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    ZFHX4 zinc finger homeobox 4 [ Homo sapiens (human) ]

    Gene ID: 79776, updated on 7-Apr-2024

    Summary

    Official Symbol
    ZFHX4provided by HGNC
    Official Full Name
    zinc finger homeobox 4provided by HGNC
    Primary source
    HGNC:HGNC:30939
    See related
    Ensembl:ENSG00000091656 MIM:606940; AllianceGenome:HGNC:30939
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    ZFH4; ZHF4
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be part of chromatin. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Apr 2022]
    Expression
    Broad expression in testis (RPKM 2.1), adrenal (RPKM 2.1) and 16 other tissues See more
    Orthologs
    NEW
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    Genomic context

    Location:
    8q21.13
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 8 NC_000008.11 (76681247..76867281)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 8 NC_060932.1 (77110392..77296418)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 8 NC_000008.10 (77593482..77779517)

    Chromosome 8 - NC_000008.11Genomic Context describing neighboring genes Neighboring gene long intergenic non-protein coding RNA 1111 Neighboring gene uncharacterized LOC107986952 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 27544 Neighboring gene ZFHX4 antisense RNA 1 Neighboring gene NANOG hESC enhancer GRCh37_chr8:77553488-77553989 Neighboring gene mitochondrial ribosomal protein L9 pseudogene 1 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr8:77585153-77585653 Neighboring gene Sharpr-MPRA regulatory region 233 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19304 Neighboring gene VISTA enhancer hs1318 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr8:77676670-77677613 Neighboring gene VISTA enhancer hs774 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 19305 Neighboring gene VISTA enhancer hs1681 Neighboring gene Sharpr-MPRA regulatory region 11833 Neighboring gene microRNA 3149 Neighboring gene peroxisomal biogenesis factor 2

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Ptosis, hereditary congenital, 1
    MedGen: C1867438 OMIM: 178300 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Genome wide association study of age at menarche in the Japanese population.
    EBI GWAS Catalog
    Many sequence variants affecting diversity of adult human height.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ16514, FLJ20980

    Gene Ontology Provided by GOA

    Process Evidence Code Pubs
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of chromatin ISA
    Inferred from Sequence Alignment
    more info
     
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    zinc finger homeobox protein 4
    Names
    zinc-finger homeodomain protein 4

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001410934.1NP_001397863.1  zinc finger homeobox protein 4 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AC011716, AC023200, AC087110
      Consensus CDS
      CCDS94320.1
      UniProtKB/TrEMBL
      E7EVZ1
      Related
      ENSP00000430848.1, ENST00000518282.5
    2. NM_024721.5NP_078997.4  zinc finger homeobox protein 4 isoform 1

      See identical proteins and their annotated locations for NP_078997.4

      Status: VALIDATED

      Source sequence(s)
      AB083343, AC011716, AC023200, AC087110, CA430749, DA658176
      Consensus CDS
      CCDS47878.2
      UniProtKB/Swiss-Prot
      G3V138, Q18PS0, Q6ZN20, Q86UP3
      Related
      ENSP00000498627.1, ENST00000651372.2
      Conserved Domains (6) summary
      PHA02682
      Location:23502506
      PHA02682; ORF080 virion core protein; Provisional
      smart00389
      Location:21302185
      HOX; Homeodomain
      COG5576
      Location:21012240
      COG5576; Homeodomain-containing transcription factor [Transcription]
      sd00017
      Location:15431567
      ZF_C2H2; C2H2 Zn finger [structural motif]
      sd00020
      Location:13991419
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam00046
      Location:22292282
      Homeobox; Homeobox domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000008.11 Reference GRCh38.p14 Primary Assembly

      Range
      76681247..76867281
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060932.1 Alternate T2T-CHM13v2.0

      Range
      77110392..77296418
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)