075.1  calcium-activated potassium channel subunit alpha-1 isoform X4

      UniProtKB/TrEMBL
      A0A1W2PNH9
      Conserved Domains (4) summary
      pfam00520
      Location:254440
      Ion_trans; Ion transport protein
      pfam03493
      Location:589677
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:350435
      Ion_trans_2; Ion channel
      cl21454
      Location:454567
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    25. XM_017016208.3XP_016871697.1  calcium-activated potassium channel subunit alpha-1 isoform X2

      UniProtKB/TrEMBL
      H0Y382
    26. XM_017016207.3XP_016871696.1  calcium-activated potassium channel subunit alpha-1 isoform X1

      UniProtKB/TrEMBL
      A0A1W2PRG5
    27. XM_017016223.1XP_016871712.1  calcium-activated potassium channel subunit alpha-1 isoform X42

      UniProtKB/TrEMBL
      A0A0A0MRC3
      Conserved Domains (4) summary
      pfam00520
      Location:30216
      Ion_trans; Ion transport protein
      pfam03493
      Location:365453
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:126211
      Ion_trans_2; Ion channel
      cl21454
      Location:230343
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    28. XM_006717826.3XP_006717889.1  calcium-activated potassium channel subunit alpha-1 isoform X27

      UniProtKB/TrEMBL
      A0A1W2PQU4
      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    29. XM_047425197.1XP_047281153.1  calcium-activated potassium channel subunit alpha-1 isoform X19

      UniProtKB/TrEMBL
      A0A1W2PQU4
      Related
      ENSP00000491300.1, ENST00000638283.1
    30. XM_011539778.3XP_011538080.1  calcium-activated potassium channel subunit alpha-1 isoform X9

      UniProtKB/TrEMBL
      A0A1W2PQU4
      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    31. XM_011539783.3XP_011538085.1  calcium-activated potassium channel subunit alpha-1 isoform X23

      UniProtKB/TrEMBL
      A0A1W2PQU4
      Related
      ENSP00000490982.1, ENST00000639823.1
      Conserved Domains (3) summary
      pfam00520
      Location:179396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    32. XM_011539777.3XP_011538079.1  calcium-activated potassium channel subunit alpha-1 isoform X8

      UniProtKB/TrEMBL
      A0A1W2PQU4
      Conserved Domains (4) summary
      pfam00520
      Location:210396
      Ion_trans; Ion transport protein
      pfam03493
      Location:545633
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:306391
      Ion_trans_2; Ion channel
      cl21454
      Location:410523
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    33. XM_011539782.3XP_011538084.1  calcium-activated potassium channel subunit alpha-1 isoform X21

      UniProtKB/TrEMBL
      A0A1W2PQU4
      Related
      ENSP00000491840.1, ENST00000638514.1
      Conserved Domains (4) summary
      pfam00520
      Location:254440
      Ion_trans; Ion transport protein
      pfam03493
      Location:589677
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:350435
      Ion_trans_2; Ion channel
      cl21454
      Location:454567
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    34. XM_017016214.3XP_016871703.1  calcium-activated potassium channel subunit alpha-1 isoform X14

      UniProtKB/TrEMBL
      A0A1W2PQU4
    35. XM_017016209.3XP_016871698.1  calcium-activated potassium channel subunit alpha-1 isoform X3

      UniProtKB/TrEMBL
      A0A1W2PQU4
    36. XM_047425195.1XP_047281151.1  calcium-activated potassium channel subunit alpha-1 isoform X11

      UniProtKB/TrEMBL
      A0A1W2PQU4
    37. XM_011539774.3XP_011538076.1  calcium-activated potassium channel subunit alpha-1 isoform X6

      UniProtKB/TrEMBL
      A0A1W2PQU4
      Conserved Domains (4) summary
      pfam00520
      Location:254440
      Ion_trans; Ion transport protein
      pfam03493
      Location:589677
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:350435
      Ion_trans_2; Ion channel
      cl21454
      Location:454567
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    38. XM_024447986.2XP_024303754.1  calcium-activated potassium channel subunit alpha-1 isoform X29

      UniProtKB/TrEMBL
      J3KQ16
      Conserved Domains (3) summary
      pfam00520
      Location:21238
      Ion_trans; Ion transport protein
      pfam03493
      Location:387475
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      cl21454
      Location:252365
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
    39. XM_047425200.1XP_047281156.1  calcium-activated potassium channel subunit alpha-1 isoform X30

      UniProtKB/TrEMBL
      J3KQ16
      Related
      ENSP00000346321.6, ENST00000354353.9
    40. XM_017016219.3XP_016871708.1  calcium-activated potassium channel subunit alpha-1 isoform X31

    41. XM_047425201.1XP_047281157.1  calcium-activated potassium channel subunit alpha-1 isoform X33

      UniProtKB/TrEMBL
      A0A1W2PQ39
      Related
      ENSP00000492236.1, ENST00000639120.1
    42. XM_011539784.3XP_011538086.1  calcium-activated potassium channel subunit alpha-1 isoform X32

      Conserved Domains (4) summary
      pfam00520
      Location:254440
      Ion_trans; Ion transport protein
      pfam03493
      Location:589677
      BK_channel_a; Calcium-activated BK potassium channel alpha subunit
      pfam07885
      Location:350435
      Ion_trans_2; Ion channel
      cl21454
      Location:454567
      NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

    RNA

    1. XR_007061964.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      77738326..78506527 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365843.1XP_054221818.1  calcium-activated potassium channel subunit alpha-1 isoform X41

      UniProtKB/TrEMBL
      A0A1W2PNQ3, H0Y382
    2. XM_054365842.1XP_054221817.1  calcium-activated potassium channel subunit alpha-1 isoform X40

      UniProtKB/TrEMBL
      A0A1W2PNW6, A0A1W2PNY9
    3. XM_054365841.1XP_054221816.1  calcium-activated potassium channel subunit alpha-1 isoform X39

      UniProtKB/TrEMBL
      A0A1W2PNY9, A0A1W2PQA0
    4. XM_054365838.1XP_054221813.1  calcium-activated potassium channel subunit alpha-1 isoform X36

      UniProtKB/TrEMBL
      A0A0A0MRR0, A0A1W2PPY5
    5. XM_054365836.1XP_054221811.1  calcium-activated potassium channel subunit alpha-1 isoform X34

      UniProtKB/TrEMBL
      A0A0A0MRR0
    6. XM_054365828.1XP_054221803.1  calcium-activated potassium channel subunit alpha-1 isoform X26

      UniProtKB/TrEMBL
      H0Y382
    7. XM_054365827.1XP_054221802.1  calcium-activated potassium channel subunit alpha-1 isoform X25

      UniProtKB/TrEMBL
      A0A1W2PNH9
    8. XM_054365820.1XP_054221795.1  calcium-activated potassium channel subunit alpha-1 isoform X18

      UniProtKB/TrEMBL
      H0Y382, Q5SVJ9
    9. XM_054365819.1XP_054221794.1  calcium-activated potassium channel subunit alpha-1 isoform X17

      UniProtKB/TrEMBL
      A0A1W2PNH9, A0A1W2PR62
    10. XM_054365837.1XP_054221812.1  calcium-activated potassium channel subunit alpha-1 isoform X35

      UniProtKB/TrEMBL
      A0A1W2PRV4, Q5SVJ8
    11. XM_054365839.1XP_054221814.1  calcium-activated potassium channel subunit alpha-1 isoform X37

      UniProtKB/TrEMBL
      H0Y382
    12. XM_054365830.1XP_054221805.1  calcium-activated potassium channel subunit alpha-1 isoform X28

      UniProtKB/TrEMBL
      A0A1W2PQ61, H0Y382
    13. XM_054365840.1XP_054221815.1  calcium-activated potassium channel subunit alpha-1 isoform X38

      UniProtKB/TrEMBL
      A0A1W2PPZ1, A0A1W2PRB0
    14. XM_054365826.1XP_054221801.1  calcium-activated potassium channel subunit alpha-1 isoform X24

      UniProtKB/TrEMBL
      A0A1W2PRG5, Q5SVJ7
    15. XM_054365818.1XP_054221793.1  calcium-activated potassium channel subunit alpha-1 isoform X16

      UniProtKB/TrEMBL
      A0A1W2PRN5, H0Y382
    16. XM_054365817.1XP_054221792.1  calcium-activated potassium channel subunit alpha-1 isoform X15

      UniProtKB/TrEMBL
      A0A1W2PNH9
    17. XM_054365824.1XP_054221799.1  calcium-activated potassium channel subunit alpha-1 isoform X22

      UniProtKB/TrEMBL
      A0A1W2PQ93
    18. XM_054365815.1XP_054221790.1  calcium-activated potassium channel subunit alpha-1 isoform X13

      UniProtKB/TrEMBL
      A0A1W2PQ93
    19. XM_054365814.1XP_054221789.1  calcium-activated potassium channel subunit alpha-1 isoform X12

      UniProtKB/TrEMBL
      A0A1W2PNH9
    20. XM_054365809.1XP_054221784.1  calcium-activated potassium channel subunit alpha-1 isoform X7

      UniProtKB/TrEMBL
      A0A1W2PNH9
    21. XM_054365822.1XP_054221797.1  calcium-activated potassium channel subunit alpha-1 isoform X20

      UniProtKB/TrEMBL
      A0A1W2PNH9
    22. XM_054365812.1XP_054221787.1  calcium-activated potassium channel subunit alpha-1 isoform X10

      UniProtKB/TrEMBL
      A0A1W2PQ93
    23. XM_054365807.1XP_054221782.1  calcium-activated potassium channel subunit alpha-1 isoform X5

      UniProtKB/TrEMBL
      A0A1W2PQ93
    24. XM_054365806.1XP_054221781.1  calcium-activated potassium channel subunit alpha-1 isoform X4

      UniProtKB/TrEMBL
      A0A1W2PNH9
    25. XM_054365804.1XP_054221779.1  calcium-activated potassium channel subunit alpha-1 isoform X2

      UniProtKB/TrEMBL
      H0Y382
    26. XM_054365803.1XP_054221778.1  calcium-activated potassium channel subunit alpha-1 isoform X1

      UniProtKB/TrEMBL
      A0A1W2PRG5
    27. XM_054365844.1XP_054221819.1  calcium-activated potassium channel subunit alpha-1 isoform X42

      UniProtKB/TrEMBL
      A0A0A0MRC3
    28. XM_054365829.1XP_054221804.1  calcium-activated potassium channel subunit alpha-1 isoform X27

      UniProtKB/TrEMBL
      A0A1W2PQU4
    29. XM_054365821.1XP_054221796.1  calcium-activated potassium channel subunit alpha-1 isoform X19

      UniProtKB/TrEMBL
      A0A1W2PQU4
    30. XM_054365811.1XP_054221786.1  calcium-activated potassium channel subunit alpha-1 isoform X9

      UniProtKB/TrEMBL
      A0A1W2PQU4
    31. XM_054365825.1XP_054221800.1  calcium-activated potassium channel subunit alpha-1 isoform X23

      UniProtKB/TrEMBL
      A0A1W2PQU4
    32. XM_054365810.1XP_054221785.1  calcium-activated potassium channel subunit alpha-1 isoform X8

      UniProtKB/TrEMBL
      A0A1W2PQU4
    33. XM_054365823.1XP_054221798.1  calcium-activated potassium channel subunit alpha-1 isoform X21

      UniProtKB/TrEMBL
      A0A1W2PQU4
    34. XM_054365816.1XP_054221791.1  calcium-activated potassium channel subunit alpha-1 isoform X14

      UniProtKB/TrEMBL
      A0A1W2PQU4
    35. XM_054365805.1XP_054221780.1  calcium-activated potassium channel subunit alpha-1 isoform X3

      UniProtKB/TrEMBL
      A0A1W2PQU4
    36. XM_054365813.1XP_054221788.1  calcium-activated potassium channel subunit alpha-1 isoform X11

      UniProtKB/TrEMBL
      A0A1W2PQU4
    37. XM_054365808.1XP_054221783.1  calcium-activated potassium channel subunit alpha-1 isoform X6

      UniProtKB/TrEMBL
      A0A1W2PQU4
    38. XM_054365832.1XP_054221807.1  calcium-activated potassium channel subunit alpha-1 isoform X29

      UniProtKB/TrEMBL
      J3KQ16
    39. XM_054365831.1XP_054221806.1  calcium-activated potassium channel subunit alpha-1 isoform X30

      UniProtKB/TrEMBL
      J3KQ16
    40. XM_054365833.1XP_054221808.1  calcium-activated potassium channel subunit alpha-1 isoform X31

    41. XM_054365835.1XP_054221810.1  calcium-activated potassium channel subunit alpha-1 isoform X33

      UniProtKB/TrEMBL
      A0A1W2PQ39
    42. XM_054365834.1XP_054221809.1  calcium-activated potassium channel subunit alpha-1 isoform X32

    RNA

    1. XR_008488214.1 RNA Sequence