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    USP26 ubiquitin specific peptidase 26 [ Homo sapiens (human) ]

    Gene ID: 83844, updated on 17-Jun-2024

    Summary

    Official Symbol
    USP26provided by HGNC
    Official Full Name
    ubiquitin specific peptidase 26provided by HGNC
    Primary source
    HGNC:HGNC:13485
    See related
    Ensembl:ENSG00000134588 MIM:300309; AllianceGenome:HGNC:13485
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    SPGFX6
    Summary
    This gene encodes a member of the ubiquitin-specific processing (UBP) family of proteases and is a deubiquitinating enzyme (DUB) with His and Cys domains. It is specifically expressed in testis tissue. Mutations in this gene have been associated with Sertoli cell-only syndrome and male infertility. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
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    Genomic context

    See USP26 in Genome Data Viewer
    Location:
    Xq26.2
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (133023168..133097109, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (131347885..131421825, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (132157196..132231137, complement)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene heparan sulfate 6-O-sulfotransferase 2 Neighboring gene NAA20 pseudogene 1 Neighboring gene uncharacterized LOC124905219 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:132092036-132092536 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:132143460-132143960 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:132143961-132144461 Neighboring gene NANOG hESC enhancer GRCh37_chrX:132188783-132189284 Neighboring gene DEAD-box helicase 53 pseudogene Neighboring gene small nucleolar RNA SNORA8

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of ubiquitin specific peptidase 26 (USP26) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC120066, MGC120067, MGC120068

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables K48-linked deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cysteine-type deubiquitinase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables deubiquitinase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G1/S transition of mitotic cell cycle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of proteasomal ubiquitin-dependent protein catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in protein deubiquitination IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in proteolysis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of androgen receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spermatogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoskeleton IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sperm flagellum IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 

    General protein information

    Preferred Names
    ubiquitin carboxyl-terminal hydrolase 26
    Names
    deubiquitinating enzyme 26
    ubiquitin specific protease 26
    ubiquitin thioesterase 26
    ubiquitin thiolesterase 26
    ubiquitin-specific processing protease 26
    NP_114113.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013268.1 RefSeqGene

      Range
      5001..8642
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_031907.3NP_114113.1  ubiquitin carboxyl-terminal hydrolase 26

      See identical proteins and their annotated locations for NP_114113.1

      Status: REVIEWED

      Source sequence(s)
      Z81365
      Consensus CDS
      CCDS14635.1
      UniProtKB/Swiss-Prot
      B9WRT6, Q5H9H4, Q9BXU7
      UniProtKB/TrEMBL
      Q495F8
      Related
      ENSP00000423390.1, ENST00000511190.6
      Conserved Domains (3) summary
      cd02257
      Location:296558
      Peptidase_C19; Peptidase C19 contains ubiquitinyl hydrolases. They are intracellular peptidases that remove ubiquitin molecules from polyubiquinated peptides by cleavage of isopeptide bonds. They hydrolyse bonds involving the carboxyl group of the C-terminal Gly ...
      pfam00443
      Location:296559
      UCH; Ubiquitin carboxyl-terminal hydrolase
      pfam16674
      Location:3103
      UCH_N; N-terminal of ubiquitin carboxyl-terminal hydrolase 37

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      133023168..133097109 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      131347885..131421825 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)