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    DICER1 dicer 1, ribonuclease III [ Homo sapiens (human) ]

    Gene ID: 23405, updated on 11-Jun-2024

    Summary

    Official Symbol
    DICER1provided by HGNC
    Official Full Name
    dicer 1, ribonuclease IIIprovided by HGNC
    Primary source
    HGNC:HGNC:17098
    See related
    Ensembl:ENSG00000100697 MIM:606241; AllianceGenome:HGNC:17098
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    DCR1; GLOW; MNG1; aviD; Dicer; HERNA; RMSE2; Dicer1e; K12H4.8-LIKE
    Summary
    This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2021]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
    Expression
    Ubiquitous expression in appendix (RPKM 6.6), placenta (RPKM 6.6) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See DICER1 in Genome Data Viewer
    Location:
    14q32.13
    Exon count:
    36
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 14 NC_000014.9 (95086228..95158010, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 14 NC_060938.1 (89316445..89388228, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 14 NC_000014.8 (95552565..95624347, complement)

    Chromosome 14 - NC_000014.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC107984646 Neighboring gene long intergenic non-protein coding RNA 2279 Neighboring gene NANOG hESC enhancer GRCh37_chr14:95446338-95446918 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:95469279-95469780 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:95511279-95511812 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:95511813-95512347 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:95522504-95523004 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6041 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6042 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8947 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8948 Neighboring gene microRNA 3173 Neighboring gene DICER1 antisense RNA 1 Neighboring gene ReSE screen-validated silencer GRCh37_chr14:95662653-95662819 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:95665195-95666123 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8949 Neighboring gene calmin Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8950 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:95719574-95720500 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:95720501-95721426 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr14:95721427-95722352 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:95725084-95725755 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:95725756-95726426 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:95727628-95728254 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr14:95731514-95732713 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr14:95769323-95769824 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6044 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8954 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8955 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 6045 Neighboring gene uncharacterized LOC105370637 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 8956

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Copy number response

    Description
    Copy number response
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2022-02-09)

    ClinGen Genome Curation PagePubMed
    Triplosensitivity

    No evidence available (Last evaluated 2022-02-09)

    ClinGen Genome Curation Page

    EBI GWAS Catalog

    Description
    Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study.
    EBI GWAS Catalog
    Genome-wide association of lipid-lowering response to statins in combined study populations.
    EBI GWAS Catalog

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of dicer 1, ribonuclease type III (DICER1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells PubMed

    Protein interactions

    Protein Gene Interaction Pubs
    Pr55(Gag) gag Knockdown of Dicer by shRNA leads to inhibit enrichment of HIV-1 Gag in intracellular vacuoles, but enhance viral particle release in Gag expressing cells PubMed
    gag Interaction of HIV-1 Gag with dicer 1, ribonuclease type III (DICER1) is identified in a series of six affinity purification/mass spectrometry screens PubMed
    Rev rev The arginine rich motif (residues 35-50) of HIV-1 Rev inhibits Dicer dependent RNAi process PubMed
    Tat tat The arginine rich motif (residues 48-58) of HIV-1 Tat inhibits Dicer dependent RNAi process PubMed
    tat HIV-1 Tat-Dicer interaction requires RNA; Dicer's helicase domain (residues 246-585) and a portion of Tat amino acids 30-72 are involved in the interaction PubMed
    Vpr vpr HIV-1 Vpr-induced downregulation of Dicer is not dependent on G2 cell cycle arrest but on the Cul4A-DCAF1-DDB1 ubiquitin ligase complex PubMed
    vpr HIV-1 Vpr complexes with Dicer and induces downregulation of Dicer in HIV-1 infected cells PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • KIAA0928

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables RNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables RNA endonuclease activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables RNA endonuclease activity IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables RNA endonuclease activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables deoxyribonuclease I activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables double-stranded RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables double-stranded RNA binding IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    enables helicase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    contributes_to pre-miRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables pre-miRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein domain specific binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables ribonuclease III activity EXP
    Inferred from Experiment
    more info
    PubMed 
    enables ribonuclease III activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables ribonuclease III activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables ribonuclease III activity TAS
    Traceable Author Statement
    more info
     
    enables siRNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in RISC complex assembly IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in apoptotic DNA fragmentation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in global gene silencing by mRNA cleavage IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in miRNA metabolic process TAS
    Traceable Author Statement
    more info
     
    involved_in miRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in miRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in miRNA processing ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in negative regulation of Schwann cell proliferation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of gene expression IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in negative regulation of transcription by RNA polymerase II ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of negative regulation of tumor necrosis factor production IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    acts_upstream_of negative regulation of tumor necrosis factor-mediated signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in nerve development ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in neuron projection morphogenesis ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in peripheral nervous system myelin formation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of Schwann cell differentiation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in positive regulation of myelination ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in pre-miRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in pre-miRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in siRNA processing IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in siRNA processing IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in siRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in siRNA processing TAS
    Traceable Author Statement
    more info
     
    involved_in tRNA decay TAS
    Traceable Author Statement
    more info
     
    Component Evidence Code Pubs
    NOT part_of RISC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of RISC complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of RISC-loading complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of RISC-loading complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of RISC-loading complex IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    located_in extracellular exosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in perinuclear region of cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    endoribonuclease Dicer
    Names
    Dicer1, Dcr-1 homolog
    dicer 1, double-stranded RNA-specific endoribonuclease
    dicer 1, ribonuclease type III
    helicase MOI
    helicase with RNAse motif
    NP_001182502.1
    NP_001258211.1
    NP_001278557.1
    NP_001382606.1
    NP_001382607.1
    NP_001382608.1
    NP_001382609.1
    NP_001382611.1
    NP_001382612.1
    NP_001382613.1
    NP_001382614.1
    NP_001382615.1
    NP_001382616.1
    NP_001382617.1
    NP_001382618.1
    NP_001382619.1
    NP_001382620.1
    NP_001382621.1
    NP_001382622.1
    NP_001382623.1
    NP_001382624.1
    NP_001382625.1
    NP_001382626.1
    NP_001382627.1
    NP_001382628.1
    NP_001382629.1
    NP_085124.2
    NP_803187.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016311.1 RefSeqGene

      Range
      4413..76195
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_492

    mRNA and Protein(s)

    1. NM_001195573.1NP_001182502.1  endoribonuclease Dicer isoform 2

      See identical proteins and their annotated locations for NP_001182502.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 2. The resulting isoform 2 (also called t-Dicer) is shorter and has a distinct C-terminus, compared to isoform 1.
      Source sequence(s)
      AL356017, AL390254, HM595745
      Consensus CDS
      CCDS55941.1
      UniProtKB/TrEMBL
      A0A8Q3SJI0, A0A8Q3WLJ5
      Related
      ENSP00000444719.1, ENST00000541352.5
      Conserved Domains (10) summary
      smart00535
      Location:12961387
      RIBOc; Ribonuclease III family
      smart00487
      Location:40242
      DEXDc; DEAD-like helicases superfamily
      COG0513
      Location:445589
      SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]
      COG0571
      Location:16661765
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd00046
      Location:58209
      DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.
      cd00593
      Location:16821767
      RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...
      cd02843
      Location:8861008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      pfam00271
      Location:445553
      Helicase_C; Helicase conserved C-terminal domain
      pfam03368
      Location:631714
      Dicer_dimer; Dicer dimerization domain
    2. NM_001271282.3NP_001258211.1  endoribonuclease Dicer isoform 1

      See identical proteins and their annotated locations for NP_001258211.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 2. Variants 1, 2, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      AF007142, AJ132261, AL390254
      Consensus CDS
      CCDS9931.1
      UniProtKB/Swiss-Prot
      A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Related
      ENSP00000435681.1, ENST00000527414.5
      Conserved Domains (7) summary
      smart00535
      Location:12961387
      RIBOc; Ribonuclease III family
      COG0571
      Location:16661918
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:8861008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:372564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      pfam03368
      Location:630718
      Dicer_dimer; Dicer dimerization domain
    3. NM_001291628.2NP_001278557.1  endoribonuclease Dicer isoform 1

      See identical proteins and their annotated locations for NP_001278557.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) lacks an internal segment in the 5' UTR, compared to variant 2. Variants 1, 2, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      AF007142, AJ132261, AL390254, AY845868, BM152875
      Consensus CDS
      CCDS9931.1
      UniProtKB/Swiss-Prot
      A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Conserved Domains (7) summary
      smart00535
      Location:12961387
      RIBOc; Ribonuclease III family
      COG0571
      Location:16661918
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:8861008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:372564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      pfam03368
      Location:630718
      Dicer_dimer; Dicer dimerization domain
    4. NM_001395677.1NP_001382606.1  endoribonuclease Dicer isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      Consensus CDS
      CCDS9931.1
      UniProtKB/Swiss-Prot
      A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Conserved Domains (7) summary
      smart00535
      Location:12961387
      RIBOc; Ribonuclease III family
      COG0571
      Location:16661918
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:8861008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:372564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      pfam03368
      Location:630718
      Dicer_dimer; Dicer dimerization domain
    5. NM_001395678.1NP_001382607.1  endoribonuclease Dicer isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      Consensus CDS
      CCDS9931.1
      UniProtKB/Swiss-Prot
      A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Conserved Domains (7) summary
      smart00535
      Location:12961387
      RIBOc; Ribonuclease III family
      COG0571
      Location:16661918
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:8861008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:372564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      pfam03368
      Location:630718
      Dicer_dimer; Dicer dimerization domain
    6. NM_001395679.1NP_001382608.1  endoribonuclease Dicer isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      Consensus CDS
      CCDS9931.1
      UniProtKB/Swiss-Prot
      A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Related
      ENSP00000376783.1, ENST00000393063.6
      Conserved Domains (7) summary
      smart00535
      Location:12961387
      RIBOc; Ribonuclease III family
      COG0571
      Location:16661918
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:8861008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:372564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      pfam03368
      Location:630718
      Dicer_dimer; Dicer dimerization domain
    7. NM_001395680.1NP_001382609.1  endoribonuclease Dicer isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      Consensus CDS
      CCDS9931.1
      UniProtKB/Swiss-Prot
      A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Conserved Domains (7) summary
      smart00535
      Location:12961387
      RIBOc; Ribonuclease III family
      COG0571
      Location:16661918
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:8861008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:372564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      pfam03368
      Location:630718
      Dicer_dimer; Dicer dimerization domain
    8. NM_001395682.1NP_001382611.1  endoribonuclease Dicer isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      Consensus CDS
      CCDS9931.1
      UniProtKB/Swiss-Prot
      A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Related
      ENSP00000502730.2, ENST00000674628.2
      Conserved Domains (7) summary
      smart00535
      Location:12961387
      RIBOc; Ribonuclease III family
      COG0571
      Location:16661918
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:8861008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:372564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      pfam03368
      Location:630718
      Dicer_dimer; Dicer dimerization domain
    9. NM_001395683.1NP_001382612.1  endoribonuclease Dicer isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      Consensus CDS
      CCDS9931.1
      UniProtKB/Swiss-Prot
      A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Conserved Domains (7) summary
      smart00535
      Location:12961387
      RIBOc; Ribonuclease III family
      COG0571
      Location:16661918
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:8861008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:372564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      pfam03368
      Location:630718
      Dicer_dimer; Dicer dimerization domain
    10. NM_001395684.1NP_001382613.1  endoribonuclease Dicer isoform 1

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      Consensus CDS
      CCDS9931.1
      UniProtKB/Swiss-Prot
      A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Conserved Domains (7) summary
      smart00535
      Location:12961387
      RIBOc; Ribonuclease III family
      COG0571
      Location:16661918
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:8861008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:372564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      pfam03368
      Location:630718
      Dicer_dimer; Dicer dimerization domain
    11. NM_001395685.1NP_001382614.1  endoribonuclease Dicer isoform 3

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Related
      ENSP00000512838.1, ENST00000696733.1
      Conserved Domains (6) summary
      smart00535
      Location:12961387
      RIBOc; Ribonuclease III family
      cd00593
      Location:16821842
      RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...
      cd02843
      Location:8861008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:372564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
    12. NM_001395686.1NP_001382615.1  endoribonuclease Dicer isoform 4

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Conserved Domains (6) summary
      smart00535
      Location:12021293
      RIBOc; Ribonuclease III family
      COG0571
      Location:15721824
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:792914
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:177271
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:278470
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:11145
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
    13. NM_001395687.1NP_001382616.1  endoribonuclease Dicer isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Conserved Domains (7) summary
      smart00535
      Location:11611252
      RIBOc; Ribonuclease III family
      COG0571
      Location:15311783
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:751873
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:136230
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:237429
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      pfam03368
      Location:495583
      Dicer_dimer; Dicer dimerization domain
      cl28899
      Location:12104
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    14. NM_001395688.1NP_001382617.1  endoribonuclease Dicer isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Conserved Domains (7) summary
      smart00535
      Location:11611252
      RIBOc; Ribonuclease III family
      COG0571
      Location:15311783
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:751873
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:136230
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:237429
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      pfam03368
      Location:495583
      Dicer_dimer; Dicer dimerization domain
      cl28899
      Location:12104
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    15. NM_001395689.1NP_001382618.1  endoribonuclease Dicer isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Related
      ENST00000696921.1
      Conserved Domains (7) summary
      smart00535
      Location:11611252
      RIBOc; Ribonuclease III family
      COG0571
      Location:15311783
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:751873
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:136230
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:237429
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      pfam03368
      Location:495583
      Dicer_dimer; Dicer dimerization domain
      cl28899
      Location:12104
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    16. NM_001395690.1NP_001382619.1  endoribonuclease Dicer isoform 5

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Conserved Domains (7) summary
      smart00535
      Location:11611252
      RIBOc; Ribonuclease III family
      COG0571
      Location:15311783
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:751873
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:136230
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:237429
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      pfam03368
      Location:495583
      Dicer_dimer; Dicer dimerization domain
      cl28899
      Location:12104
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    17. NM_001395691.1NP_001382620.1  endoribonuclease Dicer isoform 6

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Conserved Domains (6) summary
      smart00535
      Location:11071198
      RIBOc; Ribonuclease III family
      COG0571
      Location:14771729
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:697819
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:82176
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:183375
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cl28899
      Location:150
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    18. NM_001395692.1NP_001382621.1  endoribonuclease Dicer isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      Consensus CDS
      CCDS91926.1
      UniProtKB/TrEMBL
      A0A8Q3WLJ5, H0YJZ6
      Related
      ENSP00000452556.2, ENST00000532939.3
      Conserved Domains (6) summary
      smart00535
      Location:12961387
      RIBOc; Ribonuclease III family
      cd02843
      Location:8861008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      TIGR02191
      Location:16691708
      RNaseIII; ribonuclease III, bacterial
      cd15903
      Location:271365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:372564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
    19. NM_001395693.1NP_001382622.1  endoribonuclease Dicer isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      Consensus CDS
      CCDS91926.1
      UniProtKB/TrEMBL
      A0A8Q3WLJ5, H0YJZ6
      Related
      ENSP00000512841.1, ENST00000696737.1
      Conserved Domains (6) summary
      smart00535
      Location:12961387
      RIBOc; Ribonuclease III family
      cd02843
      Location:8861008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      TIGR02191
      Location:16691708
      RNaseIII; ribonuclease III, bacterial
      cd15903
      Location:271365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:372564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
    20. NM_001395694.1NP_001382623.1  endoribonuclease Dicer isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      Consensus CDS
      CCDS91926.1
      UniProtKB/TrEMBL
      A0A8Q3WLJ5, H0YJZ6
      Conserved Domains (6) summary
      smart00535
      Location:12961387
      RIBOc; Ribonuclease III family
      cd02843
      Location:8861008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      TIGR02191
      Location:16691708
      RNaseIII; ribonuclease III, bacterial
      cd15903
      Location:271365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:372564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
    21. NM_001395695.1NP_001382624.1  endoribonuclease Dicer isoform 7

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      Consensus CDS
      CCDS91926.1
      UniProtKB/TrEMBL
      A0A8Q3WLJ5, H0YJZ6
      Conserved Domains (6) summary
      smart00535
      Location:12961387
      RIBOc; Ribonuclease III family
      cd02843
      Location:8861008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      TIGR02191
      Location:16691708
      RNaseIII; ribonuclease III, bacterial
      cd15903
      Location:271365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:372564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
    22. NM_001395696.1NP_001382625.1  endoribonuclease Dicer isoform 8

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      UniProtKB/TrEMBL
      A0A8Q3WLJ5
      Conserved Domains (6) summary
      smart00535
      Location:11611252
      RIBOc; Ribonuclease III family
      cd02843
      Location:751873
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      TIGR02191
      Location:15341573
      RNaseIII; ribonuclease III, bacterial
      cd15903
      Location:136230
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:237429
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cl28899
      Location:12104
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    23. NM_001395697.1NP_001382626.1  endoribonuclease Dicer isoform 9

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      Conserved Domains (3) summary
      smart00535
      Location:735826
      RIBOc; Ribonuclease III family
      COG0571
      Location:11051357
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:325447
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
    24. NM_001395698.1NP_001382627.1  endoribonuclease Dicer isoform 10

      Status: REVIEWED

      Source sequence(s)
      AL356017
      Conserved Domains (3) summary
      cd15903
      Location:136230
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:237429
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cl28899
      Location:12104
      DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
    25. NM_001395699.1NP_001382628.1  endoribonuclease Dicer isoform 11

      Status: REVIEWED

      Source sequence(s)
      AL356017
      UniProtKB/TrEMBL
      A0A6Q8PH99
      Related
      ENSP00000502591.1, ENST00000675995.1
      Conserved Domains (3) summary
      cd15903
      Location:271365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18034
      Location:42239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      cl38915
      Location:372458
      DEAD-like_helicase_C; C-terminal helicase domain of the DEAD-like helicases
    26. NM_001395700.1NP_001382629.1  endoribonuclease Dicer isoform 12

      Status: REVIEWED

      Source sequence(s)
      AL356017
      UniProtKB/TrEMBL
      A0A6Q8PH99
      Conserved Domains (3) summary
      cd15903
      Location:271365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18034
      Location:42239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      cl38915
      Location:372459
      DEAD-like_helicase_C; C-terminal helicase domain of the DEAD-like helicases
    27. NM_030621.4NP_085124.2  endoribonuclease Dicer isoform 1

      See identical proteins and their annotated locations for NP_085124.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) represents the longest transcript. Variants 1, 2, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      AF007142, AJ132261, AL390254, AY845867, BM152875
      Consensus CDS
      CCDS9931.1
      UniProtKB/Swiss-Prot
      A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Related
      ENSP00000437256.1, ENST00000526495.6
      Conserved Domains (7) summary
      smart00535
      Location:12961387
      RIBOc; Ribonuclease III family
      COG0571
      Location:16661918
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:8861008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:372564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      pfam03368
      Location:630718
      Dicer_dimer; Dicer dimerization domain
    28. NM_177438.3NP_803187.1  endoribonuclease Dicer isoform 1

      See identical proteins and their annotated locations for NP_803187.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Variants 1, 2, 4 and 5 encode the same isoform (1).
      Source sequence(s)
      AB023145, AL356017, AL390254
      Consensus CDS
      CCDS9931.1
      UniProtKB/Swiss-Prot
      A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02
      UniProtKB/TrEMBL
      A0A8Q3WLH8
      Related
      ENSP00000343745.3, ENST00000343455.8
      Conserved Domains (7) summary
      smart00535
      Location:12961387
      RIBOc; Ribonuclease III family
      COG0571
      Location:16661918
      Rnc; dsRNA-specific ribonuclease [Transcription]
      cd02843
      Location:8861008
      PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
      cd15903
      Location:271365
      Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer
      cd18802
      Location:372564
      SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer
      cd18034
      Location:42239
      DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
      pfam03368
      Location:630718
      Dicer_dimer; Dicer dimerization domain

    RNA

    1. NR_172715.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
    2. NR_172716.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
    3. NR_172717.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
    4. NR_172718.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
      Related
      ENST00000675540.2
    5. NR_172719.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254
    6. NR_172720.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AL356017, AL390254

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000014.9 Reference GRCh38.p14 Primary Assembly

      Range
      95086228..95158010 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060938.1 Alternate T2T-CHM13v2.0

      Range
      89316445..89388228 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)