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    CDC14A cell division cycle 14A [ Homo sapiens (human) ]

    Gene ID: 8556, updated on 2-May-2024

    Summary

    Official Symbol
    CDC14Aprovided by HGNC
    Official Full Name
    cell division cycle 14Aprovided by HGNC
    Primary source
    HGNC:HGNC:1718
    See related
    Ensembl:ENSG00000079335 MIM:603504; AllianceGenome:HGNC:1718
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    cdc14; DFNB32; DFNB35; hCDC14; DFNB105
    Summary
    The protein encoded by this gene is a member of the dual specificity protein tyrosine phosphatase family. It is highly similar to Saccharomyces cerevisiae Cdc14, a protein tyrosine phosphatase involved in the exit of cell mitosis and initiation of DNA replication, suggesting a role in cell cycle control. This protein has been shown to interact with, and dephosphorylate tumor suppressor protein p53, and is thought to regulate the function of p53. Alternative splicing of this gene results in several transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]
    Expression
    Broad expression in testis (RPKM 5.6), bone marrow (RPKM 3.3) and 24 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See CDC14A in Genome Data Viewer
    Location:
    1p21.2
    Exon count:
    18
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (100345001..100520277)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (100192980..100368314)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (100810557..100985833)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene Sharpr-MPRA regulatory region 14415 Neighboring gene RNA 3'-terminal phosphate cyclase Neighboring gene microRNA 553 Neighboring gene OCT4 hESC enhancer GRCh37_chr1:100790862-100791444 Neighboring gene chromosome 5 open reading frame 15 pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1379 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1380 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1119 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 1120 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1381 Neighboring gene uncharacterized LOC105379827 Neighboring gene BCAS2 pseudogene 2 Neighboring gene OCT4-NANOG-H3K4me1 hESC enhancer GRCh37_chr1:100927704-100928325 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1383 Neighboring gene Sharpr-MPRA regulatory region 2368 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:101004119-101004968 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:101004969-101005817 Neighboring gene G protein-coupled receptor 88 Neighboring gene HNF4 motif-containing MPRA enhancer 127 Neighboring gene ribosomal protein L7a pseudogene 17

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables myosin phosphatase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein serine/threonine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein serine/threonine phosphatase activity TAS
    Traceable Author Statement
    more info
     
    enables protein tyrosine phosphatase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in cilium assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in microtubule cytoskeleton organization IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in positive regulation of cytokinesis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of exit from mitosis IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in sensory perception of sound IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    Component Evidence Code Pubs
    is_active_in centrosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in centrosome IDA
    Inferred from Direct Assay
    more info
    PubMed 
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
     
    located_in kinociliary basal body ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in kinocilium ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nuclear body IDA
    Inferred from Direct Assay
    more info
     
    is_active_in nucleolus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    is_active_in spindle pole IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in stereocilium tip ISS
    Inferred from Sequence or Structural Similarity
    more info
     

    General protein information

    Preferred Names
    dual specificity protein phosphatase CDC14A
    Names
    CDC10 (cell division cycle 10, S. cerevisiae, homolog)
    CDC14 cell division cycle 14 homolog A
    NP_001306139.1
    NP_001306140.1
    NP_001306141.1
    NP_003663.2
    NP_201569.1
    NP_201570.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_051602.2 RefSeqGene

      Range
      12506..180277
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_1418

    mRNA and Protein(s)

    1. NM_001319210.2NP_001306139.1  dual specificity protein phosphatase CDC14A isoform 4

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) differs in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (4) has a shorter and distinct C-terminus compared to isoform 2.
      Source sequence(s)
      AC104457, AL589990
      Consensus CDS
      CCDS86000.1
      UniProtKB/TrEMBL
      A0A2R8Y6L0
      Related
      ENSP00000496374.1, ENST00000644813.1
      Conserved Domains (3) summary
      COG2453
      Location:175329
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:17152
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:187326
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    2. NM_001319211.2NP_001306140.1  dual specificity protein phosphatase CDC14A isoform 5

      Status: REVIEWED

      Description
      Transcript Variant: This variant (5) differs in the 5' UTR and coding sequence compared to variant 2. The resulting isoform (5) is shorter at the N-terminus compared to isoform 2.
      Source sequence(s)
      AA929031, AC104457, AF064102, AK302310, DB029799
      Consensus CDS
      CCDS81353.1
      UniProtKB/TrEMBL
      A0A0U1RQX7, B4DY86
      Related
      ENSP00000489217.1, ENST00000635056.2
      Conserved Domains (4) summary
      COG2453
      Location:117271
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:194
      DSPn; Dual specificity protein phosphatase, N-terminal half
      pfam15279
      Location:355555
      SOBP; Sine oculis-binding protein
      cl21483
      Location:129268
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    3. NM_001319212.2NP_001306141.1  dual specificity protein phosphatase CDC14A isoform 6

      Status: REVIEWED

      Description
      Transcript Variant: This variant (6) lacks an alternate exon compared to variant 2. The resulting isoform (6) is shorter at the C-terminus compared to isoform 2.
      Source sequence(s)
      AC104457, AL589990
      UniProtKB/Swiss-Prot
      Q9UNH5
    4. NM_003672.4NP_003663.2  dual specificity protein phosphatase CDC14A isoform 1

      See identical proteins and their annotated locations for NP_003663.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) differs in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (1) has a shorter and distinct C-terminus compared to isoform 2.
      Source sequence(s)
      AC104457, AL589990
      Consensus CDS
      CCDS769.1
      UniProtKB/Swiss-Prot
      A6MA65, B1AQ14, B1AQ15, O43171, O60727, O60728, Q52LH9, Q8IXX0, Q9UNH5
      UniProtKB/TrEMBL
      Q59EF4
      Related
      ENSP00000336739.3, ENST00000336454.5
      Conserved Domains (3) summary
      COG2453
      Location:175329
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:17152
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:187326
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    5. NM_033312.3NP_201569.1  dual specificity protein phosphatase CDC14A isoform 2

      See identical proteins and their annotated locations for NP_201569.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) encodes the longest isoform (2).
      Source sequence(s)
      AC104457, AL589990
      Consensus CDS
      CCDS770.1
      UniProtKB/TrEMBL
      A0A2R8YDJ8
      Related
      ENSP00000354916.6, ENST00000361544.11
      Conserved Domains (4) summary
      COG2453
      Location:175329
      CDC14; Protein-tyrosine phosphatase [Signal transduction mechanisms]
      pfam14671
      Location:17152
      DSPn; Dual specificity protein phosphatase, N-terminal half
      pfam15279
      Location:413613
      SOBP; Sine oculis-binding protein
      cl21483
      Location:187326
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...
    6. NM_033313.3NP_201570.1  dual specificity protein phosphatase CDC14A isoform 3

      See identical proteins and their annotated locations for NP_201570.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) differs in the 3' UTR and coding sequence compared to variant 2. The resulting isoform (3) has a shorter and distinct C-terminus compared to isoform 2.
      Source sequence(s)
      AC104457, AL589990
      Consensus CDS
      CCDS771.1
      UniProtKB/TrEMBL
      A0A2R8YEK7
      Related
      ENSP00000359142.3, ENST00000370124.8
      Conserved Domains (2) summary
      pfam14671
      Location:16152
      DSPn; Dual specificity protein phosphatase, N-terminal half
      cl21483
      Location:187326
      PTPc; Protein tyrosine phosphatases (PTP) catalyze the dephosphorylation of phosphotyrosine peptides; they regulate phosphotyrosine levels in signal transduction pathways. The depth of the active site cleft renders the enzyme specific for phosphorylated Tyr ...

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      100345001..100520277
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      100192980..100368314
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)