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    KCNC2 potassium voltage-gated channel subfamily C member 2 [ Homo sapiens (human) ]

    Gene ID: 3747, updated on 17-Jun-2024

    Summary

    Official Symbol
    KCNC2provided by HGNC
    Official Full Name
    potassium voltage-gated channel subfamily C member 2provided by HGNC
    Primary source
    HGNC:HGNC:6234
    See related
    Ensembl:ENSG00000166006 MIM:176256; AllianceGenome:HGNC:6234
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    KV3.2; DEE103
    Summary
    The Shaker gene family of Drosophila encodes components of voltage-gated potassium channels and is comprised of four subfamilies. Based on sequence similarity, this gene is similar to one of these subfamilies, namely the Shaw subfamily. The protein encoded by this gene belongs to the delayed rectifier class of channel proteins and is an integral membrane protein that mediates the voltage-dependent potassium ion permeability of excitable membranes. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2012]
    Expression
    Restricted expression toward brain (RPKM 14.9) See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See KCNC2 in Genome Data Viewer
    Location:
    12q21.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 12 NC_000012.12 (75040078..75209839, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 12 NC_060936.1 (75014738..75184480, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 12 NC_000012.11 (75433858..75603619, complement)

    Chromosome 12 - NC_000012.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105369842 Neighboring gene uncharacterized LOC105369843 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr12:75600794-75601495 Neighboring gene uncharacterized LOC100130268 Neighboring gene CAPS2 antisense RNA 1 Neighboring gene cyclin G2 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC138196

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables delayed rectifier potassium channel activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables delayed rectifier potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables transmembrane transporter binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables voltage-gated monoatomic ion channel activity involved in regulation of presynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    enables voltage-gated potassium channel activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables voltage-gated potassium channel activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in action potential IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to ammonium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cellular response to nitric oxide ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in cellular response to toxic substance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in globus pallidus development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in membrane hyperpolarization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in nitric oxide-cGMP-mediated signaling ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in optic nerve development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of potassium ion transmembrane transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in potassium ion transmembrane transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in potassium ion transmembrane transport ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in potassium ion transport IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in protein heterooligomerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein homooligomerization ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of action potential firing rate ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of presynaptic membrane potential IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to amine IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to ethanol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to light intensity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to magnesium ion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to nerve growth factor IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to organic cyclic compound IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in GABA-ergic synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in apical plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in axolemma IEA
    Inferred from Electronic Annotation
    more info
     
    located_in axon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in axon terminus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in basolateral plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in cell body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in dendrite ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in dendrite membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in neuronal cell body membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in neuronal cell body membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in perikaryon ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    is_active_in postsynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in postsynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in presynaptic membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in presynaptic membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in synapse ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in terminal bouton IEA
    Inferred from Electronic Annotation
    more info
     
    located_in vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    part_of voltage-gated potassium channel complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of voltage-gated potassium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    potassium voltage-gated channel subfamily C member 2
    Names
    potassium channel, voltage gated Shaw related subfamily C, member 2
    potassium voltage-gated channel, Shaw-related subfamily, member 2
    shaw-like potassium channel
    voltage-gated potassium channel Kv3.2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001260497.2NP_001247426.1  potassium voltage-gated channel subfamily C member 2 isoform 4

      See identical proteins and their annotated locations for NP_001247426.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform KV3.2b.
      Source sequence(s)
      AC073525, AC091534, AF268897, AK309245, DA218546, DC323864
      Consensus CDS
      CCDS58257.1
      UniProtKB/Swiss-Prot
      Q96PR1
      Related
      ENSP00000376966.2, ENST00000393288.2
      Conserved Domains (2) summary
      cd18415
      Location:7166
      BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
      pfam00520
      Location:228484
      Ion_trans; Ion transport protein
    2. NM_001260498.2NP_001247427.1  potassium voltage-gated channel subfamily C member 2 isoform KV3.2d

      See identical proteins and their annotated locations for NP_001247427.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (KV3.2d) has a shorter and distinct C-terminus compared to isoform KV3.2b.
      Source sequence(s)
      AC073525, AC091534, AY243473, DA218546, DC323864
      Consensus CDS
      CCDS58256.1
      Conserved Domains (2) summary
      cd18415
      Location:7166
      BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
      pfam00520
      Location:228484
      Ion_trans; Ion transport protein
    3. NM_001260499.2NP_001247428.1  potassium voltage-gated channel subfamily C member 2 isoform 6

      See identical proteins and their annotated locations for NP_001247428.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an alternate in-frame exon compared to variant 2. The resulting isoform (6) has the same N- and C-termini but is shorter compared to isoform KV3.2b.
      Source sequence(s)
      AC073525, AC091534, AK094720, AK294269, DA218546, DC323864
      Consensus CDS
      CCDS58255.1
      UniProtKB/Swiss-Prot
      Q96PR1
      Related
      ENSP00000438423.1, ENST00000540018.5
      Conserved Domains (2) summary
      cd18415
      Location:7166
      BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
      pfam00520
      Location:228484
      Ion_trans; Ion transport protein
    4. NM_001414192.1NP_001401121.1  potassium voltage-gated channel subfamily C member 2 isoform KV3.2b

      Status: REVIEWED

      Source sequence(s)
      AC073525, AC091534
      UniProtKB/Swiss-Prot
      B7Z231, F5H030, J3KPP5, Q4LE77, Q86W09, Q8N1V9, Q96PR0, Q96PR1
    5. NM_001414193.1NP_001401122.1  potassium voltage-gated channel subfamily C member 2 isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC073525, AC091534
    6. NM_001414194.1NP_001401123.1  potassium voltage-gated channel subfamily C member 2 isoform 8

      Status: REVIEWED

      Source sequence(s)
      AC073525, AC091534
    7. NM_001414195.1NP_001401124.1  potassium voltage-gated channel subfamily C member 2 isoform KV3.2a

      Status: REVIEWED

      Source sequence(s)
      AC073525, AC091534
    8. NM_001414196.1NP_001401125.1  potassium voltage-gated channel subfamily C member 2 isoform KV3.2a

      Status: REVIEWED

      Source sequence(s)
      AC073525, AC091534
      Related
      ENSP00000449941.1, ENST00000548513.5
    9. NM_001414197.1NP_001401126.1  potassium voltage-gated channel subfamily C member 2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC073525, AC091534
    10. NM_001414198.1NP_001401127.1  potassium voltage-gated channel subfamily C member 2 isoform 10

      Status: REVIEWED

      Source sequence(s)
      AC073525, AC091534
    11. NM_001414199.1NP_001401128.1  potassium voltage-gated channel subfamily C member 2 isoform 11

      Status: REVIEWED

      Source sequence(s)
      AC073525, AC091534
    12. NM_001414202.1NP_001401131.1  potassium voltage-gated channel subfamily C member 2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC073525, AC091534
      UniProtKB/TrEMBL
      A0A3B3ISR9
      Related
      ENSP00000497415.1, ENST00000647764.1
    13. NM_001414206.1NP_001401135.1  potassium voltage-gated channel subfamily C member 2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC073525, AC091534
      UniProtKB/TrEMBL
      A0A3B3ISR9
    14. NM_001414213.1NP_001401142.1  potassium voltage-gated channel subfamily C member 2 isoform 9

      Status: REVIEWED

      Source sequence(s)
      AC073525, AC091534
      UniProtKB/TrEMBL
      A0A3B3ISR9
    15. NM_139136.4NP_631874.1  potassium voltage-gated channel subfamily C member 2 isoform KV3.2a

      See identical proteins and their annotated locations for NP_631874.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (KV3.2a) has a shorter and distinct C-terminus compared to isoform KV3.2b. Variants 1, 10, and 11 all encode the same isoform (KV3.2a).
      Source sequence(s)
      AC091534, AF268897, AK094720, DA218546, DC323864
      Consensus CDS
      CCDS9005.1
      Related
      ENSP00000298972.1, ENST00000298972.5
      Conserved Domains (2) summary
      cd18415
      Location:7166
      BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
      pfam00520
      Location:228484
      Ion_trans; Ion transport protein
    16. NM_139137.4NP_631875.1  potassium voltage-gated channel subfamily C member 2 isoform KV3.2b

      See identical proteins and their annotated locations for NP_631875.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (KV3.2b). Variants 2 and 7 both encode the same isoform (KV3.2b).
      Source sequence(s)
      AC073525, AC091534, AY118169, DA218546, DC323864
      Consensus CDS
      CCDS9007.1
      UniProtKB/Swiss-Prot
      B7Z231, F5H030, J3KPP5, Q4LE77, Q86W09, Q8N1V9, Q96PR0, Q96PR1
      Related
      ENSP00000449253.2, ENST00000549446.6
      Conserved Domains (2) summary
      cd18415
      Location:7166
      BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
      pfam00520
      Location:228484
      Ion_trans; Ion transport protein
    17. NM_153748.3NP_715624.1  potassium voltage-gated channel subfamily C member 2 isoform KV3.2c

      See identical proteins and their annotated locations for NP_715624.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon and differs in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (KV3.2c) lacks an alternate internal segment and differs in the 3' UTR and coding sequence compared to isoform KV3.2b.
      Source sequence(s)
      AC091534, AK094720, DA218546, DC323864
      Consensus CDS
      CCDS9006.1
      UniProtKB/Swiss-Prot
      Q96PR1
      Related
      ENSP00000319877.2, ENST00000350228.6
      Conserved Domains (2) summary
      cd18415
      Location:7166
      BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
      pfam00520
      Location:228484
      Ion_trans; Ion transport protein

    RNA

    1. NR_182257.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC073525, AC091534
    2. NR_182259.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AC073525, AC091534

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000012.12 Reference GRCh38.p14 Primary Assembly

      Range
      75040078..75209839 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047428818.1XP_047284774.1  potassium voltage-gated channel subfamily C member 2 isoform X6

    2. XM_047428817.1XP_047284773.1  potassium voltage-gated channel subfamily C member 2 isoform X5

    3. XM_047428810.1XP_047284766.1  potassium voltage-gated channel subfamily C member 2 isoform X1

      Related
      ENSP00000448301.1, ENST00000550433.5
    4. XM_047428812.1XP_047284768.1  potassium voltage-gated channel subfamily C member 2 isoform X3

    5. XM_047428811.1XP_047284767.1  potassium voltage-gated channel subfamily C member 2 isoform X2

    6. XM_047428816.1XP_047284772.1  potassium voltage-gated channel subfamily C member 2 isoform X4

      UniProtKB/TrEMBL
      A0A3B3ISR9
    7. XM_006719383.5XP_006719446.1  potassium voltage-gated channel subfamily C member 2 isoform X4

      See identical proteins and their annotated locations for XP_006719446.1

      UniProtKB/TrEMBL
      A0A3B3ISR9
      Conserved Domains (2) summary
      cd18415
      Location:7166
      BTB_KCNC2_4; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in potassium voltage-gated channel subfamily C members KCNC2 and KCNC4
      pfam00520
      Location:228484
      Ion_trans; Ion transport protein
    8. XM_047428813.1XP_047284769.1  potassium voltage-gated channel subfamily C member 2 isoform X4

      UniProtKB/TrEMBL
      A0A3B3ISR9
    9. XM_006719390.5XP_006719453.1  potassium voltage-gated channel subfamily C member 2 isoform X7

      Conserved Domains (2) summary
      smart00225
      Location:10159
      BTB; Broad-Complex, Tramtrack and Bric a brac
      pfam02214
      Location:10151
      BTB_2; BTB/POZ domain

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060936.1 Alternate T2T-CHM13v2.0

      Range
      75014738..75184480 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054372004.1XP_054227979.1  potassium voltage-gated channel subfamily C member 2 isoform X6

    2. XM_054372001.1XP_054227976.1  potassium voltage-gated channel subfamily C member 2 isoform X3

    3. XM_054372003.1XP_054227978.1  potassium voltage-gated channel subfamily C member 2 isoform X4

      UniProtKB/TrEMBL
      A0A3B3ISR9
    4. XM_054372002.1XP_054227977.1  potassium voltage-gated channel subfamily C member 2 isoform X4

      UniProtKB/TrEMBL
      A0A3B3ISR9
    5. XM_054372005.1XP_054227980.1  potassium voltage-gated channel subfamily C member 2 isoform X7