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    PLCE1 phospholipase C epsilon 1 [ Homo sapiens (human) ]

    Gene ID: 51196, updated on 16-Apr-2024

    Summary

    Official Symbol
    PLCE1provided by HGNC
    Official Full Name
    phospholipase C epsilon 1provided by HGNC
    Primary source
    HGNC:HGNC:17175
    See related
    Ensembl:ENSG00000138193 MIM:608414; AllianceGenome:HGNC:17175
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    PLCE; PPLC; NPHS3
    Summary
    This gene encodes a phospholipase enzyme that catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate to generate two second messengers: inositol 1,4,5-triphosphate (IP3) and diacylglycerol (DAG). These second messengers subsequently regulate various processes affecting cell growth, differentiation, and gene expression. This enzyme is regulated by small monomeric GTPases of the Ras and Rho families and by heterotrimeric G proteins. In addition to its phospholipase C catalytic activity, this enzyme has an N-terminal domain with guanine nucleotide exchange (GEF) activity. Mutations in this gene cause early-onset nephrotic syndrome; characterized by proteinuria, edema, and diffuse mesangial sclerosis or focal and segmental glomerulosclerosis. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Sep 2009]
    Expression
    Broad expression in colon (RPKM 6.3), endometrium (RPKM 5.5) and 21 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See PLCE1 in Genome Data Viewer
    Location:
    10q23.33
    Exon count:
    39
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (93993931..94332823)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (94872907..95211918)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (95753688..96092580)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378438 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2632 Neighboring gene PIP5K1A and PSMD4 like (pseudogene) Neighboring gene RNY4 pseudogene 26 Neighboring gene uncharacterized LOC107984255 Neighboring gene PLCE1 antisense RNA 2 Neighboring gene histone deacetylase 1 pseudogene 1 Neighboring gene RNA, U6 small nuclear 657, pseudogene Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3787 Neighboring gene PLCE1 antisense RNA 1 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:96117703-96118368 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:96118369-96119034 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3788 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2633 Neighboring gene NOC3 like DNA replication regulator Neighboring gene MPRA-validated peak1050 silencer Neighboring gene MED14-independent group 3 enhancer GRCh37_chr10:96140095-96141294 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3789 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2634 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2635 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3790 Neighboring gene TBC1 domain family member 12 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:96304601-96305225 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:96305226-96305850 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:96305851-96306474 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:96335135-96335636 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:96335637-96336136 Neighboring gene MPRA-validated peak1052 silencer Neighboring gene helicase, lymphoid specific

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Nephrotic syndrome, type 3 Compare labs

    EBI GWAS Catalog

    Description
    A shared susceptibility locus in PLCE1 at 10q23 for gastric adenocarcinoma and esophageal squamous cell carcinoma.
    EBI GWAS Catalog
    Genetic variants in novel pathways influence blood pressure and cardiovascular disease risk.
    EBI GWAS Catalog
    Genome-wide association study identifies six new loci influencing pulse pressure and mean arterial pressure.
    EBI GWAS Catalog
    Genome-wide association study identifies susceptibility loci for dengue shock syndrome at MICB and PLCE1.
    EBI GWAS Catalog
    Genome-wide association study identifies three new susceptibility loci for esophageal squamous-cell carcinoma in Chinese populations.
    EBI GWAS Catalog
    Genome-wide association study of personality traits in bipolar patients.
    EBI GWAS Catalog
    Genome-wide association study of smoking behaviours in patients with COPD.
    EBI GWAS Catalog
    GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease.
    EBI GWAS Catalog
    Joint analysis of three genome-wide association studies of esophageal squamous cell carcinoma in Chinese populations.
    EBI GWAS Catalog
    Meta-analysis of genome-wide association studies identifies novel loci that influence cupping and the glaucomatous process.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    Envelope surface glycoprotein gp120 env HIV-1 envelope glycoproteins gp120 and gp160 directly and specifically impair the CD3/TcR-mediated activation of phospholipase C (PLC) via the CD4 molecule in uninfected T cells PubMed
    Tat tat Phospholipase C/protein kinase C pathway-dependent phosphorylation of p44/42 and JNK MAP kinases is partially involved in IL-1beta induction by HIV-1 Tat PubMed
    tat HIV-1 Tat induces release of calcium and TNF-alpha production, an effect mediated at least in part by activation of phospholipase C PubMed

    Go to the HIV-1, Human Interaction Database

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ23659, KIAA1516, MGC167842

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables enzyme binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables guanyl-nucleotide exchange factor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables phosphatidylinositol phospholipase C activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables phosphatidylinositol phospholipase C activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables phospholipase C activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables small GTPase binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in G protein-coupled receptor signaling pathway IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Ras protein signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in Ras protein signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in calcium-mediated signaling NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in diacylglycerol biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in diacylglycerol biosynthetic process TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in epidermal growth factor receptor signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in epidermal growth factor receptor signaling pathway NAS
    Non-traceable Author Statement
    more info
    PubMed 
    involved_in glomerulus development IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in intracellular signal transduction IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in lipid catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in phosphatidylinositol metabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phosphatidylinositol-mediated signaling IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IDA
    Inferred from Direct Assay
    more info
    PubMed 
    involved_in positive regulation of lamellipodium assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in release of sequestered calcium ion into cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Golgi membrane IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in lamellipodium IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1
    Names
    PLC-epsilon-1
    pancreas-enriched phospholipase C
    phosphoinositide phospholipase C
    phosphoinositide phospholipase C-epsilon-1
    phosphoinositide-specific phospholipase C epsilon-1
    NP_001159451.1
    NP_001275918.1
    NP_057425.3
    XP_006717948.1
    XP_006717951.1
    XP_006717953.1
    XP_011538152.1
    XP_011538153.1
    XP_011538154.1
    XP_016871799.1
    XP_016871800.1
    XP_016871801.1
    XP_047281240.1
    XP_047281241.1
    XP_047281242.1
    XP_047281243.1
    XP_047281244.1
    XP_047281245.1
    XP_047281246.1
    XP_047281247.1
    XP_047281248.1
    XP_047281249.1
    XP_047281250.1
    XP_047281251.1
    XP_047281252.1
    XP_047281253.1
    XP_047281254.1
    XP_047281255.1
    XP_047281256.1
    XP_047281257.1
    XP_047281258.1
    XP_047281259.1
    XP_054221979.1
    XP_054221980.1
    XP_054221981.1
    XP_054221982.1
    XP_054221983.1
    XP_054221984.1
    XP_054221985.1
    XP_054221986.1
    XP_054221987.1
    XP_054221988.1
    XP_054221989.1
    XP_054221990.1
    XP_054221991.1
    XP_054221992.1
    XP_054221993.1
    XP_054221994.1
    XP_054221995.1
    XP_054221996.1
    XP_054221997.1
    XP_054221998.1
    XP_054221999.1
    XP_054222000.1
    XP_054222001.1
    XP_054222002.1
    XP_054222003.1
    XP_054222004.1
    XP_054222005.1
    XP_054222006.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_015799.2 RefSeqGene

      Range
      5002..343894
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001165979.2NP_001159451.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform 2

      See identical proteins and their annotated locations for NP_001159451.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks two exons and has an additional novel exon at its 5' end, compared to variant 1. These differences produce a unique 5' UTR and cause translation initiation at a novel start codon, compared to variant 1. The encoded protein (isoform 2; also known as PLCepsilon1b) has a shorter and distinct N-terminus, compared to isoform 1.
      Source sequence(s)
      AF170071, AK289852, BC151854, BX491865
      Consensus CDS
      CCDS53555.1
      UniProtKB/TrEMBL
      A0A7I2PPM5
      Related
      ENSP00000501910.1, ENST00000675218.1
      Conserved Domains (6) summary
      cd00275
      Location:15641676
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd01780
      Location:18291928
      PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
      cd08596
      Location:10831525
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      PLN02952
      Location:10101675
      PLN02952; phosphoinositide phospholipase C
      pfam00617
      Location:231405
      RasGEF; RasGEF domain
      pfam09279
      Location:10201071
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    2. NM_001288989.2NP_001275918.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform 3

      See identical proteins and their annotated locations for NP_001275918.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice site in the coding region, compared to variant 1. This results in a shorter protein (isoform 3), compared to isoform 1.
      Source sequence(s)
      AL139124, AL355341, AL365510, BC144286, BC151854
      Consensus CDS
      CCDS91304.1
      UniProtKB/TrEMBL
      A0A8I5KVG7, B7ZM61
      Related
      ENSP00000508605.1, ENST00000692396.1
      Conserved Domains (6) summary
      cd00275
      Location:18561968
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08596
      Location:13751817
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      PLN02952
      Location:13021967
      PLN02952; phosphoinositide phospholipase C
      pfam00617
      Location:539713
      RasGEF; RasGEF domain
      pfam09279
      Location:13121363
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl00155
      Location:21212220
      UBQ; Ubiquitin-like proteins
    3. NM_016341.4NP_057425.3  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform 1

      See identical proteins and their annotated locations for NP_057425.3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1; also known as PLCepsilon1a).
      Source sequence(s)
      AB040949, AF117948, AK074239, AL139124, AL355341, AL365510
      Consensus CDS
      CCDS41552.1
      UniProtKB/Swiss-Prot
      A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
      UniProtKB/TrEMBL
      A0A8I5KVG7
      Related
      ENSP00000360431.2, ENST00000371380.8
      Conserved Domains (6) summary
      cd08596
      Location:13911833
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      PLN02952
      Location:13181983
      PLN02952; phosphoinositide phospholipase C
      cd16203
      Location:11981378
      EFh_PI-PLCepsilon; EF-hand motif found in phosphoinositide phospholipase C epsilon 1 (PI-PLC-epsilon1)
      cd01780
      Location:21342236
      RA2_PLC-epsilon; Ras-associating (RA) domain 2 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
      cd17229
      Location:20072114
      RA1_PLC-epsilon; Ras-associating (RA) domain 1 found in Phosphatidylinositide-specific phospholipase C (PLC)-epsilon
      pfam00617
      Location:539713
      RasGEF; RasGEF domain

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      93993931..94332823
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047425285.1XP_047281241.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

    2. XM_047425289.1XP_047281245.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

      UniProtKB/Swiss-Prot
      A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
    3. XM_047425297.1XP_047281253.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

      UniProtKB/TrEMBL
      B7ZM61
    4. XM_047425287.1XP_047281243.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

    5. XM_017016310.3XP_016871799.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KVG7
      Conserved Domains (6) summary
      cd00275
      Location:18861998
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08596
      Location:13911847
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      PLN02952
      Location:13181997
      PLN02952; phosphoinositide phospholipase C
      pfam00617
      Location:539713
      RasGEF; RasGEF domain
      pfam09279
      Location:13281379
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl00155
      Location:21512250
      UBQ; Ubiquitin-like proteins
    6. XM_047425290.1XP_047281246.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

      UniProtKB/Swiss-Prot
      A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
    7. XM_047425286.1XP_047281242.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

    8. XM_006717885.5XP_006717948.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

      See identical proteins and their annotated locations for XP_006717948.1

      UniProtKB/TrEMBL
      A0A8I5KVG7
      Conserved Domains (6) summary
      cd00275
      Location:18861998
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08596
      Location:13911847
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      PLN02952
      Location:13181997
      PLN02952; phosphoinositide phospholipase C
      pfam00617
      Location:539713
      RasGEF; RasGEF domain
      pfam09279
      Location:13281379
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl00155
      Location:21512250
      UBQ; Ubiquitin-like proteins
    9. XM_006717888.5XP_006717951.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2

      UniProtKB/TrEMBL
      A0A8I5KVG7
      Conserved Domains (6) summary
      cd00275
      Location:18851997
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08596
      Location:13911846
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      PLN02952
      Location:13181996
      PLN02952; phosphoinositide phospholipase C
      pfam00617
      Location:539713
      RasGEF; RasGEF domain
      pfam09279
      Location:13281379
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl00155
      Location:21502249
      UBQ; Ubiquitin-like proteins
    10. XM_047425284.1XP_047281240.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

    11. XM_047425291.1XP_047281247.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

      UniProtKB/Swiss-Prot
      A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
    12. XM_047425296.1XP_047281252.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X4

    13. XM_047425298.1XP_047281254.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

      UniProtKB/TrEMBL
      B7ZM61
    14. XM_047425294.1XP_047281250.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

      UniProtKB/Swiss-Prot
      A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
    15. XM_017016311.3XP_016871800.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

      UniProtKB/TrEMBL
      A0A8I5KVG7
      Conserved Domains (6) summary
      cd00275
      Location:18861998
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd08596
      Location:13911847
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      PLN02952
      Location:13181997
      PLN02952; phosphoinositide phospholipase C
      pfam00617
      Location:539713
      RasGEF; RasGEF domain
      pfam09279
      Location:13281379
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl00155
      Location:21512250
      UBQ; Ubiquitin-like proteins
    16. XM_047425288.1XP_047281244.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2

    17. XM_047425292.1XP_047281248.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

      UniProtKB/Swiss-Prot
      A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
    18. XM_047425293.1XP_047281249.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

      UniProtKB/Swiss-Prot
      A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
      Related
      ENSP00000509490.1, ENST00000692286.1
    19. XM_011539851.4XP_011538153.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X12

      UniProtKB/TrEMBL
      A0A8I5KV08
      Conserved Domains (3) summary
      pfam00617
      Location:539713
      RasGEF; RasGEF domain
      pfam09279
      Location:13281379
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl14615
      Location:13911530
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    20. XM_011539852.4XP_011538154.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X13

      UniProtKB/TrEMBL
      A0A8I5KV08
      Related
      ENSP00000508416.1, ENST00000686954.1
      Conserved Domains (3) summary
      pfam00617
      Location:539713
      RasGEF; RasGEF domain
      pfam09279
      Location:13281379
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
      cl14615
      Location:13911530
      PI-PLCc_GDPD_SF; Catalytic domain of phosphoinositide-specific phospholipase C-like phosphodiesterases superfamily
    21. XM_047425295.1XP_047281251.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X4

    22. XM_047425300.1XP_047281256.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

      UniProtKB/TrEMBL
      B7ZM61
    23. XM_047425299.1XP_047281255.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

      UniProtKB/TrEMBL
      B7ZM61
    24. XM_006717890.4XP_006717953.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X6

      UniProtKB/TrEMBL
      A0A7I2PPM5
      Conserved Domains (6) summary
      cd00275
      Location:15781690
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd01780
      Location:18431942
      PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
      cd08596
      Location:10831539
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      PLN02952
      Location:10101689
      PLN02952; phosphoinositide phospholipase C
      pfam00617
      Location:231405
      RasGEF; RasGEF domain
      pfam09279
      Location:10201071
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    25. XM_047425302.1XP_047281258.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X8

    26. XM_017016312.3XP_016871801.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X9

      UniProtKB/TrEMBL
      A0A7I2PPM5, A0A8I5KXT2
      Related
      ENSP00000509140.1, ENST00000688810.1
    27. XM_047425301.1XP_047281257.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X7

      Related
      ENSP00000360426.1, ENST00000371375.2
    28. XM_011539850.4XP_011538152.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X10

      UniProtKB/TrEMBL
      A0A7I2PPM5
      Conserved Domains (6) summary
      cd00275
      Location:15011613
      C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
      cd01780
      Location:17661865
      PLC_epsilon_RA; Ubiquitin-like domain of Phosphatidylinositide-specific phospholipase
      cd08596
      Location:10061462
      PI-PLCc_epsilon; Catalytic domain of metazoan phosphoinositide-specific phospholipase C-epsilon
      PLN02952
      Location:9331612
      PLN02952; phosphoinositide phospholipase C
      pfam00617
      Location:154328
      RasGEF; RasGEF domain
      pfam09279
      Location:943994
      EF-hand_like; Phosphoinositide-specific phospholipase C, efhand-like
    29. XM_047425303.1XP_047281259.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X11

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      94872907..95211918
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054366006.1XP_054221981.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

    2. XM_054366015.1XP_054221990.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

      UniProtKB/Swiss-Prot
      A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
    3. XM_054366023.1XP_054221998.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

      UniProtKB/TrEMBL
      B7ZM61
    4. XM_054366016.1XP_054221991.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

      UniProtKB/Swiss-Prot
      A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
    5. XM_054366012.1XP_054221987.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

      UniProtKB/Swiss-Prot
      A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
    6. XM_054366019.1XP_054221994.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X4

    7. XM_054366020.1XP_054221995.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

      UniProtKB/TrEMBL
      B7ZM61
    8. XM_054366008.1XP_054221983.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

    9. XM_054366009.1XP_054221984.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

    10. XM_054366013.1XP_054221988.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

      UniProtKB/Swiss-Prot
      A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
    11. XM_054366007.1XP_054221982.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

    12. XM_054366005.1XP_054221980.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

    13. XM_054366010.1XP_054221985.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2

    14. XM_054366017.1XP_054221992.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

      UniProtKB/Swiss-Prot
      A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
    15. XM_054366004.1XP_054221979.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X1

    16. XM_054366011.1XP_054221986.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X2

    17. XM_054366014.1XP_054221989.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X3

      UniProtKB/Swiss-Prot
      A6NGW0, A6NLA1, A7MBN7, A8K1D7, B9EIJ6, Q1X6H8, Q5VWL4, Q5VWL5, Q9H9X8, Q9HBX6, Q9HC53, Q9P212, Q9UHV3
    18. XM_054366030.1XP_054222005.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X12

    19. XM_054366031.1XP_054222006.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X13

    20. XM_054366018.1XP_054221993.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X4

    21. XM_054366022.1XP_054221997.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

      UniProtKB/TrEMBL
      B7ZM61
    22. XM_054366021.1XP_054221996.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X5

      UniProtKB/TrEMBL
      B7ZM61
    23. XM_054366028.1XP_054222003.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X10

    24. XM_054366029.1XP_054222004.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X11

    25. XM_054366024.1XP_054221999.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X6

    26. XM_054366026.1XP_054222001.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X8

    27. XM_054366027.1XP_054222002.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X9

      UniProtKB/TrEMBL
      A0A8I5KXT2
    28. XM_054366025.1XP_054222000.1  1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 isoform X7