RB1 RB transcriptional corepressor 1 [Homo sapiens (human)] - Gene

Summary

Official Symbol: RB1provided by HGNC
Official Full Name: RB transcriptional corepressor 1provided by HGNC
Primary source: HGNC:HGNC:9884
See related: Ensembl:ENSG00000139687 MIM:614041; AllianceGenome:HGNC:9884
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: RB; pRb; OSRC; pp110; p105-Rb; PPP1R130; p110-RB1
Summary: The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in lymph node (RPKM 18.0), thyroid (RPKM 16.4) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 13q14.2

Exon count:: 29

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	13	NC_000013.11 (48303751..48481890)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	13	NC_060937.1 (47524085..47702182)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	13	NC_000013.10 (48877887..49056026)

Chromosome 13 - NC_000013.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

P53 and Rb Aberrations in Small Cell Lung Cancer (SCLC): From Molecular Mechanisms to Therapeutic Modulation.
Title: P53 and Rb Aberrations in Small Cell Lung Cancer (SCLC): From Molecular Mechanisms to Therapeutic Modulation.
Investigation of the methylation changes in the promoter region of RB1 gene in retinoblastoma: Unraveling the epigenetic puzzle in retinoblastoma.
Title: Investigation of the methylation changes in the promoter region of RB1 gene in retinoblastoma: Unraveling the epigenetic puzzle in retinoblastoma.
miR-4529-3p Promotes the Progression of Retinoblastoma by Inhibiting RB1 Expression and Activating the ERK Signaling Pathway.
Title: miR-4529-3p Promotes the Progression of Retinoblastoma by Inhibiting RB1 Expression and Activating the ERK Signaling Pathway.
Germline HPF1 retrogene insertion in RB1 gene involved in cancer predisposition.
Title: Germline HPF1 retrogene insertion in RB1 gene involved in cancer predisposition.
NEIL3 promotes cell proliferation of ccRCC via the cyclin D1-Rb-E2F1 feedback loop regulation.
Title: NEIL3 promotes cell proliferation of ccRCC via the cyclin D1-Rb-E2F1 feedback loop regulation.
Integrative analysis of multi-omics data reveals inhibition of RB1 signaling promotes apatinib resistance of hepatocellular carcinoma.
Title: Integrative analysis of multi-omics data reveals inhibition of RB1 signaling promotes apatinib resistance of hepatocellular carcinoma.
Effects of the Overexpression of Progesterone Receptors on a Precancer p53 and Rb-Defective Human Fallopian Tube Epithelial Cell Line.
Title: Effects of the Overexpression of Progesterone Receptors on a Precancer p53 and Rb-Defective Human Fallopian Tube Epithelial Cell Line.
Association of Merkel Cell Polyomavirus Status With p53, RB1, and PD-L1 Expression and Patient Prognosis in Merkel Cell Carcinomas: Clinical, Morphologic, and Immunohistochemical Evaluation of 17 Cases.
Title: Association of Merkel Cell Polyomavirus Status With p53, RB1, and PD-L1 Expression and Patient Prognosis in Merkel Cell Carcinomas: Clinical, Morphologic, and Immunohistochemical Evaluation of 17 Cases.
RB1 alteration and poor prognosis in women with high-grade neuroendocrine carcinoma of the uterine cervix: a NeCTuR study.
Title: RB1 alteration and poor prognosis in women with high-grade neuroendocrine carcinoma of the uterine cervix: a NeCTuR study.
Diagnostic Utility of TSSC3 and RB1 Immunohistochemistry in Hydatidiform Mole.
Title: Diagnostic Utility of TSSC3 and RB1 Immunohistochemistry in Hydatidiform Mole.

Submit: New GeneRIF Correction See all GeneRIFs (828)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Professional guidelines

Description
Professional guideline ACMG 2013 The ACMG recommends that laboratories performing clinical sequencing seek and report mutations in RB1 that are pathogenic or expected to be pathogenic. GuidelinePubMed

Associated conditions

Description	Tests
Bone osteosarcoma MedGen: C0585442 OMIM: 259500 GeneReviews: Not available	Compare labs
Malignant tumor of urinary bladder MedGen: C0005684 OMIM: 109800 GeneReviews: Not available	Compare labs
Retinoblastoma MedGen: C0035335 OMIM: 180200 GeneReviews: Retinoblastoma	Compare labs
Small cell lung carcinoma MedGen: C0149925 OMIM: 182280 GeneReviews: Not available	Compare labs

Copy number response

Description
Copy number response Triplosensitivity No evidence available (Last evaluated 2021-03-09) ClinGen Genome Curation Page Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated 2021-03-09) ClinGen Genome Curation PagePubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Protein interactions

Protein	Gene	Interaction	Pubs
Envelope surface glycoprotein gp120	env	The mRNA expression levels for alpha-tubulin, TRADD, IFN-gamma R2, GAS1, MADD, NF-kappaB, I-kappa B, 14-3-3 protein, APaf1, PARP, IGF-1 receptor, RB1, Rb2/p130, ARC, and caspase 6 are upregulated in human neuronal cells after treatment with HIV-1 gp120	PubMed
	env	The V3 loop of HIV-1 gp120 induces G1 arrest in IL-2-dependent cell cycle progression by reducing cyclin E expression and phosphorylation of retinoblastoma protein (pRb)	PubMed
Nef	nef	HIV-1 Nef is implicated in the upregulation of Cyclin D1, and subsequently phospho-pRb (Ser780), in infected podocytes and may be involved in the pathogenesis of HIV-associated nephropathy	PubMed
Tat	tat	Expression of HIV-1 Tat upregulates the abundance of retinoblastoma 1 (RB1) in the nucleoli of Jurkat T-cells	PubMed
	tat	Tat-expressing EBV-positive B cells show downregulation of Bcl-2, and in serum starvation conditions display the Retinoblastoma (Rb) hyper-phosphorylated form, progress throughout the cell cycle, and retain the ability to grow in small clumps	PubMed
	tat	HIV-1 Tat induces a G1 arrest in cells of glial origin, leading to a downregulation of cyclin E-Cdk2 kinase activity and phosphorylation of Rb	PubMed
	tat	Co-expression of the human retinoblastoma gene in HeLa cells with HIV-1 Tat inhibits the Tat mediated transactivation of the HIV-1 LTR promoter	PubMed
	tat	The under-phosphorylated form of Rb that is prevalent in HIV-1 Tat treated glial cells activates HIV-1 transcription by a mechanism involving the NFkappaB enhancer in the viral LTR promoter, likely through promoting the interaction of Rb with E2F-1	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

GDB:344125 (e-PCR)
- UniSTS:156672

GDB:344131 (e-PCR)
- UniSTS:156673

GDB:344140 (e-PCR)
- UniSTS:156674

GDB:344144 (e-PCR)
- UniSTS:156675

GDB:344147 (e-PCR)
- UniSTS:156676

GDB:344150 (e-PCR)
- UniSTS:156677

GDB:344155 (e-PCR)
- UniSTS:156678

GDB:344158 (e-PCR)
- UniSTS:156679

GDB:344161 (e-PCR)
- UniSTS:156680

GDB:344164 (e-PCR)
- UniSTS:156681

D2Mit39 (e-PCR), detects polymorphism
- UniSTS:129289

GDB:344168 (e-PCR)
- UniSTS:156682

GDB:344171 (e-PCR)
- UniSTS:156683

GDB:344175 (e-PCR)
- UniSTS:156684

GDB:344179 (e-PCR)
- UniSTS:156685

GDB:344182 (e-PCR)
- UniSTS:156686

GDB:632620 (e-PCR)
- UniSTS:158479

GDB:213526 (e-PCR)
- UniSTS:156179

GDB:568501 (e-PCR)
- UniSTS:157722

GDB:568504 (e-PCR)
- UniSTS:157723

GDB:568507 (e-PCR)
- UniSTS:157724

GDB:568637 (e-PCR)
- UniSTS:157729

GDB:568643 (e-PCR)
- UniSTS:157730

GDB:568650 (e-PCR)
- UniSTS:157731

GDB:568656 (e-PCR)
- UniSTS:157732

GDB:568670 (e-PCR)
- UniSTS:157733

GDB:568677 (e-PCR)
- UniSTS:157734

GDB:568683 (e-PCR)
- UniSTS:157735

G35409 (e-PCR)
- UniSTS:53800

GDB:568695 (e-PCR)
- UniSTS:157737

GDB:568702 (e-PCR)
- UniSTS:157738

GDB:568706 (e-PCR)
- UniSTS:157739

GDB:568727 (e-PCR)
- UniSTS:157742

GDB:568730 (e-PCR)
- UniSTS:157743

GDB:568733 (e-PCR)
- UniSTS:157744

GDB:568736 (e-PCR)
- UniSTS:157745

GDB:568739 (e-PCR)
- UniSTS:157746

GDB:568746 (e-PCR)
- UniSTS:157748

GDB:568749 (e-PCR)
- UniSTS:157749

D13S153 (e-PCR)
- UniSTS:43604

GDB:177827 (e-PCR)
- UniSTS:154973

GDB:438527 (e-PCR)
- UniSTS:157279

GDB:438535 (e-PCR)
- UniSTS:157280

SHGC-680 (e-PCR)
- UniSTS:173152

RH17879 (e-PCR)
- UniSTS:7010

D13S153 (e-PCR)
- UniSTS:13158

GDB:186839 (e-PCR)
- UniSTS:155508

RB1-1 (e-PCR)
- UniSTS:241528

RB1-11 (e-PCR)
- UniSTS:241529

RB1-12 (e-PCR)
- UniSTS:241530

RB1-13 (e-PCR)
- UniSTS:241531

RB1-14 (e-PCR)
- UniSTS:241532

RB1-15 (e-PCR)
- UniSTS:241533

RB1-17 (e-PCR)
- UniSTS:241534

RB1-18 (e-PCR)
- UniSTS:241535

RB1-19 (e-PCR)
- UniSTS:241536

RB1-2 (e-PCR)
- UniSTS:241537

RB1-20 (e-PCR)
- UniSTS:241538

RB1-21 (e-PCR)
- UniSTS:241539

RB1-22 (e-PCR)
- UniSTS:241540

RB1-24 (e-PCR)
- UniSTS:241541

RB1-25 (e-PCR)
- UniSTS:241542

RB1-26 (e-PCR)
- UniSTS:241543

RB1-27 (e-PCR)
- UniSTS:241544

RB1-3 (e-PCR)
- UniSTS:241545

RB1-4 (e-PCR)
- UniSTS:241546

RB1-5 (e-PCR)
- UniSTS:241547

PMC193706P1 (e-PCR)
- UniSTS:271756

RB1-7 (e-PCR)
- UniSTS:241548

RB1-8 (e-PCR)
- UniSTS:241549

GDB:181552 (e-PCR)
- UniSTS:155278

RB1-9 (e-PCR)
- UniSTS:241550

RB1-UTR1 (e-PCR)
- UniSTS:241551

RB1-UTR2 (e-PCR)
- UniSTS:241552

RB1-UTR3 (e-PCR)
- UniSTS:241553

RB1-UTR4 (e-PCR)
- UniSTS:241554

RB1-UTR5 (e-PCR)
- UniSTS:241555

GDB:171125 (e-PCR)
- UniSTS:154772

RB1-UTR6 (e-PCR)
- UniSTS:241556

GDB:171126 (e-PCR)
- UniSTS:154773

GDB:171127 (e-PCR)
- UniSTS:154774

RB1_249 (e-PCR)
- UniSTS:277661

SHGC-5978 (e-PCR)
- UniSTS:45986

A010A01 (e-PCR)
- UniSTS:92073

GDB:583298 (e-PCR)
- UniSTS:157882

RB1-3UUTF (e-PCR)
- UniSTS:43719

SHGC-171066 (e-PCR)
- UniSTS:182746

GDB:177234 (e-PCR)
- UniSTS:154843

RH17613 (e-PCR)
- UniSTS:73965

RH69055 (e-PCR)
- UniSTS:40691

GDB:632490 (e-PCR)
- UniSTS:158452

GDB:344103 (e-PCR)
- UniSTS:156665

D10S2288 (e-PCR)
- UniSTS:25849

GDB:344106 (e-PCR)
- UniSTS:156666

GDB:344109 (e-PCR)
- UniSTS:156667

GDB:177381 (e-PCR)
- UniSTS:154876

GDB:344112 (e-PCR)
- UniSTS:156668

GDB:344115 (e-PCR)
- UniSTS:156669

GDB:344118 (e-PCR)
- UniSTS:156670

GDB:344121 (e-PCR)
- UniSTS:156671

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables DNA-binding transcription factor binding	IPI Inferred from Physical Interaction more info	PubMed
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA polymerase II-specific DNA-binding transcription factor binding	IEA Inferred from Electronic Annotation more info
enables disordered domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables identical protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables importin-alpha family protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables kinase binding	IDA Inferred from Direct Assay more info	PubMed
enables molecular adaptor activity	EXP Inferred from Experiment more info	PubMed
enables phosphoprotein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription corepressor activity	TAS Traceable Author Statement more info	PubMed
enables ubiquitin protein ligase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in G1/S transition of mitotic cell cycle	IEA Inferred from Electronic Annotation more info
involved_in Ras protein signal transduction	IEP Inferred from Expression Pattern more info	PubMed
involved_in aortic valve morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in cell differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell division	IEA Inferred from Electronic Annotation more info
involved_in cell morphogenesis involved in neuron differentiation	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to insulin stimulus	IEA Inferred from Electronic Annotation more info
involved_in cellular response to xenobiotic stimulus	IEA Inferred from Electronic Annotation more info
involved_in chondrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in chromatin remodeling	TAS Traceable Author Statement more info	PubMed
involved_in chromosome organization	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in digestive tract development	IEA Inferred from Electronic Annotation more info
involved_in enucleate erythrocyte differentiation	IEA Inferred from Electronic Annotation more info
involved_in epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in glial cell apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in glial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in hepatocyte apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in heterochromatin formation	IDA Inferred from Direct Assay more info	PubMed
involved_in maintenance of mitotic sister chromatid cohesion	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in myoblast differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-binding transcription factor activity	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of DNA-templated transcription	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of G1/S transition of mitotic cell cycle	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of negative regulation of G1/S transition of mitotic cell cycle	TAS Traceable Author Statement more info	PubMed
involved_in negative regulation of apoptotic signaling pathway	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of cell cycle	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of cell growth	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of cold-induced thermogenesis	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of epithelial cell proliferation	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of glial cell proliferation	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of hepatocyte apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of inflammatory response	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of myofibroblast differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of protein kinase activity	IPI Inferred from Physical Interaction more info	PubMed
involved_in negative regulation of protein serine/threonine kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of smoothened signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in negative regulation of tau-protein kinase activity	ISS Inferred from Sequence or Structural Similarity more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	TAS Traceable Author Statement more info	PubMed
involved_in neuron apoptotic process	IEA Inferred from Electronic Annotation more info
involved_in neuron maturation	IEA Inferred from Electronic Annotation more info
involved_in neuron projection development	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of collagen fibril organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of extracellular matrix organization	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of macrophage differentiation	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of mitotic metaphase/anaphase transition	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within positive regulation of transcription regulatory region DNA binding	IDA Inferred from Direct Assay more info	PubMed
involved_in protein localization to chromosome, centromeric region	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription	ISS Inferred from Sequence or Structural Similarity more info
involved_in regulation of DNA-templated transcription	NAS Non-traceable Author Statement more info	PubMed
involved_in regulation of cell cycle	TAS Traceable Author Statement more info	PubMed
involved_in regulation of centromere complex assembly	TAS Traceable Author Statement more info	PubMed
involved_in regulation of lipid kinase activity	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sister chromatid biorientation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in skeletal muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in smoothened signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in spermatogenesis	IEA Inferred from Electronic Annotation more info
involved_in striated muscle cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in tissue homeostasis	IEA Inferred from Electronic Annotation more info
involved_in transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in PML body	IDA Inferred from Direct Assay more info	PubMed
part_of Rb-E2F complex	IBA Inferred from Biological aspect of Ancestor more info
part_of Rb-E2F complex	IDA Inferred from Direct Assay more info	PubMed
part_of Rb-E2F complex	IPI Inferred from Physical Interaction more info	PubMed
part_of Rb-E2F complex	ISS Inferred from Sequence or Structural Similarity more info
part_of Rb-E2F complex	TAS Traceable Author Statement more info	PubMed
part_of SWI/SNF complex	TAS Traceable Author Statement more info	PubMed
part_of chromatin	IBA Inferred from Biological aspect of Ancestor more info
part_of chromatin lock complex	IPI Inferred from Physical Interaction more info	PubMed
part_of cyclin/CDK positive transcription elongation factor complex	IDA Inferred from Direct Assay more info	PubMed
located_in cytosol	TAS Traceable Author Statement more info
located_in nucleoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in nucleoplasm	TAS Traceable Author Statement more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	NAS Non-traceable Author Statement more info	PubMed
located_in nucleus	TAS Traceable Author Statement more info	PubMed
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: retinoblastoma-associated protein

Names: prepro-retinoblastoma-associated protein; protein phosphatase 1, regulatory subunit 130; retinoblastoma 1; retinoblastoma suspectibility protein

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_009009.1 RefSeqGene

Range

5001..183144

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_517

mRNA and Protein(s)

NM_000321.3 → NP_000312.2 retinoblastoma-associated protein isoform 1

See identical proteins and their annotated locations for NP_000312.2

Status: REVIEWED

Source sequence(s)

AL392048, BC040540, L41870

Consensus CDS

CCDS31973.1

UniProtKB/Swiss-Prot

A8K5E3, P06400, P78499, Q5VW46, Q8IZL4

UniProtKB/TrEMBL

Q59HH0

Related

ENSP00000267163.4, ENST00000267163.6

Conserved Domains (4) summary

pfam01857
Location:646 → 765

RB_B; Retinoblastoma-associated protein B domain

pfam01858
Location:373 → 573

RB_A; Retinoblastoma-associated protein A domain

pfam08934
Location:768 → 924

Rb_C; Rb C-terminal domain

pfam11934
Location:114 → 225

DUF3452; Domain of unknown function (DUF3452)
NM_001407165.1 → NP_001394094.1 retinoblastoma-associated protein isoform 2

Status: REVIEWED

Source sequence(s)

AL136960, AL392048

UniProtKB/TrEMBL

A0A3B3IS71

Related

ENSP00000497193.1, ENST00000650461.1
NM_001407166.1 → NP_001394095.1 retinoblastoma-associated protein isoform 3

Status: REVIEWED

Source sequence(s)

AL392048
NM_001407167.1 → NP_001394096.1 retinoblastoma-associated protein isoform 4

Status: REVIEWED

Source sequence(s)

AL392048

UniProtKB/TrEMBL

A0A2R8YFL6

Related

ENSP00000496556.1, ENST00000646097.1
NM_001407168.1 → NP_001394097.1 retinoblastoma-associated protein isoform 5

Status: REVIEWED

Source sequence(s)

AL136960