U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from MedGen

    • Showing Current items.

    KIF23 kinesin family member 23 [ Homo sapiens (human) ]

    Gene ID: 9493, updated on 3-May-2024

    Summary

    Official Symbol
    KIF23provided by HGNC
    Official Full Name
    kinesin family member 23provided by HGNC
    Primary source
    HGNC:HGNC:6392
    See related
    Ensembl:ENSG00000137807 MIM:605064; AllianceGenome:HGNC:6392
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CDA3; CHO1; CDAN3; KNSL5; MKLP1; CDAIII; CDAN3A; MKLP-1
    Summary
    The protein encoded by this gene is a member of kinesin-like protein family. This family includes microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. This protein has been shown to cross-bridge antiparallel microtubules and drive microtubule movement in vitro. Alternate splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2013]
    Expression
    Broad expression in bone marrow (RPKM 9.3), testis (RPKM 8.0) and 17 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See KIF23 in Genome Data Viewer
    Location:
    15q23
    Exon count:
    25
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 15 NC_000015.10 (69414349..69448427)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 15 NC_060939.1 (67236426..67270507)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 15 NC_000015.9 (69706688..69740766)

    Chromosome 15 - NC_000015.10Genomic Context describing neighboring genes Neighboring gene PAQR5 divergent transcript Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr15:69597275-69598474 Neighboring gene progestin and adipoQ receptor family member 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:69610145-69610644 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:69615648-69615826 Neighboring gene small nucleolar RNA SNORA77 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:69634596-69635096 Neighboring gene H3K27ac hESC enhancer GRCh37_chr15:69635097-69635597 Neighboring gene ReSE screen-validated silencer GRCh37_chr15:69673828-69674009 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr15:69680714-69681358 Neighboring gene KIF23 and PAQR5 antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6598 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6599 Neighboring gene fumarylacetoacetate hydrolase domain containing 1 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9654 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9655 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6600 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 9656 Neighboring gene small nucleolar RNA U3 Neighboring gene long intergenic non-protein coding RNA 2896 Neighboring gene ribosomal protein lateral stalk subunit P1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables ATP hydrolysis activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables microtubule binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in microtubule-based movement IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic spindle elongation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in mitotic spindle midzone assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic spindle midzone assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cytokinesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Flemming body IDA
    Inferred from Direct Assay
    more info
     
    part_of centralspindlin complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in focal adhesion HDA PubMed 
    part_of kinesin complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in midbody IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in mitotic spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in spindle IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    kinesin-like protein KIF23
    Names
    congenital dyserythropoietic anemia, type III
    kinesin-like 5 (mitotic kinesin-like protein 1)

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_042269.1 RefSeqGene

      Range
      5104..39182
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1173

    mRNA and Protein(s)

    1. NM_001281301.2NP_001268230.1  kinesin-like protein KIF23 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, initiates translation at an alternate start codon, and has multiple differences in the coding region compared to variant 1. The resulting protein (isoform 3) has a distinct N-terminus and is shorter than isoform 1.
      Source sequence(s)
      AA291944, AC027237, AK308322, BG939827
      Conserved Domains (3) summary
      cl22853
      Location:106324
      Motor_domain; Myosin and Kinesin motor domain
      pfam16540
      Location:683709
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
      cl23720
      Location:447505
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    2. NM_001367804.2NP_001354733.1  kinesin-like protein KIF23 isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC027237
      UniProtKB/TrEMBL
      H7BYN4
    3. NM_001367805.3NP_001354734.1  kinesin-like protein KIF23 isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC027237
      Consensus CDS
      CCDS92033.1
      UniProtKB/TrEMBL
      A0A7I2V5Y5, H7BYN4
      Related
      ENSP00000504770.1, ENST00000679126.1
    4. NM_004856.7NP_004847.2  kinesin-like protein KIF23 isoform 2

      See identical proteins and their annotated locations for NP_004847.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 2 which is shorter compared to isoform 1.
      Source sequence(s)
      AA291944, AC027237, BC051826, BI093060
      Consensus CDS
      CCDS32279.1
      UniProtKB/TrEMBL
      A0A2U3TZL8
      Related
      ENSP00000304978.6, ENST00000352331.8
      Conserved Domains (4) summary
      cd01368
      Location:24434
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam00225
      Location:31436
      Kinesin; Kinesin motor domain
      pfam16540
      Location:700799
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
      cl23720
      Location:557615
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    5. NM_138555.4NP_612565.1  kinesin-like protein KIF23 isoform 1

      See identical proteins and their annotated locations for NP_612565.1

      Status: REVIEWED

      Source sequence(s)
      AA291944, AK310402, BC017705, BF541143, BX477359, H63163
      Consensus CDS
      CCDS32278.1
      UniProtKB/Swiss-Prot
      B4E1K0, Q02241, Q8WVP0
      UniProtKB/TrEMBL
      H7BYN4
      Related
      ENSP00000497065.1, ENST00000647715.1
      Conserved Domains (4) summary
      cd01368
      Location:24434
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam00225
      Location:31436
      Kinesin; Kinesin motor domain
      pfam12329
      Location:538611
      TMF_DNA_bd; TATA element modulatory factor 1 DNA binding
      pfam16540
      Location:804903
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1

    RNA

    1. NR_160295.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC027237
    2. NR_160296.2 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC027237

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000015.10 Reference GRCh38.p14 Primary Assembly

      Range
      69414349..69448427
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005254797.4XP_005254854.1  kinesin-like protein KIF23 isoform X1

      UniProtKB/TrEMBL
      H7BYN4
      Conserved Domains (4) summary
      smart00129
      Location:25456
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01368
      Location:24448
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam12329
      Location:552625
      TMF_DNA_bd; TATA element modulatory factor 1 DNA binding
      pfam16540
      Location:818917
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
    2. XM_005254798.4XP_005254855.1  kinesin-like protein KIF23 isoform X2

      UniProtKB/TrEMBL
      H7BYN4
      Conserved Domains (4) summary
      cd01368
      Location:24448
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam00225
      Location:31450
      Kinesin; Kinesin motor domain
      pfam12329
      Location:552625
      TMF_DNA_bd; TATA element modulatory factor 1 DNA binding
      pfam16540
      Location:807833
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
    3. XM_005254799.4XP_005254856.1  kinesin-like protein KIF23 isoform X4

      UniProtKB/TrEMBL
      A0A2U3TZL8
      Related
      ENSP00000453386.2, ENST00000559279.6
      Conserved Domains (4) summary
      cd01368
      Location:24448
      KISc_KIF23_like; Kinesin motor domain, KIF23-like subgroup
      pfam00225
      Location:31450
      Kinesin; Kinesin motor domain
      pfam16540
      Location:714813
      MKLP1_Arf_bdg; Arf6-interacting domain of mitotic kinesin-like protein 1
      cl23720
      Location:571629
      RILP-like; Rab interacting lysosomal protein-like 1 and 2 (Rilpl1 and Rilpl2)
    4. XM_017022733.3XP_016878222.1  kinesin-like protein KIF23 isoform X9

      UniProtKB/TrEMBL
      A0A2U3TZL8
    5. XM_047433367.1XP_047289323.1  kinesin-like protein KIF23 isoform X3

    6. XM_047433373.1XP_047289329.1  kinesin-like protein KIF23 isoform X11

    7. XM_047433369.1XP_047289325.1  kinesin-like protein KIF23 isoform X6

    8. XM_047433368.1XP_047289324.1  kinesin-like protein KIF23 isoform X5

    9. XM_047433371.1XP_047289327.1  kinesin-like protein KIF23 isoform X8

    10. XM_047433370.1XP_047289326.1  kinesin-like protein KIF23 isoform X7

    11. XM_047433372.1XP_047289328.1  kinesin-like protein KIF23 isoform X10

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060939.1 Alternate T2T-CHM13v2.0

      Range
      67236426..67270507
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054379246.1XP_054235221.1  kinesin-like protein KIF23 isoform X1

    2. XM_054379247.1XP_054235222.1  kinesin-like protein KIF23 isoform X2

    3. XM_054379249.1XP_054235224.1  kinesin-like protein KIF23 isoform X4

    4. XM_054379254.1XP_054235229.1  kinesin-like protein KIF23 isoform X9

    5. XM_054379248.1XP_054235223.1  kinesin-like protein KIF23 isoform X3

    6. XM_054379256.1XP_054235231.1  kinesin-like protein KIF23 isoform X11

    7. XM_054379251.1XP_054235226.1  kinesin-like protein KIF23 isoform X6

    8. XM_054379250.1XP_054235225.1  kinesin-like protein KIF23 isoform X5

    9. XM_054379253.1XP_054235228.1  kinesin-like protein KIF23 isoform X8

    10. XM_054379252.1XP_054235227.1  kinesin-like protein KIF23 isoform X7

    11. XM_054379255.1XP_054235230.1  kinesin-like protein KIF23 isoform X10