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    EIF2S3 eukaryotic translation initiation factor 2 subunit gamma [ Homo sapiens (human) ]

    Gene ID: 1968, updated on 23-Nov-2023

    Summary

    Official Symbol
    EIF2S3provided by HGNC
    Official Full Name
    eukaryotic translation initiation factor 2 subunit gammaprovided by HGNC
    Primary source
    HGNC:HGNC:3267
    See related
    Ensembl:ENSG00000130741 MIM:300161; AllianceGenome:HGNC:3267
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    EIF2; EIF2G; MEHMO; MRXSBRK; eIF-2gA; EIF2gamma
    Summary
    The protein encoded by this gene is the largest subunit of a heterotrimeric GTP-binding protein involved in the recruitment of methionyl-tRNA(i) to the 40 S ribosomal subunit. [provided by RefSeq, Jan 2010]
    Expression
    Ubiquitous expression in ovary (RPKM 61.4), lymph node (RPKM 53.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See EIF2S3 in Genome Data Viewer
    Location:
    Xp22.11
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) X NC_000023.11 (24054956..24078810)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) X NC_060947.1 (23639400..23663280)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) X NC_000023.10 (24073073..24096927)

    Chromosome X - NC_000023.11Genomic Context describing neighboring genes Neighboring gene apolipoprotein O Neighboring gene chromosome X open reading frame 58 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:23970710-23971248 Neighboring gene OCT4-NANOG-H3K27ac hESC enhancer GRCh37_chrX:23971249-23971786 Neighboring gene Sharpr-MPRA regulatory region 13558 Neighboring gene kelch like family member 15 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29495 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20708 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20709 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20710 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:24043667-24044171 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chrX:24044172-24044675 Neighboring gene H3K4me1 hESC enhancer GRCh37_chrX:24045883-24046382 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 20713 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29496 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29497 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 29498 Neighboring gene uncharacterized LOC124905261 Neighboring gene uncharacterized LOC124905260 Neighboring gene H3K27ac hESC enhancer GRCh37_chrX:24111108-24111608 Neighboring gene small nucleolar RNA SNORA68

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Rev rev HIV-1 Rev interacting protein, eukaryotic translation initiation factor 2, subunit 3 (EIF2S3), is identified by the in-vitro binding experiments involving cytosolic or nuclear extracts from HeLa. The interaction of Rev with EIF2S3 is increased by RRE PubMed
    Tat tat Expression of HIV-1 Tat upregulates the abundance of eukaryotic translation initiation factor 2, subunit 3 gamma (EIF2S3) in the nucleoli of Jurkat T-cells PubMed
    tat HIV-1 Tat competes with eukaryotic initiation factor 2, a well characterized substrate of PKR, for phosphorylation by activated PKR PubMed
    tat Eukaryotic translation initiation factor 2 (eIF2) recognizes and binds the TAR secondary structure in HIV-1 RNA, suggesting a role in Tat transactivation of the viral LTR promoter PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables GTP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables GTPase activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables cadherin binding HDA PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    contributes_to tRNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables translation factor activity, RNA binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables translation initiation factor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables translation initiation factor activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in formation of translation preinitiation complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in translational initiation IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in cytosol TAS
    Traceable Author Statement
    more info
     
    part_of eukaryotic translation initiation factor 2 complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of eukaryotic translation initiation factor 2 complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular exosome HDA PubMed 
    NOT located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    eukaryotic translation initiation factor 2 subunit 3
    Names
    eIF-2-gamma X
    eIF-2gX
    eukaryotic translation initiation factor 2 subunit gamma X
    eukaryotic translation initiation factor 2, subunit 3 gamma, 52kDa
    eukaryotic translation initiation factor 2G
    mental retardation, epileptic seizures, hypogonadism and -genitalism, microcephaly and obesity syndrome
    NP_001406.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_016387.1 RefSeqGene

      Range
      5009..28863
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001415.4NP_001406.1  eukaryotic translation initiation factor 2 subunit 3

      See identical proteins and their annotated locations for NP_001406.1

      Status: REVIEWED

      Source sequence(s)
      AI133612, BC011945, BC019906, BF435665, CB150474
      Consensus CDS
      CCDS14210.1
      UniProtKB/Swiss-Prot
      A0A024RBY4, A8K2Y2, B2R5N2, B5BTZ4, P41091, Q53HK3
      Related
      ENSP00000253039.4, ENST00000253039.9
      Conserved Domains (1) summary
      PTZ00327
      Location:13466
      PTZ00327; eukaryotic translation initiation factor 2 gamma subunit; Provisional

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000023.11 Reference GRCh38.p14 Primary Assembly

      Range
      24054956..24078810
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060947.1 Alternate T2T-CHM13v2.0

      Range
      23639400..23663280
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)