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    IL10RB interleukin 10 receptor subunit beta [ Homo sapiens (human) ]

    Gene ID: 3588, updated on 23-Nov-2023

    Summary

    Official Symbol
    IL10RBprovided by HGNC
    Official Full Name
    interleukin 10 receptor subunit betaprovided by HGNC
    Primary source
    HGNC:HGNC:5965
    See related
    Ensembl:ENSG00000243646 MIM:123889; AllianceGenome:HGNC:5965
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    CRFB4; IBD25; CRF2-4; D21S58; D21S66; CDW210B; IL-10R2; IL-10RB
    Summary
    The protein encoded by this gene belongs to the cytokine receptor family. It is an accessory chain essential for the active interleukin 10 receptor complex. Coexpression of this and IL10RA proteins has been shown to be required for IL10-induced signal transduction. This gene and three other interferon receptor genes, IFAR2, IFNAR1, and IFNGR2, form a class II cytokine receptor gene cluster located in a small region on chromosome 21. [provided by RefSeq, Jul 2008]
    Annotation information
    Note: This gene has been reviewed for its involvement in coronavirus biology, and is locus in the vicinity of disease-associated variant(s).
    Expression
    Ubiquitous expression in placenta (RPKM 32.9), colon (RPKM 23.4) and 25 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See IL10RB in Genome Data Viewer
    Location:
    21q22.11
    Exon count:
    9
    Annotation release Status Assembly Chr Location
    RS_2023_10 current GRCh38.p14 (GCF_000001405.40) 21 NC_000021.9 (33266367..33310182)
    RS_2023_10 current T2T-CHM13v2.0 (GCF_009914755.1) 21 NC_060945.1 (31635162..31678970)
    105.20220307 previous assembly GRCh37.p13 (GCF_000001405.25) 21 NC_000021.8 (34638672..34669526)

    Chromosome 21 - NC_000021.9Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105372787 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13249 Neighboring gene IFNAR2-IL10RB readthrough Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13250 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13251 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13252 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13253 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18368 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18369 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18370 Neighboring gene NANOG hESC enhancer GRCh37_chr21:34617736-34618335 Neighboring gene interferon alpha and beta receptor subunit 2 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18371 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18372 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13254 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18373 Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18374 Neighboring gene IL10RB divergent transcript Neighboring gene ATAC-STARR-seq lymphoblastoid active region 18375 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:34676441-34676940 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13255 Neighboring gene IFNAR1 promoter region Neighboring gene interferon alpha and beta receptor subunit 1 Neighboring gene upstream transcription factor 1 pseudogene 1 Neighboring gene Sharpr-MPRA regulatory region 14728 Neighboring gene MED14-independent group 3 enhancer GRCh37_chr21:34738709-34739908 Neighboring gene P300/CBP strongly-dependent group 1 enhancer GRCh37_chr21:34752348-34753547 Neighboring gene Sharpr-MPRA regulatory region 6397 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:34758349-34758554 Neighboring gene IFNGR2 promoter region Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13257 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13258 Neighboring gene ATAC-STARR-seq lymphoblastoid silent region 13259 Neighboring gene CRISPRi-FlowFISH-validated IFNGR2 regulatory element GRCh37_chr21:34776289-34777452 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr21:34784507-34785261 Neighboring gene ReSE screen-validated silencer GRCh37_chr21:34785395-34785563 Neighboring gene interferon gamma receptor 2 Neighboring gene transmembrane protein 50B

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Phenotypes

    Associated conditions

    Description Tests
    Hepatitis B virus, susceptibility to
    MedGen: C1864880 OMIM: 610424 GeneReviews: Not available
    Compare labs
    Inflammatory bowel disease 25
    MedGen: C2675508 OMIM: 612567 GeneReviews: Not available
    Compare labs

    EBI GWAS Catalog

    Description
    Genome wide analysis of narcolepsy in China implicates novel immune loci and reveals changes in association prior to versus after the 2009 H1N1 influenza pandemic.
    EBI GWAS Catalog
    Host-microbe interactions have shaped the genetic architecture of inflammatory bowel disease.
    EBI GWAS Catalog

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Potential readthrough

    Included gene: IFNAR2

    Readthrough IFNAR2-IL10RB

    Readthrough gene: IFNAR2-IL10RB, Included gene: IFNAR2

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables interleukin-10 receptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    contributes_to interleukin-10 receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    enables signaling receptor activity TAS
    Traceable Author Statement
    more info
    PubMed 
    Component Evidence Code Pubs
    part_of interleukin-28 receptor complex NAS
    Non-traceable Author Statement
    more info
    PubMed 
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in plasma membrane TAS
    Traceable Author Statement
    more info
     

    General protein information

    Preferred Names
    interleukin-10 receptor subunit beta
    Names
    IL-10 receptor subunit beta
    IL-10R subunit 2
    IL-10R subunit beta
    cytokine receptor class-II CRF2-4
    cytokine receptor class-II member 4
    cytokine receptor family 2 member 4
    cytokine receptor family II, member 4
    interleukin 10 receptor, beta
    interleukin-10 receptor subunit 2

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    Genomic

    1. NG_012089.1 RefSeqGene

      Range
      4994..35868
      Download
      GenBank, FASTA, Sequence Viewer (Graphics), LRG_152

    mRNA and Protein(s)

    1. NM_000628.5NP_000619.3  interleukin-10 receptor subunit beta isoform 1 precursor

      See identical proteins and their annotated locations for NP_000619.3

      Status: REVIEWED

      Source sequence(s)
      AI025402, AU133530, BC001903, Z17227
      Consensus CDS
      CCDS13623.1
      UniProtKB/Swiss-Prot
      Q08334, Q9BUU4
      UniProtKB/TrEMBL
      H2DF06
      Related
      ENSP00000290200.2, ENST00000290200.7
      Conserved Domains (2) summary
      pfam09294
      Location:111213
      Interfer-bind; Interferon-alpha/beta receptor, fibronectin type III
      cl21522
      Location:21100
      FN3; Fibronectin type 3 domain; One of three types of internal repeats found in the plasma protein fibronectin. Its tenth fibronectin type III repeat contains an RGD cell recognition sequence in a flexible loop between 2 strands. Approximately 2% of all ...
    2. NM_001405849.1NP_001392778.1  interleukin-10 receptor subunit beta isoform 2 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000295
      UniProtKB/TrEMBL
      A0A1B0GTI5, B4DSX5
      Related
      ENSP00000489716.2, ENST00000637650.2
    3. NM_001405850.1NP_001392779.1  interleukin-10 receptor subunit beta isoform 3 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000295
      UniProtKB/TrEMBL
      A0A1B0GU52, B4DSX5
      Related
      ENSP00000489965.2, ENST00000609556.3
    4. NM_001406840.1NP_001393769.1  interleukin-10 receptor subunit beta isoform 4 precursor

      Status: REVIEWED

      Source sequence(s)
      AP000295

    RNA

    1. NR_175973.1 RNA Sequence

      Status: REVIEWED

      Source sequence(s)
      AP000295

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2023_10

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

      Range
      33266367..33310182
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060945.1 Alternate T2T-CHM13v2.0

      Range
      31635162..31678970
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)