U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from MedGen

    • Showing Current items.

    TGDS TDP-glucose 4,6-dehydratase [ Homo sapiens (human) ]

    Gene ID: 23483, updated on 17-Jun-2024

    Summary

    Official Symbol
    TGDSprovided by HGNC
    Official Full Name
    TDP-glucose 4,6-dehydrataseprovided by HGNC
    Primary source
    HGNC:HGNC:20324
    See related
    Ensembl:ENSG00000088451 MIM:616146; AllianceGenome:HGNC:20324
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    TDPGD; SDR2E1; CATMANS
    Summary
    The protein encoded by this gene is a member of the short-chain dehydrogenases/reductases (SDR) superfamily, and is thought to contain a nicotinamide adenine dinucleotide (NAD) binding domain. This large SDR family of enzymes is involved in the metabolism of a variety of compounds, including prostaglandins, retinoids, lipids, steroid hormones, and xenobiotics. Mutations in this gene have been associated with Catel-Manzke syndrome, which is characterized by Pierre Robin sequence, and radial deviation of the index finger due to the presence of an accessory bone between the index finger and its proximal phalanx. Pierre Robin sequence is defined by an undersized jaw, backwards displacement of the tongue base that causes an obstruction of the airways, and can also be associated with a cleft palate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]
    Expression
    Ubiquitous expression in thyroid (RPKM 7.9), liver (RPKM 6.7) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TGDS in Genome Data Viewer
    Location:
    13q32.1
    Exon count:
    13
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 13 NC_000013.11 (94574054..94596273, complement)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 13 NC_060937.1 (93777561..93799780, complement)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 13 NC_000013.10 (95226308..95248406, complement)

    Chromosome 13 - NC_000013.11Genomic Context describing neighboring genes Neighboring gene dopachrome tautomerase Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr13:95143673-95144872 Neighboring gene uncharacterized LOC124903191 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 5434 Neighboring gene H3K27ac hESC enhancer GRCh37_chr13:95202297-95202796 Neighboring gene tRNA-Phe (anticodon GAA) 1-5 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 7866 Neighboring gene Sharpr-MPRA regulatory region 4462 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr13:95256499-95256998 Neighboring gene G protein-coupled receptor 180 Neighboring gene NADH:ubiquinone oxidoreductase subunit A3 pseudogene 5 Neighboring gene RNA, 5S ribosomal pseudogene 36

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    HIV-1 interactions

    Replication interactions

    Interaction Pubs
    Knockdown of TDP-glucose 4,6-dehydratase (TGDS) by siRNA inhibits HIV-1 replication in HeLa P4/R5 cells PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General protein information

    Preferred Names
    dTDP-D-glucose 4,6-dehydratase
    Names
    growth-inhibiting protein 21
    short chain dehydrogenase/reductase family 2E, member 1
    NP_001291359.1
    NP_055120.1
    XP_011519367.1
    XP_011519368.1
    XP_054230355.1
    XP_054230356.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_041837.1 RefSeqGene

      Range
      5124..27222
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001304430.2NP_001291359.1  dTDP-D-glucose 4,6-dehydratase isoform 2

      See identical proteins and their annotated locations for NP_001291359.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 5' terminal exon, and uses a downstream start codon, compared to variant 1. The encoded isoform (2) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      BC033675, BI914642
      UniProtKB/Swiss-Prot
      O95455
      Conserved Domains (2) summary
      cd05246
      Location:1304
      dTDP_GD_SDR_e; dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs
      TIGR01181
      Location:2306
      dTDP_gluc_dehyt; dTDP-glucose 4,6-dehydratase
    2. NM_014305.4NP_055120.1  dTDP-D-glucose 4,6-dehydratase isoform 1

      See identical proteins and their annotated locations for NP_055120.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) encodes the longest isoform (1).
      Source sequence(s)
      BC033675
      Consensus CDS
      CCDS9471.1
      UniProtKB/Swiss-Prot
      O95455, Q05DQ3, Q2TU31, Q5T3Z2, Q9H1T9
      Related
      ENSP00000261296.5, ENST00000261296.7
      Conserved Domains (1) summary
      cd05246
      Location:18336
      dTDP_GD_SDR_e; dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs

    RNA

    1. NR_130731.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate splice site in an internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC033675, BG702561
    2. NR_130732.2 RNA Sequence

      Status: REVIEWED

      Description
      Transcript Variant: This variant (4) lacks an alternate internal exon, compared to variant 1. This variant is represented as non-coding because the use of the 5'-most expected translational start codon renders the transcript a candidate for nonsense-mediated mRNA decay (NMD).
      Source sequence(s)
      BC033675, BG546428

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000013.11 Reference GRCh38.p14 Primary Assembly

      Range
      94574054..94596273 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_011521066.3XP_011519368.1  dTDP-D-glucose 4,6-dehydratase isoform X1

      See identical proteins and their annotated locations for XP_011519368.1

      Conserved Domains (2) summary
      cd05246
      Location:1304
      dTDP_GD_SDR_e; dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs
      TIGR01181
      Location:2306
      dTDP_gluc_dehyt; dTDP-glucose 4,6-dehydratase
    2. XM_011521065.3XP_011519367.1  dTDP-D-glucose 4,6-dehydratase isoform X1

      See identical proteins and their annotated locations for XP_011519367.1

      Conserved Domains (2) summary
      cd05246
      Location:1304
      dTDP_GD_SDR_e; dTDP-D-glucose 4,6-dehydratase, extended (e) SDRs
      TIGR01181
      Location:2306
      dTDP_gluc_dehyt; dTDP-glucose 4,6-dehydratase

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060937.1 Alternate T2T-CHM13v2.0

      Range
      93777561..93799780 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054374380.1XP_054230355.1  dTDP-D-glucose 4,6-dehydratase isoform X1

    2. XM_054374381.1XP_054230356.1  dTDP-D-glucose 4,6-dehydratase isoform X1