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    TFG trafficking from ER to golgi regulator [ Homo sapiens (human) ]

    Gene ID: 10342, updated on 4-Feb-2024

    Summary

    Official Symbol
    TFGprovided by HGNC
    Official Full Name
    trafficking from ER to golgi regulatorprovided by HGNC
    Primary source
    HGNC:HGNC:11758
    See related
    Ensembl:ENSG00000114354 MIM:602498; AllianceGenome:HGNC:11758
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TF6; HMSNP; SPG57; TRKT3
    Summary
    There are several documented fusion oncoproteins encoded partially by this gene. This gene also participates in several oncogenic rearrangements resulting in anaplastic lymphoma and mixoid chondrosarcoma, and may play a role in the NF-kappaB pathway. Multiple transcript variants have been found for this gene. [provided by RefSeq, Sep 2010]
    Expression
    Ubiquitous expression in duodenum (RPKM 35.2), placenta (RPKM 33.3) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TFG in Genome Data Viewer
    Location:
    3q12.2
    Exon count:
    10
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 3 NC_000003.12 (100709290..100748967)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 3 NC_060927.1 (103415045..103454716)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 3 NC_000003.11 (100428134..100467811)

    Chromosome 3 - NC_000003.12Genomic Context describing neighboring genes Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14573 Neighboring gene transmembrane protein 45A Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:100280470-100281334 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 14574 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20161 Neighboring gene adhesion G protein-coupled receptor G7 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20162 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 20163 Neighboring gene glia maturation factor beta pseudogene 1 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:100427906-100428797 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr3:100428798-100429688 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr3:100456051-100456928 Neighboring gene uncharacterized LOC124906260 Neighboring gene ABI family member 3 binding protein Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_63759 Neighboring gene Sharpr-MPRA regulatory region 7106 Neighboring gene Neanderthal introgressed variant-containing enhancer experimental_63902 Neighboring gene ABRAXAS1 pseudogene 1

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    protein TFG
    Names
    TRK-fused
    TRK-fused gene protein
    TRKT3 oncogene

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_027821.2 RefSeqGene

      Range
      5205..44675
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001007565.2NP_001007566.1  protein TFG isoform 1

      See identical proteins and their annotated locations for NP_001007566.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein (isoform 1).
      Source sequence(s)
      AC069223, BQ008360, DA704111
      Consensus CDS
      CCDS2939.1
      UniProtKB/Swiss-Prot
      D3DN49, G5E9V1, K0J5S8, K0J6K2, Q92734, Q969I2
      UniProtKB/TrEMBL
      Q7Z426
      Related
      ENSP00000419960.1, ENST00000490574.6
      Conserved Domains (2) summary
      cd06401
      Location:1191
      PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
      cl28271
      Location:325400
      dnaA; chromosomal replication initiation protein; Provisional
    2. NM_001195478.2NP_001182407.1  protein TFG isoform 1

      See identical proteins and their annotated locations for NP_001182407.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR, compared to variant 1. Variants 1, 2, and 3 encode the same protein (isoform 1).
      Source sequence(s)
      AC069223, BC001483
      Consensus CDS
      CCDS2939.1
      UniProtKB/Swiss-Prot
      D3DN49, G5E9V1, K0J5S8, K0J6K2, Q92734, Q969I2
      UniProtKB/TrEMBL
      Q7Z426
      Related
      ENSP00000501815.1, ENST00000675553.1
      Conserved Domains (2) summary
      cd06401
      Location:1191
      PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
      cl28271
      Location:325400
      dnaA; chromosomal replication initiation protein; Provisional
    3. NM_001195479.2NP_001182408.1  protein TFG isoform 2

      See identical proteins and their annotated locations for NP_001182408.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) utilizes an alternate splice site in the coding region, compared to variant 1. Isoform 2 is shorter than isoform 1.
      Source sequence(s)
      AC069223, BC009241, BC041600
      Consensus CDS
      CCDS56266.1
      UniProtKB/TrEMBL
      Q7Z426
      Related
      ENSP00000501892.1, ENST00000674645.1
      Conserved Domains (2) summary
      cd06401
      Location:1191
      PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
      cl28271
      Location:321396
      dnaA; chromosomal replication initiation protein; Provisional
    4. NM_006070.6NP_006061.2  protein TFG isoform 1

      See identical proteins and their annotated locations for NP_006061.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript, Variants 1, 2, and 3 encode the same protein (isoform 1).
      Source sequence(s)
      AK093456, BC009241
      Consensus CDS
      CCDS2939.1
      UniProtKB/Swiss-Prot
      D3DN49, G5E9V1, K0J5S8, K0J6K2, Q92734, Q969I2
      UniProtKB/TrEMBL
      Q7Z426
      Related
      ENSP00000240851.4, ENST00000240851.9
      Conserved Domains (2) summary
      cd06401
      Location:1191
      PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
      cl28271
      Location:325400
      dnaA; chromosomal replication initiation protein; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000003.12 Reference GRCh38.p14 Primary Assembly

      Range
      100709290..100748967
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_005247066.3XP_005247123.1  protein TFG isoform X2

      See identical proteins and their annotated locations for XP_005247123.1

      UniProtKB/TrEMBL
      Q7Z426
      Related
      ENSP00000502497.1, ENST00000675047.1
      Conserved Domains (2) summary
      cd06401
      Location:1191
      PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
      cl28271
      Location:321396
      dnaA; chromosomal replication initiation protein; Provisional
    2. XM_006713472.2XP_006713535.1  protein TFG isoform X1

      See identical proteins and their annotated locations for XP_006713535.1

      UniProtKB/Swiss-Prot
      D3DN49, G5E9V1, K0J5S8, K0J6K2, Q92734, Q969I2
      UniProtKB/TrEMBL
      Q7Z426
      Related
      ENSP00000502071.1, ENST00000676395.1
      Conserved Domains (2) summary
      cd06401
      Location:1191
      PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
      cl28271
      Location:325400
      dnaA; chromosomal replication initiation protein; Provisional
    3. XM_017005527.2XP_016861016.1  protein TFG isoform X2

      UniProtKB/TrEMBL
      Q7Z426
      Related
      ENSP00000419504.2, ENST00000463568.6
      Conserved Domains (2) summary
      cd06401
      Location:1191
      PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
      cl28271
      Location:321396
      dnaA; chromosomal replication initiation protein; Provisional
    4. XM_047447243.1XP_047303199.1  protein TFG isoform X2

      UniProtKB/TrEMBL
      Q7Z426
      Related
      ENSP00000502698.1, ENST00000676431.1
    5. XM_047447241.1XP_047303197.1  protein TFG isoform X1

      UniProtKB/Swiss-Prot
      D3DN49, G5E9V1, K0J5S8, K0J6K2, Q92734, Q969I2
      UniProtKB/TrEMBL
      Q7Z426
    6. XM_011512334.2XP_011510636.1  protein TFG isoform X1

      See identical proteins and their annotated locations for XP_011510636.1

      UniProtKB/Swiss-Prot
      D3DN49, G5E9V1, K0J5S8, K0J6K2, Q92734, Q969I2
      UniProtKB/TrEMBL
      Q7Z426
      Related
      ENSP00000420797.2, ENST00000487505.6
      Conserved Domains (2) summary
      cd06401
      Location:1191
      PB1_TFG; The PB1 domain found in TFG protein, an oncogenic gene product and fusion partner to nerve growth factor tyrosine kinase receptor TrkA and to the tyrosine kinase ALK. The PB1 domain is a modular domain mediating specific protein-protein interaction in ...
      cl28271
      Location:325400
      dnaA; chromosomal replication initiation protein; Provisional
    7. XM_047447242.1XP_047303198.1  protein TFG isoform X2

      UniProtKB/TrEMBL
      Q7Z426
    8. XM_047447244.1XP_047303200.1  protein TFG isoform X2

      UniProtKB/TrEMBL
      Q7Z426

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060927.1 Alternate T2T-CHM13v2.0

      Range
      103415045..103454716
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054344922.1XP_054200897.1  protein TFG isoform X2

      UniProtKB/TrEMBL
      Q7Z426
    2. XM_054344919.1XP_054200894.1  protein TFG isoform X1

      UniProtKB/Swiss-Prot
      D3DN49, G5E9V1, K0J5S8, K0J6K2, Q92734, Q969I2
      UniProtKB/TrEMBL
      Q7Z426
    3. XM_054344923.1XP_054200898.1  protein TFG isoform X2

      UniProtKB/TrEMBL
      Q7Z426
    4. XM_054344925.1XP_054200900.1  protein TFG isoform X2

      UniProtKB/TrEMBL
      Q7Z426
    5. XM_054344920.1XP_054200895.1  protein TFG isoform X1

      UniProtKB/Swiss-Prot
      D3DN49, G5E9V1, K0J5S8, K0J6K2, Q92734, Q969I2
      UniProtKB/TrEMBL
      Q7Z426
    6. XM_054344921.1XP_054200896.1  protein TFG isoform X1

      UniProtKB/Swiss-Prot
      D3DN49, G5E9V1, K0J5S8, K0J6K2, Q92734, Q969I2
      UniProtKB/TrEMBL
      Q7Z426
    7. XM_054344924.1XP_054200899.1  protein TFG isoform X2

      UniProtKB/TrEMBL
      Q7Z426
    8. XM_054344926.1XP_054200901.1  protein TFG isoform X2

      UniProtKB/TrEMBL
      Q7Z426