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    CRLF1 cytokine receptor like factor 1 [ Homo sapiens (human) ]

    Gene ID: 9244, updated on 31-Mar-2024

    Summary

    Official Symbol
    CRLF1provided by HGNC
    Official Full Name
    cytokine receptor like factor 1provided by HGNC
    Primary source
    HGNC:HGNC:2364
    See related
    Ensembl:ENSG00000006016 MIM:604237; AllianceGenome:HGNC:2364
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CLF; NR6; CISS; CISS1; CLF-1; zcytor5
    Summary
    This gene encodes a member of the cytokine type I receptor family. The protein forms a secreted complex with cardiotrophin-like cytokine factor 1 and acts on cells expressing ciliary neurotrophic factor receptors. The complex can promote survival of neuronal cells. Mutations in this gene result in Crisponi syndrome and cold-induced sweating syndrome. [provided by RefSeq, Oct 2009]
    Expression
    Broad expression in placenta (RPKM 4.8), brain (RPKM 3.2) and 15 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    19p13.11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 19 NC_000019.10 (18593237..18606799, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 19 NC_060943.1 (18728303..18741874, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 19 NC_000019.9 (18704047..18717609, complement)

    Chromosome 19 - NC_000019.10Genomic Context describing neighboring genes Neighboring gene KxDL motif containing 1 Neighboring gene ubiquitin A-52 residue ribosomal protein fusion product 1 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18682001-18682677 Neighboring gene H3K27ac hESC enhancer GRCh37_chr19:18683356-18684032 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10409 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18702459-18702982 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18703866-18704367 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10410 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 10411 Neighboring gene required for excision 1-B domain containing Neighboring gene Sharpr-MPRA regulatory region 11645 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr19:18716731-18717649 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr19:18724873-18725393 Neighboring gene transmembrane protein 59 like Neighboring gene ATAC-STARR-seq lymphoblastoid active region 14329 Neighboring gene RNA, 7SL, cytoplasmic 155, pseudogene

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    Related articles in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Tat tat Both HIV-1 Tat 47-59 and FITC-labeled Tat 47-59 peptides downregulate gene expression of cytokine receptor-like factor 1 (CRLF1) in U-937 macrophages PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    contributes_to ciliary neurotrophic factor receptor binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    contributes_to cytokine activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables cytokine binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables cytokine binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables cytokine receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of CRLF-CLCF1 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of CRLF-CLCF1 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    is_active_in external side of plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    located_in extracellular space TAS
    Traceable Author Statement
    more info
    PubMed 
    part_of receptor complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    cytokine receptor-like factor 1
    Names
    class I cytokine receptor
    cytokine type 1 receptor CRLP-1
    cytokine-like factor 1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_013370.1 RefSeqGene

      Range
      5052..18614
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_004750.5NP_004741.1  cytokine receptor-like factor 1 precursor

      See identical proteins and their annotated locations for NP_004741.1

      Status: REVIEWED

      Source sequence(s)
      AF073515, AY358291
      Consensus CDS
      CCDS32962.1
      UniProtKB/Swiss-Prot
      O75462, Q9UHH5
      UniProtKB/TrEMBL
      A0A804HI12
      Related
      ENSP00000376188.2, ENST00000392386.8
      Conserved Domains (3) summary
      cd00063
      Location:236338
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
      pfam06328
      Location:41104
      Lep_receptor_Ig; Ig-like C2-type domain
      cl21522
      Location:133228
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000019.10 Reference GRCh38.p14 Primary Assembly

      Range
      18593237..18606799 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060943.1 Alternate T2T-CHM13v2.0

      Range
      18728303..18741874 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)