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    MSMB microseminoprotein beta [ Homo sapiens (human) ]

    Gene ID: 4477, updated on 2-Nov-2024

    Summary

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    Official Symbol
    MSMBprovided by HGNC
    Official Full Name
    microseminoprotein betaprovided by HGNC
    Primary source
    HGNC:HGNC:7372
    See related
    Ensembl:ENSG00000263639 MIM:157145; AllianceGenome:HGNC:7372
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    MSP; PSP; IGBF; MSPB; PN44; PRPS; HPC13; PSP57; PSP94; PSP-94
    Summary
    The protein encoded by this gene is a member of the immunoglobulin binding factor family. It is synthesized by the epithelial cells of the prostate gland and secreted into the seminal plasma. This protein has inhibin-like activity. It may have a role as an autocrine paracrine factor in uterine, breast and other female reproductive tissues. The expression of the encoded protein is found to be decreased in prostate cancer. Two alternatively spliced transcript variants encoding different isoforms are described for this gene. The use of alternate polyadenylation sites has been found for this gene. [provided by RefSeq, Jul 2008]
    Expression
    Restricted expression toward prostate (RPKM 2642.5) See more
    Orthologs
    mouse all
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    Genomic context

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    See MSMB in Genome Data Viewer
    Location:
    10q11.22
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 10 NC_000010.11 (46033313..46046269, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 10 NC_060934.1 (46914187..46927144, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 10 NC_000010.10 (51549553..51562509)

    Chromosome 10 - NC_000010.11Genomic Context describing neighboring genes Neighboring gene translocase of inner mitochondrial membrane 23 Neighboring gene small nucleolar RNA, H/ACA box 74C-1 Neighboring gene NANOG hESC enhancer GRCh37_chr10:51396871-51397413 Neighboring gene Sharpr-MPRA regulatory region 10440 Neighboring gene nuclear receptor coactivator 4 Neighboring gene ReSE screen-validated silencer GRCh37_chr10:51574030-51574225 Neighboring gene Sharpr-MPRA regulatory region 5969 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 2350 Neighboring gene uncharacterized LOC105378287 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 3324 Neighboring gene H3K27ac hESC enhancer GRCh37_chr10:51551103-51551604 Neighboring gene Sharpr-MPRA regulatory region 2638 Neighboring gene OCT4-NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr10:51541582-51542406 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr10:51528729-51529229 Neighboring gene ribosomal protein L23a pseudogene 61 Neighboring gene Sharpr-MPRA regulatory region 10026 Neighboring gene Sharpr-MPRA regulatory regions 2667 and 7132 Neighboring gene ArfGAP with GTPase domain, ankyrin repeat and PH domain 7, pseudogene

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: HPA RNA-seq normal tissues HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

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    Related articles in PubMed

    1. Disulphide bond reduction and S-carboxamidomethylation of PSP94 affects its conformation but not the ability to bind immunoglobulin. Jagtap DD, et al. Biochim Biophys Acta, 2007 Jun. PMID 17493883
    2. Association of prostate cancer susceptibility variant (MSMB) rs10993994 with risk of spermatogenic failure. Wu W, et al. Gene, 2013 Jul 25. PMID 23608167
    3. Human gene for beta-microseminoprotein: its promoter structure and chromosomal localization. Ochiai Y, et al. J Biochem, 1995 Feb. PMID 7608123
    4. Human seminal plasma beta-microseminoprotein: its purification, characterization, and immunohistochemical localization. Ohkubo I, et al. Int J Biochem Cell Biol, 1995 Jun. PMID 7671139
    5. beta-Microseminoprotein/prostatic secretory protein is a member of immunoglobulin binding factor family. Kamada M, et al. Biochim Biophys Acta, 1998 Oct 14. PMID 9774712

    See all (103) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Validation of prostate cancer risk variants rs10993994 and rs7098889 by CRISPR/Cas9 mediated genome editing.
      Title: Validation of prostate cancer risk variants rs10993994 and rs7098889 by CRISPR/Cas9 mediated genome editing.
    2. A meta-analysis of influence of MSMB promoter rs10993994 polymorphisms on prostate cancer risk.
      Title: A meta-analysis of influence of MSMB promoter rs10993994 polymorphisms on prostate cancer risk.
    3. Low plasma microseminoprotein-beta levels are associated with prostate cancer.
      Title: The role of plasma microseminoprotein-beta in prostate cancer: an observational nested case-control and Mendelian randomization study in the European prospective investigation into cancer and nutrition.
    4. Aggressive prostate tumors suppress MSMB synthesis in the benign prostate and this could explain why serum levels of MSMB are decreased in prostate cancer patients.
      Title: Prostate tumors downregulate microseminoprotein-beta (MSMB) in the surrounding benign prostate epithelium and this response is associated with tumor aggressiveness.
    5. Studies indicate prostate secretory protein of 94 amino acids (PSP94) as a prostate tumor marker [Review].
      Title: Structural and molecular biology of PSP94: Its significance in prostate pathophysiology.
    6. this meta-analysis indicates that MSMB gene rs10993994 polymorphism increases the risk of PC.
      Title: MSMB gene rs10993994 polymorphism increases the risk of prostate cancer.
    7. PSP94 levels differed among idiopathic pulmonary fibrosis, pulmonary sarcoidosis and chronic pulmonary obstructive disease.
      Title: Prognostic significance of surfactant protein A, surfactant protein D, Clara cell protein 16, S100 protein, trefoil factor 3, and prostatic secretory protein 94 in idiopathic pulmonary fibrosis, sarcoidosis, and chronic pulmonary obstructive disease.
    8. Results identified CRISP2 as a potential binding protein of PSP94 from human sperm.
      Title: Identification of CRISP2 from human sperm as PSP94-binding protein and generation of CRISP2-specific anti-peptide antibodies.
    9. decreased expression of MSMB parallels the clinical progression of PC and adjusted serum MSMB levels are associated with PC risk
      Title: Microseminoprotein-Beta Expression in Different Stages of Prostate Cancer.
    10. Based on nasopharyngeal MSP gene expression in readily available Nasopharyngeal aspirate samples , we can discriminate between severity of disease in Respiratory syncytial virus infected infants.
      Title: Nasopharyngeal gene expression, a novel approach to study the course of respiratory syncytial virus infection.
    Submit: New GeneRIF Correction See all GeneRIFs (54)

    Phenotypes

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    Find tests for this gene in the NIH Genetic Testing Registry (GTR)

    Review eQTL and phenotype association data in this region using PheGenI

    Associated conditions

    Description Tests
    Prostate cancer, hereditary, 13
    MedGen: C2677821 OMIM: 611928 GeneReviews: Not available
    		not available

    EBI GWAS Catalog

    Description
    Genetic correction of PSA values using sequence variants associated with PSA levels.
    EBI GWAS Catalog
    Genetic variants at 1q32.1, 10q11.2 and 19q13.41 are associated with prostate-specific antigen for prostate cancer screening in two Korean population-based cohort studies.
    EBI GWAS Catalog
    Genetic variation in prostate-specific antigen-detected prostate cancer and the effect of control selection on genetic association studies.
    EBI GWAS Catalog
    Genome-wide association scan for variants associated with early-onset prostate cancer.
    EBI GWAS Catalog
    Genome-wide association study identified novel genetic variant on SLC45A3 gene associated with serum levels prostate-specific antigen (PSA) in a Chinese population.
    EBI GWAS Catalog
    Genome-wide association study identifies five new susceptibility loci for prostate cancer in the Japanese population.
    EBI GWAS Catalog
    Genome-wide association study identifies genetic determinants of urine PCA3 levels in men.
    EBI GWAS Catalog
    Genome-wide association study identifies new prostate cancer susceptibility loci.
    EBI GWAS Catalog
    Genome-wide association study of hematological and biochemical traits in a Japanese population.
    EBI GWAS Catalog
    Multiple loci identified in a genome-wide association study of prostate cancer.
    EBI GWAS Catalog
    Multiple newly identified loci associated with prostate cancer susceptibility.
    EBI GWAS Catalog

    Variation

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    See variants in ClinVar

    See studies and variants in dbVar

    See Variation Viewer (GRCh37.p13)

    See Variation Viewer (GRCh38)

    Genotypes

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Potential readthrough

    Included gene: NCOA4

    Homology

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables molecular_function ND
    No biological Data available
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    Component Evidence Code Pubs
    located_in extracellular space TAS
    Traceable Author Statement
    more info
    		 PubMed 
    located_in nucleus TAS
    Traceable Author Statement
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    beta-microseminoprotein
    Names
    immunoglobulin binding factor
    prostate secreted seminal plasma protein
    prostate secretory protein of 94 amino acids
    seminal plasma beta-inhibin

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_011551.1 RefSeqGene

      Range
      5001..17957
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_002443.4 → NP_002434.1  beta-microseminoprotein isoform a precursor

      See identical proteins and their annotated locations for NP_002434.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (PSP94) encodes the full length isoform (a).
      Source sequence(s)
      BC005257, BM856408
      Consensus CDS
      CCDS73096.1
      UniProtKB/Swiss-Prot
      B1API6, P08118, P11999, Q13125, Q6IAY9, Q9UC59
      UniProtKB/TrEMBL
      B2R597
      Related
      ENSP00000463092.1, ENST00000582163.3
      Conserved Domains (1) summary
      pfam05825
      Location:21 → 114
      PSP94; Beta-microseminoprotein (PSP-94)

    2. NM_138634.3 → NP_619540.1  beta-microseminoprotein isoform b precursor

      See identical proteins and their annotated locations for NP_619540.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (PSP57) lacks an alternate coding exon compared to variant PSP94, that causes a frameshift. The resulting isoform (b) has a shorter and distinct C-terminus compared to isoform a.
      Source sequence(s)
      BF680662
      Consensus CDS
      CCDS73095.1
      UniProtKB/Swiss-Prot
      P08118
      Related
      ENSP00000462641.1, ENST00000581478.5

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000010.11 Reference GRCh38.p14 Primary Assembly

      Range
      46033313..46046269 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060934.1 Alternate T2T-CHM13v2.0

      Range
      46914187..46927144 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P08118.1 GenPept UniProtKB/Swiss-Prot:P08118

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