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    DPM1 dolichyl-phosphate mannosyltransferase subunit 1, catalytic [ Homo sapiens (human) ]

    Gene ID: 8813, updated on 4-Feb-2024

    Summary

    Official Symbol
    DPM1provided by HGNC
    Official Full Name
    dolichyl-phosphate mannosyltransferase subunit 1, catalyticprovided by HGNC
    Primary source
    HGNC:HGNC:3005
    See related
    Ensembl:ENSG00000000419 MIM:603503; AllianceGenome:HGNC:3005
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MPDS; CDGIE
    Summary
    Dolichol-phosphate mannose (Dol-P-Man) serves as a donor of mannosyl residues on the lumenal side of the endoplasmic reticulum (ER). Lack of Dol-P-Man results in defective surface expression of GPI-anchored proteins. Dol-P-Man is synthesized from GDP-mannose and dolichol-phosphate on the cytosolic side of the ER by the enzyme dolichyl-phosphate mannosyltransferase. Human DPM1 lacks a carboxy-terminal transmembrane domain and signal sequence and is regulated by DPM2. Mutations in this gene are associated with congenital disorder of glycosylation type Ie. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2015]
    Expression
    Ubiquitous expression in adrenal (RPKM 24.6), thyroid (RPKM 23.5) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DPM1 in Genome Data Viewer
    Location:
    20q13.13
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 20 NC_000020.11 (50934855..50958564, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 20 NC_060944.1 (52705454..52729167, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 20 NC_000020.10 (49551392..49575101, complement)

    Chromosome 20 - NC_000020.11Genomic Context describing neighboring genes Neighboring gene breast carcinoma amplified sequence 4 Neighboring gene uncharacterized LOC124904929 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:49486444-49487157 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:49487158-49487870 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:49488585-49489297 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:49491439-49492150 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:49492678-49493258 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:49495917-49496418 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:49496419-49496918 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13031 Neighboring gene activity dependent neuroprotector homeobox Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:49541986-49542486 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:49542487-49542987 Neighboring gene proteasome 26S subunit, non-ATPase, 10 pseudogene 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13033 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13032 Neighboring gene H3K27ac hESC enhancer GRCh37_chr20:49546803-49547593 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13036 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18107 Neighboring gene ReSE screen-validated silencer GRCh37_chr20:49548232-49548419 Neighboring gene ADNP antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18108 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:49575528-49576138 Neighboring gene molybdenum cofactor synthesis 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:49606180-49607142 Neighboring gene Sharpr-MPRA regulatory region 8647 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr20:49620535-49621036 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr20:49637285-49637848 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13038 Neighboring gene potassium voltage-gated channel modifier subfamily G member 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of dolichyl-phosphate mannosyltransferase polypeptide 1, catalytic subunit (DPM1) by siRNA inhibits HIV-1 replication in HeLa-derived TZM-bl cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables alcohol binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables dolichyl-phosphate beta-D-mannosyltransferase activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables dolichyl-phosphate beta-D-mannosyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables dolichyl-phosphate beta-D-mannosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables dolichyl-phosphate-mannose-protein mannosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables mannose binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 

    General protein information

    Preferred Names
    dolichol-phosphate mannosyltransferase subunit 1
    Names
    DPM synthase complex, catalytic subunit
    DPM synthase subunit 1
    MPD synthase subunit 1
    dolichol monophosphate mannose synthase
    dolichol-phosphate mannose synthase subunit 1
    dolichyl-phosphate beta-D-mannosyltransferase subunit 1
    dolichyl-phosphate mannosyltransferase polypeptide 1 catalytic subunit
    mannose-P-dolichol synthase subunit 1
    NP_001303963.1
    NP_001303964.1
    NP_001303965.1
    NP_003850.1
    XP_047296533.1
    XP_054180171.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008923.1 RefSeqGene

      Range
      4992..28654
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001317034.1NP_001303963.1  dolichol-phosphate mannosyltransferase subunit 1 isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AL034553, BC007073, CA865473, DR156925
      Consensus CDS
      CCDS93059.1
      UniProtKB/TrEMBL
      H0Y368
      Related
      ENSP00000360640.5, ENST00000371584.9
      Conserved Domains (3) summary
      cd06442
      Location:29291
      DPM1_like; DPM1_like represents putative enzymes similar to eukaryotic DPM1
      PLN02726
      Location:23295
      PLN02726; dolichyl-phosphate beta-D-mannosyltransferase
      pfam13900
      Location:175206
      GVQW; Putative domain of unknown function
    2. NM_001317035.1NP_001303964.1  dolichol-phosphate mannosyltransferase subunit 1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice site in the 3' coding region, compared to variant 1. The encoded isoform (2) is shorter than isoform 1.
      Source sequence(s)
      AL034553, BC007073, BM922866, CA865473
      Consensus CDS
      CCDS82628.1
      UniProtKB/TrEMBL
      Q5QPK2
      Related
      ENSP00000360638.4, ENST00000371582.8
      Conserved Domains (2) summary
      cd06442
      Location:29283
      DPM1_like; DPM1_like represents putative enzymes similar to eukaryotic DPM1
      PLN02726
      Location:23287
      PLN02726; dolichyl-phosphate beta-D-mannosyltransferase
    3. NM_001317036.1NP_001303965.1  dolichol-phosphate mannosyltransferase subunit 1 isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks two alternate in-frame exons in the 3' coding region, compared to variant 1. The encoded isoform (4) is shorter than isoform 1.
      Source sequence(s)
      AL034553, BC007073, BQ441542, CA865473
      UniProtKB/Swiss-Prot
      O60762
      Conserved Domains (2) summary
      cd06442
      Location:29233
      DPM1_like; DPM1_like represents putative enzymes similar to eukaryotic DPM1
      PLN02726
      Location:23237
      PLN02726; dolichyl-phosphate beta-D-mannosyltransferase
    4. NM_003859.3NP_003850.1  dolichol-phosphate mannosyltransferase subunit 1 isoform 3

      See identical proteins and their annotated locations for NP_003850.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region, compared to variant 1. The encoded isoform (3) is shorter than isoform 1.
      Source sequence(s)
      BC016322, D86198
      Consensus CDS
      CCDS13434.1
      UniProtKB/Swiss-Prot
      O15157, O60762, Q6IB78, Q96HK0
      UniProtKB/TrEMBL
      A0A0S2Z4Y5, Q5QPJ9
      Related
      ENSP00000360644.5, ENST00000371588.10
      Conserved Domains (1) summary
      PLN02726
      Location:23260
      PLN02726; dolichyl-phosphate beta-D-mannosyltransferase

    RNA

    1. NR_133648.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an alternate internal exon, and uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most supported translational start codon, as used in variant 1, renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      AL034553, BC008427
      Related
      ENST00000466152.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000020.11 Reference GRCh38.p14 Primary Assembly

      Range
      50934855..50958564 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047440577.1XP_047296533.1  dolichol-phosphate mannosyltransferase subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A804HIK9

    RNA

    1. XR_007067482.1 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060944.1 Alternate T2T-CHM13v2.0

      Range
      52705454..52729167 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054324196.1XP_054180171.1  dolichol-phosphate mannosyltransferase subunit 1 isoform X1

      UniProtKB/TrEMBL
      A0A804HIK9

    RNA

    1. XR_008485315.1 RNA Sequence