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    SPRED2 sprouty related EVH1 domain containing 2 [ Homo sapiens (human) ]

    Gene ID: 200734, updated on 4-Feb-2024

    Summary

    Official Symbol
    SPRED2provided by HGNC
    Official Full Name
    sprouty related EVH1 domain containing 2provided by HGNC
    Primary source
    HGNC:HGNC:17722
    See related
    Ensembl:ENSG00000198369 MIM:609292; AllianceGenome:HGNC:17722
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NS14; Spred-2
    Summary
    SPRED2 is a member of the Sprouty (see SPRY1; MIM 602465)/SPRED family of proteins that regulate growth factor-induced activation of the MAP kinase cascade (see MAPK1; MIM 176948) (Nonami et al., 2004 [PubMed 15465815]).[supplied by OMIM, Mar 2008]
    Expression
    Ubiquitous expression in brain (RPKM 9.3), fat (RPKM 9.2) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See SPRED2 in Genome Data Viewer
    Location:
    2p14
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 2 NC_000002.12 (65307175..65432599, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 2 NC_060926.1 (65316846..65442268, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 2 NC_000002.11 (65537985..65659733, complement)

    Chromosome 2 - NC_000002.12Genomic Context describing neighboring genes Neighboring gene H3K27ac hESC enhancer GRCh37_chr2:65454846-65455734 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15927 Neighboring gene actin related protein 2 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_58697 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr2:65502227-65502894 Neighboring gene uncharacterized LOC124907781 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:65522924-65523106 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15928 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15929 Neighboring gene NANOG hESC enhancer GRCh37_chr2:65584660-65585161 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15930 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr2:65604858-65605439 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15931 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15932 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr2:65614878-65615414 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15933 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15934 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 15936 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:65647515-65648016 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr2:65648017-65648516 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11579 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11580 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11581 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11582 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 11583 Neighboring gene ReSE screen-validated silencer GRCh37_chr2:65663730-65663888 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr2:65664483-65665289 Neighboring gene uncharacterized LOC105374780 Neighboring gene uncharacterized LOC124907784

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Noonan syndrome 14
    MedGen: C5676916 OMIM: 619745 GeneReviews: Not available
    not available

    EBI GWAS Catalog

    Description
    Genetics of rheumatoid arthritis contributes to biology and drug discovery.
    EBI GWAS Catalog
    Genome-wide association study meta-analysis identifies seven new rheumatoid arthritis risk loci.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies in celiac disease and rheumatoid arthritis identifies fourteen non-HLA shared loci.
    EBI GWAS Catalog
    Novel risk loci for rheumatoid arthritis in Han Chinese and congruence with risk variants in Europeans.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ21897, FLJ31917, MGC163164

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine/threonine kinase inhibitor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    enables stem cell factor receptor binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Component Evidence Code Pubs
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in transport vesicle membrane IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    sprouty-related, EVH1 domain-containing protein 2
    Names
    sprouty protein with EVH-1 domain 2, related sequence

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001128210.2NP_001121682.1  sprouty-related, EVH1 domain-containing protein 2 isoform b

      See identical proteins and their annotated locations for NP_001121682.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and coding sequence compared to variant 1. The resulting isoform (b) has a shorter and distinct N-terminus compared to isoform a.
      Source sequence(s)
      AK056479, AY299090, BC130292, DC335282
      Consensus CDS
      CCDS46308.1
      UniProtKB/TrEMBL
      B3KPL5
      Related
      ENSP00000393697.2, ENST00000443619.6
      Conserved Domains (3) summary
      cd10574
      Location:9121
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
      pfam05210
      Location:303408
      Sprouty; Sprouty protein (Spry)
      pfam08633
      Location:226298
      Rox3; Rox3 mediator complex subunit
    2. NM_181784.3NP_861449.2  sprouty-related, EVH1 domain-containing protein 2 isoform a

      See identical proteins and their annotated locations for NP_861449.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (a).
      Source sequence(s)
      AC012370, AK056479, AY299090, BC130292, DA102390
      Consensus CDS
      CCDS33211.1
      UniProtKB/Swiss-Prot
      A1L3V4, B7Z5K7, D6W5F7, E9PEP0, Q2NKX6, Q7Z698
      UniProtKB/TrEMBL
      B3KPL5
      Related
      ENSP00000348753.4, ENST00000356388.9
      Conserved Domains (3) summary
      cd10574
      Location:12124
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
      pfam05210
      Location:306411
      Sprouty; Sprouty protein (Spry)
      pfam08633
      Location:229301
      Rox3; Rox3 mediator complex subunit

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000002.12 Reference GRCh38.p14 Primary Assembly

      Range
      65307175..65432599 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005264202.6XP_005264259.1  sprouty-related, EVH1 domain-containing protein 2 isoform X6

      Conserved Domains (1) summary
      cd10574
      Location:12124
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
    2. XM_005264200.6XP_005264257.2  sprouty-related, EVH1 domain-containing protein 2 isoform X3

      Conserved Domains (1) summary
      cd10574
      Location:12124
      EVH1_SPRED-like; Sprouty-related EVH1 domain-containing-like proteins EVH1 domain
    3. XM_047443712.1XP_047299668.1  sprouty-related, EVH1 domain-containing protein 2 isoform X7

    4. XM_047443710.1XP_047299666.1  sprouty-related, EVH1 domain-containing protein 2 isoform X4

    5. XM_047443709.1XP_047299665.1  sprouty-related, EVH1 domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      B3KPL5
    6. XM_047443711.1XP_047299667.1  sprouty-related, EVH1 domain-containing protein 2 isoform X5

    7. XM_017003576.2XP_016859065.1  sprouty-related, EVH1 domain-containing protein 2 isoform X2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060926.1 Alternate T2T-CHM13v2.0

      Range
      65316846..65442268 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054341012.1XP_054196987.1  sprouty-related, EVH1 domain-containing protein 2 isoform X6

    2. XM_054341009.1XP_054196984.1  sprouty-related, EVH1 domain-containing protein 2 isoform X3

    3. XM_054341013.1XP_054196988.1  sprouty-related, EVH1 domain-containing protein 2 isoform X7

    4. XM_054341010.1XP_054196985.1  sprouty-related, EVH1 domain-containing protein 2 isoform X4

    5. XM_054341007.1XP_054196982.1  sprouty-related, EVH1 domain-containing protein 2 isoform X1

      UniProtKB/TrEMBL
      B3KPL5
    6. XM_054341011.1XP_054196986.1  sprouty-related, EVH1 domain-containing protein 2 isoform X5

    7. XM_054341008.1XP_054196983.1  sprouty-related, EVH1 domain-containing protein 2 isoform X2