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    SLC27A4 solute carrier family 27 member 4 [ Homo sapiens (human) ]

    Gene ID: 10999, updated on 2-Nov-2024

    Summary

    Official Symbol
    SLC27A4provided by HGNC
    Official Full Name
    solute carrier family 27 member 4provided by HGNC
    Primary source
    HGNC:HGNC:10998
    See related
    Ensembl:ENSG00000167114 MIM:604194; AllianceGenome:HGNC:10998
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    IPS; FATP4; ACSVL4
    Summary
    This gene encodes a member of a family of fatty acid transport proteins, which are involved in translocation of long-chain fatty acids cross the plasma membrane. This protein is expressed at high levels on the apical side of mature enterocytes in the small intestine, and appears to be the principal fatty acid transporter in enterocytes. Clinical studies suggest this gene as a candidate gene for the insulin resistance syndrome. Mutations in this gene have been associated with ichthyosis prematurity syndrome. [provided by RefSeq, Apr 2010]
    Expression
    Broad expression in duodenum (RPKM 32.2), small intestine (RPKM 21.2) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SLC27A4 in Genome Data Viewer
    Location:
    9q34.11
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 9 NC_000009.12 (128340527..128361470)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 9 NC_060933.1 (140547613..140568573)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 9 NC_000009.11 (131102806..131123749)

    Chromosome 9 - NC_000009.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20335 Neighboring gene coenzyme Q4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:131095861-131096360 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:131099538-131099696 Neighboring gene ReSE screen-validated silencer GRCh37_chr9:131102183-131102824 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20337 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29079 Neighboring gene tRNA-Arg (anticodon TCT) 3-1 Neighboring gene TMSB4X pseudogene 4 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:131126318-131127208 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:131127209-131128100 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:131131960-131132824 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr9:131132825-131133688 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29080 Neighboring gene ubiquitin related modifier 1 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr9:131145413-131146057 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr9:131147991-131148635 Neighboring gene MIR219A2 host gene Neighboring gene microRNA 219a-2 Neighboring gene microRNA 219b

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Vpu vpu HIV-1 Vpu is identified to have a physical interaction with solute carrier family 27 (fatty acid transporter), member 4 (SLC27A4) in human HEK293 and/or Jurkat cell lines by using affinity tagging and purification mass spectrometry analyses PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables arachidonate-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables fatty acid transmembrane transporter activity TAS
    Traceable Author Statement
    more info
     
    enables long-chain fatty acid transmembrane transporter activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables long-chain fatty acid transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables long-chain fatty acid-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables nucleotide binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables oleate transmembrane transporter activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables oleoyl-CoA ligase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables oleoyl-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables oleoyl-CoA ligase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables palmitoyl-CoA ligase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables very long-chain fatty acid-CoA ligase activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    acts_upstream_of_or_within activation of GTPase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in establishment of localization in cell IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in fatty acid transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in glucose import in response to insulin stimulus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in lipid transport across blood-brain barrier IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in long-chain fatty acid import into cell IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in long-chain fatty acid import into cell IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in long-chain fatty acid import into cell ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in long-chain fatty acid metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in long-chain fatty acid metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in long-chain fatty acid transport IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in long-chain fatty acid transport TAS
    Traceable Author Statement
    more info
     
    involved_in medium-chain fatty acid transport IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in negative regulation of all-trans-retinyl-ester hydrolase, 11-cis retinol forming activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of insulin receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of apoptotic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in response to nutrient IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skin development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in transport across blood-brain barrier NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in very long-chain fatty acid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in brush border membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endoplasmic reticulum IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in endoplasmic reticulum membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in membrane HDA PubMed 
    located_in microvillus IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    long-chain fatty acid transport protein 4
    Names
    acyl-CoA synthetase very long chain family member 4
    arachidonate--CoA ligase
    long-chain-fatty-acid--CoA ligase
    solute carrier family 27 (fatty acid transporter), member 4
    very long-chain acyl-CoA synthetase 4
    NP_005085.2
    XP_016869711.1
    XP_024303159.1
    XP_047278620.1
    XP_054217791.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_017057.1 RefSeqGene

      Range
      4968..25911
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_005094.4NP_005085.2  long-chain fatty acid transport protein 4

      See identical proteins and their annotated locations for NP_005085.2

      Status: REVIEWED

      Source sequence(s)
      AA350218, AI478495, AK290222, AL359091, BC065003, H16504
      Consensus CDS
      CCDS6899.1
      UniProtKB/Swiss-Prot
      A8K2F7, O95186, Q6P1M0, Q96G53
      Related
      ENSP00000300456.3, ENST00000300456.5
      Conserved Domains (1) summary
      cd05939
      Location:99608
      hsFATP4_like; Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000009.12 Reference GRCh38.p14 Primary Assembly

      Range
      128340527..128361470
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_024447391.2XP_024303159.1  long-chain fatty acid transport protein 4 isoform X2

      UniProtKB/Swiss-Prot
      A8K2F7, O95186, Q6P1M0, Q96G53
      Conserved Domains (1) summary
      cd05939
      Location:99608
      hsFATP4_like; Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins
    2. XM_017014222.2XP_016869711.1  long-chain fatty acid transport protein 4 isoform X2

      UniProtKB/Swiss-Prot
      A8K2F7, O95186, Q6P1M0, Q96G53
      Conserved Domains (1) summary
      cd05939
      Location:99608
      hsFATP4_like; Fatty acid transport proteins (FATP), including FATP4 and FATP1, and similar proteins
    3. XM_047422664.1XP_047278620.1  long-chain fatty acid transport protein 4 isoform X1

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060933.1 Alternate T2T-CHM13v2.0

      Range
      140547613..140568573
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054361816.1XP_054217791.1  long-chain fatty acid transport protein 4 isoform X2

      UniProtKB/Swiss-Prot
      A8K2F7, O95186, Q6P1M0, Q96G53