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    GSN gelsolin [ Homo sapiens (human) ]

    Gene ID: 2934, updated on 9-Jun-2024

    Summary

    Official Symbol
    GSNprovided by HGNC
    Official Full Name
    gelsolinprovided by HGNC
    Primary source
    HGNC:HGNC:4620
    See related
    Ensembl:ENSG00000148180 MIM:137350; AllianceGenome:HGNC:4620
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ADF; AGEL; AMYLD4
    Summary
    The protein encoded by this gene binds to the "plus" ends of actin monomers and filaments to prevent monomer exchange. The encoded calcium-regulated protein functions in both assembly and disassembly of actin filaments. Defects in this gene are a cause of familial amyloidosis Finnish type (FAF). Multiple transcript variants encoding several different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in fat (RPKM 444.2), heart (RPKM 172.6) and 23 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See GSN in Genome Data Viewer
    Location:
    9q33.2
    Exon count:
    42
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (121201483..121332842)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (133397510..133528852)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (123963761..124095120)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene complement C5 Neighboring gene uncharacterized LOC124902261 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28914 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:123836497-123836693 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28915 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20229 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20230 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28917 Neighboring gene NANOG hESC enhancer GRCh37_chr9:123883693-123884194 Neighboring gene centriolin Neighboring gene uncharacterized LOC124902357 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20231 Neighboring gene H3K27ac hESC enhancer GRCh37_chr9:123963761-123964260 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28919 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28920 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:123983210-123983860 Neighboring gene RNA, 7SL, cytoplasmic 181, pseudogene Neighboring gene RAB14, member RAS oncogene family Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28921 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124023585-124024084 Neighboring gene ATPase H+ transporting V1 subunit B2 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20233 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr9:124043752-124044951 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124047035-124047535 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr9:124048350-124049549 Neighboring gene Sharpr-MPRA regulatory region 178 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124056667-124057289 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:124061747-124062407 Neighboring gene GSN antisense RNA 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:124089303-124090216 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 28922 Neighboring gene uncharacterized LOC102723324 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:124132533-124133493 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr9:124148517-124149463 Neighboring gene stomatin Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:124215525-124216026 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:124216027-124216526 Neighboring gene NANOG hESC enhancer GRCh37_chr9:124234601-124235163 Neighboring gene glycoprotein alpha-galactosyltransferase 1 (inactive) Neighboring gene RNA, 7SL, cytoplasmic 187, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of gelsolin by siRNA inhibits early HIV-1 infection and HIV-1 Env (gp120/gp41)-mediated membrane fusion in permissive lymphocytes PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env Gelsolin overexpression impairs HIV-1 gp120-induced cortical F-actin reorganization and capping and gp120-mediated CD4-CCR5 and CD4-CXCR4 redistribution in permissive lymphocytes PubMed
    Tat tat In Jurkat cells expressing HIV-1 Tat, decreased expression levels are found for basic cytoskeletal proteins such as actin, beta-tubulin, annexin, cofilin, gelsolin, and Rac/Rho-GDI complex PubMed
    Vpr vpr A stable-isotope labeling by amino acids in cell culture coupled with mass spectrometry-based proteomics identifies upregulation of gelsolin (GSN) expression by HIV-1 Vpr in Vpr transduced macrophages PubMed
    vpr The G5 domain of gelsolin inhibits HIV-Vpr-induced T-cell apoptosis by blocking the interaction between Vpr and VDAC PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • DKFZp313L0718

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables actin filament binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables calcium ion binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables myosin II binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables phosphatidylinositol 3-kinase catalytic subunit binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables phosphatidylinositol-4,5-bisphosphate binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in actin filament capping IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in actin filament capping ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in actin filament depolymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in actin filament organization IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in actin filament polymerization IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in actin filament polymerization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in actin filament severing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in actin filament severing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in actin filament severing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in actin polymerization or depolymerization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in amyloid fibril formation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in barbed-end actin filament capping IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cardiac muscle cell contraction ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in cell projection assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cellular response to type II interferon IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in central nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cilium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    NOT involved_in extracellular matrix disassembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in hepatocyte apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of viral entry into host cell IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in phagocytosis, engulfment ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of actin nucleation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of keratinocyte apoptotic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of protein processing in phagocytic vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in protein destabilization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of establishment of T cell polarity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of plasma membrane raft polarization IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of podosome assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of receptor clustering IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in relaxation of cardiac muscle ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in renal protein absorption IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in response to muscle stretch ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in sequestering of actin monomers IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in striated muscle atrophy IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in actin cap IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in actin cytoskeleton IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in blood microparticle HDA PubMed 
    colocalizes_with cortical actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cortical actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome HDA PubMed 
    located_in extracellular region HDA PubMed 
    located_in extracellular region IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular region NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ficolin-1-rich granule lumen TAS
    Traceable Author Statement
    more info
     
    located_in focal adhesion HDA PubMed 
    located_in lamellipodium IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in phagocytic vesicle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in podosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in sarcoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in secretory granule lumen TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    gelsolin
    Names
    actin-depolymerizing factor
    brevin
    epididymis secretory sperm binding protein

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012872.2 RefSeqGene

      Range
      72081..136761
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_000177.5NP_000168.1  gelsolin isoform a precursor

      See identical proteins and their annotated locations for NP_000168.1

      Status: REVIEWED

      Source sequence(s)
      BC026033, DB250757
      Consensus CDS
      CCDS6828.1
      UniProtKB/Swiss-Prot
      A2A418, A8MUD1, A8MYN7, B7Z373, B7Z5V1, F5H1A8, P06396, Q5T0I2, Q8WVV7
      UniProtKB/TrEMBL
      A0A384MEF1, B7Z9A0
      Related
      ENSP00000362924.4, ENST00000373818.8
      Conserved Domains (6) summary
      cd11288
      Location:561649
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:186275
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:59171
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:666764
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:295395
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:439539
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    2. NM_001127662.2NP_001121134.1  gelsolin isoform b

      See identical proteins and their annotated locations for NP_001121134.1

      Status: REVIEWED

      Source sequence(s)
      AK096280, BC017491, DA450851
      Consensus CDS
      CCDS6829.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:510598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    3. NM_001127663.2NP_001121135.2  gelsolin isoform f

      Status: REVIEWED

      Source sequence(s)
      AK096280, BC017491, DA294394, DA394782
      Consensus CDS
      CCDS75890.1
      UniProtKB/TrEMBL
      A0A0A0MT01, B7Z6N2
      Related
      ENSP00000409358.2, ENST00000449733.7
      Conserved Domains (6) summary
      cd11288
      Location:546634
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:171260
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:44156
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:651749
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:280380
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:424524
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    4. NM_001127664.2NP_001121136.1  gelsolin isoform b

      See identical proteins and their annotated locations for NP_001121136.1

      Status: REVIEWED

      Source sequence(s)
      AK096280, BC017491, DA294394, DB170452
      Consensus CDS
      CCDS6829.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:510598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    5. NM_001127665.2NP_001121137.1  gelsolin isoform b

      See identical proteins and their annotated locations for NP_001121137.1

      Status: REVIEWED

      Source sequence(s)
      AK096280, BC017491, DC370937
      Consensus CDS
      CCDS6829.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:510598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    6. NM_001127666.2NP_001121138.1  gelsolin isoform c

      See identical proteins and their annotated locations for NP_001121138.1

      Status: REVIEWED

      Source sequence(s)
      AK096280, BC017491, DC341948
      Consensus CDS
      CCDS48011.1
      UniProtKB/TrEMBL
      B7Z992
      Related
      ENSP00000362914.3, ENST00000373808.8
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    7. NM_001127667.2NP_001121139.1  gelsolin isoform c

      See identical proteins and their annotated locations for NP_001121139.1

      Status: REVIEWED

      Source sequence(s)
      AK096280, BC017491, DC316173
      Consensus CDS
      CCDS48011.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    8. NM_001258029.2NP_001244958.1  gelsolin isoform d

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS75891.1
      UniProtKB/TrEMBL
      A0A0A0MS51, B7Z992
      Related
      ENSP00000377882.3, ENST00000394353.7
      Conserved Domains (6) summary
      cd11288
      Location:527615
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:152241
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:25137
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:632730
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:261361
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:405505
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    9. NM_001258030.2NP_001244959.1  gelsolin isoform e

      Status: REVIEWED

      Source sequence(s)
      AK295572, AK299453, AL513122, BC017491, DC378873
      Consensus CDS
      CCDS65118.1
      UniProtKB/TrEMBL
      B7Z992
      Related
      ENSP00000445823.1, ENST00000545652.6
      Conserved Domains (6) summary
      cd11288
      Location:518606
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:143232
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:16128
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:623721
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:252352
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:396496
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    10. NM_001353053.1NP_001339982.1  gelsolin isoform b

      Status: REVIEWED

      Source sequence(s)
      AL137068, AL513122
      Consensus CDS
      CCDS6829.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:510598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    11. NM_001353054.1NP_001339983.1  gelsolin isoform b

      Status: REVIEWED

      Source sequence(s)
      AL137068, AL513122
      Consensus CDS
      CCDS6829.1
      UniProtKB/TrEMBL
      B7Z992
      Related
      ENSP00000362929.2, ENST00000373823.7
      Conserved Domains (6) summary
      cd11288
      Location:510598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    12. NM_001353055.2NP_001339984.1  gelsolin isoform b

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS6829.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:510598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    13. NM_001353056.2NP_001339985.1  gelsolin isoform b

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS6829.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:510598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    14. NM_001353057.2NP_001339986.1  gelsolin isoform b

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS6829.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:510598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    15. NM_001353058.2NP_001339987.1  gelsolin isoform b

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS6829.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:510598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    16. NM_001353059.2NP_001339988.1  gelsolin isoform b

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS6829.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:510598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    17. NM_001353060.2NP_001339989.1  gelsolin isoform b

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS6829.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:510598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    18. NM_001353061.2NP_001339990.1  gelsolin isoform b

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS6829.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:510598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    19. NM_001353062.1NP_001339991.1  gelsolin isoform b

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS6829.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:510598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    20. NM_001353063.2NP_001339992.1  gelsolin isoform c

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    21. NM_001353064.2NP_001339993.1  gelsolin isoform c

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    22. NM_001353065.2NP_001339994.1  gelsolin isoform c

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    23. NM_001353066.2NP_001339995.1  gelsolin isoform c

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    24. NM_001353067.2NP_001339996.1  gelsolin isoform c

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    25. NM_001353068.2NP_001339997.1  gelsolin isoform c

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    26. NM_001353069.2NP_001339998.1  gelsolin isoform c

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    27. NM_001353070.2NP_001339999.1  gelsolin isoform c

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    28. NM_001353071.2NP_001340000.1  gelsolin isoform c

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    29. NM_001353072.2NP_001340001.1  gelsolin isoform c

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    30. NM_001353073.2NP_001340002.1  gelsolin isoform c

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    31. NM_001353074.2NP_001340003.1  gelsolin isoform c

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    32. NM_001353075.1NP_001340004.1  gelsolin isoform c

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    33. NM_001353076.2NP_001340005.1  gelsolin isoform g

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS94475.1
      UniProtKB/TrEMBL
      A0A8V8TND7, B7Z9A0
      Related
      ENSP00000514432.1, ENST00000699558.1
      Conserved Domains (6) summary
      cd11288
      Location:534622
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:159248
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:32144
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:639737
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:268368
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:412512
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    34. NM_001353077.1NP_001340006.1  gelsolin isoform c

      Status: REVIEWED

      Source sequence(s)
      AL513122
      Consensus CDS
      CCDS48011.1
      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    35. NM_001353078.2NP_001340007.1  gelsolin isoform h

      Status: REVIEWED

      Source sequence(s)
      AL513122
      UniProtKB/TrEMBL
      B3KS49
      Conserved Domains (4) summary
      cd11288
      Location:292380
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:397495
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:26126
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:170270
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    36. NM_198252.3NP_937895.1  gelsolin isoform b

      See identical proteins and their annotated locations for NP_937895.1

      Status: REVIEWED

      Source sequence(s)
      AK096280, BC017491
      Consensus CDS
      CCDS6829.1
      UniProtKB/TrEMBL
      B7Z992
      Related
      ENSP00000404226.2, ENST00000432226.7
      Conserved Domains (6) summary
      cd11288
      Location:510598
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:135224
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:8120
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:615713
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:244344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:388488
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      121201483..121332842
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047423273.1XP_047279229.1  gelsolin isoform X5

      UniProtKB/TrEMBL
      B7Z992
    2. XM_047423267.1XP_047279223.1  gelsolin isoform X4

      UniProtKB/TrEMBL
      B7Z992
    3. XM_047423268.1XP_047279224.1  gelsolin isoform X4

      UniProtKB/TrEMBL
      B7Z992
    4. XM_047423272.1XP_047279228.1  gelsolin isoform X5

      UniProtKB/TrEMBL
      B7Z992
    5. XM_047423265.1XP_047279221.1  gelsolin isoform X1

      UniProtKB/TrEMBL
      B7Z6N2
    6. XM_017014645.2XP_016870134.1  gelsolin isoform X3

      UniProtKB/TrEMBL
      B7Z9A0
      Conserved Domains (6) summary
      cd11288
      Location:531619
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:156245
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:29141
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:636734
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:265365
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:409509
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    7. XM_047423271.1XP_047279227.1  gelsolin isoform X4

      UniProtKB/TrEMBL
      B7Z992
    8. XM_011518585.2XP_011516887.1  gelsolin isoform X2

      UniProtKB/TrEMBL
      B7Z9A0
      Conserved Domains (6) summary
      cd11288
      Location:540628
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:165254
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:38150
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:645743
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:274374
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:418518
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    9. XM_047423270.1XP_047279226.1  gelsolin isoform X4

      UniProtKB/TrEMBL
      B7Z992
    10. XM_047423266.1XP_047279222.1  gelsolin isoform X3

      UniProtKB/TrEMBL
      B7Z9A0
    11. XM_047423269.1XP_047279225.1  gelsolin isoform X4

      UniProtKB/TrEMBL
      B7Z992
    12. XM_005251944.2XP_005252001.1  gelsolin isoform X4

      See identical proteins and their annotated locations for XP_005252001.1

      UniProtKB/TrEMBL
      B7Z992
      Conserved Domains (6) summary
      cd11288
      Location:521609
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:146235
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:19131
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:626724
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:255355
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:399499
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
    13. XM_011518594.2XP_011516896.1  gelsolin isoform X6

      Conserved Domains (5) summary
      cd11288
      Location:352440
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:457555
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:86186
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:230330
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins
      cl15697
      Location:1266
      ADF_gelsolin; Actin depolymerization factor/cofilin- and gelsolin-like domains

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      133397510..133528852
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054362811.1XP_054218786.1  gelsolin isoform X1

      UniProtKB/TrEMBL
      B7Z6N2
    2. XM_054362812.1XP_054218787.1  gelsolin isoform X1

      UniProtKB/TrEMBL
      B7Z6N2
    3. XM_054362815.1XP_054218790.1  gelsolin isoform X3

      UniProtKB/TrEMBL
      B7Z9A0
    4. XM_054362818.1XP_054218793.1  gelsolin isoform X4

      UniProtKB/TrEMBL
      B7Z992
    5. XM_054362813.1XP_054218788.1  gelsolin isoform X2

      UniProtKB/TrEMBL
      B7Z9A0
    6. XM_054362817.1XP_054218792.1  gelsolin isoform X4

      UniProtKB/TrEMBL
      B7Z992
    7. XM_054362814.1XP_054218789.1  gelsolin isoform X3

      UniProtKB/TrEMBL
      B7Z9A0
    8. XM_054362816.1XP_054218791.1  gelsolin isoform X4

      UniProtKB/TrEMBL
      B7Z992
    9. XM_054362819.1XP_054218794.1  gelsolin isoform X6