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    POLR1C RNA polymerase I and III subunit C [ Homo sapiens (human) ]

    Gene ID: 9533, updated on 23-Nov-2023

    Summary

    Official Symbol
    POLR1Cprovided by HGNC
    Official Full Name
    RNA polymerase I and III subunit Cprovided by HGNC
    Primary source
    HGNC:HGNC:20194
    See related
    Ensembl:ENSG00000171453 MIM:610060; AllianceGenome:HGNC:20194
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    AC40; RPA5; TCS3; HLD11; RPA39; RPA40; RPAC1; RPC40
    Summary
    The protein encoded by this gene is a subunit of both RNA polymerase I and RNA polymerase III complexes. The encoded protein is part of the Pol core element. Mutations in this gene have been associated with Treacher Collins syndrome (TCS) and hypomyelinating leukodystrophy 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
    Expression
    Ubiquitous expression in testis (RPKM 7.7), skin (RPKM 5.6) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See POLR1C in Genome Data Viewer
    Location:
    6p21.1
    Exon count:
    14
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 6 NC_000006.12 (43517089..44461400)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 6 NC_060930.1 (43345828..44296039)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 6 NC_000006.11 (43484827..44429137)

    Chromosome 6 - NC_000006.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17233 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17234 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24602 Neighboring gene MPRA-validated peak5815 silencer Neighboring gene U7 small nuclear RNA Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17235 Neighboring gene small Cajal body-specific RNA 15 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr6:43514706-43515905 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24603 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43545520-43546020 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24604 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17236 Neighboring gene leucine rich repeat containing 73 Neighboring gene ribosomal protein S2 pseudogene 29 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:43579698-43579923 Neighboring gene Yip1 domain family member 3 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17237 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17238 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24605 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24606 Neighboring gene exportin 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43604555-43605342 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43605343-43606129 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:43612192-43612380 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24607 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24609 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24608 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24610 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24611 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17239 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43639230-43639862 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24612 Neighboring gene MAD2L1 binding protein Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:43655287-43655898 Neighboring gene uncharacterized LOC124901320 Neighboring gene DNA polymerase eta Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43670641-43671626 Neighboring gene GTP binding protein 2 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr6:43674891-43675733 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24614 Neighboring gene Sharpr-MPRA regulatory region 12588 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24615 Neighboring gene mitochondrial ribosomal protein S18A Neighboring gene radial spoke head component 9 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43726130-43726666 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43728022-43728522 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43728523-43729023 Neighboring gene EXOSC8 pseudogene 1 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43732509-43733010 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17241 Neighboring gene H3K27ac hESC enhancers GRCh37_chr6:43738373-43739138 and GRCh37_chr6:43739139-43739904 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43739905-43740670 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43740671-43741436 Neighboring gene Sharpr-MPRA regulatory region 8365 Neighboring gene uncharacterized LOC105375070 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24617 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43766999-43767583 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24618 Neighboring gene Sharpr-MPRA regulatory region 5169 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24619 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24620 Neighboring gene uncharacterized LOC105375069 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43819080-43819726 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43818433-43819079 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43819727-43820373 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43825966-43826637 Neighboring gene uncharacterized LOC105375068 Neighboring gene vascular endothelial growth factor A Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43845203-43845710 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43845711-43846218 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24621 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43857224-43858185 Neighboring gene long intergenic non-protein coding RNA 2537 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43854868-43855768 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43878694-43879258 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43879259-43879821 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43880895-43881684 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24622 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43893291-43894024 Neighboring gene long intergenic non-protein coding RNA 1512 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43911713-43912238 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43918399-43919384 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43932755-43933254 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24623 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43952691-43953286 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:43957693-43958202 Neighboring gene uncharacterized LOC124901321 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43961654-43962154 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24624 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17244 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:43972319-43972950 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:43977969-43979168 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44007317-44008074 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44009776-44010524 Neighboring gene Sharpr-MPRA regulatory region 2143 Neighboring gene long intergenic non-protein coding RNA 3040 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24625 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:44019358-44019952 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:44022316-44022816 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24626 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17245 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44030458-44031420 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24627 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24628 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17247 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17248 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24629 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24630 Neighboring gene stem cell inhibitory RNA transcript Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_91788 Neighboring gene Sharpr-MPRA regulatory region 9341 Neighboring gene Sharpr-MPRA regulatory region 15428 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:44069931-44070480 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:44070481-44071029 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_91802 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_91811 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:44075151-44075650 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_91827 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_91835 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_91840 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17250 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17251 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17252 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17253 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17254 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:44098898-44099057 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:44100902-44101867 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:44101868-44102832 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_91847 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_91852 Neighboring gene ribosomal protein L29 pseudogene 16 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_91874 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_91884 Neighboring gene uncharacterized LOC107986599 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_91890 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17255 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44134475-44135357 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr6:44137200-44138399 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44144390-44145092 Neighboring gene uncharacterized LOC105375072 Neighboring gene mitochondrial ribosomal protein L14 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44168290-44169290 Neighboring gene transmembrane protein 63B Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44170291-44171291 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44171292-44172291 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44169291-44170290 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:44181066-44181247 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44184149-44185034 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44185035-44185920 Neighboring gene Sharpr-MPRA regulatory region 7869 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17257 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44191161-44192019 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:44194558-44195156 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24631 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17259 Neighboring gene calpain 11 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44213140-44213894 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17260 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44214649-44215403 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24632 Neighboring gene RNA, 7SL, cytoplasmic 811, pseudogene Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:44222709-44223424 Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:44224854-44225567 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24637 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:44232415-44232914 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24636 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24635 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24634 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24633 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr6:44243146-44243938 Neighboring gene solute carrier family 29 member 1 (Augustine blood group) Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17263 Neighboring gene heat shock protein 90 alpha family class B member 1 Neighboring gene uncharacterized LOC124901322 Neighboring gene myomixer, myoblast fusion factor Neighboring gene H3K27ac hESC enhancer GRCh37_chr6:44280829-44281388 Neighboring gene microRNA 4647 Neighboring gene transmembrane protein 151B Neighboring gene solute carrier family 35 member B2 Neighboring gene NFKB inhibitor epsilon Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_91950 Neighboring gene t-complex-associated-testis-expressed 1 Neighboring gene uncharacterized LOC124901323 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24638 Neighboring gene alanyl-tRNA synthetase 2, mitochondrial Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24639 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 24640 Neighboring gene spermatogenesis associated serine rich 1 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 17264 Neighboring gene CRISPRi-validated cis-regulatory element chr6.3216 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44443176-44443706 Neighboring gene ReSE screen-validated silencer GRCh37_chr6:44447928-44448147 Neighboring gene cell division cycle 5 like Neighboring gene microRNA 4642 Neighboring gene uncharacterized LOC105375074 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr6:44510389-44511019 Neighboring gene uncharacterized LOC105375075

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA-directed 5'-3' RNA polymerase activity TAS
    Traceable Author Statement
    more info
    PubMed 
    contributes_to RNA polymerase I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to RNA polymerase III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein dimerization activity IEA
    Inferred from Electronic Annotation
    more info
     
    Process Evidence Code Pubs
    involved_in transcription by RNA polymerase I TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in transcription by RNA polymerase III IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    part_of RNA polymerase I complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of RNA polymerase III complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of RNA polymerase III complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in fibrillar center IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    DNA-directed RNA polymerases I and III subunit RPAC1
    Names
    DNA-directed RNA polymerase I subunit C
    DNA-directed RNA polymerases I and III 40 kDa polypeptide
    RNA polymerase I subunit C
    RNA polymerases I and III subunit AC1
    polymerase (RNA) I polypeptide C, 30kDa
    polymerase (RNA) I subunit C

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_028283.4 RefSeqGene

      Range
      5002..9426
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001318876.2NP_001305805.1  DNA-directed RNA polymerases I and III subunit RPAC1 isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 3' terminal exon, resulting in a different 3' coding region and 3' UTR compared to variant 1. The encoded isoform (2) has a shorter, distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AF047441, BC008863, DW415914
      UniProtKB/TrEMBL
      A0A2R8Y5D3
      Conserved Domains (2) summary
      cd07032
      Location:49307
      RNAP_I_II_AC40; AC40 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III
      smart00662
      Location:61267
      RPOLD; RNA polymerases D
    2. NM_001363658.2NP_001350587.1  DNA-directed RNA polymerases I and III subunit RPAC1 isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 1. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 1.
      Source sequence(s)
      AL355802
      Consensus CDS
      CCDS87408.1
      UniProtKB/TrEMBL
      A0A2R8Y5D3, A0A2R8YEZ4
      Related
      ENSP00000496018.1, ENST00000643341.1
      Conserved Domains (1) summary
      cd07032
      Location:49307
      RNAP_I_II_AC40; AC40 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III
    3. NM_203290.4NP_976035.1  DNA-directed RNA polymerases I and III subunit RPAC1 isoform 1

      See identical proteins and their annotated locations for NP_976035.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BC008863, DW415914
      Consensus CDS
      CCDS4901.1
      UniProtKB/Swiss-Prot
      O15160, O75395, Q5JTE3
      UniProtKB/TrEMBL
      Q96HT3
      Related
      ENSP00000496044.1, ENST00000642195.1
      Conserved Domains (1) summary
      cd07032
      Location:49339
      RNAP_I_II_AC40; AC40 subunit of Eukaryotic RNA polymerase (RNAP) I and RNAP III

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000006.12 Reference GRCh38.p14 Primary Assembly

      Range
      43517089..44461400
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047419577.1XP_047275533.1  DNA-directed RNA polymerases I and III subunit RPAC1 isoform X1

      UniProtKB/TrEMBL
      A0A2R8Y5D3
      Related
      ENSP00000307212.3, ENST00000304004.7

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060930.1 Alternate T2T-CHM13v2.0

      Range
      43345828..44296039
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054356856.1XP_054212831.1  DNA-directed RNA polymerases I and III subunit RPAC1 isoform X1

      UniProtKB/TrEMBL
      A0A2R8Y5D3

    Suppressed Reference Sequence(s)

    The following Reference Sequences have been suppressed. Explain

    1. NM_004875.2: Suppressed sequence

      Description
      NM_004875.2: This RefSeq was permanently suppressed because currently there is insufficient support for the transcript and the protein.