KIF23 kinesin family member 23 [Homo sapiens (human)] - Gene

Summary

Official Symbol: KIF23provided by HGNC
Official Full Name: kinesin family member 23provided by HGNC
Primary source: HGNC:HGNC:6392
See related: Ensembl:ENSG00000137807 MIM:605064; AllianceGenome:HGNC:6392
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: CDA3; CHO1; CDAN3; KNSL5; MKLP1; CDAIII; CDAN3A; MKLP-1
Summary: The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]
Expression: Broad expression in bone marrow (RPKM 9.3), testis (RPKM 8.0) and 17 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 15q23

Exon count:: 25

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	15	NC_000015.10 (69414349..69448427)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	15	NC_060939.1 (67236426..67270507)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	15	NC_000015.9 (69706688..69740766)

Chromosome 15 - NC_000015.10 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Identification and validation of KIF23 as a hypoxia-regulated lactate metabolism-related oncogene in uterine corpus endometrial carcinoma.
Title: Identification and validation of KIF23 as a hypoxia-regulated lactate metabolism-related oncogene in uterine corpus endometrial carcinoma.
SIRT7 promotes the proliferation and migration of anaplastic thyroid cancer cells by regulating the desuccinylation of KIF23.
Title: SIRT7 promotes the proliferation and migration of anaplastic thyroid cancer cells by regulating the desuccinylation of KIF23.
A Therapeutically Targetable TAZ-TEAD2 Pathway Drives the Growth of Hepatocellular Carcinoma via ANLN and KIF23.
Title: A Therapeutically Targetable TAZ-TEAD2 Pathway Drives the Growth of Hepatocellular Carcinoma via ANLN and KIF23.
KCNQ1OT1 promotes retinoblastoma progression by targeting miR-339-3p that suppresses KIF23.
Title: KCNQ1OT1 promotes retinoblastoma progression by targeting miR-339-3p that suppresses KIF23.
Kinesin family member 23 knockdown inhibits cell proliferation and epithelial-mesenchymal transition in esophageal carcinoma by inactivating the Wnt/beta-catenin pathway.
Title: Kinesin family member 23 knockdown inhibits cell proliferation and epithelial-mesenchymal transition in esophageal carcinoma by inactivating the Wnt/β-catenin pathway.
KIF23, under regulation by androgen receptor, contributes to nasopharyngeal carcinoma deterioration by activating the Wnt/beta-catenin signaling pathway.
Title: KIF23, under regulation by androgen receptor, contributes to nasopharyngeal carcinoma deterioration by activating the Wnt/β-catenin signaling pathway.
[MicroRNA 424-5p promotes the sensitivity of hepatocellular carcinoma cells to sorafenib by targeting Kinesin family member 23].
Title: [MicroRNA 424-5p promotes the sensitivity of hepatocellular carcinoma cells to sorafenib by targeting Kinesin family member 23].
Kinesin family member 23, regulated by FOXM1, promotes triple negative breast cancer progression via activating Wnt/beta-catenin pathway.
Title: Kinesin family member 23, regulated by FOXM1, promotes triple negative breast cancer progression via activating Wnt/β-catenin pathway.
Inhibition of KIF23 Alleviates IPAH by Targeting Pyroptosis and Proliferation of PASMCs.
Title: Inhibition of KIF23 Alleviates IPAH by Targeting Pyroptosis and Proliferation of PASMCs.
DEP domain containing 1B (DEPDC1B) exerts the tumor promoter in hepatocellular carcinoma through activating p53 signaling pathway via kinesin family member 23 (KIF23).
Title: DEP domain containing 1B (DEPDC1B) exerts the tumor promoter in hepatocellular carcinoma through activating p53 signaling pathway via kinesin family member 23 (KIF23).

Submit: New GeneRIF Correction See all GeneRIFs (40)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Congenital dyserythropoietic anemia, type III MedGen: C5676874 OMIM: 105600 GeneReviews: Not available	Compare labs

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

RH70137 (e-PCR)
- UniSTS:38196

RH68564 (e-PCR)
- UniSTS:57430

STS-X67155 (e-PCR)
- UniSTS:78428

D15S1166 (e-PCR)
- UniSTS:75218

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables ATP hydrolysis activity	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IBA Inferred from Biological aspect of Ancestor more info
enables microtubule binding	IDA Inferred from Direct Assay more info	PubMed
enables microtubule motor activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in microtubule-based movement	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in mitotic spindle elongation	TAS Traceable Author Statement more info	PubMed
involved_in mitotic spindle midzone assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in mitotic spindle midzone assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of cytokinesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in Flemming body	IDA Inferred from Direct Assay more info
part_of centralspindlin complex	IDA Inferred from Direct Assay more info	PubMed
located_in centrosome	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in focal adhesion	HDA more info	PubMed
part_of kinesin complex	IBA Inferred from Biological aspect of Ancestor more info
is_active_in microtubule	IBA Inferred from Biological aspect of Ancestor more info
located_in midbody	IDA Inferred from Direct Assay more info	PubMed
located_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	IDA Inferred from Direct Assay more info
located_in nucleoplasm	TAS Traceable Author Statement more info
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: kinesin-like protein KIF23

Names: congenital dyserythropoietic anemia, type III; kinesin-like 5 (mitotic kinesin-like protein 1)

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_042269.1 RefSeqGene

Range

5104..39182

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_1173

mRNA and Protein(s)

NM_001281301.2 → NP_001268230.1 kinesin-like protein KIF23 isoform 3

Status: REVIEWED

Description

Transcript Variant: This variant (3) differs in the 5' UTR, initiates translation at an alternate start codon, and has multiple differences in the coding region compared to variant 1. The resulting protein (isoform 3) has a distinct N-terminus and is shorter than isoform 1.

Source sequence(s)

AA291944, AC027237, AK308322, BG939827

Conserved Domains (3) summary

cl22853
Location:106 → 324

Motor_domain; Myosin and Kinesin motor domain

pfam16540
Location:683 → 709

MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

cl23720
Location:447 → 505

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_001367804.2 → NP_001354733.1 kinesin-like protein KIF23 isoform 4

Status: REVIEWED

Source sequence(s)

AC027237

UniProtKB/TrEMBL

H7BYN4
NM_001367805.3 → NP_001354734.1 kinesin-like protein KIF23 isoform 5

Status: REVIEWED

Source sequence(s)

AC027237

Consensus CDS

CCDS92033.1

UniProtKB/TrEMBL

A0A7I2V5Y5, H7BYN4

Related

ENSP00000504770.1, ENST00000679126.1
NM_004856.7 → NP_004847.2 kinesin-like protein KIF23 isoform 2

See identical proteins and their annotated locations for NP_004847.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.

Source sequence(s)

AA291944, AC027237, BC051826, BI093060

Consensus CDS

CCDS32279.1

UniProtKB/TrEMBL

A0A2U3TZL8

Related

ENSP00000304978.6, ENST00000352331.8

Conserved Domains (4) summary

cd01368
Location:24 → 434

KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup

pfam00225
Location:31 → 436

Kinesin; Kinesin motor domain

pfam16540
Location:700 → 799

MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

cl23720
Location:557 → 615

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
NM_138555.4 → NP_612565.1 kinesin-like protein KIF23 isoform 1

See identical proteins and their annotated locations for NP_612565.1

Status: REVIEWED

Source sequence(s)

AA291944, AK310402, BC017705, BF541143, BX477359, H63163

Consensus CDS

CCDS32278.1

UniProtKB/Swiss-Prot

B4E1K0, Q02241, Q8WVP0

UniProtKB/TrEMBL

H7BYN4

Related

ENSP00000497065.1, ENST00000647715.1

Conserved Domains (4) summary

cd01368
Location:24 → 434

KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup

pfam00225
Location:31 → 436

Kinesin; Kinesin motor domain

pfam12329
Location:538 → 611

TMF_DNA_bd; TATA element modulatory factor 1 DNA binding

pfam16540
Location:804 → 903

MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

RNA

NR_160295.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC027237
NR_160296.2 RNA Sequence

Status: REVIEWED

Source sequence(s)

AC027237

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

NC_000015.10 Reference GRCh38.p14 Primary Assembly

Range

69414349..69448427

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_005254797.4 → XP_005254854.1 kinesin-like protein KIF23 isoform X1

UniProtKB/TrEMBL

H7BYN4

Conserved Domains (4) summary

smart00129
Location:25 → 456

KISc; Kinesin motor, catalytic domain. ATPase

cd01368
Location:24 → 448

KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup

pfam12329
Location:552 → 625

TMF_DNA_bd; TATA element modulatory factor 1 DNA binding

pfam16540
Location:818 → 917

MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
XM_005254798.4 → XP_005254855.1 kinesin-like protein KIF23 isoform X2

UniProtKB/TrEMBL

H7BYN4

Conserved Domains (4) summary

cd01368
Location:24 → 448

KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup

pfam00225
Location:31 → 450

Kinesin; Kinesin motor domain

pfam12329
Location:552 → 625

TMF_DNA_bd; TATA element modulatory factor 1 DNA binding

pfam16540
Location:807 → 833

MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
XM_005254799.4 → XP_005254856.1 kinesin-like protein KIF23 isoform X4

UniProtKB/TrEMBL

A0A2U3TZL8

Related

ENSP00000453386.2, ENST00000559279.6

Conserved Domains (4) summary

cd01368
Location:24 → 448

KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup

pfam00225
Location:31 → 450

Kinesin; Kinesin motor domain

pfam16540
Location:714 → 813

MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

cl23720
Location:571 → 629

RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
XM_017022733.3 → XP_016878222.1 kinesin-like protein KIF23 isoform X9

UniProtKB/TrEMBL

A0A2U3TZL8
XM_047433367.1 → XP_047289323.1 kinesin-like protein KIF23 isoform X3
XM_047433373.1 → XP_047289329.1 kinesin-like protein KIF23 isoform X11
XM_047433369.1 → XP_047289325.1 kinesin-like protein KIF23 isoform X6
XM_047433368.1 → XP_047289324.1 kinesin-like protein KIF23 isoform X5
XM_047433371.1 → XP_047289327.1 kinesin-like protein KIF23 isoform X8
XM_047433370.1 → XP_047289326.1 kinesin-like protein KIF23 isoform X7
XM_047433372.1 → XP_047289328.1 kinesin-like protein KIF23 isoform X10