DICER1 dicer 1, ribonuclease III [Homo sapiens (human)] - Gene

Summary

Official Symbol: DICER1provided by HGNC
Official Full Name: dicer 1, ribonuclease IIIprovided by HGNC
Primary source: HGNC:HGNC:17098
See related: Ensembl:ENSG00000100697 MIM:606241; AllianceGenome:HGNC:17098
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Homo sapiens
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
Also known as: DCR1; GLOW; MNG1; aviD; Dicer; HERNA; RMSE2; Dicer1e; K12H4.8-LIKE
Summary: This gene encodes a protein possessing an RNA helicase motif containing a DEXH box in its amino terminus and an RNA motif in the carboxy terminus. The encoded protein functions as a ribonuclease and is required by the RNA interference and small temporal RNA (stRNA) pathways to produce the active small RNA component that represses gene expression. This protein also acts as a strong antiviral agent with activity against RNA viruses, including the Zika and SARS-CoV-2 viruses. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2021]
Annotation information: Note: This gene has been reviewed for its involvement in coronavirus biology, and is involved in immune response or antiviral activity.
Expression: Ubiquitous expression in appendix (RPKM 6.6), placenta (RPKM 6.6) and 25 other tissues See more
Orthologs: mouse all
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Genomic context

Location:: 14q32.13

Exon count:: 36

Annotation release	Status	Assembly	Chr	Location
RS_2023_10	current	GRCh38.p14 (GCF_000001405.40)	14	NC_000014.9 (95086228..95158010, complement)
RS_2023_10	current	T2T-CHM13v2.0 (GCF_009914755.1)	14	NC_060938.1 (89316445..89388228, complement)
105.20220307	previous assembly	GRCh37.p13 (GCF_000001405.25)	14	NC_000014.8 (95552565..95624347, complement)

Chromosome 14 - NC_000014.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: HPA RNA-seq normal tissues
Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
BioProject: PRJEB4337
Publication: PMID 24309898
Analysis date: Wed Apr 4 07:08:55 2018

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Clinicopathological analysis of 22 Mullerian adenosarcomas and the sequencing of DICER1 mutation.
Title: Clinicopathological analysis of 22 Müllerian adenosarcomas and the sequencing of DICER1 mutation.
Spermatid perinuclear RNA-binding protein promotes UBR5-mediated proteolysis of Dicer to accelerate triple-negative breast cancer progression.
Title: Spermatid perinuclear RNA-binding protein promotes UBR5-mediated proteolysis of Dicer to accelerate triple-negative breast cancer progression.
Two-motif model illuminates DICER cleavage preferences.
Title: Two-motif model illuminates DICER cleavage preferences.
Prevalence of DICER1 variants in large multinodular goiter: thyroid function, clinical and imaging characteristics.
Title: Prevalence of DICER1 variants in large multinodular goiter: thyroid function, clinical and imaging characteristics.
No Pathogenic DICER1 Gene Variants in a Cohort Study of 28 Children With Congenital Pulmonary Airway Malformation.
Title: No Pathogenic DICER1 Gene Variants in a Cohort Study of 28 Children With Congenital Pulmonary Airway Malformation.
Fetal Type Morphologies Suggest the Presence of DICER1 Hotspot Mutations in Non-small Cell Lung Cancer.
Title: Fetal Type Morphologies Suggest the Presence of DICER1 Hotspot Mutations in Non-small Cell Lung Cancer.
Substrate promiscuity of Dicer toward precursors of the let-7 family and their 3'-end modifications.
Title: Substrate promiscuity of Dicer toward precursors of the let-7 family and their 3'-end modifications.
DiCleave: a deep learning model for predicting human Dicer cleavage sites.
Title: DiCleave: a deep learning model for predicting human Dicer cleavage sites.
USP7 reduces the level of nuclear DICER, impairing DNA damage response and promoting cancer progression.
Title: USP7 reduces the level of nuclear DICER, impairing DNA damage response and promoting cancer progression.
Specifications of the ACMG/AMP Variant Classification Guidelines for Germline DICER1 Variant Curation.
Title: Specifications of the ACMG/AMP Variant Classification Guidelines for Germline DICER1 Variant Curation.

Submit: New GeneRIF Correction See all GeneRIFs (478)

Phenotypes

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Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

Associated conditions

Description	Tests
Euthyroid goiter MedGen: C0302859 OMIM: 138800 GeneReviews: DICER1 Tumor Predisposition	Compare labs
Global developmental delay - lung cysts - overgrowth - Wilms tumor syndrome MedGen: C4748924 OMIM: 618272 GeneReviews: Not available	Compare labs
Pleuropulmonary blastoma MedGen: C1266144 OMIM: 601200 GeneReviews: DICER1 Tumor Predisposition	Compare labs
Rhabdomyosarcoma, embryonal, 2 MedGen: C1867234 OMIM: 180295 GeneReviews: DICER1 Tumor Predisposition	Compare labs

Copy number response

Description
Copy number response Haploinsufficency Sufficient evidence for dosage pathogenicity (Last evaluated 2022-02-09) ClinGen Genome Curation PagePubMed Triplosensitivity No evidence available (Last evaluated 2022-02-09) ClinGen Genome Curation Page

EBI GWAS Catalog

Description
Gene-environment interactions and obesity traits among postmenopausal African-American and Hispanic women in the Women's Health Initiative SHARe Study. EBI GWAS Catalog EBI GWAS CatalogPubMed
Genome-wide association of lipid-lowering response to statins in combined study populations. EBI GWAS Catalog EBI GWAS CatalogPubMed

Variation

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See variants in ClinVar

See studies and variants in dbVar

See Variation Viewer (GRCh37.p13)

See Variation Viewer (GRCh38)

HIV-1 interactions

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Replication interactions

Interaction	Pubs
Knockdown of dicer 1, ribonuclease type III (DICER1) by shRNA library screening inhibits HIV-1 replication in cultured Jurkat T-cells	PubMed

Protein interactions

Protein	Gene	Interaction	Pubs
Pr55(Gag)	gag	Knockdown of Dicer by shRNA leads to inhibit enrichment of HIV-1 Gag in intracellular vacuoles, but enhance viral particle release in Gag expressing cells	PubMed
	gag	Interaction of HIV-1 Gag with dicer 1, ribonuclease type III (DICER1) is identified in a series of six affinity purification/mass spectrometry screens	PubMed
Rev	rev	The arginine rich motif (residues 35-50) of HIV-1 Rev inhibits Dicer dependent RNAi process	PubMed
Tat	tat	The arginine rich motif (residues 48-58) of HIV-1 Tat inhibits Dicer dependent RNAi process	PubMed
	tat	HIV-1 Tat-Dicer interaction requires RNA; Dicer's helicase domain (residues 246-585) and a portion of Tat amino acids 30-72 are involved in the interaction	PubMed
Vpr	vpr	HIV-1 Vpr-induced downregulation of Dicer is not dependent on G2 cell cycle arrest but on the Cul4A-DCAF1-DDB1 ubiquitin ligase complex	PubMed
	vpr	HIV-1 Vpr complexes with Dicer and induces downregulation of Dicer in HIV-1 infected cells	PubMed

Go to the HIV-1, Human Interaction Database

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Dicer1 (e-PCR), detects polymorphism
- UniSTS:498692

D14S1030 (e-PCR)
- UniSTS:10763

RH48955 (e-PCR)
- UniSTS:10299

DICER1_2299 (e-PCR)
- UniSTS:280643

D14S892E (e-PCR)
- UniSTS:153948

RH103309 (e-PCR)
- UniSTS:97640

RH47658 (e-PCR)
- UniSTS:14968

Cda1bd03 (e-PCR)
- UniSTS:92027

RH68069 (e-PCR)
- UniSTS:47483

RH70750 (e-PCR)
- UniSTS:71042

G35622 (e-PCR)
- UniSTS:70811

SHGC-59954 (e-PCR)
- UniSTS:82340

A003B15 (e-PCR)
- UniSTS:34468

RH78640 (e-PCR)
- UniSTS:92621

RH98980 (e-PCR)
- UniSTS:92622

Gene Ontology Provided by GOA

Function	Evidence Code	Pubs
enables ATP binding	IEA Inferred from Electronic Annotation more info
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables RNA binding	IBA Inferred from Biological aspect of Ancestor more info
enables RNA endonuclease activity	IDA Inferred from Direct Assay more info	PubMed
enables RNA endonuclease activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables RNA endonuclease activity	TAS Traceable Author Statement more info	PubMed
enables deoxyribonuclease I activity	IBA Inferred from Biological aspect of Ancestor more info
enables double-stranded RNA binding	IDA Inferred from Direct Assay more info	PubMed
enables double-stranded RNA binding	IMP Inferred from Mutant Phenotype more info	PubMed
enables helicase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
contributes_to pre-miRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables pre-miRNA binding	IDA Inferred from Direct Assay more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein domain specific binding	IPI Inferred from Physical Interaction more info	PubMed
enables ribonuclease III activity	EXP Inferred from Experiment more info	PubMed
enables ribonuclease III activity	IBA Inferred from Biological aspect of Ancestor more info
enables ribonuclease III activity	IDA Inferred from Direct Assay more info	PubMed
enables ribonuclease III activity	TAS Traceable Author Statement more info
enables siRNA binding	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
involved_in RISC complex assembly	IDA Inferred from Direct Assay more info	PubMed
involved_in apoptotic DNA fragmentation	IBA Inferred from Biological aspect of Ancestor more info
involved_in global gene silencing by mRNA cleavage	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in miRNA metabolic process	TAS Traceable Author Statement more info
involved_in miRNA processing	IDA Inferred from Direct Assay more info	PubMed
involved_in miRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in miRNA processing	ISS Inferred from Sequence or Structural Similarity more info
involved_in negative regulation of Schwann cell proliferation	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of gene expression	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of transcription by RNA polymerase II	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of negative regulation of tumor necrosis factor production	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of negative regulation of tumor necrosis factor-mediated signaling pathway	IDA Inferred from Direct Assay more info	PubMed
involved_in nerve development	ISS Inferred from Sequence or Structural Similarity more info
involved_in neuron projection morphogenesis	ISS Inferred from Sequence or Structural Similarity more info
involved_in peripheral nervous system myelin formation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of Schwann cell differentiation	ISS Inferred from Sequence or Structural Similarity more info
involved_in positive regulation of myelination	ISS Inferred from Sequence or Structural Similarity more info
involved_in pre-miRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in pre-miRNA processing	IDA Inferred from Direct Assay more info	PubMed
involved_in siRNA processing	IBA Inferred from Biological aspect of Ancestor more info
involved_in siRNA processing	IDA Inferred from Direct Assay more info	PubMed
involved_in siRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in siRNA processing	TAS Traceable Author Statement more info
involved_in tRNA decay	TAS Traceable Author Statement more info

Component	Evidence Code	Pubs
NOT part_of RISC complex	IDA Inferred from Direct Assay more info	PubMed
part_of RISC complex	IDA Inferred from Direct Assay more info	PubMed
part_of RISC-loading complex	IBA Inferred from Biological aspect of Ancestor more info
part_of RISC-loading complex	IDA Inferred from Direct Assay more info	PubMed
part_of RISC-loading complex	IPI Inferred from Physical Interaction more info	PubMed
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
located_in cytosol	TAS Traceable Author Statement more info
located_in extracellular exosome	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
located_in perinuclear region of cytoplasm	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: endoribonuclease Dicer

Names: Dicer1, Dcr-1 homolog; dicer 1, double-stranded RNA-specific endoribonuclease; dicer 1, ribonuclease type III; helicase MOI; helicase with RNAse motif

NP_001182502.1

EC 3.1.26.3

NP_001258211.1

EC 3.1.26.3

NP_001278557.1

EC 3.1.26.3

NP_001382606.1

EC 3.1.26.3

NP_001382607.1

EC 3.1.26.3

NP_001382608.1

EC 3.1.26.3

NP_001382609.1

EC 3.1.26.3

NP_001382611.1

EC 3.1.26.3

NP_001382612.1

EC 3.1.26.3

NP_001382613.1

EC 3.1.26.3

NP_001382614.1

EC 3.1.26.3

NP_001382615.1

EC 3.1.26.3

NP_001382616.1

EC 3.1.26.3

NP_001382617.1

EC 3.1.26.3

NP_001382618.1

EC 3.1.26.3

NP_001382619.1

EC 3.1.26.3

NP_001382620.1

EC 3.1.26.3

NP_001382621.1

EC 3.1.26.3

NP_001382622.1

EC 3.1.26.3

NP_001382623.1

EC 3.1.26.3

NP_001382624.1

EC 3.1.26.3

NP_001382625.1

EC 3.1.26.3

NP_001382626.1

EC 3.1.26.3

NP_001382627.1

EC 3.1.26.3

NP_001382628.1

EC 3.1.26.3

NP_001382629.1

EC 3.1.26.3

NP_085124.2

EC 3.1.26.3

NP_803187.1

EC 3.1.26.3

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

Genomic

NG_016311.1 RefSeqGene

Range

4413..76195

Download

GenBank, FASTA, Sequence Viewer (Graphics), LRG_492

mRNA and Protein(s)

NM_001195573.1 → NP_001182502.1 endoribonuclease Dicer isoform 2

See identical proteins and their annotated locations for NP_001182502.1

Status: REVIEWED

Description

Transcript Variant: This variant (3) lacks an exon in the 3' coding region, which results in a frameshift and an early stop codon, compared to variant 2. The resulting isoform 2 (also called t-Dicer) is shorter and has a distinct C-terminus, compared to isoform 1.

Source sequence(s)

AL356017, AL390254, HM595745

Consensus CDS

CCDS55941.1

UniProtKB/TrEMBL

A0A8Q3SJI0, A0A8Q3WLJ5

Related

ENSP00000444719.1, ENST00000541352.5

Conserved Domains (10) summary

smart00535
Location:1296 → 1387

RIBOc; Ribonuclease III family

smart00487
Location:40 → 242

DEXDc; DEAD-like helicases superfamily

COG0513
Location:445 → 589

SrmB; Superfamily II DNA and RNA helicase [Replication, recombination and repair]

COG0571
Location:1666 → 1765

Rnc; dsRNA-specific ribonuclease [Transcription]

cd00046
Location:58 → 209

DEXDc; DEAD-like helicases superfamily. A diverse family of proteins involved in ATP-dependent RNA or DNA unwinding. This domain contains the ATP-binding region.

cd00593
Location:1682 → 1767

RIBOc; RIBOc. Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in ...

cd02843
Location:886 → 1008

PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...

cd15903
Location:271 → 365

Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

pfam00271
Location:445 → 553

Helicase_C; Helicase conserved C-terminal domain

pfam03368
Location:631 → 714

Dicer_dimer; Dicer dimerization domain
NM_001271282.3 → NP_001258211.1 endoribonuclease Dicer isoform 1

See identical proteins and their annotated locations for NP_001258211.1

Status: REVIEWED

Description

Transcript Variant: This variant (4) differs in the 5' UTR, compared to variant 2. Variants 1, 2, 4 and 5 encode the same isoform (1).

Source sequence(s)

AF007142, AJ132261, AL390254

Consensus CDS

CCDS9931.1

UniProtKB/Swiss-Prot

A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02

UniProtKB/TrEMBL

A0A8Q3WLH8

Related

ENSP00000435681.1, ENST00000527414.5

Conserved Domains (7) summary

smart00535
Location:1296 → 1387

RIBOc; Ribonuclease III family

COG0571
Location:1666 → 1918

Rnc; dsRNA-specific ribonuclease [Transcription]

cd02843
Location:886 → 1008

PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...

cd15903
Location:271 → 365

Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

cd18802
Location:372 → 564

SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer

cd18034
Location:42 → 239

DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

pfam03368
Location:630 → 718

Dicer_dimer; Dicer dimerization domain
NM_001291628.2 → NP_001278557.1 endoribonuclease Dicer isoform 1

See identical proteins and their annotated locations for NP_001278557.1

Status: REVIEWED

Description

Transcript Variant: This variant (5) lacks an internal segment in the 5' UTR, compared to variant 2. Variants 1, 2, 4 and 5 encode the same isoform (1).

Source sequence(s)

AF007142, AJ132261, AL390254, AY845868, BM152875

Consensus CDS

CCDS9931.1

UniProtKB/Swiss-Prot

A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02

UniProtKB/TrEMBL

A0A8Q3WLH8

Conserved Domains (7) summary

smart00535
Location:1296 → 1387

RIBOc; Ribonuclease III family

COG0571
Location:1666 → 1918

Rnc; dsRNA-specific ribonuclease [Transcription]

cd02843
Location:886 → 1008

PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...

cd15903
Location:271 → 365

Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

cd18802
Location:372 → 564

SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer

cd18034
Location:42 → 239

DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

pfam03368
Location:630 → 718

Dicer_dimer; Dicer dimerization domain
NM_001395677.1 → NP_001382606.1 endoribonuclease Dicer isoform 1

Status: REVIEWED

Source sequence(s)

AL356017, AL390254

Consensus CDS

CCDS9931.1

UniProtKB/Swiss-Prot

A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02

UniProtKB/TrEMBL

A0A8Q3WLH8

Conserved Domains (7) summary

smart00535
Location:1296 → 1387

RIBOc; Ribonuclease III family

COG0571
Location:1666 → 1918

Rnc; dsRNA-specific ribonuclease [Transcription]

cd02843
Location:886 → 1008

PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...

cd15903
Location:271 → 365

Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

cd18802
Location:372 → 564

SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer

cd18034
Location:42 → 239

DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

pfam03368
Location:630 → 718

Dicer_dimer; Dicer dimerization domain
NM_001395678.1 → NP_001382607.1 endoribonuclease Dicer isoform 1

Status: REVIEWED

Source sequence(s)

AL356017, AL390254

Consensus CDS

CCDS9931.1

UniProtKB/Swiss-Prot

A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02

UniProtKB/TrEMBL

A0A8Q3WLH8

Conserved Domains (7) summary

smart00535
Location:1296 → 1387

RIBOc; Ribonuclease III family

COG0571
Location:1666 → 1918

Rnc; dsRNA-specific ribonuclease [Transcription]

cd02843
Location:886 → 1008

PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...

cd15903
Location:271 → 365

Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

cd18802
Location:372 → 564

SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer

cd18034
Location:42 → 239

DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

pfam03368
Location:630 → 718

Dicer_dimer; Dicer dimerization domain
NM_001395679.1 → NP_001382608.1 endoribonuclease Dicer isoform 1

Status: REVIEWED

Source sequence(s)

AL356017, AL390254

Consensus CDS

CCDS9931.1

UniProtKB/Swiss-Prot

A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02

UniProtKB/TrEMBL

A0A8Q3WLH8

Related

ENSP00000376783.1, ENST00000393063.6

Conserved Domains (7) summary

smart00535
Location:1296 → 1387

RIBOc; Ribonuclease III family

COG0571
Location:1666 → 1918

Rnc; dsRNA-specific ribonuclease [Transcription]

cd02843
Location:886 → 1008

PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...

cd15903
Location:271 → 365

Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

cd18802
Location:372 → 564

SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer

cd18034
Location:42 → 239

DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

pfam03368
Location:630 → 718

Dicer_dimer; Dicer dimerization domain
NM_001395680.1 → NP_001382609.1 endoribonuclease Dicer isoform 1

Status: REVIEWED

Source sequence(s)

AL356017, AL390254

Consensus CDS

CCDS9931.1

UniProtKB/Swiss-Prot

A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02

UniProtKB/TrEMBL

A0A8Q3WLH8

Conserved Domains (7) summary

smart00535
Location:1296 → 1387

RIBOc; Ribonuclease III family

COG0571
Location:1666 → 1918

Rnc; dsRNA-specific ribonuclease [Transcription]

cd02843
Location:886 → 1008

PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...

cd15903
Location:271 → 365

Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

cd18802
Location:372 → 564

SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer

cd18034
Location:42 → 239

DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

pfam03368
Location:630 → 718

Dicer_dimer; Dicer dimerization domain
NM_001395682.1 → NP_001382611.1 endoribonuclease Dicer isoform 1

Status: REVIEWED

Source sequence(s)

AL356017, AL390254

Consensus CDS

CCDS9931.1

UniProtKB/Swiss-Prot

A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02

UniProtKB/TrEMBL

A0A8Q3WLH8

Related

ENSP00000502730.2, ENST00000674628.2

Conserved Domains (7) summary

smart00535
Location:1296 → 1387

RIBOc; Ribonuclease III family

COG0571
Location:1666 → 1918

Rnc; dsRNA-specific ribonuclease [Transcription]

cd02843
Location:886 → 1008

PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...

cd15903
Location:271 → 365

Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

cd18802
Location:372 → 564

SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer

cd18034
Location:42 → 239

DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

pfam03368
Location:630 → 718

Dicer_dimer; Dicer dimerization domain
NM_001395683.1 → NP_001382612.1 endoribonuclease Dicer isoform 1

Status: REVIEWED

Source sequence(s)

AL356017, AL390254

Consensus CDS

CCDS9931.1

UniProtKB/Swiss-Prot

A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02

UniProtKB/TrEMBL

A0A8Q3WLH8

Conserved Domains (7) summary

smart00535
Location:1296 → 1387

RIBOc; Ribonuclease III family

COG0571
Location:1666 → 1918

Rnc; dsRNA-specific ribonuclease [Transcription]

cd02843
Location:886 → 1008

PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...

cd15903
Location:271 → 365

Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

cd18802
Location:372 → 564

SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer

cd18034
Location:42 → 239

DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

pfam03368
Location:630 → 718

Dicer_dimer; Dicer dimerization domain
NM_001395684.1 → NP_001382613.1 endoribonuclease Dicer isoform 1

Status: REVIEWED

Source sequence(s)

AL356017, AL390254

Consensus CDS

CCDS9931.1

UniProtKB/Swiss-Prot

A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02

UniProtKB/TrEMBL

A0A8Q3WLH8

Conserved Domains (7) summary

smart00535
Location:1296 → 1387

RIBOc; Ribonuclease III family

COG0571
Location:1666 → 1918

Rnc; dsRNA-specific ribonuclease [Transcription]

cd02843
Location:886 → 1008

PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...

cd15903
Location:271 → 365

Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

cd18802
Location:372 → 564

SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer

cd18034
Location:42 → 239

DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

pfam03368
Location:630 → 718

Dicer_dimer; Dicer dimerization domain
NM_001395685.1 → NP_001382614.1 endoribonuclease Dicer isoform 3

Status: REVIEWED

Source sequence(s)

AL356017, AL390254

UniProtKB/TrEMBL

A0A8Q3WLH8

Related

ENSP00000512838.1, ENST00000696733.1

Conserved Domains (6) summary

smart00535
Location:1296 → 1387

RIBOc; Ribonuclease III family

cd00593
Location:1682 → 1842

RIBOc; Ribonuclease III C terminal domain. This group consists of eukaryotic, bacterial and archeal ribonuclease III (RNAse III) proteins. RNAse III is a double stranded RNA-specific endonuclease. Prokaryotic RNAse III is important in post-transcriptional ...

cd02843
Location:886 → 1008

PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...

cd15903
Location:271 → 365

Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

cd18802
Location:372 → 564

SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer

cd18034
Location:42 → 239

DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
NM_001395686.1 → NP_001382615.1 endoribonuclease Dicer isoform 4

Status: REVIEWED

Source sequence(s)

AL356017, AL390254

UniProtKB/TrEMBL

A0A8Q3WLH8

Conserved Domains (6) summary

smart00535
Location:1202 → 1293

RIBOc; Ribonuclease III family

COG0571
Location:1572 → 1824

Rnc; dsRNA-specific ribonuclease [Transcription]

cd02843
Location:792 → 914

PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...

cd15903
Location:177 → 271

Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

cd18802
Location:278 → 470

SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer

cd18034
Location:11 → 145

DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
NM_001395687.1 → NP_001382616.1 endoribonuclease Dicer isoform 5

Status: REVIEWED

Source sequence(s)

AL356017, AL390254

UniProtKB/TrEMBL

A0A8Q3WLH8

Conserved Domains (7) summary

smart00535
Location:1161 → 1252

RIBOc; Ribonuclease III family

COG0571
Location:1531 → 1783

Rnc; dsRNA-specific ribonuclease [Transcription]

cd02843
Location:751 → 873

PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...

cd15903
Location:136 → 230

Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

cd18802
Location:237 → 429

SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer

pfam03368
Location:495 → 583

Dicer_dimer; Dicer dimerization domain

cl28899
Location:12 → 104

DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
NM_001395688.1 → NP_001382617.1 endoribonuclease Dicer isoform 5

Status: REVIEWED

Source sequence(s)

AL356017, AL390254

UniProtKB/TrEMBL

A0A8Q3WLH8

Conserved Domains (7) summary

smart00535
Location:1161 → 1252

RIBOc; Ribonuclease III family

COG0571
Location:1531 → 1783

Rnc; dsRNA-specific ribonuclease [Transcription]

cd02843
Location:751 → 873

PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...

cd15903
Location:136 → 230

Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

cd18802
Location:237 → 429

SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer

pfam03368
Location:495 → 583

Dicer_dimer; Dicer dimerization domain

cl28899
Location:12 → 104

DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
NM_001395689.1 → NP_001382618.1 endoribonuclease Dicer isoform 5

Status: REVIEWED

Source sequence(s)

AL356017, AL390254

UniProtKB/TrEMBL

A0A8Q3WLH8

Related

ENST00000696921.1

Conserved Domains (7) summary

smart00535
Location:1161 → 1252

RIBOc; Ribonuclease III family

COG0571
Location:1531 → 1783

Rnc; dsRNA-specific ribonuclease [Transcription]

cd02843
Location:751 → 873

PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...

cd15903
Location:136 → 230

Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

cd18802
Location:237 → 429

SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer

pfam03368
Location:495 → 583

Dicer_dimer; Dicer dimerization domain

cl28899
Location:12 → 104

DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
NM_001395690.1 → NP_001382619.1 endoribonuclease Dicer isoform 5

Status: REVIEWED

Source sequence(s)

AL356017, AL390254

UniProtKB/TrEMBL

A0A8Q3WLH8

Conserved Domains (7) summary

smart00535
Location:1161 → 1252

RIBOc; Ribonuclease III family

COG0571
Location:1531 → 1783

Rnc; dsRNA-specific ribonuclease [Transcription]

cd02843
Location:751 → 873

PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...

cd15903
Location:136 → 230

Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

cd18802
Location:237 → 429

SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer

pfam03368
Location:495 → 583

Dicer_dimer; Dicer dimerization domain

cl28899
Location:12 → 104

DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
NM_001395691.1 → NP_001382620.1 endoribonuclease Dicer isoform 6

Status: REVIEWED

Source sequence(s)

AL356017, AL390254

UniProtKB/TrEMBL

A0A8Q3WLH8

Conserved Domains (6) summary

smart00535
Location:1107 → 1198

RIBOc; Ribonuclease III family

COG0571
Location:1477 → 1729

Rnc; dsRNA-specific ribonuclease [Transcription]

cd02843
Location:697 → 819

PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...

cd15903
Location:82 → 176

Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

cd18802
Location:183 → 375

SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer

cl28899
Location:1 → 50

DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
NM_001395692.1 → NP_001382621.1 endoribonuclease Dicer isoform 7

Status: REVIEWED

Source sequence(s)

AL356017, AL390254

Consensus CDS

CCDS91926.1

UniProtKB/TrEMBL

A0A8Q3WLJ5, H0YJZ6

Related

ENSP00000452556.2, ENST00000532939.3

Conserved Domains (6) summary

smart00535
Location:1296 → 1387

RIBOc; Ribonuclease III family

cd02843
Location:886 → 1008

PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...

TIGR02191
Location:1669 → 1708

RNaseIII; ribonuclease III, bacterial

cd15903
Location:271 → 365

Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

cd18802
Location:372 → 564

SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer

cd18034
Location:42 → 239

DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
NM_001395693.1 → NP_001382622.1 endoribonuclease Dicer isoform 7

Status: REVIEWED

Source sequence(s)

AL356017, AL390254

Consensus CDS

CCDS91926.1

UniProtKB/TrEMBL

A0A8Q3WLJ5, H0YJZ6

Related

ENSP00000512841.1, ENST00000696737.1

Conserved Domains (6) summary

smart00535
Location:1296 → 1387

RIBOc; Ribonuclease III family

cd02843
Location:886 → 1008

PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...

TIGR02191
Location:1669 → 1708

RNaseIII; ribonuclease III, bacterial

cd15903
Location:271 → 365

Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

cd18802
Location:372 → 564

SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer

cd18034
Location:42 → 239

DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
NM_001395694.1 → NP_001382623.1 endoribonuclease Dicer isoform 7

Status: REVIEWED

Source sequence(s)

AL356017, AL390254

Consensus CDS

CCDS91926.1

UniProtKB/TrEMBL

A0A8Q3WLJ5, H0YJZ6

Conserved Domains (6) summary

smart00535
Location:1296 → 1387

RIBOc; Ribonuclease III family

cd02843
Location:886 → 1008

PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...

TIGR02191
Location:1669 → 1708

RNaseIII; ribonuclease III, bacterial

cd15903
Location:271 → 365

Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

cd18802
Location:372 → 564

SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer

cd18034
Location:42 → 239

DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
NM_001395695.1 → NP_001382624.1 endoribonuclease Dicer isoform 7

Status: REVIEWED

Source sequence(s)

AL356017, AL390254

Consensus CDS

CCDS91926.1

UniProtKB/TrEMBL

A0A8Q3WLJ5, H0YJZ6

Conserved Domains (6) summary

smart00535
Location:1296 → 1387

RIBOc; Ribonuclease III family

cd02843
Location:886 → 1008

PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...

TIGR02191
Location:1669 → 1708

RNaseIII; ribonuclease III, bacterial

cd15903
Location:271 → 365

Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

cd18802
Location:372 → 564

SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer

cd18034
Location:42 → 239

DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer
NM_001395696.1 → NP_001382625.1 endoribonuclease Dicer isoform 8

Status: REVIEWED

Source sequence(s)

AL356017, AL390254

UniProtKB/TrEMBL

A0A8Q3WLJ5

Conserved Domains (6) summary

smart00535
Location:1161 → 1252

RIBOc; Ribonuclease III family

cd02843
Location:751 → 873

PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...

TIGR02191
Location:1534 → 1573

RNaseIII; ribonuclease III, bacterial

cd15903
Location:136 → 230

Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

cd18802
Location:237 → 429

SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer

cl28899
Location:12 → 104

DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
NM_001395697.1 → NP_001382626.1 endoribonuclease Dicer isoform 9

Status: REVIEWED

Source sequence(s)

AL356017, AL390254

Conserved Domains (3) summary

smart00535
Location:735 → 826

RIBOc; Ribonuclease III family

COG0571
Location:1105 → 1357

Rnc; dsRNA-specific ribonuclease [Transcription]

cd02843
Location:325 → 447

PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...
NM_001395698.1 → NP_001382627.1 endoribonuclease Dicer isoform 10

Status: REVIEWED

Source sequence(s)

AL356017

Conserved Domains (3) summary

cd15903
Location:136 → 230

Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

cd18802
Location:237 → 429

SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer

cl28899
Location:12 → 104

DEAD-like_helicase_N; N-terminal helicase domain of the DEAD-box helicase superfamily
NM_001395699.1 → NP_001382628.1 endoribonuclease Dicer isoform 11

Status: REVIEWED

Source sequence(s)

AL356017

UniProtKB/TrEMBL

A0A6Q8PH99

Related

ENSP00000502591.1, ENST00000675995.1

Conserved Domains (3) summary

cd15903
Location:271 → 365

Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

cd18034
Location:42 → 239

DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

cl38915
Location:372 → 458

DEAD-like_helicase_C; C-terminal helicase domain of the DEAD-like helicases
NM_001395700.1 → NP_001382629.1 endoribonuclease Dicer isoform 12

Status: REVIEWED

Source sequence(s)

AL356017

UniProtKB/TrEMBL

A0A6Q8PH99

Conserved Domains (3) summary

cd15903
Location:271 → 365

Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

cd18034
Location:42 → 239

DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

cl38915
Location:372 → 459

DEAD-like_helicase_C; C-terminal helicase domain of the DEAD-like helicases
NM_030621.4 → NP_085124.2 endoribonuclease Dicer isoform 1

See identical proteins and their annotated locations for NP_085124.2

Status: REVIEWED

Description

Transcript Variant: This variant (2) represents the longest transcript. Variants 1, 2, 4 and 5 encode the same isoform (1).

Source sequence(s)

AF007142, AJ132261, AL390254, AY845867, BM152875

Consensus CDS

CCDS9931.1

UniProtKB/Swiss-Prot

A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02

UniProtKB/TrEMBL

A0A8Q3WLH8

Related

ENSP00000437256.1, ENST00000526495.6

Conserved Domains (7) summary

smart00535
Location:1296 → 1387

RIBOc; Ribonuclease III family

COG0571
Location:1666 → 1918

Rnc; dsRNA-specific ribonuclease [Transcription]

cd02843
Location:886 → 1008

PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...

cd15903
Location:271 → 365

Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

cd18802
Location:372 → 564

SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer

cd18034
Location:42 → 239

DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

pfam03368
Location:630 → 718

Dicer_dimer; Dicer dimerization domain
NM_177438.3 → NP_803187.1 endoribonuclease Dicer isoform 1

See identical proteins and their annotated locations for NP_803187.1

Status: REVIEWED

Description

Transcript Variant: This variant (1) differs in the 5' UTR, compared to variant 2. Variants 1, 2, 4 and 5 encode the same isoform (1).

Source sequence(s)

AB023145, AL356017, AL390254

Consensus CDS

CCDS9931.1

UniProtKB/Swiss-Prot

A7E2D3, B3KRG4, E0AD28, O95943, Q9UPY3, Q9UQ02

UniProtKB/TrEMBL

A0A8Q3WLH8

Related

ENSP00000343745.3, ENST00000343455.8

Conserved Domains (7) summary

smart00535
Location:1296 → 1387

RIBOc; Ribonuclease III family

COG0571
Location:1666 → 1918

Rnc; dsRNA-specific ribonuclease [Transcription]

cd02843
Location:886 → 1008

PAZ_dicer_like; PAZ domain, dicer_like subfamily. Dicer is an RNAse involved in cleaving dsRNA in the RNA interference pathway. It generates dsRNAs which are approximately 20 bp long (siRNAs), which in turn target hydrolysis of homologous RNAs. PAZ domains are named ...

cd15903
Location:271 → 365

Dicer_PBD; Partner-binding domain of the endoribonuclease Dicer

cd18802
Location:372 → 564

SF2_C_dicer; C-terminal helicase domain of the endoribonuclease Dicer

cd18034
Location:42 → 239

DEXHc_dicer; DEXH-box helicase domain of endoribonuclease Dicer

pfam03368
Location:630 → 718

Dicer_dimer; Dicer dimerization domain

RNA

NR_172715.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL356017, AL390254
NR_172716.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL356017, AL390254
NR_172717.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL356017, AL390254
NR_172718.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL356017, AL390254

Related

ENST00000675540.2
NR_172719.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL356017, AL390254
NR_172720.1 RNA Sequence

Status: REVIEWED

Source sequence(s)

AL356017, AL390254