U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from MedGen

    • Showing Current items.

    LRP5 LDL receptor related protein 5 [ Homo sapiens (human) ]

    Gene ID: 4041, updated on 4-Nov-2024

    Summary

    Official Symbol
    LRP5provided by HGNC
    Official Full Name
    LDL receptor related protein 5provided by HGNC
    Primary source
    HGNC:HGNC:6697
    See related
    Ensembl:ENSG00000162337 MIM:603506; AllianceGenome:HGNC:6697
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    HBM; LR3; OPS; EVR1; EVR4; LRP7; OPPG; BMND1; LRP-5; LRP-7; OPTA1; PCLD4; VBCH2
    Summary
    This gene encodes a transmembrane low-density lipoprotein receptor that binds and internalizes ligands in the process of receptor-mediated endocytosis. This protein also acts as a co-receptor with Frizzled protein family members for transducing signals by Wnt proteins and was originally cloned on the basis of its association with type 1 diabetes mellitus in humans. This protein plays a key role in skeletal homeostasis and many bone density related diseases are caused by mutations in this gene. Mutations in this gene also cause familial exudative vitreoretinopathy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
    Expression
    Ubiquitous expression in fat (RPKM 20.9), small intestine (RPKM 15.5) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See LRP5 in Genome Data Viewer
    Location:
    11q13.2
    Exon count:
    28
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (68298412..68449275)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (68302748..68454184)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (68080059..68216743)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene MPRA-validated peak1319 silencer Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:68034746-68035945 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:68039550-68040404 Neighboring gene uncharacterized LOC105369363 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3666 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5133 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5134 Neighboring gene chromosome 11 open reading frame 24 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68066209-68066956 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68067706-68068453 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3667 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68080045-68080920 Neighboring gene uncharacterized LOC124900302 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68080921-68081795 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68082507-68083006 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68084075-68084742 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68095823-68096400 Neighboring gene uncharacterized LOC124902698 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68099859-68100434 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68110204-68111055 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68120602-68121235 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68121869-68122501 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5135 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68141212-68141935 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5136 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5137 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5138 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:68154179-68154402 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68164501-68165000 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5139 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3671 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:68185667-68186590 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68213843-68214446 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68214447-68215051 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68215052-68215655 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3673 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 5140 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3674 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3675 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 3676 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68237400-68237900 Neighboring gene protein phosphatase 6 regulatory subunit 3 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68278329-68278907 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68278908-68279485 Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 pseudogene 2 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr11:68307752-68308457 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:68310718-68311218 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:68311219-68311719 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68351250-68351750 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:68370649-68370853 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68376961-68377462 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68377463-68377962 Neighboring gene NANOG hESC enhancer GRCh37_chr11:68390073-68390603 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr11:68399697-68400286 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:68400287-68400875 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr11:68400876-68401464 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:68419596-68420268 Neighboring gene uncharacterized LOC107984343 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:68450731-68451406 Neighboring gene H3K27ac hESC enhancer GRCh37_chr11:68452083-68452758 Neighboring gene galanin and GMAP prepropeptide

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Autosomal dominant osteopetrosis 1
    MedGen: C1843330 OMIM: 607634 GeneReviews: Not available
    not available
    Bone mineral density quantitative trait locus 1
    MedGen: C1866079 OMIM: 601884 GeneReviews: Not available
    not available
    Exudative vitreoretinopathy 1
    MedGen: C1851402 OMIM: 133780 GeneReviews: Not available
    not available
    Exudative vitreoretinopathy 4
    MedGen: C1866176 OMIM: 601813 GeneReviews: Not available
    not available
    Osteoporosis with pseudoglioma
    MedGen: C0432252 OMIM: 259770 GeneReviews: Not available
    not available
    Polycystic liver disease 4 with or without kidney cysts
    MedGen: C4693479 OMIM: 617875 GeneReviews: Not available
    not available
    Worth disease
    MedGen: C0432273 OMIM: 144750 GeneReviews: Not available
    not available

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    Little evidence for dosage pathogenicity (Last evaluated 2024-04-09)

    ClinGen Genome Curation PagePubMed
    Triplosensitivity

    No evidence available (Last evaluated 2024-04-09)

    ClinGen Genome Curation Page

    EBI GWAS Catalog

    Description
    Bone mineral density, osteoporosis, and osteoporotic fractures: a genome-wide association study.
    EBI GWAS Catalog
    Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture.
    EBI GWAS Catalog
    Multistage genome-wide association meta-analyses identified two new loci for bone mineral density.
    EBI GWAS Catalog
    Phenotypic dissection of bone mineral density reveals skeletal site specificity and facilitates the identification of novel loci in the genetic regulation of bone mass attainment.
    EBI GWAS Catalog
    Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables Wnt receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Wnt receptor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables Wnt receptor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables Wnt-protein binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables Wnt-protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables Wnt-protein binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables Wnt-protein binding TAS
    Traceable Author Statement
    more info
    PubMed 
    enables coreceptor activity IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables coreceptor activity NAS
    Non-traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    NOT enables toxin transmembrane transporter activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Norrin signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in adipose tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in amino acid transport IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in anatomical structure regression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in anterior/posterior pattern specification IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic process involved in blood vessel morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in bone marrow development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in bone morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in bone remodeling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in branching involved in mammary gland duct morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cell migration involved in gastrulation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cell-cell signaling involved in mammary gland development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cholesterol homeostasis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in cholesterol metabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic digit morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in endocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of blood-brain barrier IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of blood-retinal barrier IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in extracellular matrix-cell signaling IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gastrulation with mouth forming second IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in glucose catabolic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mesodermal cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of osteoblast differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of protein serine/threonine kinase activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in osteoblast development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in osteoblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-binding transcription factor activity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of cell population proliferation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of fat cell differentiation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mesenchymal cell proliferation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of mitotic nuclear division IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of osteoblast differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of osteoblast proliferation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of blood pressure IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of insulin secretion involved in cellular response to glucose stimulus IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to peptide hormone IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in retina morphogenesis in camera-type eye IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in retinal blood vessel morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in somatic stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of Wnt signalosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    part_of Wnt-Frizzled-LRP5/6 complex TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in endoplasmic reticulum IEA
    Inferred from Electronic Annotation
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    part_of receptor complex IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    low-density lipoprotein receptor-related protein 5
    Names
    low density lipoprotein receptor-related protein 5
    low density lipoprotein receptor-related protein 7

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_015835.3 RefSeqGene

      Range
      19181..155865
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001291902.2NP_001278831.1  low-density lipoprotein receptor-related protein 5 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in its 5' UTR and uses and alternate start codon, compared to variant 1. The encoded isoform (2) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AB017498, AI583742, AP000807, AP002813, BC098397, BC150595, DN999254
      UniProtKB/Swiss-Prot
      O75197
      Conserved Domains (6) summary
      smart00135
      Location:129171
      LY; Low-density lipoprotein-receptor YWTD domain
      cd00112
      Location:755789
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:139175
      NHL; NHL repeat [structural motif]
      pfam00057
      Location:677714
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam14670
      Location:2459
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl18310
      Location:104297
      NHL; NHL repeat unit of beta-propeller proteins
    2. NM_002335.4NP_002326.2  low-density lipoprotein receptor-related protein 5 isoform 1 precursor

      See identical proteins and their annotated locations for NP_002326.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1).
      Source sequence(s)
      AB017498, AI583742, AP000807, AP002813, BC150595, DN999254
      Consensus CDS
      CCDS8181.1
      UniProtKB/Swiss-Prot
      O75197, Q96TD6, Q9UES7, Q9UP66
      Related
      ENSP00000294304.6, ENST00000294304.12
      Conserved Domains (7) summary
      smart00135
      Location:408450
      LY; Low-density lipoprotein-receptor YWTD domain
      cd00112
      Location:13361370
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:720756
      NHL; NHL repeat [structural motif]
      pfam00057
      Location:12581295
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:163203
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:299336
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl18310
      Location:685878
      NHL; NHL repeat unit of beta-propeller proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      68298412..68449275
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011545031.2XP_011543333.1  low-density lipoprotein receptor-related protein 5 isoform X4

      Conserved Domains (7) summary
      smart00135
      Location:417459
      LY; Low-density lipoprotein-receptor YWTD domain
      cd00112
      Location:13451379
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:729765
      NHL; NHL repeat [structural motif]
      pfam00057
      Location:12671304
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:172212
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:308345
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl18310
      Location:694887
      NHL; NHL repeat unit of beta-propeller proteins
    2. XM_011545029.2XP_011543331.1  low-density lipoprotein receptor-related protein 5 isoform X1

      Conserved Domains (7) summary
      smart00135
      Location:417459
      LY; Low-density lipoprotein-receptor YWTD domain
      cd00112
      Location:13451379
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:729765
      NHL; NHL repeat [structural motif]
      pfam00057
      Location:12671304
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:172212
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:308345
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl18310
      Location:694887
      NHL; NHL repeat unit of beta-propeller proteins
    3. XM_011545030.2XP_011543332.1  low-density lipoprotein receptor-related protein 5 isoform X3

      Conserved Domains (7) summary
      smart00135
      Location:417459
      LY; Low-density lipoprotein-receptor YWTD domain
      cd00112
      Location:13451379
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:729765
      NHL; NHL repeat [structural motif]
      pfam00057
      Location:12671304
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:172212
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:308345
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl18310
      Location:694887
      NHL; NHL repeat unit of beta-propeller proteins
    4. XM_047426949.1XP_047282905.1  low-density lipoprotein receptor-related protein 5 isoform X6

    5. XM_047426948.1XP_047282904.1  low-density lipoprotein receptor-related protein 5 isoform X5

    6. XM_047426950.1XP_047282906.1  low-density lipoprotein receptor-related protein 5 isoform X7

    7. XM_005273994.3XP_005274051.1  low-density lipoprotein receptor-related protein 5 isoform X2

      Conserved Domains (7) summary
      smart00135
      Location:408450
      LY; Low-density lipoprotein-receptor YWTD domain
      cd00112
      Location:13361370
      LDLa; Low Density Lipoprotein Receptor Class A domain, a cysteine-rich repeat that plays a central role in mammalian cholesterol metabolism; the receptor protein binds LDL and transports it into cells by endocytosis; 7 successive cysteine-rich repeats of about ...
      cd05819
      Location:720756
      NHL; NHL repeat [structural motif]
      pfam00057
      Location:12581295
      Ldl_recept_a; Low-density lipoprotein receptor domain class A
      pfam00058
      Location:163203
      Ldl_recept_b; Low-density lipoprotein receptor repeat class B
      pfam14670
      Location:299336
      FXa_inhibition; Coagulation Factor Xa inhibitory site
      cl18310
      Location:685878
      NHL; NHL repeat unit of beta-propeller proteins
    8. XM_017017735.2XP_016873224.1  low-density lipoprotein receptor-related protein 5 isoform X8

    9. XM_017017736.2XP_016873225.1  low-density lipoprotein receptor-related protein 5 isoform X9

    RNA

    1. XR_001747874.2 RNA Sequence

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      68302748..68454184
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054368788.1XP_054224763.1  low-density lipoprotein receptor-related protein 5 isoform X4

    2. XM_054368785.1XP_054224760.1  low-density lipoprotein receptor-related protein 5 isoform X1

    3. XM_054368787.1XP_054224762.1  low-density lipoprotein receptor-related protein 5 isoform X3

    4. XM_054368790.1XP_054224765.1  low-density lipoprotein receptor-related protein 5 isoform X6

    5. XM_054368789.1XP_054224764.1  low-density lipoprotein receptor-related protein 5 isoform X5

    6. XM_054368791.1XP_054224766.1  low-density lipoprotein receptor-related protein 5 isoform X7

    7. XM_054368793.1XP_054224768.1  low-density lipoprotein receptor-related protein 5 isoform X10

    8. XM_054368786.1XP_054224761.1  low-density lipoprotein receptor-related protein 5 isoform X2

    9. XM_054368792.1XP_054224767.1  low-density lipoprotein receptor-related protein 5 isoform X8