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    FGF3 fibroblast growth factor 3 [ Homo sapiens (human) ]

    Gene ID: 2248, updated on 11-Apr-2024

    Summary

    Official Symbol
    FGF3provided by HGNC
    Official Full Name
    fibroblast growth factor 3provided by HGNC
    Primary source
    HGNC:HGNC:3681
    See related
    Ensembl:ENSG00000186895 MIM:164950; AllianceGenome:HGNC:3681
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    INT2; HBGF-3
    Summary
    The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities and are involved in a variety of biological processes including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. This gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary tumors in the mouse. Frequent amplification of this gene has been found in human tumors, which may be important for neoplastic transformation and tumor progression. Studies of the similar genes in mouse and chicken suggested the role in inner ear formation. [provided by RefSeq, Jul 2008]
    Expression
    Low expression observed in reference dataset See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Location:
    11q13.3
    Exon count:
    3
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 11 NC_000011.10 (69809968..69819416, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 11 NC_060935.1 (69826890..69836324, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 11 NC_000011.9 (69624736..69634184, complement)

    Chromosome 11 - NC_000011.10Genomic Context describing neighboring genes Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69555555-69556140 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69556141-69556725 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69565172-69565761 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69565762-69566352 Neighboring gene DNAJB6 pseudogene 5 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69579027-69580027 Neighboring gene FGF4 3' enhancer Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69588083-69589008 Neighboring gene FGF4 promoter region Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69596435-69596972 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69596973-69597508 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69604158-69604702 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69603612-69604157 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69605134-69605838 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69605839-69606541 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69612316-69613027 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69613028-69613738 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69615738-69616268 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69631724-69632244 Neighboring gene FGF3 5' regulatory region Neighboring gene uncharacterized LOC107984368 Neighboring gene fibroblast growth factor 4 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69640403-69641083 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69647091-69647682 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69649493-69650298 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69651106-69651911 Neighboring gene MPRA-validated peak1329 silencer Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:69657667-69658333 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr11:69661705-69662302 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_21658 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69679525-69680082 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69680083-69680640 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69680641-69681198 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69693599-69694230 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69698210-69698710 Neighboring gene Sharpr-MPRA regulatory region 8845 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69705859-69706454 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69720311-69720812 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69724011-69724512 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr11:69778215-69779191 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69789289-69790190 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr11:69794428-69795627 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69810871-69811654 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69812439-69813222 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69823537-69824036 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69827276-69827998 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr11:69827999-69828721 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69832189-69833006 Neighboring gene anoctamin 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr11:69871617-69872015 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr11:69881245-69881784 Neighboring gene uncharacterized LOC105369371 Neighboring gene long intergenic non-protein coding RNA 2753

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    EBI GWAS Catalog

    Description
    A genome-wide association study identifies protein quantitative trait loci (pQTLs).
    EBI GWAS Catalog
    Genome-wide association study identifies five new breast cancer susceptibility loci.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables fibroblast growth factor receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables growth factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in anatomical structure morphogenesis TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in animal organ morphogenesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell differentiation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in cell-cell signaling TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in fibroblast growth factor receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within fibroblast growth factor receptor signaling pathway IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in negative regulation of cardiac muscle tissue development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in positive regulation of MAPK cascade IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in positive regulation of cell population proliferation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    acts_upstream_of_or_within positive regulation of cell population proliferation IGI
    Inferred from Genetic Interaction
    more info
    PubMed 
    involved_in positive regulation of gene expression IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of protein phosphorylation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of cell migration IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in signal transduction TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular region TAS
    Traceable Author Statement
    more info
     
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    fibroblast growth factor 3
    Names
    FGF-3
    INT-2 proto-oncogene protein
    V-INT2 murine mammary tumor virus integration site oncogene homolog
    fibroblast growth factor 3 (murine mammary tumor virus integration site (v-int-2) oncogene homolog)
    heparin-binding growth factor 3
    murine mammary tumor virus integration site 2, mouse
    oncogene INT2
    proto-oncogene Int-2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_009016.1 RefSeqGene

      Range
      5009..14457
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1303

    mRNA and Protein(s)

    1. NM_005247.4NP_005238.1  fibroblast growth factor 3 precursor

      See identical proteins and their annotated locations for NP_005238.1

      Status: REVIEWED

      Source sequence(s)
      AP006345, BC113739
      Consensus CDS
      CCDS8195.1
      UniProtKB/Swiss-Prot
      P11487, Q0VG69
      UniProtKB/TrEMBL
      A0A7U3JVY0
      Related
      ENSP00000334122.2, ENST00000334134.4
      Conserved Domains (1) summary
      pfam00167
      Location:44179
      FGF; Fibroblast growth factor

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000011.10 Reference GRCh38.p14 Primary Assembly

      Range
      69809968..69819416 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060935.1 Alternate T2T-CHM13v2.0

      Range
      69826890..69836324 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)