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    WNT7A Wnt family member 7A [ Homo sapiens (human) ]

    Gene ID: 7476, updated on 17-Jun-2024

    Summary

    Official Symbol
    WNT7Aprovided by HGNC
    Official Full Name
    Wnt family member 7Aprovided by HGNC
    Primary source
    HGNC:HGNC:12786
    See related
    Ensembl:ENSG00000154764 MIM:601570; AllianceGenome:HGNC:12786
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    Wnt-7a
    Summary
    This gene is a member of the WNT gene family, which consists of structurally related genes that encode secreted signaling proteins. These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate and patterning during embryogenesis. This gene is involved in the development of the anterior-posterior axis in the female reproductive tract, and also plays a critical role in uterine smooth muscle pattering and maintenance of adult uterine function. Mutations in this gene are associated with Fuhrmann and Al-Awadi/Raas-Rothschild/Schinzel phocomelia syndromes. [provided by RefSeq, Jul 2008]
    Expression
    Biased expression in brain (RPKM 3.1), placenta (RPKM 2.3) and 9 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See WNT7A in Genome Data Viewer
    Location:
    3p25.1
    Exon count:
    7
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (13816258..13880071, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (13816895..13880668, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (13857755..13921568, complement)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC100293612 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13696034-13696534 Neighboring gene Sharpr-MPRA regulatory region 4110 Neighboring gene long intergenic non-protein coding RNA 620 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13716597-13717098 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13723071-13723616 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13738746-13739365 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13739985-13740604 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13742088-13742588 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13769563-13770149 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chr3:13770150-13770736 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13814826-13815326 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13822297-13822796 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13828435-13829175 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13829176-13829915 Neighboring gene tRNA suppressor (anticodon CTA) 2-1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13834054-13834694 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13875041-13875541 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13876230-13876730 Neighboring gene Sharpr-MPRA regulatory region 1149 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13894067-13894571 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr3:13895244-13896443 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:13920041-13920542 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr3:13921045-13921546 Neighboring gene uncharacterized LOC105376957 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 19494 Neighboring gene Sharpr-MPRA regulatory region 1925 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_64801 Neighboring gene vomeronasal 1 receptor 20 pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Fuhrmann syndrome
    MedGen: C1856728 OMIM: 228930 GeneReviews: Not available
    Compare labs
    Schinzel phocomelia syndrome
    MedGen: C1848651 OMIM: 276820 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Genome-wide association analysis of blood biomarkers in chronic obstructive pulmonary disease.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables cytokine activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables frizzled binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables receptor ligand activity IC
    Inferred by Curator
    more info
    PubMed 
    enables receptor ligand activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables signaling receptor binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in Wnt signaling pathway, planar cell polarity pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in angiogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in asymmetric protein localization involved in cell fate determination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in axonogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in canonical Wnt signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in canonical Wnt signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cartilage condensation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cell fate commitment IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell proliferation in forebrain IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in cellular response to transforming growth factor beta stimulus IEP
    Inferred from Expression Pattern
    more info
    PubMed 
    involved_in central nervous system vasculogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cerebellar granule cell differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in chondrocyte differentiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dendritic spine morphogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in dorsal/ventral pattern formation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in embryonic axis specification IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic digit morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic forelimb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in embryonic hindlimb morphogenesis IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in establishment of blood-brain barrier IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in establishment of cell polarity IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in excitatory synapse assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in lens fiber cell development ISS
    Inferred from Sequence or Structural Similarity
    more info
    PubMed 
    involved_in negative regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of neurogenesis IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in neuron differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in neurotransmitter secretion IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in oviduct development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of DNA-templated transcription IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of JNK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of endothelial cell migration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of epithelial cell proliferation involved in wound healing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of excitatory postsynaptic potential IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of excitatory synapse assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of gene expression IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of protein localization to presynapse TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in positive regulation of protein metabolic process IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of synapse assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of transcription by RNA polymerase II IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in postsynapse assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in presynapse assembly TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in regulation of axon diameter IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of postsynapse organization IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of presynapse assembly EXP
    Inferred from Experiment
    more info
    PubMed 
    involved_in regulation of presynapse assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in regulation of presynapse assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in regulation of synaptic vesicle exocytosis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to estradiol IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in response to estrogen IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in secondary palate development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in sex differentiation TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in skeletal muscle satellite cell activation IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in skeletal muscle satellite cell maintenance involved in skeletal muscle regeneration IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in somatic stem cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in somatic stem cell population maintenance IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in stem cell development IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in synaptic vesicle recycling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in uterus morphogenesis IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in wound healing, spreading of epidermal cells IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in Golgi lumen TAS
    Traceable Author Statement
    more info
     
    located_in Schaffer collateral - CA1 synapse IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cell surface IEA
    Inferred from Electronic Annotation
    more info
     
    located_in endocytic vesicle membrane TAS
    Traceable Author Statement
    more info
     
    located_in endoplasmic reticulum lumen TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome TAS
    Traceable Author Statement
    more info
     
    located_in extracellular matrix IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    is_active_in glutamatergic synapse EXP
    Inferred from Experiment
    more info
    PubMed 
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     
    located_in presynapse IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    protein Wnt-7a
    Names
    proto-oncogene Wnt7a protein
    wingless-type MMTV integration site family, member 7A

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_008088.1 RefSeqGene

      Range
      5001..66537
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004625.4NP_004616.2  protein Wnt-7a precursor

      See identical proteins and their annotated locations for NP_004616.2

      Status: REVIEWED

      Source sequence(s)
      AC090646, BC008811
      Consensus CDS
      CCDS2616.1
      UniProtKB/Swiss-Prot
      O00755, Q96H90, Q9Y560
      Related
      ENSP00000285018.4, ENST00000285018.5
      Conserved Domains (1) summary
      cd19349
      Location:32349
      Wnt_Wnt7a; Wnt domain found in protein Wnt-7a and similar proteins

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      13816258..13880071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047448863.1XP_047304819.1  protein Wnt-7a isoform X1

    2. XM_011534091.3XP_011532393.1  protein Wnt-7a isoform X1

      See identical proteins and their annotated locations for XP_011532393.1

      Conserved Domains (1) summary
      cl38924
      Location:1282
      Wnt; Wnt domain found in the WNT signaling gene family, also called Wingless-type mouse mammary tumor virus (MMTV) integration site family

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      13816895..13880668 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054347760.1XP_054203735.1  protein Wnt-7a isoform X1

    2. XM_054347759.1XP_054203734.1  protein Wnt-7a isoform X1