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    KAT6B lysine acetyltransferase 6B [ Homo sapiens (human) ]

    Gene ID: 23522, updated on 25-Jan-2024

    Summary

    Official Symbol
    KAT6Bprovided by HGNC
    Official Full Name
    lysine acetyltransferase 6Bprovided by HGNC
    Primary source
    HGNC:HGNC:17582
    See related
    Ensembl:ENSG00000156650 MIM:605880; AllianceGenome:HGNC:17582
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    qkf; MORF; MOZ2; GTPTS; MYST4; ZC2HC6B; querkopf
    Summary
    The protein encoded by this gene is a histone acetyltransferase and component of the MOZ/MORF protein complex. In addition to its acetyltransferase activity, the encoded protein has transcriptional activation activity in its N-terminal end and transcriptional repression activity in its C-terminal end. This protein is necessary for RUNX2-dependent transcriptional activation and could be involved in brain development. Mutations have been found in patients with genitopatellar syndrome. A translocation of this gene and the CREBBP gene results in acute myeloid leukemias. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
    Expression
    Ubiquitous expression in ovary (RPKM 9.9), testis (RPKM 7.9) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See KAT6B in Genome Data Viewer
    Location:
    10q22.2
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (74824936..75032624)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (75698186..75906154)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (76585013..76792382)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC124902459 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3598 Neighboring gene VISTA enhancer hs1500 Neighboring gene family with sequence similarity 32 member C, pseudogene Neighboring gene MPRA-validated peak1017 silencer Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:76555535-76556121 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2500 Neighboring gene H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:76584665-76585436 Neighboring gene NANOG-H3K27ac hESC enhancer GRCh37_chr10:76585437-76586208 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2504 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:76615828-76616038 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:76630209-76630443 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3600 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3601 Neighboring gene MPRA-validated peak1019 silencer Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3602 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:76776654-76776821 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2505 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76789883-76790382 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3603 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3604 Neighboring gene small nucleolar RNA, C/D box 172 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3605 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3606 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76817979-76818530 Neighboring gene dual specificity phosphatase 29 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76829139-76829638 Neighboring gene OCT4-NANOG hESC enhancer GRCh37_chr10:76836023-76836606 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:76839152-76839713 Neighboring gene NANOG-H3K4me1 hESC enhancer GRCh37_chr10:76839714-76840274 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76842102-76842602 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:76844610-76845110 Neighboring gene peptidylprolyl isomerase A pseudogene 13

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Copy number response

    Description
    Copy number response
    Triplosensitivity

    No evidence available (Last evaluated 2018-04-25)

    ClinGen Genome Curation Page
    Haploinsufficency

    Sufficient evidence for dosage pathogenicity (Last evaluated 2018-04-25)

    ClinGen Genome Curation PagePubMed

    EBI GWAS Catalog

    Description
    Genetic variants associated with breast size also influence breast cancer risk.
    EBI GWAS Catalog

    HIV-1 interactions

    Protein interactions

    Protein Gene Interaction Pubs
    integrase gag-pol Cellular acetyltransferase binds HIV-1 integrase both in vitro and in cells and acetylates three specific lysine's (K264, K266, K273) in the carboxy-terminus of integrase PubMed

    Go to the HIV-1, Human Interaction Database

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ90335, KIAA0383, DKFZp313G1618

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables DNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables chromatin binding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone H3 acetyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables histone H3K14 acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables histone acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables metal ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables peptide-lysine-N-acetyltransferase activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables protein-containing complex binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables transcription coactivator activity IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables transcription coregulator activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    part_of MOZ/MORF histone acetyltransferase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of MOZ/MORF histone acetyltransferase complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of MOZ/MORF histone acetyltransferase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleoplasm TAS
    Traceable Author Statement
    more info
     
    part_of nucleosome NAS
    Non-traceable Author Statement
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in nucleus TAS
    Traceable Author Statement
    more info
    PubMed 

    General protein information

    Preferred Names
    histone acetyltransferase KAT6B
    Names
    K(lysine) acetyltransferase 6B
    MOZ, YBF2/SAS3, SAS2 and TIP60 protein 4
    MOZ-related factor
    MYST histone acetyltransferase (monocytic leukemia) 4
    MYST-4
    histone acetyltransferase MORF
    histone acetyltransferase MOZ2
    histone acetyltransferase MYST4
    monocytic leukemia zinc finger protein-related factor
    NP_001243397.1
    NP_001243398.1
    NP_001357061.1
    NP_001357062.1
    NP_001357063.1
    NP_001357064.1
    NP_001357065.1
    NP_001357066.1
    NP_001357067.1
    NP_001357068.1
    NP_001357069.1
    NP_001357070.1
    NP_001357071.1
    NP_001357072.1
    NP_001357073.1
    NP_036462.2
    XP_005269721.1
    XP_016871493.1
    XP_047280867.1
    XP_047280868.1
    XP_047280869.1
    XP_047280871.1
    XP_047280872.1
    XP_047280873.1
    XP_047280874.1
    XP_047280875.1
    XP_047280876.1
    XP_047280877.1
    XP_047280878.1
    XP_047280879.1
    XP_047280880.1
    XP_047280882.1
    XP_047280883.1
    XP_047280884.1
    XP_047280885.1
    XP_054187567.1
    XP_054187568.1
    XP_054187569.1
    XP_054187570.1
    XP_054187571.1
    XP_054187572.1
    XP_054187573.1
    XP_054187574.1
    XP_054187575.1
    XP_054187576.1
    XP_054187577.1
    XP_054187578.1
    XP_054187579.1
    XP_054187580.1
    XP_054187581.1
    XP_054187582.1
    XP_054187583.1
    XP_054187584.1
    XP_054187585.1
    XP_054221326.1
    XP_054221327.1
    XP_054221328.1
    XP_054221329.1
    XP_054221330.1
    XP_054221331.1
    XP_054221332.1
    XP_054221333.1
    XP_054221334.1
    XP_054221335.1
    XP_054221336.1
    XP_054221337.1
    XP_054221338.1
    XP_054221339.1
    XP_054221340.1
    XP_054221341.1
    XP_054221342.1
    XP_054221343.1
    XP_054221344.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_032048.1 RefSeqGene

      Range
      5188..211212
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001256468.2NP_001243397.1  histone acetyltransferase KAT6B isoform 2

      See identical proteins and their annotated locations for NP_001243397.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (2) has the same N- and C-termini but is shorter compared to isoform 1. Variants 2 and 10 both encode the same isoform (2).
      Source sequence(s)
      AC018511, AF119230, AF217500, BC150618, DA488537
      Consensus CDS
      CCDS58085.1
      UniProtKB/TrEMBL
      A7E2B6
      Related
      ENSP00000361809.2, ENST00000372724.6
      Conserved Domains (5) summary
      smart00526
      Location:113167
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:538806
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:271317
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15689
      Location:212270
      PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)
      pfam05466
      Location:12521381
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
    2. NM_001256469.2NP_001243398.1  histone acetyltransferase KAT6B isoform 3

      See identical proteins and their annotated locations for NP_001243398.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) uses an alternate in-frame splice junction at the 3' end of an exon compared to variant 1. The resulting isoform (3) has the same N- and C-termini but is shorter compared to isoform 1. Variants 3 and 11-14 all encode the same isoform (3).
      Source sequence(s)
      AC018511, AF113514, AF217500, BC150618, DA488537
      Consensus CDS
      CCDS58084.1
      UniProtKB/TrEMBL
      A7E2B6
      Related
      ENSP00000497048.1, ENST00000648892.1
      Conserved Domains (5) summary
      smart00526
      Location:113167
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:429697
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:271317
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      NF033845
      Location:12031459
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
      cl22851
      Location:212270
      PHD_SF; PHD finger superfamily
    3. NM_001370132.1NP_001357061.1  histone acetyltransferase KAT6B isoform 4

      Status: REVIEWED

      Source sequence(s)
      AC018511, AC063962
      UniProtKB/TrEMBL
      A7E2B6
      Conserved Domains (5) summary
      smart00526
      Location:113167
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:429643
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:271317
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      pfam05466
      Location:10891218
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      cl22851
      Location:212270
      PHD_SF; PHD finger superfamily
    4. NM_001370133.1NP_001357062.1  histone acetyltransferase KAT6B isoform 5

      Status: REVIEWED

      Source sequence(s)
      AC018511, AC063962
      UniProtKB/TrEMBL
      A7E2B6
      Conserved Domains (4) summary
      smart00526
      Location:113167
      H15; Domain in histone families 1 and 5
      cd15618
      Location:212269
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      pfam05466
      Location:8721001
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      pfam01853
      Location:283390
      MOZ_SAS; MOZ/SAS family
    5. NM_001370134.1NP_001357063.1  histone acetyltransferase KAT6B isoform 6

      Status: REVIEWED

      Source sequence(s)
      AC018511, AC063962
      Conserved Domains (2) summary
      PLN00104
      Location:80294
      PLN00104; MYST -like histone acetyltransferase; Provisional
      pfam05466
      Location:740869
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
    6. NM_001370135.1NP_001357064.1  histone acetyltransferase KAT6B isoform 7

      Status: REVIEWED

      Source sequence(s)
      AC018511, AC063962
      Conserved Domains (2) summary
      pfam05466
      Location:654783
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      pfam01853
      Location:65172
      MOZ_SAS; MOZ/SAS family
    7. NM_001370136.1NP_001357065.1  histone acetyltransferase KAT6B isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (8), as well as variants 1 and 9, encodes isoform 1.
      Source sequence(s)
      AC018511, AC063962
      Consensus CDS
      CCDS7345.1
      UniProtKB/Swiss-Prot
      O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0
      UniProtKB/TrEMBL
      B2RWN8
      Related
      ENSP00000497166.1, ENST00000649463.1
      Conserved Domains (5) summary
      smart00526
      Location:113167
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:721989
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:271317
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:212269
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      pfam05466
      Location:14351564
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
    8. NM_001370137.1NP_001357066.1  histone acetyltransferase KAT6B isoform 1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (9), as well as variants 1 and 8, encodes isoform 1.
      Source sequence(s)
      AC018511, AC063962
      Consensus CDS
      CCDS7345.1
      UniProtKB/Swiss-Prot
      O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0
      UniProtKB/TrEMBL
      B2RWN8
      Conserved Domains (5) summary
      smart00526
      Location:113167
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:721989
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:271317
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:212269
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      pfam05466
      Location:14351564
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
    9. NM_001370138.1NP_001357067.1  histone acetyltransferase KAT6B isoform 2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (10), as well as variant 2, encodes isoform 2.
      Source sequence(s)
      AC018511, AC063962
      Consensus CDS
      CCDS58085.1
      UniProtKB/TrEMBL
      A7E2B6
      Conserved Domains (5) summary
      smart00526
      Location:113167
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:538806
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:271317
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15689
      Location:212270
      PHD1_MORF; PHD finger 1 found in monocytic leukemia zinc finger protein-related factor (MORF)
      pfam05466
      Location:12521381
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
    10. NM_001370139.1NP_001357068.1  histone acetyltransferase KAT6B isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (11), as well as variants 3 and 12-14, encodes isoform 3.
      Source sequence(s)
      AC018511, AC063962
      Consensus CDS
      CCDS58084.1
      UniProtKB/TrEMBL
      A7E2B6
      Conserved Domains (5) summary
      smart00526
      Location:113167
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:429697
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:271317
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      NF033845
      Location:12031459
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
      cl22851
      Location:212270
      PHD_SF; PHD finger superfamily
    11. NM_001370140.1NP_001357069.1  histone acetyltransferase KAT6B isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (12), as well as variants 3, 11, 13, and 14, encodes isoform 3.
      Source sequence(s)
      AC018511, AC063962
      Consensus CDS
      CCDS58084.1
      UniProtKB/TrEMBL
      A7E2B6
      Conserved Domains (5) summary
      smart00526
      Location:113167
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:429697
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:271317
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      NF033845
      Location:12031459
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
      cl22851
      Location:212270
      PHD_SF; PHD finger superfamily
    12. NM_001370141.1NP_001357070.1  histone acetyltransferase KAT6B isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (13), as well as variants 3, 11, 12, and 14, encodes isoform 3.
      Source sequence(s)
      AC018511, AC063962
      Consensus CDS
      CCDS58084.1
      UniProtKB/TrEMBL
      A7E2B6
      Related
      ENSP00000361810.1, ENST00000372725.6
      Conserved Domains (5) summary
      smart00526
      Location:113167
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:429697
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:271317
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      NF033845
      Location:12031459
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
      cl22851
      Location:212270
      PHD_SF; PHD finger superfamily
    13. NM_001370142.1NP_001357071.1  histone acetyltransferase KAT6B isoform 3

      Status: REVIEWED

      Description
      Transcript Variant: This variant (14), as well as variants 3 and 11-13, encodes isoform 3.
      Source sequence(s)
      AC018511, AC063962
      Consensus CDS
      CCDS58084.1
      UniProtKB/TrEMBL
      A7E2B6
      Related
      ENSP00000361799.1, ENST00000372714.6
      Conserved Domains (5) summary
      smart00526
      Location:113167
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:429697
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:271317
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      NF033845
      Location:12031459
      MSCRAMM_ClfB; MSCRAMM family adhesin clumping factor ClfB
      cl22851
      Location:212270
      PHD_SF; PHD finger superfamily
    14. NM_001370143.1NP_001357072.1  histone acetyltransferase KAT6B isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (15), as well as variant 16, encodes isoform 8.
      Source sequence(s)
      AC018511, AC063962
      UniProtKB/TrEMBL
      A7E2B6
      Conserved Domains (5) summary
      smart00526
      Location:113167
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:366634
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:271309
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      pfam05466
      Location:10801209
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      cl22851
      Location:212270
      PHD_SF; PHD finger superfamily
    15. NM_001370144.1NP_001357073.1  histone acetyltransferase KAT6B isoform 8

      Status: REVIEWED

      Description
      Transcript Variant: This variant (16), as well as variant 15, encodes isoform 8.
      Source sequence(s)
      AC018511, AC063962
      UniProtKB/TrEMBL
      A7E2B6
      Conserved Domains (5) summary
      smart00526
      Location:113167
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:366634
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:271309
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      pfam05466
      Location:10801209
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
      cl22851
      Location:212270
      PHD_SF; PHD finger superfamily
    16. NM_012330.4NP_036462.2  histone acetyltransferase KAT6B isoform 1

      See identical proteins and their annotated locations for NP_036462.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1). Variants 1, 8, and 9 all encode the same isoform (1).
      Source sequence(s)
      AC018511, AF217500, BC014143, BC150618, DA488537
      Consensus CDS
      CCDS7345.1
      UniProtKB/Swiss-Prot
      O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0
      UniProtKB/TrEMBL
      B2RWN8
      Related
      ENSP00000287239.4, ENST00000287239.10
      Conserved Domains (5) summary
      smart00526
      Location:113167
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:721989
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:271317
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:212269
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      pfam05466
      Location:14351564
      BASP1; Brain acid soluble protein 1 (BASP1 protein)

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      74824936..75032624
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_047424912.1XP_047280868.1  histone acetyltransferase KAT6B isoform X1

      UniProtKB/Swiss-Prot
      O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0
      UniProtKB/TrEMBL
      B2RWN8
    2. XM_047424919.1XP_047280875.1  histone acetyltransferase KAT6B isoform X3

      UniProtKB/TrEMBL
      A7E2B6
    3. XM_047424927.1XP_047280883.1  histone acetyltransferase KAT6B isoform X5

      UniProtKB/TrEMBL
      A7E2B6
    4. XM_005269664.3XP_005269721.1  histone acetyltransferase KAT6B isoform X1

      See identical proteins and their annotated locations for XP_005269721.1

      UniProtKB/Swiss-Prot
      O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0
      UniProtKB/TrEMBL
      B2RWN8
      Related
      ENSP00000497841.1, ENST00000648725.1
      Conserved Domains (5) summary
      smart00526
      Location:113167
      H15; Domain in histone families 1 and 5
      PLN00104
      Location:721989
      PLN00104; MYST -like histone acetyltransferase; Provisional
      cd15527
      Location:271317
      PHD2_KAT6A_6B; PHD finger 2 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      cd15618
      Location:212269
      PHD1_MOZ_MORF; PHD finger 1 found in monocytic leukemia zinc-finger protein (MOZ) and its factor (MORF)
      pfam05466
      Location:14351564
      BASP1; Brain acid soluble protein 1 (BASP1 protein)
    5. XM_047424913.1XP_047280869.1  histone acetyltransferase KAT6B isoform X2

      UniProtKB/TrEMBL
      B2RWN8
    6. XM_047424916.1XP_047280872.1  histone acetyltransferase KAT6B isoform X3

      UniProtKB/TrEMBL
      A7E2B6
    7. XM_047424923.1XP_047280879.1  histone acetyltransferase KAT6B isoform X5

      UniProtKB/TrEMBL
      A7E2B6
    8. XM_047424929.1XP_047280885.1  histone acetyltransferase KAT6B isoform X6

      UniProtKB/TrEMBL
      A7E2B6
    9. XM_047424911.1XP_047280867.1  histone acetyltransferase KAT6B isoform X1

      UniProtKB/Swiss-Prot
      O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0
      UniProtKB/TrEMBL
      B2RWN8
    10. XM_047424918.1XP_047280874.1  histone acetyltransferase KAT6B isoform X3

      UniProtKB/TrEMBL
      A7E2B6
    11. XM_047424922.1XP_047280878.1  histone acetyltransferase KAT6B isoform X4

      UniProtKB/TrEMBL
      A7E2B6
    12. XM_047424924.1XP_047280880.1  histone acetyltransferase KAT6B isoform X5

      UniProtKB/TrEMBL
      A7E2B6
    13. XM_017016004.3XP_016871493.1  histone acetyltransferase KAT6B isoform X2

      UniProtKB/TrEMBL
      B2RWN8
    14. XM_047424920.1XP_047280876.1  histone acetyltransferase KAT6B isoform X4

      UniProtKB/TrEMBL
      A7E2B6
    15. XM_047424928.1XP_047280884.1  histone acetyltransferase KAT6B isoform X6

      UniProtKB/TrEMBL
      A7E2B6
    16. XM_047424917.1XP_047280873.1  histone acetyltransferase KAT6B isoform X3

      UniProtKB/TrEMBL
      A7E2B6
    17. XM_047424926.1XP_047280882.1  histone acetyltransferase KAT6B isoform X5

      UniProtKB/TrEMBL
      A7E2B6
    18. XM_047424915.1XP_047280871.1  histone acetyltransferase KAT6B isoform X2

      UniProtKB/TrEMBL
      B2RWN8
    19. XM_047424921.1XP_047280877.1  histone acetyltransferase KAT6B isoform X4

      UniProtKB/TrEMBL
      A7E2B6

    Reference GRCh38.p14 PATCHES

    Genomic

    1. NW_009646202.1 Reference GRCh38.p14 PATCHES

      Range
      29342..237300
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054331598.1XP_054187573.1  histone acetyltransferase KAT6B isoform X3

      UniProtKB/TrEMBL
      A7E2B6
    2. XM_054331592.1XP_054187567.1  histone acetyltransferase KAT6B isoform X1

      UniProtKB/Swiss-Prot
      O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0
      UniProtKB/TrEMBL
      B2RWN8
    3. XM_054331596.1XP_054187571.1  histone acetyltransferase KAT6B isoform X2

      UniProtKB/TrEMBL
      B2RWN8
    4. XM_054331605.1XP_054187580.1  histone acetyltransferase KAT6B isoform X5

      UniProtKB/TrEMBL
      A7E2B6
    5. XM_054331610.1XP_054187585.1  histone acetyltransferase KAT6B isoform X6

      UniProtKB/TrEMBL
      A7E2B6
    6. XM_054331593.1XP_054187568.1  histone acetyltransferase KAT6B isoform X1

      UniProtKB/Swiss-Prot
      O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0
      UniProtKB/TrEMBL
      B2RWN8
    7. XM_054331600.1XP_054187575.1  histone acetyltransferase KAT6B isoform X3

      UniProtKB/TrEMBL
      A7E2B6
    8. XM_054331608.1XP_054187583.1  histone acetyltransferase KAT6B isoform X5

      UniProtKB/TrEMBL
      A7E2B6
    9. XM_054331594.1XP_054187569.1  histone acetyltransferase KAT6B isoform X1

      UniProtKB/Swiss-Prot
      O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0
      UniProtKB/TrEMBL
      B2RWN8
    10. XM_054331601.1XP_054187576.1  histone acetyltransferase KAT6B isoform X3

      UniProtKB/TrEMBL
      A7E2B6
    11. XM_054331604.1XP_054187579.1  histone acetyltransferase KAT6B isoform X4

      UniProtKB/TrEMBL
      A7E2B6
    12. XM_054331606.1XP_054187581.1  histone acetyltransferase KAT6B isoform X5

      UniProtKB/TrEMBL
      A7E2B6
    13. XM_054331595.1XP_054187570.1  histone acetyltransferase KAT6B isoform X2

      UniProtKB/TrEMBL
      B2RWN8
    14. XM_054331602.1XP_054187577.1  histone acetyltransferase KAT6B isoform X4

      UniProtKB/TrEMBL
      A7E2B6
    15. XM_054331609.1XP_054187584.1  histone acetyltransferase KAT6B isoform X6

      UniProtKB/TrEMBL
      A7E2B6
    16. XM_054331599.1XP_054187574.1  histone acetyltransferase KAT6B isoform X3

      UniProtKB/TrEMBL
      A7E2B6
    17. XM_054331607.1XP_054187582.1  histone acetyltransferase KAT6B isoform X5

      UniProtKB/TrEMBL
      A7E2B6
    18. XM_054331597.1XP_054187572.1  histone acetyltransferase KAT6B isoform X2

      UniProtKB/TrEMBL
      B2RWN8
    19. XM_054331603.1XP_054187578.1  histone acetyltransferase KAT6B isoform X4

      UniProtKB/TrEMBL
      A7E2B6

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      75698186..75906154
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054365357.1XP_054221332.1  histone acetyltransferase KAT6B isoform X3

      UniProtKB/TrEMBL
      A7E2B6
    2. XM_054365351.1XP_054221326.1  histone acetyltransferase KAT6B isoform X1

      UniProtKB/Swiss-Prot
      O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0
      UniProtKB/TrEMBL
      B2RWN8
    3. XM_054365355.1XP_054221330.1  histone acetyltransferase KAT6B isoform X2

      UniProtKB/TrEMBL
      B2RWN8
    4. XM_054365364.1XP_054221339.1  histone acetyltransferase KAT6B isoform X5

      UniProtKB/TrEMBL
      A7E2B6
    5. XM_054365369.1XP_054221344.1  histone acetyltransferase KAT6B isoform X6

      UniProtKB/TrEMBL
      A7E2B6
    6. XM_054365352.1XP_054221327.1  histone acetyltransferase KAT6B isoform X1

      UniProtKB/Swiss-Prot
      O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0
      UniProtKB/TrEMBL
      B2RWN8
    7. XM_054365359.1XP_054221334.1  histone acetyltransferase KAT6B isoform X3

      UniProtKB/TrEMBL
      A7E2B6
    8. XM_054365367.1XP_054221342.1  histone acetyltransferase KAT6B isoform X5

      UniProtKB/TrEMBL
      A7E2B6
    9. XM_054365353.1XP_054221328.1  histone acetyltransferase KAT6B isoform X1

      UniProtKB/Swiss-Prot
      O15087, Q86Y05, Q8WU81, Q8WYB5, Q9UKW2, Q9UKW3, Q9UKX0
      UniProtKB/TrEMBL
      B2RWN8
    10. XM_054365360.1XP_054221335.1  histone acetyltransferase KAT6B isoform X3

      UniProtKB/TrEMBL
      A7E2B6
    11. XM_054365363.1XP_054221338.1  histone acetyltransferase KAT6B isoform X4

      UniProtKB/TrEMBL
      A7E2B6
    12. XM_054365365.1XP_054221340.1  histone acetyltransferase KAT6B isoform X5

      UniProtKB/TrEMBL
      A7E2B6
    13. XM_054365354.1XP_054221329.1  histone acetyltransferase KAT6B isoform X2

      UniProtKB/TrEMBL
      B2RWN8
    14. XM_054365361.1XP_054221336.1  histone acetyltransferase KAT6B isoform X4

      UniProtKB/TrEMBL
      A7E2B6
    15. XM_054365368.1XP_054221343.1  histone acetyltransferase KAT6B isoform X6

      UniProtKB/TrEMBL
      A7E2B6
    16. XM_054365358.1XP_054221333.1  histone acetyltransferase KAT6B isoform X3

      UniProtKB/TrEMBL
      A7E2B6
    17. XM_054365366.1XP_054221341.1  histone acetyltransferase KAT6B isoform X5

      UniProtKB/TrEMBL
      A7E2B6
    18. XM_054365356.1XP_054221331.1  histone acetyltransferase KAT6B isoform X2

      UniProtKB/TrEMBL
      B2RWN8
    19. XM_054365362.1XP_054221337.1  histone acetyltransferase KAT6B isoform X4

      UniProtKB/TrEMBL
      A7E2B6