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    NUDT2 nudix hydrolase 2 [ Homo sapiens (human) ]

    Gene ID: 318, updated on 17-Jun-2024

    Summary

    Official Symbol
    NUDT2provided by HGNC
    Official Full Name
    nudix hydrolase 2provided by HGNC
    Primary source
    HGNC:HGNC:8049
    See related
    Ensembl:ENSG00000164978 MIM:602852; AllianceGenome:HGNC:8049
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    APAH1; IDDPN
    Summary
    This gene encodes a member of the MutT family of nucleotide pyrophosphatases, a subset of the larger NUDIX hydrolase family. The gene product possesses a modification of the MutT sequence motif found in certain nucleotide pyrophosphatases. The enzyme asymmetrically hydrolyzes Ap4A to yield AMP and ATP and is responsible for maintaining the intracellular level of the dinucleotide Ap4A, the function of which has yet to be established. This gene may be a candidate tumor suppressor gene. Alternative splicing has been observed at this locus and four transcript variants, all encoding the same protein, have been identified. [provided by RefSeq, Sep 2011]
    Expression
    Ubiquitous expression in ovary (RPKM 11.6), prostate (RPKM 10.9) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See NUDT2 in Genome Data Viewer
    Location:
    9p13.3
    Exon count:
    5
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (34329569..34343699)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (34348133..34362241)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (34329567..34343697)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene kinesin family member 24 Neighboring gene RNA, U2 small nuclear 50, pseudogene Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:34318623-34319288 Neighboring gene serpin family H member 1 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28307 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28308 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:34329280-34329787 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34371826-34372326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34372327-34372827 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34375663-34376244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34376245-34376825 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19844 Neighboring gene uncharacterized LOC124902144 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:34380811-34381416 Neighboring gene myogenesis regulating glycosidase (putative) Neighboring gene sperm microtubule inner protein 6

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]
    Names
    Ap4A hydrolase 1
    Ap4Aase
    bis(5'-nucleosyl)-tetraphosphatase (asymmetrical)
    diadenosine 5',5'''-P1,P4-tetraphosphate asymmetrical hydrolase
    diadenosine 5',5''-P1,P4-tetraphosphate pyrophosphohydrolase
    diadenosine tetraphosphatase
    nucleoside diphosphate-linked moiety X motif 2
    nudix (nucleoside diphosphate linked moiety X)-type motif 2
    nudix motif 2
    NP_001152.1
    NP_001231319.1
    NP_671701.1
    NP_671702.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001161.5NP_001152.1  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

      See identical proteins and their annotated locations for NP_001152.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) is the full-length transcript. All four variants encode the same protein.
      Source sequence(s)
      AA398857, AL356494, BG825757, BQ007098
      Consensus CDS
      CCDS6552.1
      UniProtKB/Swiss-Prot
      D3DRM0, P50583, Q5T589
      Related
      ENSP00000368455.1, ENST00000379158.7
      Conserved Domains (1) summary
      cd03428
      Location:2140
      Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...
    2. NM_001244390.2NP_001231319.1  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

      See identical proteins and their annotated locations for NP_001231319.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate 5' UTR exons compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AA310093, BQ007098
      Consensus CDS
      CCDS6552.1
      UniProtKB/Swiss-Prot
      D3DRM0, P50583, Q5T589
      Related
      ENSP00000482384.1, ENST00000618590.1
      Conserved Domains (1) summary
      cd03428
      Location:2140
      Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...
    3. NM_147172.3NP_671701.1  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

      See identical proteins and their annotated locations for NP_671701.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site on a 5' non-coding exon, compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      BG622439, BQ007098
      Consensus CDS
      CCDS6552.1
      UniProtKB/Swiss-Prot
      D3DRM0, P50583, Q5T589
      Related
      ENSP00000368452.5, ENST00000379155.9
      Conserved Domains (1) summary
      cd03428
      Location:2140
      Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...
    4. NM_147173.3NP_671702.1  bis(5'-nucleosyl)-tetraphosphatase [asymmetrical]

      See identical proteins and their annotated locations for NP_671702.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks a 5' non-coding exon, compared to variant 1. All four variants encode the same protein.
      Source sequence(s)
      AA398857, BQ007098, DN992111
      Consensus CDS
      CCDS6552.1
      UniProtKB/Swiss-Prot
      D3DRM0, P50583, Q5T589
      Related
      ENSP00000344187.4, ENST00000346365.8
      Conserved Domains (1) summary
      cd03428
      Location:2140
      Ap4A_hydrolase_human_like; Diadenosine tetraphosphate (Ap4A) hydrolase is a member of the Nudix hydrolase superfamily. Ap4A hydrolases are well represented in a variety of prokaryotic and eukaryotic organisms. Phylogenetic analysis reveals two distinct subgroups where plant ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      34329569..34343699
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      34348133..34362241
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)