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    SEC23A SEC23 homolog A, COPII coat complex component [ Homo sapiens (human) ]

    Gene ID: 10484, updated on 9-Jun-2024

    Summary

    Official Symbol
    SEC23Aprovided by HGNC
    Official Full Name
    SEC23 homolog A, COPII coat complex componentprovided by HGNC
    Primary source
    HGNC:HGNC:10701
    See related
    Ensembl:ENSG00000100934 MIM:610511; AllianceGenome:HGNC:10701
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CLSD; hSec23A
    Summary
    The protein encoded by this gene is a member of the SEC23 subfamily of the SEC23/SEC24 family. It is part of a protein complex and found in the ribosome-free transitional face of the endoplasmic reticulum (ER) and associated vesicles. This protein has similarity to yeast Sec23p component of COPII. COPII is the coat protein complex responsible for vesicle budding from the ER. The encoded protein is suggested to play a role in the ER-Golgi protein trafficking. [provided by RefSeq, Jul 2008]
    Expression
    Ubiquitous expression in duodenum (RPKM 27.6), small intestine (RPKM 25.4) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See SEC23A in Genome Data Viewer
    Location:
    14q21.1
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (39031919..39103235, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (33220592..33291912, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (39501123..39572439, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 639 Neighboring gene uncharacterized LOC105370457 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr14:39401304-39402503 Neighboring gene uncharacterized LOC102723516 Neighboring gene RIPPLY3 pseudogene 1 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:39486106-39486616 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:39486617-39487127 Neighboring gene Sharpr-MPRA regulatory region 2779 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5684 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5685 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5686 Neighboring gene uncharacterized LOC105370459 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:39579989-39580506 Neighboring gene SEC23A antisense RNA 1 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8285 Neighboring gene peptidylprolyl isomerase A pseudogene 4 Neighboring gene gem nuclear organelle associated protein 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • MGC26267

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTPase activator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables zinc ion binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in COPII-coated vesicle cargo loading IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in COPII-coated vesicle cargo loading IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in COPII-coated vesicle cargo loading IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in intracellular protein transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein localization to plasma membrane IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of COPII vesicle coat IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of COPII vesicle coat IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in ER to Golgi transport vesicle membrane IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    located_in ER to Golgi transport vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in endoplasmic reticulum exit site IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in endoplasmic reticulum exit site IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in endoplasmic reticulum membrane TAS
    Traceable Author Statement
    more info
     
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein transport protein Sec23A
    Names
    SEC23-related protein A
    Sec23 homolog A, coat complex II component

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012157.1 RefSeqGene

      Range
      4999..76315
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_006364.4NP_006355.2  protein transport protein Sec23A

      See identical proteins and their annotated locations for NP_006355.2

      Status: REVIEWED

      Source sequence(s)
      BC036649, BM541968, DC335582, X97064
      Consensus CDS
      CCDS9668.1
      UniProtKB/Swiss-Prot
      B2R5P4, B3KXI2, Q15436, Q8NE16
      UniProtKB/TrEMBL
      F5H365
      Related
      ENSP00000306881.6, ENST00000307712.11
      Conserved Domains (1) summary
      PLN00162
      Location:12763
      PLN00162; transport protein sec23; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      39031919..39103235 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005267262.2XP_005267319.1  protein transport protein Sec23A isoform X1

      UniProtKB/TrEMBL
      F5H365
      Conserved Domains (6) summary
      cd11287
      Location:634754
      Sec23_C; C-terminal Actin depolymerization factor-homology domain of Sec23
      PLN00162
      Location:12787
      PLN00162; transport protein sec23; Provisional
      cd01478
      Location:126388
      Sec23-like; Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
      pfam04810
      Location:5897
      zf-Sec23_Sec24; Sec23/Sec24 zinc finger
      pfam04815
      Location:522639
      Sec23_helical; Sec23/Sec24 helical domain
      pfam08033
      Location:401504
      Sec23_BS; Sec23/Sec24 beta-sandwich domain
    2. XM_011536355.4XP_011534657.1  protein transport protein Sec23A isoform X2

      UniProtKB/TrEMBL
      F5H365
      Conserved Domains (6) summary
      cd11287
      Location:634754
      Sec23_C; C-terminal Actin depolymerization factor-homology domain of Sec23
      PLN00162
      Location:12762
      PLN00162; transport protein sec23; Provisional
      cd01478
      Location:126388
      Sec23-like; Sec23-like: Protein and membrane traffic in eukaryotes is mediated by at least in part by the budding and fusion of intracellular transport vesicles that selectively carry cargo proteins and lipids from donor to acceptor organelles. The two main classes ...
      pfam04810
      Location:5897
      zf-Sec23_Sec24; Sec23/Sec24 zinc finger
      pfam04815
      Location:522639
      Sec23_helical; Sec23/Sec24 helical domain
      pfam08033
      Location:401504
      Sec23_BS; Sec23/Sec24 beta-sandwich domain
    3. XM_017020928.3XP_016876417.1  protein transport protein Sec23A isoform X3

      UniProtKB/TrEMBL
      F5H365

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      33220592..33291912 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054375271.1XP_054231246.1  protein transport protein Sec23A isoform X1

      UniProtKB/TrEMBL
      F5H365
    2. XM_054375272.1XP_054231247.1  protein transport protein Sec23A isoform X2

      UniProtKB/TrEMBL
      F5H365
    3. XM_054375273.1XP_054231248.1  protein transport protein Sec23A isoform X3

      UniProtKB/TrEMBL
      F5H365